The expression of hypoxia-inducible factor-1α (HIF-1α) and angiogenesis markers in hyperplastic and malignant prostate tissue

Anticancer Research

Volumn 26, Issue 4 B, 2006, Pages 2989-2993

  Lekas, Alexandros ^a,d   Lazaris, Andreas C ^b   Deliveliotcs, Charalampos ^c   Chrisofos, Michail ^c   Zoubouli, Christina ^c   Lapas, Dimitrios ^b   Papathomas, Thomas ^b   Fokitis, Ioannis ^a   Nakopoulou, Lydia ^c  

^a GENERAL HOSPITAL OF NIKEA   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c UNIVERSITY OF ATHENS   (Greece)

^d NONE   (Greece)

Author keywords

Angiogenesis; Benign prostate hyperplasia; CD34; Hypoxia inducible factor 1 ; Prostate cancer; Vascular endothelial growth factor

Indexed keywords

BIOLOGICAL MARKER; CD34 ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MONOCLONAL ANTIBODY; VASCULOTROPIN ANTIBODY;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION;

AGED; AGED, 80 AND OVER; ANTIGENS, CD34; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33746679830     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. MacDonagh R and Pearcy R: Quality of life aspects in urology-benign prostatic hyperplasia. World J Urol 17: 199-204, 1999.
2. Gittes RF: Carcinoma of the prostate. N Engl J Med 324: 236-245, 1991.
3. Ellis LM and Fidler IJ: Angiogenesis and metastasis. Eur J Cancer 324: 2451-2460, 1996.
4. Campbell SC: Advances in angiogenesis research: relevance to urological oncology. J Urol 58: 1663-1674, 1997.
5. Burchardt M, Burchardt T, Chen MW, Hayck OR, Knight C, Shabsigh A, de La Taille A and Buttyan R: Vascular endothelial growth factor-A expression in the rat ventral prostate gland and the early effect of castration. Prostate 43: 184-194, 2000.
6. Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW and Koos RD: Activation of vascular endothelial growth factor gene transcription by hypoxia inducible factor 1. Mol Cell Biol 16: 4604-4613, 1996.
7. Zhong H, Hanrahan C, Van der Poel H and Simons JV: Hypoxia-inducible factor 1α and 1β proteins share common signaling pathways in human prostate cancer cells. Biochem Biol Res Comm 284: 352-356, 2001.
8. 2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 12: 149-162, 1998.
9. Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K and Dewerchin M: Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394: 485-490, 1998.
10. Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA and Zagzag D: Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases. Cancer Res 59: 5830-5835, 1999.
11. Aebersold DM, Burri P, Beer KT, Laissue J, Djonov V and Greiner RH: Expression of hypoxia-inducible factor 1 alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 61: 2911-2916, 2001.
12. Theodoropoulos V, Lazaris AC, Sofras F, Gerzelis I, Tsoukala V, Ghikonti I, Manikas K and Kastriotis I: Hypoxia-inducible factor 1α expression correlates with angiogenesis and unfavourable prognosis in bladder cancer. Eur Urol 46: 200-208, 2004.
13. Birner P, Schindl M, Obermair A, Plank C, Breitenecker G and Oberhuber G: Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavourable prognosis in early-stage invasive cervical cancer. Cancer Res 60: 4693-4696, 2000.
14. Rubin E and Farber JL: Neoplasia. In: Pathology (Third edition). (Winters R, Murphy MB, Monroe K, eds.). Lippincott and Raven, pp. 172, 1999.
15. Stefanou D, Batistatou A, Kamina S, Arkoumani E, Papachristou D and Agnantis N: Expression of vascular endothelial growth factor (VEGF) and association with microvessel density in benign prostatic hyperplasia and prostate cancer. In Vivo 18: 155-160, 2004.
16. Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Talks K, Pezzella F et al: Relation of hypoxia-inducible factors 1alpha and 2alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer 85: 881-890, 2001.
17. Theodoropoulos G, Larazis AC, Theodoropoulos V, Papatheodosiou K, Gazouli M, Bramis J, Patsouris E and Panousopoulos D: Hypoxia, angiogenesis and apoptosis markers in locally advanced rectal cancer. Int J Colorectal Disease, in press, 2005.
18. Semenza GL: Angiogenesis in ischemic and neoplastic disorders. Annu Rev Med 54: 17-28, 2003.
19. Folkam J, Watson K, Ingber D et al: Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339: 58-61, 1989.
20. Zhong H, Semenza G, Simons J and De Marzo AM: Upregulation of hypoxia-inducible factor 1α is an early event in prostate carcinogenesis. Cancer Detect Prevent 28: 88-93, 2004.
21. Giatromanolaki A and Harris AL: Tumour hypoxia, hypoxia signalling pathways and hypoxia inducible factor expression in human cancer. Anticancer Res 21(6B): 4317-4324, 2001.