Epidemiology and drug treatment of epilepsy in elderly people

Drugs and Aging

Volumn 15, Issue 4, 1999, Pages 255-269

  Faught, Edward ^a,b  

^a The University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CALCIUM ANTAGONIST; CARBAMAZEPINE; CIMETIDINE; CLARITHROMYCIN; CYCLOSPORIN; DIGOXIN; ERYTHROMYCIN; GABAPENTIN; HALOPERIDOL; IBUPROFEN; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN; SALICYLIC ACID; TIAGABINE; TOPIRAMATE; VALPROIC ACID; VIGABATRIN; WARFARIN;

ADULT; AGED; ALZHEIMER DISEASE; ATAXIA; DRUG BLOOD LEVEL; DRUG CHOICE; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG INTERACTION; DRUG PROTEIN BINDING; DRUG USE; EPILEPSY; EPILEPTIC STATE; FATIGUE; HEADACHE; HEART ARRHYTHMIA; HUMAN; KIDNEY FUNCTION; LEUKOPENIA; LIVER FUNCTION; LIVER METABOLISM; MAJOR CLINICAL STUDY; NEUROLOGIC DISEASE; PRIORITY JOURNAL; PROGNOSIS; RASH; REVIEW; SOMNOLENCE; THROMBOCYTOPENIA; TREMOR; VERTIGO; VISUAL DISORDER;

AGED; ANTICONVULSANTS; EPILEPSY; HUMANS; INCIDENCE; PREVALENCE;

EID: 0032720424     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-199915040-00002     Document Type: Review

References (65)

