Juvenile idiopathic arthritis

Autoimmunity Reviews

Volumn 5, Issue 4, 2006, Pages 279-298

  Borchers, Andrea T ^a   Selmi, Carlo ^b,c   Cheema, Gurtej ^b   Keen, Carl L ^a   Shoenfeld, Yehuda ^d   Gershwin, M Eric ^b  

^a Department of Nutrition ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c San Paolo School of Medicine   (Italy)

^d Sheba Cancer Research Center   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; AZATHIOPRINE; BIOLOGICAL FACTOR; CHLORAMBUCIL; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; IMMUNOMODULATING AGENT; INFLIXIMAB; INTERLEUKIN 6 ANTIBODY; LEFLUNOMIDE; METHOTREXATE; MYDRIATIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; SALAZOSULFAPYRIDINE; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; ANTINUCLEAR ANTIBODY; ANTIRHEUMATIC AGENT; MONOCLONAL ANTIBODY;

AMYLOIDOSIS; ARTHRITIS; AUTOIMMUNE DISEASE; AUTOIMMUNITY; AUTOLOGOUS STEM CELL TRANSPLANTATION; BLINDNESS; BONE ATROPHY; CATARACT; CLINICAL FEATURE; CLINICAL TRIAL; DISEASE CLASSIFICATION; DISEASE EXACERBATION; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG MEGADOSE; DRUG TOLERABILITY; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; FUNCTIONAL DISEASE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETICS; GLAUCOMA; HEMOPHAGOCYTIC SYNDROME; HUMAN; IMMUNOLOGY; IMMUNOPATHOLOGY; INCIDENCE; INFECTION; JUVENILE RHEUMATOID ARTHRITIS; KERATOPATHY; LIVER TOXICITY; LOW DRUG DOSE; MACROPHAGE ACTIVATION SYNDROME; MORTALITY; NONHUMAN; ONSET AGE; OSTEOLYSIS; PATIENT CARE; PHYSICAL DISABILITY; POLYARTHRITIS; QUALITY OF LIFE; RADIODIAGNOSIS; REMISSION; REPRODUCTION; RETINA MACULA CYSTOID EDEMA; REVIEW; RHEUMATOLOGY; SEROLOGY; SKIN DISEASE; SOCIAL PSYCHOLOGY; SOCIOECONOMICS; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; UVEITIS; ADOLESCENT; CHILD; FEMALE; IMMUNOTHERAPY; MALE; METHODOLOGY; PATHOLOGY;

ADOLESCENT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, MONOCLONAL; ANTIRHEUMATIC AGENTS; ARTHRITIS, JUVENILE RHEUMATOID; CHILD; FEMALE; HUMANS; IMMUNOTHERAPY; MALE; METHOTREXATE; QUALITY OF LIFE;

EID: 33746882867     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2005.09.011     Document Type: Review

References (156)

1. Al-Matar M.J., Petty R.E., Tucker L.B., Malleson P.N., Schroeder M.L., and Cabral D.A. The early pattern of joint involvement predicts disease progression in children with oligoarticular (pauciarticular) juvenile rheumatoid arthritis. Arthritis Rheum 46 (2002) 2708-2715
2. Guillaume S., Prieur A.M., Coste J., and Job-Deslandre C. Long-term outcome and prognosis in oligoarticular-onset juvenile idiopathic arthritis. Arthritis Rheum 43 (2000) 1858-1865
3. Gäre B.A., and Fasth A. The natural history of juvenile chronic arthritis: a population based cohort study: I. Onset and disease process. J Rheumatol 22 (1995) 295-307
4. Minden K., Kiessling U., Listing J., et al. Prognosis of patients with juvenile chronic arthritis and juvenile spondyloarthropathy. J Rheumatol 27 (2000) 2256-2263
5. Huemer C., Malleson P.N., Cabral D.A., Huemer M., Falger J., Zidek T., et al. Patterns of joint involvement at onset differentiate oligoarticular juvenile psoriatic arthritis from pauciarticular juvenile rheumatoid arthritis. J Rheumatol 29 7 (2002 Jul) 1531-1535
6. Brewer Jr. E.J., Bass J., Baum J., Cassidy J.T., Fink C., Jacobs J., et al. Current proposed revision of JRA Criteria. JRA Criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Section of The Arthritis Foundation. Arthritis Rheum 20 2 Suppl (1977 Mar) 195-199
7. Wood P.H. Special meeting on nomenclature and classification of arthritis in children (1978), EULAR Publishers, Basel 47-50
8. Petty R.E., Southwood T.R., Baum J., et al. Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997. J Rheumatol 25 (1998) 1991-1994
9. Petty R.E., Southwood T.R., Manners P., et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 31 (2004) 390-392
10. Berntson L., Anderssonäre B., Fasth A., et al. Incidence of juvenile idiopathic arthritis in the Nordic countries. A population based study with special reference to the validity of the ILAR and EULAR criteria. J Rheumatol 30 (2003) 2275-2282
11. Flatø B., Aasland A., Vinje O., and Førre Ø. Outcome and predictive factors in juvenile rheumatoid arthritis and juvenile spondyloarthropathy. J Rheumatol 25 (1998) 366-375
