Effects of chronic betaine ingestion on methionine-loading induced plasma homocysteine elevation in rats

Journal of Nutritional Science and Vitaminology

Volumn 52, Issue 3, 2006, Pages 194-199

  Yagisawa, Masako ^a   Shigematsu, Norihiro ^a   Nakata, Rieko ^b  

^a Central Research Development Laboratory Fancl Corporation   (Japan)

^b NARA WOMEN'S UNIVERSITY   (Japan)

Author keywords

Betaine; Chronic ingestion; Homocysteine; Methionine loading; Rats

Indexed keywords

AMINO ACID; BETAINE; HOMOCYSTEINE; METHIONINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; COMPARATIVE STUDY; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; FOOD INTAKE; INGESTION; JAPAN; MALE; NONHUMAN; NUTRIENT LOADING; PLASMA; RAT;

ANALYSIS OF VARIANCE; ANIMALS; AREA UNDER CURVE; BETAINE; BETAINE-HOMOCYSTEINE S-METHYLTRANSFERASE; CARNITINE; CHOLINE; GASTROINTESTINAL AGENTS; HOMOCYSTEINE; INJECTIONS, INTRAVENOUS; LIVER; MALE; METHIONINE; RATS; RATS, WISTAR; TIME FACTORS;

EID: 33746897013     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.52.194     Document Type: Article

References (31)

1. Zeisel SH, Mar MH, Howe JC, Holden JM. 2003. Concentrations of choline-containing compounds and betaine in common foods. J Nutr 133: 1302-1307.
2. Zeisel SH. 1998. Choline and phosphatidylcholine. In: Modern Nutrition in Health and Disease (Shils ME, Olson JA, Shike M, Ross AC, eds), Chapter 32. Lippincott Williams & Wilkins, Philadelphia.
3. Craig SA. 2004. Betaine in human nutrition. Am J Clin Nutr 80: 539-549.
4. Selhub J. 1999. Homocysteine metabolism. Annu Rev Nutr 19: 217-246.
5. Urgert R, Vliet T, Zock PL, Katan MB. 2000. Heavy coffee consumption and plasma homocysteine: a randomized controlled trial in healthy volunteers. Am J Clin Nutr 72: 1107-1110.
6. Broekmans WMR, Klöpping-Ketelaars IAA, Schuurman CRWC, Verhagen H, Berg H, Kok FJ, Poppel G. 2000. Fruits and vegetables increase plasma carotenoids and vitamins and decrease homocysteine in humans. J Nutr 130: 1578-1583.
7. Stein JH, Bushara M, Bushara K, McBride PE, Jorenby DE, Fiore MC. 2002. Smoking cessation, but not smoking reduction, reduces plasma homocysteine levels. Clin Cardiol 25: 23-26.
8. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. 1995. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 274: 1049-1057.
9. Duell PB, Malinow MR. 1997. Homocyst(e)ine: an important risk factor for atherosclerotic vascular disease. Curr Opin Lipidol 8: 28-34.
10. Pietrzik K, Bronstrup A. 1997. Causes and consequences of hyperhomocyst(e)inemia. Int J Vitam Nutr Res 67: 389-395.
11. Mayer EL, Jacobsen DW. Robinson K. 1996. Homocysteine and coronary atherosclerosis. J Am Coll Cardiol 27: 517-527.
12. Buccianti G, Baragetti I, Bamonti F, Furiani S, Dorighet V, Patrosso C. 2004. Plasma homocysteine levels and cardiovascular mortality in patients with end-stage renal disease. J Nephrol 17: 405-410.
13. Schwab U, Torronen A, Toppinen L, Alfthan G, Saarinen M, Aro A, Uusitupa M. 2002. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 76: 961-967.
14. Fohr IP, Prinz-Langenohl R, Brönstrup A, Bohlmann AM, Nau H, Berthold HK, Pietrzik K. 2002. 5,10-Methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women. Am J Clin Nutr 75: 275-282.
15. Brouwer IA, Dusseldorp M, Thomas CMG, Duran M, Hautvast JGAJ, Eskes TKAB, Steegers-Theunissen RPM. 1999. Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial. Am J Clin Nutr 69: 99-104.
16. Steenge GR, Verhoef P, Katan MB. 2003. Betaine supplementation lowers plasma homocysteine in healthy men and women. J Nutr 133: 1291-1295.
17. Yagisawa M, Okawa N, Shigematsu N, Nakata R. 2004. Effects of intravenous betaine on methionine-loading-induced plasma homocysteine elevation in rats. J Nutr Biochem 15: 666-671.
18. Walzern RL, Clifford AJ. 1988. Folate deficiency in rats fed diets containing free amino acids or intact proteins. J Nutr 118: 1089-1096.
19. American Institute of Nurtition. 1977. Report of the American Institute of Nurtition ad hoc Committee on Standards for Nutritional Studies. J Nutr 107: 1340-1348.
20. Erlund I, Meririnne E, Alfthan G, Aro A. 2001. Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice. J Nutr 131: 235-241.
21. Paulson SK, Vaughn MB, Jessen SM, Lawal Y, Gresk CJ, Yan B, Maziasz TJ, Cook CS, Karim A. 2001. Pharmacokinetics of celecoxib after oral administration in dogs and humans: effect of food and site of absorption. J Pharmacol Exp Ther 297: 638-645.
22. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275.
23. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA. 2002. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346: 476-483.
24. Leboeuf R. 2003. Homocysteine and Alzheimer's disease. J Am Diet Assoc 103: 304-307.
25. Wu LL, Wu JT. 2002. Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker. Clin Chim Acta 322: 21-28.
26. Ellenberg SS, Orloff DG, Temple RJ. 2004. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 351: 1027-1030.
27. Schwahn BC, Hafner D, Hohlfeld T, Balkenhol N, Laryea MD, Wendel U. 2003. Pharmacokinetics of oral betaine in healthy subjects and patients with homocystinuria. Br J Clin Pharmacol 55:6-13.
28. McKeever MP, Weir DG, Molloy A, Scott JM. 1991. Betaine-homocysteine methyltransferase: organ distribution in man, pig and rat and subcellular distribution in the rat. Clin Sci 81: 551-556.
29. Kuhn SH, Gemperli B, Shephard EG, Joubert JR, Weidemann PA, Weissmann G, Finkelstein MC. 1983. Interaction of liposomes with human leukocytes in whole blood. Biochim Biophys Acta 762: 119-127.
30. Park EI, Garrow TA. 1999. Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene. J Biol Chem 274: 7816-7824.
31. Holm PI, Ueland PM, Vollset SE, Midttun O, Blom HJ, Keijzer MB, den Heijer M. 2005. Betaine and folate status as cooperative determinants of plasma homocysteine in humans. Arterioscler Thromb Vasc Biol 25: 379-385.