Miniaturisation of assay development and screening

Drug Discovery World

Volumn 7, Issue 3, 2006, Pages 17-27

  Boettcher, Andreas ^a   Mayr, Lorenz M ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL COMPOUND;

ARTICLE; BIOASSAY; BIOTECHNOLOGY; DRUG DESIGN; DRUG INDUSTRY; ELECTRONICS; HIGH THROUGHPUT SCREENING; LABORATORY; MEDICAL RESEARCH; MICROTITER PLATE ASSAY;

EID: 33746879155     PISSN: 14694344     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Klumpp, M, Boettcher A, Becker, D, Meder, G, Blank, J, Leder, L, Forstner, M, Ottl, J, Mayr, LM. (2006) Readout Technologies for Highly Miniaturized Kinase Assays Applicable to High-Throughput Screening in a 1536-Well Format. J. Biomol. Screen., in press.
2. Berg, M, Undisz, K, Thiericke, R, Moore, T and Posten, C. (2000): J. Biomol. Screen. 5, 71-63.
3. Brandish, PE, Chiu, CS, Schneeweis, J, Brandon, NJ, Leech, CL, Kornienko, O, Scolnick, EM, Strulovici, B and Zheng, W. (2006): J. Biomol. Screen., in press.
4. Jager, S, Brand, L and Eggeling, C. (2003) New fluorescence techniques for high-throughput drug discovery. Curr. Pharm. Biotechnol. 4, 463-476.
5. Buehler, C, Dreessen, J, Mueller, K, So, PT, Schilb, A, Hassiepen, U, Stoeckli, KA and Auer, M. (2005) Multi-photon excitation of intrinsic protein fluorescence and its application to pharmaceutical drug screening. Assay Drug Dev Technol. 3, 155-167.
6. Mayr, LM. (2006) Tackling the Chemo-Genomic Space by Novel Screening Technologies; Monograph of ESRF Workshop 58 "Chemical Genomics: Small Molecule Probes to Study Cellular Function"; edited by S. Jaroch & H. Weinmann, Springer Verlag, Weinheim/Germany, III-173
7. Zhang, JH, Chung, TD and Oldenburg, KR. (1999): A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen 4, 67-73.
8. Muckenschnabel, I, Falchetto, R, Mayr, LM and Filipuzzi, I. (2004) SpeedScreen: label-free liquid chromatography-mass spectrometry-based high-throughput screening for the discovery of orphan protein ligands. Anal. Biochem. 324, 241-249.
9. Zehender, H, Le Goff, F, Lehmann, N and Mayr, LM. (2004) SpeedScreen: The 'Missing Link' between Genomics and Lead Discovery. J. Biomol. Screen 9, 498-505.