A single chondroitin 6-sulfate oligosaccharide unit at Ser-2730 of human thyroglobulin enhances hormone formation and limits proteolytic accessibility at the carboxyl terminus: Potential insights into thyroid homeostasis and autoimmunity

Journal of Biological Chemistry

Volumn 281, Issue 31, 2006, Pages 22200-22211

  Conte, Marisa ^a   Arcaro, Alessia ^b   D'Angelo, Daniela ^a   Gnata, Ariele ^a   Mamone, Gianfranco ^c   Ferranti, Pasquale ^b   Formisano, Silvestro ^a   Gentile, Fabrizio ^b  

^a UNIVERSITY OF MOLISE   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNITY; GLUCURONIC ACID; HUMAN THYROGLOBULIN (HTG); PROTEOLYTIC ACCESSIBILITY;

BIOASSAY; CARBOXYLATION; ELECTRON MOBILITY; ENZYMES; GLUCOSE; IMMUNOLOGY; SACCHARIFICATION; SULFUR;

HORMONES;

CHONDROITIN 6 SULFATE; GLUCURONIC ACID; LIOTHYRONINE; NONAPEPTIDE; OLIGOSACCHARIDE; PROTEINASE; SERINE; THYROGLOBULIN; THYROXINE;

ARTICLE; AUTOIMMUNE DISEASE; CARBOXY TERMINAL SEQUENCE; ELECTROSPRAY MASS SPECTROMETRY; GEL MOBILITY SHIFT ASSAY; HOMEOSTASIS; HORMONAL REGULATION; HORMONE SYNTHESIS; HUMAN; IODINATION; ION EXCHANGE CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN ISOLATION; SEQUENCE ANALYSIS; THYROID DISEASE;

AMINO ACID SEQUENCE; AUTOIMMUNITY; CHONDROITIN SULFATES; HOMEOSTASIS; HORMONES; HUMANS; OLIGOSACCHARIDES; PEPTIDE HYDROLASES; SERINE; THYROGLOBULIN; THYROID GLAND; THYROIDITIS, AUTOIMMUNE; THYROXINE; TRIIODOTHYRONINE;

EID: 33746846527     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M513382200     Document Type: Article

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