1. Lennox WE, Lennox MA. Epilepsy and related disorders. Boston (MA): Little Brown, 1960
2. Gudmundsson GE. Epilepsy in Iceland: a clinical and epidemiological investigation. Acta Neurol Stand 1966; 43 Suppl. 25: 1-124
3. Luhdorf K, Hensen LK, Plesner AM. Epilepsy in the elderly: incidence, social function, and disability. Epilepsia 1986; 27: 135-41
4. Olaffson E, Hauser WA, Ludviggson P, et al. Incidence and prevalence of epilepsy in rural Iceland, Epilepsia 1994; 35: 151-6
5. Sander JWA, Hart YM, Johnson AL, et al. National general practice study of epilepsy with newly diagnosed epileptic seizures in a general population. Lancet 1990; 336: 1267-72
6. Hildick-Smith M. Late-onset epilepsy, Br J Clin Pract 1994; 48: 87-90
7. Willmore LJ. Management of epilepsy in the elderly. Epilepsia 1996; 37: 23-33
8. Scheuer ML, Cohen I. Seizures and epilepsy in the elderly. Neural Clin 1993; 11: 787-804
9. Hauser WA, Annegers JK, Kurland LT. The incidence of epilepsy in Rochester, Minnesota, 1935 1984. Epilepsia 1993; 34: 453-9
10. Hauser WA. Epidemiology of seizures in the elderly. In: Rowan AJ, Ramsay RE, editors, Seizures and epilepsy in the elderly, Newton (MA): Butterworth-Heinemann, 1997: 7-20
11. Tallis R, Hall G, Craig I, et al. How common are epileptic seizures in old age? Age Ageing 1991; 20: 442-8
12. Wallace H, Shorvon S, Tallis R. Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2052 922 and age-specific fertility rates of women with epilepsy. Lancet 1998; 352: 1970-3
13. Hesdorffer DC, Hauser WA, Annegers JF, et al. Dementia and adult-onset unprovoked seizures. Neurology 1996; 46: 727-30
14. McArcavey MJ, Ballinger BR, Fenton GW. Epileptic seizures in elderly patients with dementia. Epilepsia 1992; 33: 657-60
15. Hanser WA. Morris ML, Hewton LL, et al. Seizures and myoclonus in patients with Alzheimer's disease. Neurology 1986; 36: 1226-30
16. Romanelli MF, Morris JC, Ashkin K, et al. Advanced Alzheimer's disease as a risk factor for late onset seizures. Arch Neurol 1990; 47: 847-51
17. Mendez MF, Catanzaro P, Doss RC, et al. Seizures in Alzheimer's disease: clinicopathologic study, J Geriatr Psychiatry Neurol 1994; 7: 230-3
18. Tinuper P, Provini F, Marini C, et al. Partial epilepsy of long duration: changing semiology with age. Epilepsia 1996: 37: 162-4
19. Drury I, Beydoun A. Interictal epileptiform activity in elderly patients with epilepsy. Electroencephalogr Clin Neurophysiol 1998; 106: 369-73
20. DeLorenzo RJ. Clinical and epidemiologic study of status epilepticus in the elderly. In: Rowan AJ, Ramsay RE, editors. Seizures and epilepsy in the elderly. Newton (MA): Butterworth-Heinemann, 1997; 191-206
21. Smith DF, Baker GA, Dewey M, et al. Seizure frequency, patient-perceived seizure frequency, and the psychosocial consequences of intractable epilepsy. Epilepsy Res 1991; 9: 231-41
22. Grisso JA, Kelsey JL, Strom BL, et al. Risk factors for falls as a cause of hip fracture in women. New Engl J Med 1991; 324: 1326-8
23. Eadie ML. Anticonvulsants in the elderly. Med J Aust 1994; 160: 440-3
24. Burn J, Dennis M, Bamford J, et al. Epileptic seizures after a first stroke: the Oxfordshire Community Stroke Project. BMJ 1997; 315: 1582-7
25. Maltson RH, Cramer JA, Collins JF. Prognosis for total control of complex partial and secondary generalized tonic-clonic seizures. Neurology 1996; 47: 68-76
26. Ramsay RE, Rowan AJ, Slater JD, et al. Effect of age on epilepsy and its treatment: results from the VA Cooperative Study [abstract], Epilepsia 1994; 35 Suppl. 8
27. Cloyd JC, Lackner TE, Leppik IE. Antiepileptics in the elderly: pharmacoepidemiology and pharmacokinetics. Arch Fam Med 1994; 3: 589-98
28. Willmore LJ. The effect of age on pharmacokinetics of antiepileptic drugs. Epilepsia 1995; 36: 514-21
29. Drusano GL, Muncie HL, Hoopes JM, et al. Commonly used methods of estimating creatinine clearance are inadequate for elderly debilitated nursing home patients. J Am Geriatr Soc 1988; 36: 437-41
30. Leppik IE, Wolf D. Drug interactions in the elderly with epilepsy. In: Rowan AJ, Ramsay RE, editors. Seizures and epilepsy in the elderly. Newton (MA): Butterworth Heinemann, 1997: 291-302
31. Kuh H. Interactions between antiepileptic other drugs. In: Pitlick WH editor. Drug interactions New York: Demos 1989: 39-49
32. Peck AW. Clinical pharmacology of lamotrigine. Epilepsia 1991; 32 Suppl.: S9-S12
33. Cameron H, Macphee GJA. Anticonvulsant therapy in the elderly: a need for placebo-controlled trials. Epilepsy Res 1995; 21: 149-57
