Molecular mechanism of glutathione-mediated protection from oxidized low-density lipoprotein-induced cell injury in human macrophages: Role of glutathione reductase and glutaredoxin

Free Radical Biology and Medicine

Volumn 41, Issue 5, 2006, Pages 775-785

  Wang, Yanmei ^a   Qiao, Mu ^b   Mieyal, John J ^c   Asmis, Lars M ^d   Asmis, Reto ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Atherosclerosis; Cell death; Glutaredoxin; Glutathione; Glutathione reductase; Macrophage

Indexed keywords

CARMUSTINE; GLUTAMIC ACID DIETHYL ESTER; GLUTAREDOXIN; GLUTATHIONE REDUCTASE; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXY RADICAL; PROTEIN S; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TROLOX C;

ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL DAMAGE; CELL DEATH; CELL LEVEL; CELL PROTECTION; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; PROTEIN METHYLATION;

CELL DEATH; GLUTAREDOXINS; GLUTATHIONE; GLUTATHIONE REDUCTASE; HUMANS; LIPOPROTEINS; LIPOPROTEINS, LDL; MACROPHAGES; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MONOCYTES; OXIDOREDUCTASES; OXYGEN; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING;

EID: 33746758797     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2006.05.029     Document Type: Article

References (39)

1. Ross R., and Glomset J.A. The pathogenesis of atherosclerosis (first of two parts). N. Engl. J. Med. 295 (1976) 369-377
2. Ross R. Mechanisms of disease-Atherosclerosis-An inflammatory disease. N. Engl. J. Med. 340 (1999) 115-126
3. Kockx M.M. Apoptosis in the atherosclerotic plaque: quantitative and qualitative aspects. Arterioscler. Thromb. Vasc. Biol. 18 (1998) 1519-1522
4. Mitchinson M.J., Hardwick S.J., and Bennett M.R. Cell death in atherosclerotic plaques. Curr. Opin. Lipidol. 7 (1996) 324-329
5. Colles S.M., Maxson J.M., Carlson S.G., and Chisolm G.M. Oxidized LDL-induced injury and apoptosis in atherosclerosis-Potential roles for oxysterols. Trends Cardiovasc. Med. 11 (2001) 131-138
6. Geng Y.J., and Libby P. Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme. Am. J. Pathol. 147 (1995) 251-266
7. Hegyi L., Skepper J.N., Cary N.R., and Mitchinson M.J. Foam cell apoptosis and the development of the lipid core of human atherosclerosis. J. Pathol. 180 (1996) 423-429
8. Ball R.Y., Stowers E.C., Burton J.H., Cary N.R., Skepper J.N., and Mitchinson M.J. Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma. Atherosclerosis 114 (1995) 45-54
9. Crisby M., Kallin B., Thyberg J., Zhivotovsky B., Orrenius S., Kostulas V., and Nilsson J. Cell death in human atherosclerotic plaques involves both oncosis and apoptosis. Atherosclerosis 130 (1997) 17-27
10. Lee R.T., and Libby P. The unstable atheroma. Arterioscler. Thromb. Vasc. Biol. 17 (1997) 1859-1867
11. Palinski W., Rosenfeld M.E., Yla Herttuala S., Gurtner G.C., Socher S.S., Butler S.W., Parthasarathy S., Carew T.E., Steinberg D., and Witztum J.L. Low density lipoprotein undergoes oxidative modification in vivo. Proc. Natl. Acad. Sci. USA 86 (1989) 1372-1376
12. Steinberg D., and Witztum J.L. Lipoproteins, lipoprotein oxidation, and atherogenesis. In: Chien K.R. (Ed). Molecular basis of cardiovascular disease (1998), Sanders, Philadelphia, PA 458-475
13. Chisolm G.M., and Steinberg D. The oxidative modification hypothesis of atherogenesis: an overview. Free Radic. Biol. Med. 28 (2000) 1815-1826
14. Bea F., Hudson F.N., Chait A., Kavanagh T.J., and Rosenfeld M.E. Induction of glutathione synthesis in macrophages by oxidized low-density lipoproteins is mediated by consensus antioxidant response elements. Circ. Res. 92 (2003) 386-393
15. Shen L.J., and Sevanian A. OxLDL induces macrophage gamma-GCS-HS protein expression: a role for oxLDL-associated lipid hydroperoxide in GSH synthesis. J. Lipid Res. 42 (2001) 813-823
16. Gotoh N., Graham A., Nikl E., and Darley-Usmar V.M. Inhibition of glutathione synthesis increases the toxicity of oxidized low-density lipoprotein to human monocytes and macrophages. Biochem. J. 296 Pt 1 (1993) 151-154
17. Darley-Usmar V.M., Severn A., O'Leary V.J., and Rogers M. Treatment of macrophages with oxidized low-density lipoprotein increases their intracellular glutathione content. Biochem. J. 278 Pt 2 (1991) 429-434