12. Serra C.R., Rodrigues S.H., Silva N.P., Sztajnbok F.R., and Andrade L.E. Clinical significance of anticardiolipin antibodies in juvenile idiopathic arthritis. Clin Exp Rheumatol 17 (1999) 375-380
13. Kotaniemi K., Kaipiainen-Seppänen O., Savolainen A., and Karma A. A population-based study on uveitis in juvenile rheumatoid arthritis. Clin Exp Rheumatol 17 (1999) 119-122
14. Moroldo M.B., Chaudhari M., Shear E., Thompson S.D., Glass D.N., and Giannini E.H. Juvenile rheumatoid arthritis affected sibpairs: extent of clinical phenotype concordance. Arthritis Rheum 50 (2004) 1928-1934
15. Säilä H.M., Savolainen H.A., Kotaniemi K.M., Kaipianen-Seppänen O.A., Leirisalo-Repo M.T., and Aho K.V. Juvenile idiopathic arthritis in multicase families. Clin Exp Rheumatol 19 (2001) 218-220
16. Packham J.C., and Hall M.A. Long-term follow-up of 246 adults with juvenile idiopathic arthritis: functional outcome. Rheumatology (Oxford) 41 (2002) 1428-1435
17. Kotaniemi K., Kautiainen H., Karma A., and Aho K. Occurrence of uveitis in recently diagnosed juvenile chronic arthritis: a prospective study. Ophthalmology 108 (2001) 2071-2075
18. Cabral D.A., Petty R.E., Malleson P.N., Ensworth S., McCormick A.Q., and Shroeder M.L. Visual prognosis in children with chronic anterior uveitis and arthritis. J Rheumatol 21 (1994) 2370-2375
19. Dana M.R., Merayo-Lloves J., Schaumberg D.A., and Foster C.S. Visual outcomes prognosticators in juvenile rheumatoid arthritis-associated uveitis. Ophthalmology 104 (1997) 236-244
20. Ruperto N., Ravelli A., Levinson J.E., et al. Long-term health outcomes and quality of life in American and Italian inception cohorts of patients with juvenile rheumatoid arthritis: II. Early predictors of outcome. J Rheumatol 24 (1997) 952-958
21. Oen K., Malleson P.N., Cabral D.A., Rosenberg A.M., Petty R.E., Reed M., et al. Early predictors of longterm outcome in patients with juvenile rheumatoid arthritis: subset-specific correlations. J Rheumatol 30 3 (2003 Mar) 585-593
22. Ravelli A., Felici E., Magni-Manzoni S., Pistorio A., Novarini C., Bozzola E., et al. Patients with antinuclear antibody-positive juvenile idiopathic arthritis constitute a homogeneous subgroup irrespective of the course of joint disease. Arthritis Rheum 52 3 (2005 Mar) 826-832
23. Szer I.S., Sierakowska H., and Szer W. A novel autoantibody to the putative oncoprotein DEK in pauciarticular onset juvenile rheumatoid arthritis. J Rheumatol 21 (1994) 2136-2142
24. Murray K.J., Szer W., Grom A.A., et al. Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular onset juvenile rheumatoid arthritis and iridocyclitis: selective association with MHC gene. J Rheumatol 24 (1997) 560-567
25. Adams B.S., Cha H.C., Cleary J., Haiying T., Wang H., Sitwala K., et al. DEK binding to class II MHC Y-box sequences is gene- and allele-specific. Arthritis Res Ther 5 4 (2003) R226-R233 [Epub 2003 May 23]
26. Thomson W., Barrett J.H., Donn R., Pepper L., Kennedy L.J., Ollier W.E., et al. Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients. Rheumatology (Oxford) 41 10 (2002 Oct) 1183-1189
27. Fantini F., Gerloni V., Gattinara M., Cimaz R., Arnoldi C., and Lupi E. Remission in juvenile chronic arthritis: a cohort study of 683 consecutive cases with a mean 10 year followup. J Rheumatol 30 (2003) 579-584
28. Bowyer S.L., Roettcher P.A., Higgins G.C., Adams B., Myers L.K., Wallace C., et al. Health status of patients with juvenile rheumatoid arthritis at 1 and 5 years after diagnosis. J Rheumatol 30 2 (2003 Feb) 394-400
29. Flato B., Lien G., Smerdel A., Vinje O., Dale K., Johnston V., et al. Prognostic factors in juvenile rheumatoid arthritis: a case-control study revealing early predictors and outcome after 14.9 years. J Rheumatol 30 2 (2003 Feb) 386-393
30. Gäre B.A., and Fasth A. The natural history of juvenile chronic arthritis: a population based cohort study: II. Outcome. J Rheumatol 22 (1995) 308-319
31. van Rossum M.A., Zwinderman A.H., Boers M., Dijkmans B.A., van Soesbergen R.M., Fiselier T.J., et al. Radiologic features in juvenile idiopathic arthritis: a first step in the development of a standardized assessment method. Arthritis Rheum 48 2 (2003 Feb) 507-515
32. Nesher G., Moore T.L., Grisanti M.W., el-Najdawi E., and Osborn T.G. Antiperinuclear factor in juvenile rheumatoid arthritis. Ann Rheum Dis 51 (1992) 350-352