34. Craig I, Tallis R. Impact of valproate and phenytoin on cognitive function in elderly patients: results of a single-blind randomized comparative study. Epilepsia 1994; 35: 381-90
35. Read CL, Stephen LJ, Stolarck IH, et al. Cognitive effects of anticonvulsant monotherapy in elderly patients: a placebo-controlled study. Seizure 1998; 7: 159-62
36. Vermeulen J, Aldencamp AP. Cognitive side effects of chronic antiepileptic drug treatment: a review of 25 years of research. Epilepsy Res 1995; 22: 65-95
37. Meador KJ, Loring DW, Allen ME, et al. Comparative cognitive effects of carbamazepine and phenytoin in healthy adults. Neurology 1991; 41: 1537-40
38. Dodrill CB, Cognitive and adjustmental consequences of seizures and antiepileptic drugs in the elderly, In: Rowan AJ, Ramsay RE, editors. Seizures and epilepsy in the elderly, Newton (MA): Butterworth-Heinemann, 1997: 179-90
39. Hasegawa H, Kanner AM. Seizure control after chronic pharmacotherapy in epileptic disorders beginning after 40 years of age, Clin Neuropharmacol 1995; 18: 13-22
40. Bauer LA, Blouin RA. Age and phenytoin kinetics in adult epileptics, Clin Pharmacol Ther 1982; 32; 3010-3
41. Stolarek IH, Brodie AF, Brodie MJ. Management of seizures in the elderly: a survey of UK geriatricians, J R Soc Med 1995; 88: 686-9
42. Kalff R, Houtkooper MA, Meyer JW, et al. Carbamazepine and serum sodium levels. Epilepsia 1984; 25: 390-7
43. Kenneback G, Bergfeldt L, Vallin H, et al. Electrophysiological effects and clinical hazards of carbamazepine treatment for neurologic disorders in patients with abnormalities of the cardiac conduction system. Am Heart J 1991; 121: 1421-4
44. Pellock JM. Carbamazepine side effects in children and adults. Epilepsia 1987; 28: 64-7
45. Perucca E, Grimaldi R, Gatti G, et al. Pharmacokinetics of valproic acid in the elderly. Br J Clin Pharmacol 1984; 17: 665-9
46. Ammon C, Shin C, Miller P, et al. Reversible parkinsonism and cognitive impairment with chronic valproate use. Neurology 1998; 47: 626-35
47. Dreifuss FE. Valproate toxicity. In: Levy RH, Mattson RH, Meldrum BS, et al., editors. Antiepileptic drugs. 3rd ed. New York: Raven Press, 1989: 643-5
48. Smith D. Cognitive effects of antiepileptic drugs. In: Smith D, Treiman D, Trimble M, editors. Advances in neurology. New York: Raven Press, 1991: 197-212
49. Marson AG, Kadir ZA, Chadwick DW. New antiepileptic drugs: a systematic review of their efficacy and tolerability. BMJ 1996; 313: 1169-74
50. The US Gabapentin Study Group No, 5, Gabapentin as add-on therapy in refractory epilepsy; a double-blind, placebo-controlled, parallel group study. Neurology 1993; 43: 2292-8
51. Morris GL. Use of gabapentin in patients over 50 years of age [abstract]. J Epilepsy 1996; 9:144
52. Brodie MJ, Richens A, Yuen AWC. Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy. Lancet 1995; 345: 476-9
53. Gilliam F, Vasquez B, Sackellares JC, et al. An active-control trial of lamotrigine monotherapy for partial-onset seizures. Neurology 1998; 51: 1018-25
54. Faught E, Morris G, Jacobson M, et al. Adding lamotrigine to valproate: incidence of rash and other adverse effects. Epilepsia 1999; 40: 1135-40
55. Faught E, Wilder BJ, Ramsay RE, et al. Topiramate placebo. controlled dose-ranging trial in refractory partial epilepsy using 200, 400, and 600mg daily dosages. Neurology 1996; 6: 1684-90
56. Reife RA. Pledger GW. Topiramate as adjunctive therapy in refractory partial epilepsy: pooled analysis of data from five double-blind, placebo-controlled trials. Epilepsia 1997; 38: 31-3
57. Privitera M, Fincham R, Penry J, et al. Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600, 800, 1000mg daily dosages. Neurology 1996; 6: 1678-83
58. Faught E, Kuzniecky RI, Gilliam F. Cognitive adverse effects of topiramate [abstract]. Neurology 1997; 48: A336
59. Leppik IE. Tiagabine: the safety landscape. Epilepsia 1995; 36: 510-3
60. Snel S, Jansen JA, Mengel HB. The pharmacokinetics of tiagabine in healthy elderly volunteers and elderly patients with epilepsy. J Clin Pharmacol 1997; 37: 1015-30
61. Dean C, Mosier M, Penry K, et al. Dose-response study of vigabatrin as add-on therapy in patients with uncontrolled complex partial seizures. Epilepsia 1999; 40: 74-82
62. Eke T, Talbot JF, Lawden MC. Severe persistent visual field constriction associated with vigahatrin. BMJ 1997; 314: 180-1
63. Drury I, Selwa LM, Schuh LA, et al. Value of inpatient CCTV-EEG monitoring in the elderly. Epilepsia 1999; 40: 1100-2
64. Heinz ER, Heinz TR, Radtke R, et al. Efficacy of MRI vs CT in epilepsy. Am J Neuroradiol 1988; 9: 1123-8
65. Kuzniccky RI, Jackson GD. Magnetic resonance in epilepsy. New York: Raven Press, 1995