Indoline and piperazine containing derivatives as a novel class of mixed D2/D4 receptor antagonists. Part 2: Asymmetric synthesis and biological evaluation

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 21, 2002, Pages 3111-3115

  Zhao, He ^a   He, Xiaoshu ^a   Thurkauf, Andrew ^a   Hoffman, Diane ^a   Kieltyka, Andrzej ^a   Brodbeck, Robbin ^a   Primus, Renee ^a   Wasley, Jan W F ^a  

^a NEUROGEN CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(4 CHLOROBENZYL)PIPERAZINE; 2 [4 (4 CHLOROBENZYL)PIPERAZIN 1 YL] 1 (2 METHY 2,3 DIHYDROINDOL 1 YL)ETHANONE; 2 [4 (4 METHYLBENZYL)PIPERAZIN 1 YL] 1 (2 METHY 2,3 DIHYDROINDOL 1 YL)ETHANONE; ACETONITRILE; CLOZAPINE; DICHLOROMETHANE; DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; EMONAPRIDE; ESTER DERIVATIVE; HALOPERIDOL; INDOLINE 2 CARBOXYLIC ACID METHYL ESTER; KETONE DERIVATIVE; PIPERAZINE DERIVATIVE; POTASSIUM CARBONATE; QUINPIROLE; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIORAL SCIENCE; BINDING AFFINITY; CATALEPSY; CONTROLLED STUDY; DRUG EFFICACY; DRUG HALF LIFE; DRUG SCREENING; DRUG SYNTHESIS; MALE; NONHUMAN; PSYCHOSIS; RAT; RAT STRAIN; RECEPTOR AFFINITY;

AMPHETAMINE; ANIMALS; ANTIPSYCHOTIC AGENTS; BINDING, COMPETITIVE; CATALEPSY; CENTRAL NERVOUS SYSTEM STIMULANTS; CLOZAPINE; DOPAMINE ANTAGONISTS; DRUG EVALUATION, PRECLINICAL; DYSKINESIA, DRUG-INDUCED; HALF-LIFE; HALOPERIDOL; HUMANS; INDICATORS AND REAGENTS; INDOLES; MOTOR ACTIVITY; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037020743     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00656-X     Document Type: Article

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