33. Gabay C., Prieur A.M., and Meyer O. Occurrence of antiperinuclear, antikeratin, and anti-RA 33 antibodies in juvenile chronic arthritis. Ann Rheum Dis 52 (1993) 785-789
34. Hromadnikova I., Vavrincova P., Stechova K., and Hridelova D. Anti-keratin antibodies in patients with juvenile idiopathic arthritis. Clin Exp Rheumatol 19 (2001) 470-473
35. van Rossum M., van Soesbergen R., de Kort S., ten Cate R., Zwinderman A.H., de Jong B., et al. Anti-cyclic citrullinated peptide (anti-CCP) antibodies in children with juvenile idiopathic arthritis. J Rheumatol 30 4 (2003 Apr) 825-828
36. Ferucci E.D., Majka D.S., Parrish L.A., Moroldo M.B., Ryan M., Passo M., et al. Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis. Arthritis Rheum 52 1 (2005 Jan) 239-246
37. Low J.M., Chauhan A.K., Kietz D.A., Daud U., Pepmueller P.H., and Moore T.L. Determination of anti-cyclic citrullinated peptide antibodies in the sera of patients with juvenile idiopathic arthritis. J Rheumatol 31 (2004) 1829-1833
38. Hill J.A., Southwood S., Sette A., Jevnikar A.M., Bell D.A., and Cairns E. Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule. J Immunol 171 (2003) 538-541
39. Gedalia A., Molina J.F., García C.O., Doggett S., Espinoza L.R., and Gharavi A.E. Anticardiolipin antibodies in childhood rheumatic disorders. Lupus 7 (1998) 551-553
40. 2 glycoprotein I antibodies and lupus anticoagulant in a prospective longitudinal study of children with juvenile idiopathic arthritis. Clin Exp Rheumatol 20 (2002) 101-108
41. Parekh R.B., Roitt I.M., Isenberg D.A., Dwek R.A., Ansell B.M., and Rademacher T.W. Galactosylation of IgG associated oligosaccharides: reduction in patients with adult and juvenile onset rheumatoid arthritis and relation to disease activity. Lancet 1 (1988) 966-969
42. Bond A., Alavi A., Axford J.S., Youinou P., and Hay F.C. The relationship between exposed galactose and N-acetylglucosamine residues on IgG in rheumatoid arthritis (RA), juvenile chronic arthritis (JCA) and Sjögren's syndrome (SS). Clin Exp Immunol 105 (1996) 99-103
43. Das H., Atsumi T., Fukushima Y., Shibuya H., Ito K., Yamada Y., et al. Diagnostic value of antiagalactosyl IgG antibodies in rheumatoid arthritis. Clin Rheumatol 23 3 (2004 Jun) 218-222 [Epub 2004 Feb 26]
44. Maeno N., Takei S., Fujikawa S., Yamada Y., Imanaka H., Hokonohara M., et al. Antiagalactosyl IgG antibodies in juvenile idiopathic arthritis, juvenile onset Sjogren's syndrome, and healthy children. J Rheumatol 31 6 (2004 Jun) 1211-1217
45. Petty R.E., Smith J.R., and Rosenbaum J.T. Arthritis and uveitis in children. A pediatric rheumatology perspective. Am J Ophthalmol 135 (2003) 879-884
46. Foster C.S. Diagnosis and treatment of juvenile idiopathic arthritis-associated uveitis. Curr Opin Ophthalmol 14 (2003) 395-398
47. Sawhney S., Woo P., and Murray K.J. Macrophage activation syndrome: a potentially fatal complication of rheumatic disorders. Arch Dis Child 85 (2001) 421-426
48. Stéphan J.L., Koné-Paut I., Galambrun C., Mouy R., Bader-Meunier B., and Prieur A.M. Reactive haemophagocytic syndrome in children with inflammatory disorders. A retrospective study of 24 patients. Rheumatology (Oxford) 40 (2001) 1285-1292
49. Bowyer S., Roettcher P., and Pediatric Rheumatology Database Research Group. Pediatric rheumatology clinic populations in the United States: results of a 3 year survey. J Rheumatol 23 (1996) 1968-1974
50. Peterson L.S., Mason T., Nelson A.M., O'Fallon W.M., and Gabriel S.E. Juvenile rheumatoid arthritis in Rochester, Minnesota 1960-1993. Is the epidemiology changing?. Arthritis Rheum 39 (1996) 1385-1390
51. Kaipiainen-Seppänen O., and Savolainen A. Incidence of chronic juvenile rheumatic diseases in Finland during 1980-1990. Clin Exp Rheumatol 14 (1996) 441-444
52. Oen K.G., and Cheang M. Epidemiology of chronic arthritis in childhood. Semin Arthritis Rheum 26 (1996) 575-591
53. Oen K., Malleson P.N., Cabral D.A., Rosenberg A.M., Petty R.E., and Cheang M. Disease course and outcome of juvenile rheumatoid arthritis in a multicenter cohort. J Rheumatol 29 (2002) 1989-1999
54. Minden K., Niewerth M., Listing J., Biedermann T., Bollow M., Schontube M., et al. Long-term outcome in patients with juvenile idiopathic arthritis. Arthritis Rheum 46 9 (2002 Sep) 2392-2401
