Efficient large-scale synthesis of 5′-O-dimethoxytrityl-N 4-benzoyl-5-methyl-2′-deoxycytidine

Nucleosides, Nucleotides and Nucleic Acids

Volumn 25, Issue 7, 2006, Pages 765-770

  Ross, Bruce ^a   Han, Mingming ^a   Ravikumar, Vasulinga ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

5 O DMT N4 Benzoyl 5 Methyl 2 Deoxycytidine; Antisense; Deoxynucleoside; Oligonucleotides

Indexed keywords

5' O DIMETHOXYTRITYL N4 BENZOYL 5 METHYL 2' DEOXYCYTIDINE; CYTIDINE DERIVATIVE; ESTER DERIVATIVE; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; BENZOYLATION; CHEMICAL REACTION; HYDROLYSIS; SYNTHESIS; TECHNIQUE;

DEOXYCYTIDINE; MOLECULAR CONFORMATION; STEREOISOMERISM;

EID: 33746797707     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770600726059     Document Type: Article

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16. 1,4-Dioxane may be used instead of acetonitrile.
17. The reaction with ammonium hydroxide is usually complete in 1 h.
18. The product had a melting point between 215 and 217°C.