The mitochondrial electron transfer flavoprotein complex is essential for survival of Arabidopsis in extended darkness

Plant Journal

Volumn 47, Issue 5, 2006, Pages 751-760

  Ishizaki, Kimitsune ^a   Schauer, Nicolas ^b   Larson, Tony R ^c   Graham, Ian A ^c   Fernie, Alisdair R ^b   Leaver, Christopher J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b MAX PLANCK INSTITUTE OF MOLECULAR PLANT PHYSIOLOGY   (Germany)

^c UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Arabidopsis thaliana; Carbohydrate deprivation; Electron transfer flavoprotein (ETF); Isovaleryl CoA; Mitochondria; Phytanoyl CoA

Indexed keywords

CARBOHYDRATES; DNA; ELECTRON TRANSITIONS; ELECTRONS; ENZYMES;

ARABIDOPSIS THALIANA; CARBOHYDRATE DEPRIVATION; ELECTRON TRANSFER FLAVOPROTEIN (ETF); ISOVALERYL COA; PHYTANOYL COA;

PROTEINS;

ARABIDOPSIS PROTEIN; ELECTRON TRANSFERRING FLAVOPROTEIN; MITOCHONDRIAL PROTEIN; PROTEIN SUBUNIT;

ARABIDOPSIS; ARTICLE; BIOLOGICAL MODEL; DARKNESS; GENETICS; HISTOLOGY; METABOLISM; MITOCHONDRION; MUTATION; PHENOTYPE; PHYSIOLOGY; TWO HYBRID SYSTEM; YEAST;

ARABIDOPSIS; ARABIDOPSIS PROTEINS; DARKNESS; ELECTRON-TRANSFERRING FLAVOPROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MODELS, BIOLOGICAL; MUTATION; PHENOTYPE; PROTEIN SUBUNITS; TWO-HYBRID SYSTEM TECHNIQUES; YEASTS;

CARBOHYDRATES; ENZYMES; MITOCHONDRIA; NUCLEIC ACIDS; PROTEINS;

ARABIDOPSIS; MAMMALIA;

EID: 33747037187     PISSN: 09607412     EISSN: 1365313X     Source Type: Journal    
DOI: 10.1111/j.1365-313X.2006.02826.x     Document Type: Article

References (38)