55. Gäre B.A., and Fasth A. Epidemiology of juvenile chronic arthritis in southwestern Sweden: a 5-year prospective population study. Pediatrics 90 (1992) 950-958
56. Grom A.A., and Hirsch R. T-cell and T-cell receptor abnormalities in the immunopathogenesis of juvenile rheumatoid arthritis. Curr Opin Rheumatol 12 (2000) 420-424
57. + memory T cells homing to the joints in juvenile idiopathic arthritis. Arthritis Res Ther 7 2 (2005) R256-R267
58. Murray K.J., Luyrink L., Grom A.A., Passo M.H., Emery H., Witte D., et al. Immunohistological characteristics of T cell infiltrates in different forms of childhood onset chronic arthritis. J Rheumatol 23 12 (1996 Dec) 2116-2124
59. Wedderburn L.R., Robinson N., Patel A., Varsani H., and Woo P. Selective recruitment of polarized T cells expressing CCR5 and CXCR3 to the inflamed joints of children with juvenile idiopathic arthritis. Arthritis Rheum 43 (2000) 765-774
60. + T cells in juvenile rheumatoid arthritis synovial fluid defines a subset of cells with increased IL-4 : IFN-γ mRNA ratios. J Immunol 166 11 (2001 Jun 1) 6899-6906
61. Wedderburn L.R., Patel A., Varsani H., and Woo P. Divergence in the degree of clonal expansions in inflammatory T cell subpopulations mirrors HLA-associated risk alleles in genetically and clinically distinct subtypes of childhood arthritis. Int Immunol 13 (2001) 1541-1550
62. Thompson S.D., Murray K.J., Grom A.A., Passo M.H., Choi E., and Glass D.N. Comparative sequence analysis of the human T cell receptor β chain in juvenile rheumatoid arthritis and juvenile spondylarthropathies: evidence for antigenic selection of T cells in the synovium. Arthritis Rheum 41 (1998) 482-497
63. Chiesa S., Prigione I., Morandi F., Buoncompagni A., Picco P., Bocca P., et al. Cytokine flexibility of early and differentiated memory T helper cells in juvenile idiopathic arthritis. J Rheumatol 31 10 (2004 Oct) 2048-2054
64. Murray K.J., Grom A.A., Thompson S.D., Lieuwen D., Passo M.H., and Glass D.N. Contrasting cytokine profiles in the synovium of different forms of juvenile rheumatoid arthritis and juvenile spondyloarthropathy: prominence of interleukin 4 in restricted disease. J Rheumatol 25 (1998) 1388-1398
65. Ozen S., Tucker L.B., and Miller L.C. Identification of Th subsets in juvenile rheumatoid arthritis confirmed by intracellular cytokine staining. J Rheumatol 25 (1998) 1651-1653
66. Gattorno M., Facchetti P., Ghiotto F., Vignola S., Buoncompagni A., Prigione I., et al. Synovial fluid T cell clones from oligoarticular juvenile arthritis patients display a prevalent Th1/Th0-type pattern of cytokine secretion irrespective of immunophenotype. Clin Exp Immunol 109 1 (1997 Jul) 4-11
67. Scola M.P., Thompson S.D., Brunner H.I., Tsoras M.K., Witte D., Van Dijk M.A., et al. Interferon-γ: interleukin 4 ratios and associated type 1 cytokine expression in juvenile rheumatoid arthritis synovial tissue. J Rheumatol 29 2 (2002 Feb) 369-378
68. Gattorno M., Picco P., Vignola S., Stalla F., Buoncompagni A., and Pistoia V. Serum interleukin 12 concentration in juvenile chronic arthritis. Ann Rheum Dis 57 (1998) 425-428
69. Yilmaz M., Kendirli S.G., Altintas D., Bingöl G., and Antmen B. Cytokine levels in serum of patients with juvenile rheumatoid arthritis. Clin Rheumatol 20 (2001) 30-35
70. Kawaguchi Y., Terajima H., Harigai M., Hara M., and Kamatani N. Interleukin-18 as a novel diagnostic marker and indicator of disease severity in adult-onset Still's disease. Arthritis Rheum 44 (2001) 1716-1717
71. Kawashima M., Yamamura M., Taniai M., Yamauchi H., Tanimoto T., Kurimoto M., et al. Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease. Arthritis Rheum 44 3 (2001 Mar) 550-560
72. Maeno N., Takei S., Nomura Y., Imanaka H., Hokonohara M., and Miyata K. Highly elevated serum levels of interleukin-18 in systemic juvenile idiopathic arthritis but not in other juvenile idiopathic arthritis subtypes or in Kawasaki disease: comment on the article by Kawashima et al. Arthritis Rheum 46 (2002) 2539-2541 [author reply 41-42]
73. Mangge H., Gallistl S., and Schauenstein K. Long-term follow-up of cytokines and soluble cytokine receptors in peripheral blood of patients with juvenile rheumatoid arthritis. J Interferon Cytokine Res 19 (1999) 1005-1010
