Enzymatic activity is necessary for the tumor-suppressive effects of MnSOD

Antioxidants and Redox Signaling

Volumn 8, Issue 7-8, 2006, Pages 1283-1293

  Zhang, Yuping ^a   Smith, Brian J ^b   Oberley, Larry W ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIOXIDANT; COMPLEMENTARY DNA; HISTIDINE; LEUCINE; MANGANESE SUPEROXIDE DISMUTASE; MUTANT PROTEIN; RNA;

ADENOVIRUS; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PLASMID; PRIORITY JOURNAL; REGULATORY MECHANISM;

ADENOCARCINOMA; AMINO ACID SUBSTITUTION; CELL CULTURE TECHNIQUES; CELL LINE; CELL LINE, TUMOR; HUMANS; LEUCINE; LIPIDS; NEOPLASMS; PANCREATIC NEOPLASMS; PLASMIDS; SUPEROXIDE DISMUTASE; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

ADENOVIRIDAE;

EID: 33746851285     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2006.8.1283     Document Type: Article

References (46)

1. Beauchamp C and Fridovich I. Superoxide dismutase: improved assay and an assay applicable to acrylamide gels. Anal Biochem 44: 276-287, 1971.
2. Beckman BS, Balin AK, and Allen RG. Superoxide dismutase induces differentiation of erythroleukemia cells. J Cell Physiol 139: 370-376, 1989.
3. Borgstahl GED, Parge HE, Hickey MJ, Beyer WF, Hallewell RA, and Tainer JA. The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles. Cell 71: 107-118, 1992.
4. Borgstahl GE, Parge HE, Hickey MJ, Johnson MJ, Boissinot M, Hallewell RA, Lepock JR, Cabelli DE, and Tainer JA. Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface. Biochemistry 35: 4287-4297, 1996.
5. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
6. Bravard A, Sabatier L, Hoffschir F, Luccioni C, and Dutrillaux B. SOD2: a new type of tumor suppressor gene? Int J Cancer 51: 475-480, 1992.
7. Cerutti PA. Proxidant states and cancer. Science 227: 375-381, 1985.
8. Church SL, Grant JW, Ridnour LA, Oberley LW, Swanson PE, Meltzer PS, and Trent JM. Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells. Proc Natl Acad Sci USA 90: 3113-3117, 1993.
9. Cullen JJ, Weydert C, Hinkhouse MM, Ritchie JM, Domann FE, Spitz DR, and Oberley LW. The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma. Cancer Res 63: 1297-1303, 2003.
10. Elchuri S, Oberley TD, Qi W, Eisenstein RS, Jackson Roberts L, Van Remmen HV, Epstein CJ, and Huang T-T. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene 24: 367-380, 2005.
11. Fernandez-Pol JA, Hamilton PD, and Klos DJ. Correlation between the loss of the transformed phenotype and an increase in superoxide dismutase activity in a revertant subclone of sarcoma virus-infected mammalian cells. Cancer Res 42: 609-617, 1982.
12. Kim A, Oberley LW, and Oberley TD. Induction of apoptosis by adenovirus-mediated manganese superoxide dismutase overexpression in SV-40-transformed human fibroblasts. Free Radic Biol Med 39: 1128-1141, 2005.
13. Kondo T, Reaume AG, Huang TT, Murakami K, Carlson E, Chen S, Scott RW, Epstein CJ, and Chan PH. Edema formation exacerbates neurological and histological outcomes after focal cerebral ischemia in CuZn-superoxide dismutase knockout mutant mice. Acta Neurochir Suppl 70: 62-64, 1997.
14. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
15. Lam EWN, Hammad HM, Zwacka R, et al. Immunolocalization and adenoviral vector-mediated manganese superoxide dismutase gene transfer to experimental oral tumors. J Dent Res 79: 1410-1417, 2000.
16. Lam EWN, Zwacka R, Engelhardt JF, Davidson BL, Domann FE Jr, and Oberley LW. Adenovirus-mediated manganese superoxide dismutase gene transfer to hamster cheek pouch carcinoma cells. Cancer Res 57: 5550-5556, 1997.
17. Lebovitz RM, Zhang H, Vogel H, Cartwright J Jr, Dionne L, Lu N, Huang S, and Matsuk MM. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci U S A 493: 9782-9787, 1996.
18. Li JJ, Oberley LW, St Clair DK, Ridnour LA, and Oberley TD. Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase. Oncogene 10: 1989-2000, 1995.
19. Li N, Oberley TD, Oberley LW, and Zhong W. Overexpression of manganese superoxide dismutase in DU145 human prostate carcinoma cells has multiple effects on cell phenotype. Prostate 35: 221-223, 1998.
20. Li Y, Huang T-T, Carlson EJ, Melov S, Ursell PC, Olson, JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, and Epstein CJ. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet 11: 376-381, 1995.
