Development of a rat pilocarpine model of seizure/status epilepticus that mimics chemical warfare nerve agent exposure

Toxicology and Industrial Health

Volumn 22, Issue 6, 2006, Pages 255-266

  Tetz, Lauren M ^a   Rezk, Peter E ^a   Ratcliffe, Ruthie H ^a   Gordon, Richard K ^a   Steele, Keith E ^a   Nambiar, Madhusoodana P ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

chemical warfare agents; drug development; lithium pilocarpine; neuroprotection; organo phosphates; rats; seizure; status epileptics

Indexed keywords

CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; LITHIUM CHLORIDE; NEUROPROTECTIVE AGENT; ORGANOPHOSPHATE; PILOCARPINE; SCOPOLAMINE METHYL BROMIDE; SOMAN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BLOOD BRAIN BARRIER; BODY TEMPERATURE; CENTRAL NERVOUS SYSTEM; CHEMICAL WARFARE; CONTROLLED STUDY; CONVULSION; ELECTROCARDIOGRAM; ELECTROENCEPHALOGRAM; EPILEPTIC STATE; HIPPOCAMPUS; HISTOPATHOLOGY; NERVE CELL LESION; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PHYSICAL ACTIVITY; RAT; SEIZURE; TELEMETRY;

ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; BODY TEMPERATURE; BRAIN; CHEMICAL WARFARE AGENTS; CHOLINERGIC ANTAGONISTS; DRUG EVALUATION, PRECLINICAL; ELECTROENCEPHALOGRAPHY; HEART RATE; LETHAL DOSE 50; LITHIUM CHLORIDE; MALE; MODELS, ANIMAL; MOTOR ACTIVITY; MUSCARINIC AGONISTS; N-METHYLSCOPOLAMINE; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; PILOCARPINE; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SOMAN; STATUS EPILEPTICUS;

ANIMALIA;

EID: 33746907449     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1191/0748233706th268oa     Document Type: Article

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