74. De Benedetti F., Pignatti P., Massa M., Sartirana P., Ravelli A., and Martini A. Circulating levels of interleukin 1β and of interleukin 1 receptor antagonist in systemic juvenile chronic arthritis. Clin Exp Rheumatol 13 (1995) 779-784
75. Madson K.L., Moore T.L., Lawrence III J.M., and Osborn T.G. Cytokine levels in serum and synovial fluid of patients with juvenile rheumatoid arthritis. J Rheumatol 21 (1994) 2359-2363
76. Mangge H., Kenzian H., Gallistl S., Neuwirth G., Liebmann P., Kaulfersch W., et al. Serum cytokines in juvenile rheumatoid arthritis. Correlation with conventional inflammation parameters and clinical subtypes. Arthritis Rheum 38 2 (1995 Feb) 211-220
77. Müller K., Zak M., Nielsen S., Pedersen F.K., de Nully P., and Bendtzen K. Interleukin-1 receptor antagonist in neonates, children and adults, and in patients with pauci- and polyarticular onset juvenile chronic arthritis. Clin Exp Rheumatol 15 (1997) 439-444
78. Lepore L., Pennesi M., Saletta S., Perticarari S., Presani G., and Prodan M. Study of IL-2, IL-6, TNFα, IFNγ and β in the serum and synovial fluid of patients with juvenile chronic arthritis. Clin Exp Rheumatol 12 (1994) 561-565
79. Kutukculer N., Caglayan S., and Aydogdu F. Study of pro-inflammatory (TNF-α, IL-1α, IL-6) and T-cell-derived (IL-2, IL-4) cytokines in plasma and synovial fluid of patients with juvenile chronic arthritis: correlations with clinical and laboratory parameters. Clin Rheumatol 17 (1998) 288-292
80. Gattorno M., Picco P., Buoncompagni A., Stalla F., Facchetti P., Sormani M.P., et al. Serum p55 and p75 tumour necrosis factor receptors as markers of disease activity in juvenile chronic arthritis. Ann Rheum Dis 55 4 (1996 Apr) 243-247
81. de Benedetti F., Pignatti P., Massa M., Sartirana P., Ravelli A., Cassani G., et al. Soluble tumour necrosis factor receptor levels reflect coagulation abnormalities in systemic juvenile chronic arthritis. Br J Rheumatol 36 5 (1997 May) 581-588
82. Rooney M., David J., Symons J., Di Giovine F., Varsani H., and Woo P. Inflammatory cytokine responses in juvenile chronic arthritis. Br J Rheumatol 34 (1995) 454-460
83. de Benedetti F., Massa M., Robbioni P., Ravelli A., Burgio G.R., and Martini A. Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis. Arthritis Rheum 34 (1991) 1158-1163
84. De Benedetti F., Pignatti P., Gerloni V., Massa M., Sartirana P., Caporali R., et al. Differences in synovial fluid cytokine levels between juvenile and adult rheumatoid arthritis. J Rheumatol 24 7 (1997 Jul) 1403-1409
85. Grom A.A., Murray K.J., Luyrink L., Emery H., Passo M.H., Glass D.N., et al. Patterns of expression of tumor necrosis factor α, tumor necrosis factor β, and their receptors in synovia of patients with juvenile rheumatoid arthritis and juvenile spondylarthropathy. Arthritis Rheum 39 10 (1996 Oct) 1703-1710
86. Murray K.J., and Lovell D.J. Advanced therapy for juvenile arthritis. Best Pract Res Clin Rheumatol 16 (2002) 361-378
87. Giannini E.H., Brewer E.J., Kuzmina N., Shaikov A., Maximov A., Vorontsov I., et al. Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and The Cooperative Children's Study Group. N Engl J Med 326 16 (1992 Apr) 1043-1049
88. Woo P., Southwood T.R., Prieur A.M., Dore C.J., Grainger J., David J., et al. Randomized, placebo-controlled, crossover trial of low-dose oral methotrexate in children with extended oligoarticular or systemic arthritis. Arthritis Rheum 43 8 (2000 Aug) 1849-1857
89. Ruperto N., Murray K.J., Gerloni V., Wulffraat N., de Oliveira S.K., Falcini F., et al. A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate. Arthritis Rheum 50 7 (2004 Jul) 2191-2201
90. van Rossum M.A., Fiselier T.J., Franssen M.J., Zwinderman A.H., ten Cate R., van Suijlekom-Smit L.W., et al. Sulfasalazine in the treatment of juvenile chronic arthritis: a randomized, double-blind, placebo-controlled, multicenter study. Dutch Juvenile Chronic Arthritis Study Group. Arthritis Rheum 41 5 (1998 May) 808-816
91. Silverman E., Mouy R., Spiegel L., Jung L.K., Saurenmann R.K., Lahdenne P., et al. Leflunomide or methotrexate for juvenile rheumatoid arthritis. N Engl J Med 352 16 (2005 Apr) 1655-1666
