Novel anthraquinone conjugate of 2,2-bis(hydroxymethyl)propionic acid incorporated to a TFO with phosphodiester linkage facilitates triplex formation with dsDNA bearing a pyrimidine-gapped polypurine sequence

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 5, 2004, Pages 1305-1308

  Sato, Megumi ^a   Moriguchi, Tomohisa ^a   Shinozuka, Kazuo ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

Triplex intercalator inversion

Indexed keywords

ANTHRAQUINONE DERIVATIVE; GK 302; GK 303; GK 304; OLIGONUCLEOTIDE; PHOSPHORAMIDIC ACID; PROPIONIC ACID DERIVATIVE; THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DNA DRUG COMPLEX; DNA SEQUENCE; DRUG CONJUGATION; DRUG EFFECT; DRUG SYNTHESIS; THERMOSTABILITY; TRIPLE HELIX;

EID: 1242316368     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.12.028     Document Type: Article

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