Alterations of markers related to synaptic function in aging rat brain, in normal conditions or under conditions of long-term dietary manipulation

Neurochemistry International

Volumn 44, Issue 8, 2004, Pages 579-584

  Monti, Barbara ^a   Virgili, Marco ^a   Contestabile, Antonio ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

GABAergic system; Long term dietary restriction; N acetylcysteine

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; BIOLOGICAL MARKER; CHOLINE ACETYLTRANSFERASE; GLUTAMATE DECARBOXYLASE; GLUTAMATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; POLYAMINE DERIVATIVE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CALORIC INTAKE; CENTRAL NERVOUS SYSTEM; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DIET RESTRICTION; ENZYME ACTIVITY; GABAERGIC SYSTEM; MALE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD; SYNAPSE;

ACETYLCYSTEINE; AGING; ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; BODY WEIGHT; BRAIN; BRAIN CHEMISTRY; CHOLINE O-ACETYLTRANSFERASE; DENSITOMETRY; DIET; FREE RADICAL SCAVENGERS; MALE; ORNITHINE DECARBOXYLASE; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD; SYNAPSES;

ANIMALIA;

EID: 1542298188     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2003.10.007     Document Type: Article

References (30)

1. Baija G. Rate of generation of oxidative stress-related damage and animal longevity. Free Radic. Biol. Med. 33:2002;1167-1172.
2. Bartus R.T., Dean R.L. III, Beer B., Lippa A.S. The cholinergic hypothesis of geriatric memory disfunction. Science. 217:1982;408-417.
3. Colombo P.G., Gallagher M. Individual differences in spatial memory and striatal ChAT activity among young and aged rats. Neurobiol. Learn. Mem. 70:1998;314-327.
4. Contestabile A. Oxidative stress in neurodegeneration: mechanisms and therapeutic perspectives. Curr. Top. Med. Chem. 1:2001;553-568.
5. De Flora S., Izzotti A., D'Agostini F., Balansky R.M. Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference tp smoking-related end-points. Carcinogenesis. 22:2001;999-1013.
6. Fonnum F. A rapid radiochemical method for the determination of choline acetyltransferase. J. Neurochem. 24:1975;407-409.
7. Fonnum F., Grofova I., Rinvik E., Storm-Mathiesen J., Walberg F. Origin and distribution of glutamate decarboxylase in the substantia nigra of the cat. Brain Res. 71:1974;77-92.
8. Fonnum F., Malthe-Sorenssen D., Lund-Karlsen R., Oddan E. Changes in neurotransmitter parameters in the brain induced by L-cysteine injections in young rat. Brain Res. 579:1992;74-78.
9. Golden T.R., Hinerfeld D.A., Melov S. Oxidative stress and aging: beyond correlation. Aging Cell. 1:2002;117-123.
10. Harman D. Aging: Overview. Ann. N. Y. Acad. Sci. 928:2001;1-21.
11. Henderson J.T., Javaheri M., Kopko S., Roder J.C. Reduction of lower motor neuron degeneration in wobbler mice by N-acetyl-L-cysteine. J. Neurosci. 16:1996;7574-7582.
12. Ingran D.K., London E.D., Goodrick C.L. Age and neurochemical correlates of radial maze performance in rats. Neurobiol. Aging. 2:1981;41-47.
13. Ingram D.K., Juker M., Spangler E.R. Behavioral manifestations of aging. Pathobiol. Aging Rat. 2:1994;149-170.
14. Lee C.-K., Weindruck R., Prolla T.A. Gene-expression profile of the ageing brain in mice. Nat. Genet. 25:2000;294-297.
15. Lee J., Seroogy K.B., Mattson M.P. Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice. J. Neurochem. 80:2002;539-547.
16. Lowry O.H., Rosenbrough R.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
17. Magnusson K.R., Nelson S.E., Young A.B. Age-related changes in the protein expression of subunits of the NMDA receptor. Mol. Brain Res. 99:2002;40-45.
18. Martinez M., Hernandez A.I., Martinez N. N-acetylcysteine delays age-associated memory impairment in mice: role in synaptic mitochondria. Brain Res. 855:2000;100-106.
19. Mattson P., Chan S.L., Duan W. Modification of brain aging and neurodegenerative disorders by genes, diet and behavior. Physiol. Rev. 82:2002;637-672.
20. Mattson P., Duan W., Guo Z. Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms. J. Neurochem. 84:2003;417-431.
21. Morrison J.H., Hof P.R. Life and death of neurons in the aging brain. Science. 278:1997;412-419.
22. Mrak R.E., Griffin S.T., Graham D.I. Aging-associated changes in human brain. J. Neuropathol. Exp. Neurol. 56:1997;1269-1275.
23. O'Donnel E., Lynch M.A. Dietary antioxidant supplementation reverses age-related neuronal changes. Neurobiol. Aging. 19:1998;461-467.
24. Prolla T.A., Mattson M.P. Molecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restriction. Trends Neurosci. 24(Suppl. 11):2001;521-531.
25. Shelke R.R.J., Leeuwenburgh C. Life-long caloric restriction (CR) increases expression of apoptosis repressor with a caspase recruitment domain (ARC) in the brain. FASEB J. 17(3):2003;494-496.
26. Strong R. Neurochemical changes in the aging hum brain: Implications for behavioral impairmant and neurodegenerative diseases. Geriatrics. 53(Suppl. 1):1998;S9-S12.
27. Strong R., Samorajski T., Gottesfeld Z. Regional mapping of neostriatal neurotransmitter systems as a function of aging. J. Neurochem. 39:1982;831-836.
28. Van Schooten F.J., Nia A.B., De Flora S., D'Agostini F., Izzotti A., Camoirano A., Balm A.J., Dallinga J.W., Bast A., Haenen G.R., Van't Veer L., Baas P., Sakai H., Van Zandwijk N. Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers. Cancer Epidemiol. Biomarkers. 11:2002;167-175.
29. Virgili M., Monti B., Polazzi E., Angiolini G., Contestabile A. Topography of neurochemical alterations in the CNS of aged rats. Int. J. Dev. Neurosci. 19:2001a;109-116.
30. Virgili M., Necchi D., Scherini E., Contestabile A. Increase of the ornithine decarboxylase/polyamine system and transglutaminase upregulation in the spinal cord of aged rats. Neurosci. Lett. 309:2001b;62-66.