92. Gerloni V., Cimaz R., Gattinara M., Arnoldi C., Pontikaki I., and Fantini F. Efficacy and safety profile of cyclosporin A in the treatment of juvenile chronic (idiopathic) arthritis. Results of a 10-year prospective study. Rheumatology (Oxford) 40 (2001) 907-913
93. Lovell D.J., Giannini E.H., Reiff A., Cawkwell G.D., Silverman E.D., Nocton J.J., et al. Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group. N Engl J Med 342 11 (2000 Mar 16) 763-769
94. Lovell D.J., Giannini E.H., Reiff A., Jones O.Y., Schneider R., Olson J.C., et al. Long-term efficacy and safety of etanercept in children with polyarticular-course juvenile rheumatoid arthritis: interim results from an ongoing multicenter, open-label, extended-treatment trial. Arthritis Rheum 48 1 (2003 Jan) 218-226
95. Horneff G., Schmeling H., Biedermann T., Foeldvari I., Ganser G., Girschick H.J., et al. The German etanercept registry for treatment of juvenile idiopathic arthritis. Ann Rheum Dis 63 12 (2004 Dec) 1638-1644
96. Kietz D.A., Pepmueller P.H., and Moore T.L. Therapeutic use of etanercept in polyarticular course juvenile idiopathic arthritis over a two year period. Ann Rheum Dis 61 (2002) 171-173
97. Quartier P., Taupin P., Bourdeaut F., Lemelle I., Pillet P., Bost M., et al. Efficacy of etanercept for the treatment of juvenile idiopathic arthritis according to the onset type. Arthritis Rheum 48 4 (2003 Apr) 1093-1101
98. Kimura Y., Pinho P., Walco G., Higgins G., Hummell D., Szer I., et al. Etanercept treatment in patients with refractory systemic onset juvenile rheumatoid arthritis. J Rheumatol 32 5 (2005 May) 935-942
99. Takei S., Groh D., Bernstein B., Shaham B., Gallagher K., and Reiff A. Safety and efficacy of high dose etanercept in treatment of juvenile rheumatoid arthritis. J Rheumatol 28 (2001) 1677-1680
100. Lahdenne P., Vähäsalo P., and Honkanen V. Infliximab or etanercept in the treatment of children with refractory juvenile idiopathic arthritis: an open label study. Ann Rheum Dis 62 (2003) 245-247
101. Weiss J.E., and Ilowite N.T. Juvenile idiopathic arthritis. Pediatr Clin North Am 52 (2005) 413-442 [vi]
102. Pascual V., Allantaz F., Arce E., Punaro M., and Banchereau J. Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. J Exp Med 201 (2005) 1479-1486
103. Verbsky J.W., and White A.J. Effective use of the recombinant interleukin 1 receptor antagonist anakinra in therapy resistant systemic onset juvenile rheumatoid arthritis. J Rheumatol 31 (2004) 2071-2075
104. Yokota S., Miyamae T., Imagawa T., Iwata N., Katakura S., Mori M., et al. Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum 52 3 (2005 Mar) 818-825
105. De Kleer I.M., Brinkman D.M., Ferster A., Abinun M., Quartier P., Van Der Net J., et al. Autologous stem cell transplantation for refractory juvenile idiopathic arthritis: analysis of clinical effects, mortality, and transplant related morbidity. Ann Rheum Dis 63 10 (2004 Oct) 1318-1326
106. Foeldvari I., and Wierk A. Methotrexate is an effective treatment for chronic uveitis associated with juvenile idiopathic arthritis. J Rheumatol 32 (2005) 362-365
107. Reiff A., Takei S., Sadeghi S., Stout A., Shaham B., Bernstein B., et al. Etanercept therapy in children with treatment-resistant uveitis. Arthritis Rheum 44 6 (2001 Jun) 1411-1415
108. Smith J.A., Thompson D.J., Whitcup S.M., Suhler E., Clarke G., Smith S., et al. A randomized, placebo-controlled, double-masked clinical trial of etanercept for the treatment of uveitis associated with juvenile idiopathic arthritis. Arthritis Rheum 53 1 (2005 Feb 15) 18-23
109. Schmeling H., and Horneff G. Etanercept and uveitis in patients with juvenile idiopathic arthritis. Rheumatology (Oxford) (2005)
110. Grateau G. Musculoskeletal disorders in secondary amyloidosis and hereditary fevers. Best Pract Res Clin Rheumatol 17 (2003) 929-944
111. Oen K. Long-term outcomes and predictors of outcomes for patients with juvenile idiopathic arthritis. Best Pract Res Clin Rheumatol 16 (2002) 347-360
112. Wallace C.A., Ruperto N., and Giannini E. Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis. J Rheumatol 31 (2004) 2290-2294
113. Zak M., and Pedersen F.K. Juvenile chronic arthritis into adulthood: a long-term follow-up study. Rheumatology (Oxford) 39 (2000) 198-204
114. Foster H.E., Marshall N., Myers A., Dunkley P., and Griffiths I.D. Outcome in adults with juvenile idiopathic arthritis: a quality of life study. Arthritis Rheum 48 (2003) 767-775