18. Asmis R., and Begley J.G. Oxidized LDL promotes peroxide-mediated mitochondrial dysfunction and cell death in human macrophages: a caspase-3-independent pathway. Circ. Res. 92 (2003) E20-E29
19. Wintergerst E.S., Jelk J., and Asmis R. Differential expression of CD14, CD36 and the LDL receptor on human monocyte-derived macrophages. A novel cell culture system to study macrophage differentiation and heterogeneity. Histochem. Cell Biol. 110 (1998) 231-241
20. Asmis R., Llorente V.C., and Gey K.F. Prevention of cholesteryl ester accumulation in P388D1 macrophage-like cells by increased cellular vitamin E depends on species of extracellular cholesterol. Conventional heterologous non-human cell cultures are poor models of human atherosclerotic foam cell formation. Eur. J. Biochem. 233 (1995) 171-178
21. Esterbauer H., Striegl G., Puhl H., and Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic. Res. Commun. 6 (1989) 67-75
22. Asmis R., and Wintergerst E.S. Dehydroascorbic acid prevents apoptosis induced by oxidized low density lipoprotein in human monocyte-derived macrophages. Eur. J. Biochem. 255 (1998) 147-155
23. Reid V.C., and Mitchinson M.J. Toxicity of oxidised low density lipoprotein towards mouse peritoneal macrophages in vitro. Atherosclerosis 98 (1993) 17-24
24. Asmis R., Wang Y., Xu l., Kisgati M., Begley J.G., and Mieyal J.J. A novel thiol oxidation-based mechanism for adriamycin-induced cell injury in human macrophages. FASEB J. 19 (2005) 1866-1868
25. Chrestensen C.A., Starke D.W., and Mieyal J.J. Acute cadmium exposure inactivates thioltransferase (Glutaredoxin), inhibits intracellular reduction of protein-glutathionyl-mixed disulfides, and initiates apoptosis. J. Biol. Chem. 275 (2000) 26556-26565
26. Schafer F.Q., and Buettner G.R. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic. Biol. Med. 30 (2001) 1191-1212
27. Esterbauer H., Schaur R.J., and Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med. 11 (1991) 81-128
28. Klatt P., and Lamas S. Regulation of protein function by S-glutathiolation in response to oxidative and nitrosative stress. Eur. J. Biochem. 267 (2000) 4928-4944
29. Fratelli M., Gianazza E., and Ghezzi P. Redox proteomics: identification and functional role of glutathionylated proteins. Expert. Rev. Proteomics 1 (2004) 365-376
30. Untucht-Grau R., Schirmer R.H., Schirmer I., and Krauth-Siegel R.L. Glutathione reductase from human erythrocytes: amino-acid sequence of the structurally known FAD-binding domain. Eur. J. Biochem. 120 (1981) 407-419
31. Savvides S.N., Scheiwein M., Böhme C.C., Arteel G.E., Karplus P.A., Becker K., and Schirmer R.H. Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite. J. Biol. Chem. 277 (2002) 2779-2784
32. Meister A. Glutathione metabolism. Methods Enzymol 251 (1995) 3-7
33. Hardwick S.J., Carpenter K.L., Allen E.A., and Mitchinson M.J. Glutathione (GSH) and the toxicity of oxidised low-density lipoprotein to human monocyte-macrophages. Free Radic. Res. 30 (1999) 11-19
34. Asmis R., Begley J.G., Jelk J., and Everson W.V. Lipoprotein aggregation protects human monocyte-derived macrophages from OxLDL-induced cytotoxicity. J. Lipid Res. 46 (2005) 1124-1132
35. Coffey M.D., Cole R.A., Colles S.M., and Chisolm G.M. In vitro cell injury by oxidized low density lipoprotein involves lipid hydroperoxide-induced formation of alkoxyl, lipid, and peroxyl radicals. J. Clin. Invest. 96 (1995) 1866-1873
36. Kallianpur A.R. Iron and oxidative injury- a commentary on "Fatty acid-mediated iron translocation: a synergistic mechanism of oxidative injury" by D. Yao et al. Free Radic. Biol. Med. 39 (2005) 1305-1309
37. Kruszewski M. Labile iron pool: the main determinant of cellular response to oxidative stress. Mutat. Res. 531 (2003) 81-92
38. Sarkar J., Seshadri V., Tripoulas N.A., Ketterer M.E., and Fox P.L. Role of ceruloplasmin in macrophage iron efflux during hypoxia. J. Biol. Chem. 278 (2003) 44018-44024
39. Li W., Hellsten A., Xu L.H., Zhuang D.M., Jansson K., Brunk U.T., and Yuan X.M. Foam cell death induced by 7beta-hydroxycholesterol is mediated by labile iron-driven oxidative injury: mechanisms underlying induction of ferritin in human atheroma. Free Radic. Biol. Med. 39 (2005) 864-875