Long-term treatment with N-acetylcysteine, but not caloric restriction, protects mesenchymal stem cells of aged rats against tumor necrosis factor-induced death

Experimental Gerontology

Volumn 41, Issue 8, 2006, Pages 800-804

  Muscari, Claudio ^a   Bonafe', Francesca ^a   Farruggia, Giovanna ^a   Stanic, Ivana ^b   Gamberini, Chiara ^b   Carboni, Marco ^b   Basile, Ilaria ^a   Giordano, Emanuele ^a   Caldarera, Claudio Marcello ^b   Guarnieri, Carlo ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b National Institute for Cardiovascular Research   (Italy)

Author keywords

Caloric restriction; Cell death; Cell proliferation; Mesenchymal stem cells; N Acetylcysteine; Tumor necrosis factor

Indexed keywords

ACETYLCYSTEINE; TRYPAN BLUE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BONE MARROW; CALORIC RESTRICTION; CELL DEATH; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DEATH; DIET SUPPLEMENTATION; IN VITRO STUDY; LONG TERM CARE; LOW CALORY DIET; MALE; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCYSTEINE; AGING; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CALORIC RESTRICTION; CELL DEATH; CELL PROLIFERATION; DRUG ADMINISTRATION SCHEDULE; MALE; MESENCHYMAL STEM CELLS; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33747111309     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2006.05.003     Document Type: Article

References (27)

1. Armandola E. Caloric restriction and life expectancy. Med. Gen. Med. 6 (2004) 16
2. Belmin J., Bernad C., Corman B., Merval R., Esposito B., and Tedgui A. Increased production of tumor necrosis factor and interleukin-6 by arterial wall of aged rats. J. Physiol. 268 (1995) H2288-H2293
3. Bergman R.J., Gazit D., Kahn A.J., Gruber H., McDougall S., and Hahn T.J. Age-related changes in osteogenic stem cells in mice. J. Bone Miner. Res. 11 (1996) 568-577
4. Csiszar A., Ungvari Z., Koller A., Edwards J.G., and Kaley G. Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries. FASEB J. 17 (2003) 1183-1185
5. Darzynkiewicz Z. Flow cytometry in cytopathology. Overview and perspectives. Anal. Quant. Cytol. Histol. 10 (1988) 459-461
6. De Flora S., Izzotti A., D'Agostini F., and Balansky R.M. Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis 22 (2001) 999-1013
7. Fehrer C., and Lepperdinger G. Mesenchymal stem cell aging. Exp. Gerontol. 40 (2005) 926-930
8. Finkel T., and Holbrook N.J. Oxidant, oxidative stress and the biology of ageing. Nature 408 (2000) 239-247
9. Foster K.D., Conn C.A., and Kluger M.J. Fever, tumor necrosis factor, and interleukin-6 in young, mature, and aged Fischer 344 rats. Am. J. Physiol. 262 2 Pt. 2 (1992) R211-R215
10. Grattagliano I., Portincasa P., Cocco T., Moschetta A., Di Paola M., Palmieri V.O., and Palasciano G. Effect of dietary restriction and N-acetylcysteine supplementation on intestinal mucosa and liver mitochondrial redox status and function in aged rats. Exp. Gerontol. 39 (2004) 1323-1332
11. Grimble R.F. Inflammatory response in the elderly. Curr. Opin. Clin. Nutr. Metab. Care 6 (2003) 21-29
12. Gupta S. A decision between life and death during TNFα-induced signaling. J. Clin. Immunol. 22 (2002) 185-194
13. Handerson J.T., Javaheri M., Kopko S., and Roder J.C. Reduction of lower motor neuron degeneration in wobbler mice by N-acetyl-l-cysteine. J. Neurosci. 16 (1996) 7574-7582
14. Hotamisligil G.S., Shargill N.S., and Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259 (1993) 87-91
15. Krabbe K.S., Pedeersen M., and Bruunsgaard H. Inflammatory mediators in the elderly. Exp. Gerontol. 39 (2004) 687-699
16. Lin Y., Choksi S., Shen H.M., Yang Q.F., Hur G.M., Kim Y.S., Tran J.H., Nedospasov S.A., and Liu Z.G. Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J. Biol. Chem. 279 (2004) 10822-10828
17. Martinez M., Hernandez A.I., and Martinez N. N-Acetylcysteine delays age-associated memory impairment in mice: role in synaptic mitochondria. Brain Res. 855 (2000) 100-106
18. Monti B., Virgili M., and Contestabile A. Alterations of markers related to synaptic function in aging rat brain, in normal conditions or under conditions of long-term dietary manipulation. Neurochem. Int. 44 (2004) 579-584
19. 132-induced apoptosis in bone marrow stromal cells. Stem Cells 23 (2005) 983-991
20. Waf1/Cip1-modulated induction of cell death by the antioxidants N-acetylcysteine and vitamin E. Neoplasia 1 (1999) 544-556
21. Park Y., and Gerson S.L. DNA repair defects in stem cell function and aging. Annu. Rev. Med. 56 (2005) 495-508
22. Schulze-Osthoff K., Krammer P.H., and Droge W. Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death. EMBO J. 13 (1994) 4587-4596
23. Sethe S., Scutt A., and Stolzing A. Aging of mesenchymal stem cells. Ageing Res. Rev. 5 (2006) 91-116
24. Siren A.L., Liu Y., Feuerstein G., and Hallenbeck J.M. Increased release of tumor necrosis factor-alpha into the cerebrospinal fluid an peripheral circulation of aged rats. Stroke 24 (1993) 880-886
25. Stefanelli C., Bonavita F., Stanic I., Pignatti C., Farruggia G., Masotti L., Guarnieri C., and Caldarera C.M. Inhibition of etoposide-induced apoptosis with peptide aldehyde inhibitors of proteasome. Biochem. J. 332 (1998) 661-665
26. Tsuji T., Hughes F.J., McCulloch C.A., and Melcher A.H. Effect of donor age on osteogenic cells of rat bone marrow in vitro. Mech. Ageing Dev. 51 (1990) 121-132
27. Van Zant G., and Liang Y. The role of stem cell in aging. Exp. Hematol. 31 (2003) 659-672