115. Adib N., Silman A., and Thomson W. Outcome following onset of juvenile idiopathic inflammatory arthritis: II. Predictors of outcome in juvenile arthritis. Rheumatology (Oxford) (2005)
116. Dempster H., Porepa M., Young N., and Feldman B.M. The clinical meaning of functional outcome scores in children with juvenile arthritis. Arthritis Rheum 44 (2001) 1768-1774
117. Ravelli A., and Martini A. Early predictors of outcome in juvenile idiopathic arthritis. Clin Exp Rheumatol 21 (2003) S89-S93
118. Magni-Manzoni S., Rossi F., Pistorio A., Temporini F., Viola S., Beluffi G., et al. Prognostic factors for radiographic progression, radiographic damage, and disability in juvenile idiopathic arthritis. Arthritis Rheum 48 12 (2003 Dec) 3509-3517
119. Oen K., Reed M., Malleson P.N., Cabral D.A., Petty R.E., Rosenberg A.M., et al. Radiologic outcome and its relationship to functional disability in juvenile rheumatoid arthritis. J Rheumatol 30 4 (2003 Apr) 832-840
120. McDonagh J.E. Osteoporosis in juvenile idiopathic arthritis. Curr Opin Rheumatol 13 (2001) 399-404
121. Lien G., Flato B., Haugen M., Vinje O., Sorskaar D., Dale K., et al. Frequency of osteopenia in adolescents with early-onset juvenile idiopathic arthritis: a long-term outcome study of one hundred five patients. Arthritis Rheum 48 8 (2003 Aug) 2214-2223
122. Peterson L.S., Mason T., Nelson A.M., O'Fallon W.M., and Gabriel S.E. Psychosocial outcomes and health status of adults who have had juvenile rheumatoid arthritis: a controlled, population-based study. Arthritis Rheum 40 (1997) 2235-2240
123. Packham J.C., Hall M.A., and Pimm T.J. Long-term follow-up of 246 adults with juvenile idiopathic arthritis: predictive factors for mood and pain. Rheumatology (Oxford) 41 (2002) 1444-1449
124. Sawyer M.G., Whitham J.N., Roberton D.M., Taplin J.E., Varni J.W., and Baghurst P.A. The relationship between health-related quality of life, pain and coping strategies in juvenile idiopathic arthritis. Rheumatology (Oxford) 43 (2004) 325-330
125. Sallfors C., Hallberg L.R., and Fasth A. Well-being in children with juvenile chronic arthritis. Clin Exp Rheumatol 22 (2004) 125-130
126. Aasland A., Flatø B., and Vandvik I.H. Psychosocial outcome in juvenile chronic arthritis: a nine-year follow-up. Clin Exp Rheumatol 15 (1997) 561-568
127. Ruperto N., Levinson J.E., Ravelli A., Shear E.S., Link Tague B., Murray K., et al. Long-term health outcomes and quality of life in American and Italian inception cohorts of patients with juvenile rheumatoid arthritis. I. Outcome status. J Rheumatol 24 5 (1997 May) 945-951
128. Reiter-Purtill J., Gerhardt C.A., Vannatta K., Passo M.H., and Noll R.B. A controlled longitudinal study of the social functioning of children with juvenile rheumatoid arthritis. J Pediatr Psychol 28 (2003) 17-28
129. LeBovidge J.S., Lavigne J.V., and Miller M.L. Adjustment to chronic arthritis of childhood: the roles of illness-related stress and attitude toward illness. J Pediatr Psychol 30 (2005) 273-286
130. David J., Cooper C., Hickey L., Lloyd J., Dore C., McCullough C., et al. The functional and psychological outcomes of juvenile chronic arthritis in young adulthood. Br J Rheumatol 33 9 (1994 Sep) 876-881
131. Packham J.C., and Hall M.A. Long-term follow-up of 246 adults with juvenile idiopathic arthritis: social function, relationships and sexual activity. Rheumatology (Oxford) 41 (2002) 1440-1443
132. Ostensen M., Almberg K., and Koksvik H.S. Sex, reproduction, and gynecological disease in young adults with a history of juvenile chronic arthritis. J Rheumatol 27 (2000) 1783-1787
133. Østensen M. Pregnancy in patients with a history of juvenile rheumatoid arthritis. Arthritis Rheum 34 (1991) 881-887
134. Musiej-Nowakowska E., and Ploski R. Pregnancy and early onset pauciarticular juvenile chronic arthritis. Ann Rheum Dis 58 (1999) 475-480
135. Packham J.C., and Hall M.A. Long-term follow-up of 246 adults with juvenile idiopathic arthritis: education and employment. Rheumatology (Oxford) 41 (2002) 1436-1439
136. Koivuniemi R., and Leirisalo-Repo M. Juvenile chronic arthritis in adult life: a study of long-term outcome in patients with juvenile chronic arthritis or adult rheumatoid arthritis. Clin Rheumatol 18 (1999) 220-226