21. Liang BC, Ross DA, Greenburg HS, Meltzer PS, and Trent JM. Evidence for allelic imbalance of chromosome 6 in human astrocytomas. Neurology 44: 533-536, 1994.
22. Liu R, Oberley TD, and Oberley LW. Transfection and expression of MnSOD cDNA decreases tumor malignancy of human oral squamous carcinoma SCC-25 cells. Human Gene Ther 8: 585-595, 1997.
23. McCord JM, Keele BB, and Fridovich I. An enzyme based theory of obligate anaerobiosis: the physiological function of superoxide dismutase. Proc Natl Acad Sci USA 68: 1024-1027, 1971.
24. Melendez JA, Melathe RP, Rodriguez AM, Mazurkiewicz JE, and Davies KJA. Nitric oxide enhances the manganese superoxide-dependent suppression of proliferation in HT-1080 fibrosarcoma cells. Cell Growth Differ 10: 655-664, 1999.
25. Millikan D, Meese E, Vogelstein B, Witkowski C, and Trent J. Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma. Cancer Res 51: 5449-5453, 1991.
26. Oberley LW. Superoxide dismutase and cancer. In: Oberley LW, ed. Superoxide Dismutase. Vol II. Boca Raton, Fla: CRC Press, 1982.
27. Oberley LW and Buettner GR. Role of superoxide dismutase in cancer: a review. Cancer Res 39: 1141-1149, 1979.
28. Oberley LW and Oberley TD. Free radicals, cancer, and aging. In: Walford R, Harmon D, Miguel J, eds. Free Radicals, Aging, and Degenerative Diseases. New York: Alan R Liss, 1986: 325-381.
29. Oberley LW and Oberley TD. Role of antioxidant enzymes in cell immortalization and transformation. Mol Cell Biochem 84: 147-153, 1988.
30. Oberley LW and Oberley TD. Reactive oxygen species in the aetiology of cancer. In: Ioannides C, Lewis DV, eds. Drugs, Diet, and Disease. Vol 1. New York: Prentice Hall, 1994: 49-63.
31. Oberley TD and Oberley LW. Oxygen radicals and cancer. In: Yu BP, ed. Free Radicals in Aging. Boca Raton, Fla: CRC Press, 1993: 248-267.
32. Oberley LW, Spitz DR. Assay of superoxide dismutase activity in tumor tissues. Methods Enzymol 105: 457-469, 1984.
33. Oberley LW, Spitz DR. Assay of superoxide dismutase using nitroblue tetrazolium. In: Greenwald RA, ed. Handbook of Methods for Oxy Radical Research. Boca Raton, Fla: CRC Press, 1985: 217-225.
34. Ough M, Lewis A, Zhang YP, Hinkhouse MM, Ritchie JM, Oberley LW, and Cullen JJ. Inhibition of cell growth by overexpression of manganese superoxide dismutase (MnSOD) in human pancreatic carcinoma. Free Radic Res 38: 1223-1233, 2004.
35. Safford SE, Oberley TD, Urano M, and St Clair DK. Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase. Cancer Res 54: 4261-4265, 1994.
36. 2-resistant Chinese hamster fibroblast cell lines. Arch Biochem Biophys 279: 249-260, 1990.
37. Spitz DR, Oberley LW. An assay for superoxide dismutase activity in mammalian tissue homogenates. Anal Biochem 179: 8-18, 1989.
38. St. Clair DK, Wan XS, Kuroda M, Vichitbandha S, Tsuchida E, and Urano M. Suppression of tumor metastasis by manganese superoxide dismutase is associated with reduced tumorigenicity and elevated fibronectin. Oncol Rep 4: 753-757, 1997.
39. St Clair DK, Wan XS, Oberley TD, Muse KE, and St Clair WH. Suppression of radiation-induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase. Mol Carcinog 6: 238-242, 1992.
40. Sun Y, Elwell JH, Oberley LW. A simultaneous visualization of the antioxidant enzymes glutathione peroxidase and catalase on polyacrylamide gels. Free Rad Res Commun 5: 57-67, 1988.
41. Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, Alderson NL, Baynes JW, Epstein CJ, Huang T-T, Nelson J, Strong R, and Richardson A. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics 16: 29-37, 2003.
42. Yan T, Oberley LW, Zhong W, and St. Clair DK. Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts. Cancer Res 56: 2864-2871, 1996.
43. Zhang HJ, Yan T, Oberley TD, and Oberley LW. Comparison of effects of two polymorphic variants of manganese superoxide dismutase on human breast MCF-7 cancer cell phenotype. Cancer Res 59: 6276-6283, 1999.
44. Zhang HJ, Zhao W, Venkataraman S, et al. Metalloproteinase-2 by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species. J Biol Chem 277: 20919-20926, 2002.
45. Zhong W, Oberley LW, Oberley TD, Yan T, Domann FE, and St. Clair DK. Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells. Cell Growth Differ 7: 1175-1186, 1996.
46. Zhong W, Oberley LW, Oberley TD, and St. Clair DK. Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase. Oncogene 14: 481-490, 1997.