In vitro metabolism of the epoxide substructure of cryptophycins by cytosolic glutathione S-transferase: Species differences and stereoselectivity

Xenobiotica

Volumn 36, Issue 8, 2006, Pages 659-670

  Cannady, E A ^a   Chien, C ^b   Jones, T M ^a   Borel, A G ^a  

^a ELI LILLY AND COMPANY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Cryptophycin; Cytosol; Gluthathione S transferase (GST)

Indexed keywords

CRYPTOPHYCIN 52; CRYPTOPHYCIN 53; CRYPTOPHYCIN DERIVATIVE; EPOXIDE; EPOXIDE HYDROLASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG CONJUGATION; DRUG METABOLISM; DRUG SOLUBILITY; ENZYME ACTIVITY; ENZYME KINETICS; HUMAN; IN VITRO STUDY; LIVER CYTOSOL; LIVER MICROSOME; MALE; MICHAELIS CONSTANT; MICHAELIS MENTEN KINETICS; MONKEY; MOUSE; NONHUMAN; RAT; SPECIES DIFFERENCE; STEREOCHEMISTRY; STEREOISOMERISM;

ANIMALS; CHROMATOGRAPHY, LIQUID; CYTOSOL; DEPSIPEPTIDES; DINITROCHLOROBENZENE; DOGS; EPOXIDE HYDROLASES; EPOXY COMPOUNDS; GLUTATHIONE TRANSFERASE; HUMANS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; SPECIES SPECIFICITY;

CANIS FAMILIARIS;

EID: 33746903530     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250600720593     Document Type: Article

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