Effects of sivelestat, a new elastase inhibitor, on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells

Journal of Anesthesia

Volumn 20, Issue 3, 2006, Pages 159-165

  Misumi, Takuyo ^a   Tanaka, Takanori ^a   Mikawa, Katsuya ^a   Nishina, Kahoru ^a   Morikawa, Osamu ^a   Obara, Hidefumi ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Chemokine; Elastase inhibitors; Messenger RNA; Pneumocytes; Real time PCR

Indexed keywords

CHEMOKINE; COMPLEMENTARY DNA; ENDOTOXIN; INTERLEUKIN 8; LEUKOCYTE ELASTASE INHIBITOR; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; SIVELESTAT; TUMOR NECROSIS FACTOR ALPHA;

ANALYSIS OF VARIANCE; ARTICLE; CELL CULTURE; CELL LINE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DNA SYNTHESIS; DOSE TIME EFFECT RELATION; DRUG MECHANISM; DRUG MEGADOSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; PHARMACOGENETICS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS REGULATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION;

CELLS, CULTURED; CHEMOKINE CCL2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; GLYCINE; HUMANS; INTERLEUKIN-8; POLYMERASE CHAIN REACTION; PULMONARY ALVEOLI; RESPIRATORY MUCOSA; RNA, MESSENGER; SERINE PROTEINASE INHIBITORS; SULFONAMIDES; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33746910212     PISSN: 09138668     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00540-006-0391-z     Document Type: Article

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