1. Arabidopsis Genome Initiative. (2000) Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature, 408, 796-815.
2. Bartlett, K. and Eaton, S. (2004) Mitochondrial beta-oxidation. Eur. J. Biochem. 271, 462-469.
3. Beckmann, J.D. and Frerman, F.E. (1985) Reaction of electron-transfer flavoprotein with electron-transfer flavoprotein-ubiquinone oxidoreductase. Biochemistry, 24, 3922-3925.
4. Buchanan-Wollaston, V., Page, T., Harrison, E. et al. (2005) Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 42, 567-585.
5. Chien, C.T., Bartel, P.L., Sternglanz, R. and Fields, S. (1991) The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest. Proc. Natl Acad. Sci. USA, 88, 9578-9582.
6. Christensen, C.A., Gorsich, S.W., Brown, R.H., Jones, L.G., Brown, J., Shaw, J.M. and Drews, G.N. (2002) Mitochondrial GFA2 is required for synergid cell death in Arabidopsis. Plant Cell, 14, 2215-2232.
7. Claros, M.G. and Vincens, P. (1996) Computational method to predict mitochondrially imported proteins and their targeting sequences. Eur. J. Biochem. 241, 779-786.
8. Contento, A.L., Kim, S.J. and Bassham, D.C. (2004) Transcriptome profiling of the response of Arabidopsis suspension culture cells to Suc starvation. Plant Physiol. 135, 2330-2347.
9. Däschner, K., Couèe, I. and Binder, S. (2001) The mitochondrial isovaleryl-coenzyme A dehydrogenase of Arabidopsis oxidizes intermediates of leucine and valine catabolism. Plant Physiol. 126, 601-612.
10. Eden, A. and Benvenisty, N. (1999) Involvement of branched-chain amino acid aminotransferase (Bcat1/Eca39) in apoptosis. FEBS Lett. 457, 255-261.
11. Frerman, F.E. (1987) Reaction of electron-transfer flavoprotein ubiquinone oxidoreductase with the mitochondrial respiratory chain. Biochim. Biophys. Acta, 893, 161-169.
12. Frerman, F.E. (1988) Acyl-CoA dehydrogenases, electron transfer flavoprotein and electron transfer flavoprotein dehydrogenase. Biochem. Soc. Trans. 16, 416-418.
13. Frerman, F.E. and Goodman, S.I. (2001) Defects of electron transfer flavoprotein and electron transfer flavoprotein-ubiquinone oxidoreductase: glutaric acidemia type II. In The Metabolic and Molecular Bases of Inherited Disease, Vol. 2 (Scriver, C.R., Sly, W.S., Childs, B., Beaudet, A.L. and Valle, D., eds). New York: McGraw-Hill, pp. 2357-2365.
14. Graham, I.A. and Eastmond, P.J. (2002) Pathways of straight and branched chain fatty acid catabolism in higher plants. Progress in Lipid Research, 41, 156-181.
15. Heazlewood, J.L., Tonti-Filippini, J.S., Gout, A.M., Day, D.A., Whelan, J. and Millar, A.H. (2004) Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Plant Cell, 16, 241-256.
16. Ikeda, Y., Dabrowski, C. and Tanaka, K. (1983) Separation and properties of five distinct acyl-CoA dehydrogenases from rat liver mitochondria. Identification of a new 2-methyl branched chain acyl-CoA dehydrogenase. J. Biol. Chem., 258, 1066-1076.
17. Ishizaki, K., Larson, T.R., Schauer, N., Fernie, A.R., Graham, I.A. and Leaver, C.J. (2005) The critical role of Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase during dark-induced starvation. Plant Cell, 17, 2587-2600.
18. Kruft, V., Eubel, H., Jänsch, L., Werhahn, W. and Braun, H.P. (2001) Proteomic approach to identify novel mitochondrial proteins in Arabidopsis. Plant Physiol. 127, 1694-1710.
19. Landschütze, V., Willmitzer, L. and Müller-Röber, B. (1995) Inhibition of flower formation by antisense repression of mitochondrial citrate synthase in transgenic potato plants leads to a specific disintegration of the ovary tissues of flowers. EMBO J. 14, 660-666.
20. Larson, T.R. and Graham, I.A. (2001) Technical advance: a novel technique for the sensitive quantification of acyl CoA esters from plant tissues. Plant J. 25, 115-125.
21. Larson, T.R., Edgell, T., Byrne, J., Dehesh, K. and Graham, I.A. (2002) Acyl CoA profiles of transgenic plants that accumulate mediumchain fatty acids indicate inefficient storage lipid synthesis in developing oilseeds. Plant J. 32, 519-527.
22. Lin, J.F. and Wu, S.H. (2004) Molecular events in senescing Arabidopsis leaves. Plant J. 39, 612-628.
23. May, M.J. and Leaver, C.J. (1993) Oxidative stimulation of glutathione synthesis in Arabidopsis thaliana suspension cultures. Plant Physiol. 103, 621-627.
24. McKean, M.C., Beckmann, J.D. and Frerman, F.E. (1983) Subunit structure of electron transfer flavoprotein. J. Biol. Chem. 258, 1866-1870.
25. Nakai, K. and Horton, P. (1999) PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization. Trends Biochem. Sci. 24, 34-36.
26. Ogier de Baulny, H. and Saudubray, J.M. (2002) Branched-chain organic acidurias. Semin. Neonatol. 7, 65-74.
27. Oh, S.A., Lee, S.Y., Chung, I.K., Lee, C.H. and Nam, H.G. (1996) A senescence-associated gene of Arabidopsis thaliana is distinctively regulated during natural and artificially induced leaf senescence. Plant Mol. Biol. 30, 739-754.
28. Parker, A. and Engel, P.C. (2000) Preliminary evidence for the existence of specific functional assemblies between enzymes of the beta-oxidation pathway and the respiratory chain. Biochem J, 345, 429-435.
29. Roberts, D.L., Frerman, F.E. and Kim, J.J. (1996) Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution. Proc. Natl Acad. Sci. USA, 93, 14355-14360.
30. Roessner, U., Luedemann, A., Brust, D., Fiehn, O., Linke, T., Willmitzer, L. and Fernie, A. (2001a) Metabolic profiling allows comprehensive phenotyping of genetically or environmentally modified plant systems. Plant Cell, 13, 11-29.
31. Roessner, U., Willmitzer, L. and Fernie, A.R. (2001b) High-resolution metabolic phenotyping of genetically and environmentally diverse potato tuber systems. Identification of phenocopies. Plant Physiol. 127, 749-764.
32. Roessner-Tunali, U., Hegemann, B., Lytovchenko, A., Carrari, F., Bruedigam, C., Granot, D. and Fernie, A.R. (2003) Metabolic profiling of transgenic tomato plants overexpressing hexokinase reveals that the influence of hexose phosphorylation diminishes during fruit development. Plant Physiol. 133, 84-99.
33. Schauer, N., Steinhauser, D., Strelkov, S. et al. (2005) GC-MS libraries for the rapid identification of metabolites in complex biological samples. FEBS Lett. 579, 1332-1337.
34. Schuster, J. and Binder, S. (2005) The mitochondrial branched-chain aminotransferase (AtBCAT-1) is capable to initiate degradation of leucine, isoleucine and valine in almost all tissues in Arabidopsis thaliana. Plant Mol. Biol. 57, 241-254.
35. Skinner, D.J., Baker, S.C., Meister, R.J., Broadhvest, J., Schneitz, K. and Gasser, C.S. (2001) The Arabidopsis HUELLENLOS gene, which is essential for normal ovule development, encodes a mitochondrial ribosomal protein. Plant Cell, 13, 2719-2730.
36. Swidzinski, J.A., Sweetlove, L.J. and Leaver, C.J. (2002) A custom microarray analysis of gene expression during programmed cell death in Arabidopsis thaliana. Plant J. 30, 431-446.
37. Taylor, N.L., Heazlewood, J.L., Day, D.A. and Millar, A.H. (2004) Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. Plant Physiol. 134, 838-848.
38. Zimmermann, P., Hirsch-Hoffmann, M., Hennig, L. and Gruissem, W. (2004) GENEVESTIGATOR. Arabidopsis microarray database and analysis toolbox. Plant Physiol. 136, 2621-2632.