137. Thomas E., Symmons D.P., Brewster D.H., Black R.J., and Macfarlane G.J. National study of cause-specific mortality in rheumatoid arthritis, juvenile chronic arthritis, and other rheumatic conditions: a 20 year followup study. J Rheumatol 30 (2003) 958-965
138. French A.R., Mason T., Nelson A.M., O'Fallon W.M., and Gabriel S.E. Increased mortality in adults with a history of juvenile rheumatoid arthritis: a population-based study. Arthritis Rheum 44 (2001) 523-527
139. Savolainen H.A., and Isomaki H.A. Decrease in the number of deaths from secondary amyloidosis in patients with juvenile rheumatoid arthritis. J Rheumatol 20 (1993) 1201-1203
140. Savolainen A., Säilä H., Kotaniemi K., Kaipianen-Seppänen O., Leirisalo-Repo M., and Aho K. Magnitude of the genetic component in juvenile idiopathic arthritis. Ann Rheum Dis 59 (2000) 1001
141. Glass D.N., and Giannini E.H. Juvenile rheumatoid arthritis as a complex genetic trait. Arthritis Rheum 42 (1999) 2261-2268
142. Moroldo M.B., Tague B.L., Shear E.S., Glass D.N., and Giannini E.H. Juvenile rheumatoid arthritis in affected sibpairs. Arthritis Rheum 40 (1997) 1962-1966
143. Albert E.D., and Scholz S. Juvenile arthritis: genetic update. Baillieres Clin Rheumatol 12 (1998) 209-218
144. Flato B., Smerdel A., Johnston V., Lien G., Dale K., Vinje O., et al. The influence of patient characteristics, disease variables, and HLA alleles on the development of radiographically evident sacroiliitis in juvenile idiopathic arthritis. Arthritis Rheum 46 4 (2002 Apr) 986-994
145. Zeggini E., Donn R.P., Ollier W.E., and Thomson W. Evidence for linkage of HLA loci in juvenile idiopathic oligoarthritis: independent effects of HLA-A and HLA-DRB1. Arthritis Rheum 46 (2002) 2716-2720
146. Runstadler J.A., Saila H., Savolainen A., Leirisalo-Repo M., Aho K., Tuomilehto-Wolf E., et al. Analysis of MHC region genetics in Finnish patients with juvenile idiopathic arthritis: evidence for different locus-specific effects in polyarticular vs pauciarticular subsets and a shared DRB1 epitope. Genes Immun 4 5 (2003 Jul) 326-335
147. Rosen P., Thompson S., and Glass D. Non-HLA gene polymorphisms in juvenile rheumatoid arthritis. Clin Exp Rheumatol 21 (2003) 650-656
148. Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphries S., et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102 7 (1998 Oct 1) 1369-1376
149. Ogilvie E.M., Fife M.S., Thompson S.D., Twine N., Tsoras M., Moroldo M., et al. The - 174G allele of the interleukin-6 gene confers susceptibility to systemic arthritis in children: a multicenter study using simplex and multiplex juvenile idiopathic arthritis families.
150. Donn R.P., Barrett J.H., Farhan A., Stopford A., Pepper L., Shelley E., et al. Cytokine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. British Paediatric Rheumatology Study Group. Arthritis Rheum 44 4 (2001 Apr) 802-810
151. Donn R., Alourfi Z., De Benedetti F., Meazza C., Zeggini E., Lunt M., et al. Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis. Arthritis Rheum 46 9 (2002 Sep) 2402-2409
152. Donn R., Alourfi Z., Zeggini E., Lamb R., Jury F., Lunt M., et al. A functional promoter haplotype of macrophage migration inhibitory factor is linked and associated with juvenile idiopathic arthritis. Arthritis Rheum 50 5 (2004 May) 1604-1610
153. De Benedetti F., Meazza C., Vivarelli M., Rossi F., Pistorio A., Lamb R., et al. Functional and prognostic relevance of the - 173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum 48 5 (2003 May) 1398-1407
154. Sanjeevi C.B., Miller E.N., Dabadghao P., Rumba I., Shtauvere A., Denisova A., et al. Polymorphism at NRAMP1 and D2S1471 loci associated with juvenile rheumatoid arthritis. Arthritis Rheum 43 6 (2000 Jun) 1397-1404
155. Runstadler J.A., Saila H., Savolainen A., Leirisalo-Repo M., Aho K., Tuomilehto-Wolf E., et al. Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor-negative juvenile idiopathic arthritis in Finnish patients: haplotype analysis in Finnish families. Arthritis Rheum 52 1 (2005 Jan) 247-256
156. Spiegel L.R., Schneider R., Lang B.A., Birdi N., Silverman E.D., Laxer R.M., et al. Early predictors of poor functional outcome in systemic-onset juvenile rheumatoid arthritis: a multicenter cohort study. Arthritis Rheum 43 11 (2000 Nov) 2402-2409