The potential for dietary restriction to increase longevity in humans: Extrapolation from monkey studies

Biogerontology

Volumn 7, Issue 3, 2006, Pages 143-148

  Ingram, Donald K ^a   Roth, George S ^b   Lane, Mark A ^a   Ottinger, Mary Ann ^c   Zou, Sige ^a   de Cabo, Rafael ^a   Mattison, Julie A ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b GeroScience Inc   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

Author keywords

Aging; Cancer; Diabetes; Glucose; Heart disease; Insulin; Nutrition; Obesity; Primates

Indexed keywords

ARTICLE; DATA ANALYSIS; DIET RESTRICTION; DISEASE MARKER; EXPERIMENTAL STUDY; HEALTH HAZARD; HEALTH STATUS; HUMAN; INCIDENCE; LIFESPAN; LONGEVITY; LOW CALORY DIET; MEDICAL LITERATURE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; RISK ASSESSMENT;

AGING; ANIMALS; BIOLOGICAL EVOLUTION; CALORIC RESTRICTION; EATING; EVOLUTION; HAPLORHINI; HUMANS; LONGEVITY; MODELS, BIOLOGICAL; SPECIES SPECIFICITY;

EID: 33746656872     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-006-9013-2     Document Type: Article

References (38)

1. Bodkin NL, Alexander TM, Ortmeyer HK, Johnson E, Hansen BC (2003) Mortality and morbidity in laboratory-maintained Rhesus monkeys and effects of long-term dietary restriction. J Gerontol Biol Sci 58:212-219
2. de Grey AD (2005) The unfortunate influence of the weather on the rate of ageing: Why human caloric restriction or its emulation may only extend life expectancy by 2-3 years. Gerontology 51:73-82
3. Dirks AJ, Leeuwenburgh C (2006) Caloric restriction in humans: Potential pitfalls and health concerns. Mech Ageing Dev 127:1-7
4. Fontana L, Meyer TE, Klein S, Holloszy JO (2004) Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci USA 101:6659-6663
5. Hansen BC, Bodkin NL, Ortmeyer HK (1999) Calorie restriction in nonhuman primates: Mechanisms of reduced morbidity and Mortality. Toxicol Sci 52(2 Suppl):56-60
6. Heilbronn LK, Ravussin E (2003) Calorie restriction and aging: Review of the literature and implications for studies in humans. Am J Clin Nutr 78:361-369
7. Heilbronn LK, Smith SR, Martin CK, Anton SD, Ravussin E (2005) Alternate-day fasting in nonobese subjects: Effects on body weight, body composition, and energy metabolism. Am J Clin Nutr 81:69-73
8. Heilbronn LK, Ravussin E (2005) Calorie restriction extends life span - but which calories? PLoS Med 2:e231
9. Hursting SD, Lavigne JA, Berrigan D, Perkins SN, Barrett JC (2003) Calorie restriction, aging, and cancer prevention: Mechanisms of action and applicability to humans. Annu Rev Med 54:131-152
10. Ingram DK, Cutler RG, Weindruch R, Renquist DM, Knapka JJ, April MA, Belcher CT, Clark MA, Hatcherson CD, Marriott BM, Roth GS (1990) Dietary restriction and aging: The initiation of a primate study. J Gerontol Biol Sci 45:B148-B163
11. Ingram DK, Nakamura E, Smucny D, Roth GS, Lane MA (2001) Strategy for identifying biomarkers of aging in long-lived species. Exp Gerontol 36:1025-1034
12. Ingram DK, Anson RM, de Cabo R, Mamczarz J, Zhu M, Mattison J, Lane MA, Roth GS (2004) Development of calorie restriction mimetics as a prolongevity strategy. Ann NYAS Sci 1019:412-423
13. Ingram DK, Roth GS, Ottinger MA, Lane MA, Anson A, de Cabo R, Mattison J (2005) Calorie restriction in nonhuman primates: Impact on aging, disease, and frailty. In: Carey JR, Robine J-M, Michel J-P, Christen Y (eds) Longevity and frailty. Springer-Verlag, Berlin, pp 39-56
14. Kemnitz JW, Weindruch R, Roecker EB, Crawford K, Kaufman PL, Ershler WB (1993) Dietary restriction of adult male rhesus monkeys: Design, methodology, and preliminary findings from the first year of study. J Gerontol 48:B17-B26
15. Lane MA, Mattison JA, Roth GS, Brant LJ, Ingram DK (2004) Effects of long-term diet restriction on aging and longevity in primates remain uncertain. J Gerontol: Biol Sci 59A:405-407
16. Magwere T, Chapman T, Partridge L (2004) Sex differences in the effect of dietary restriction on life span and mortality rates in female and male Drosophila melanogaster. J Gerontol A Biol Sci Med Sci 59:3-9
17. Maswood N, Young J, Tilmont E, Zhang Z, Gash DM, Gerhardt GA, Grondin R, Roth GS, Mattison J, Lane MA, Carson RE, Cohen RM, Mouton PR, Quigley C, Mattson MP, Ingram DK (2004) Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc Natl Acad Sci USA 101:18171-18176
18. Mattison JA, Lane MA, Roth GS, Ingram DK (2003) Calorie restriction in rhesus monkeys. Exp Gerontol 38:35-46
19. Mattson MP (2005) Energy intake, meal frequency, and health: A neurobiological perspective. Annu Rev Nutr 25:237-260
20. Meyer TE, Kovacs SJ, Ehsani AA, Klein S, Holloszy JO, Fontana L (2006) Long-term caloric restriction ameliorates the decline in diastolic function in humans. J Am Coll Cardiol 47:398-402
21. Phelan JP, Rose MR (2005) Why dietary restriction substantially increases longevity in animal models but won't in humans. Ageing Res Rev 4:339-345
22. Pittas AG, Das SK, Hajduk CL, Golden J, Saltzman E, Stark PC, Greenberg AS, Roberts SB (2005) A low-glycemic load diet facilitates greater weight loss in overweight adults with high insulin secretion but not in overweight adults with low insulin secretion in the CALERIE trial. Diabetes Care 28:2939-2941
23. Ramsey JJ, Colman RJ, Binkley NC, Christensen JD, Gresl TA, Kemnitz JW, Weindruch R (2000) Dietary restriction and aging in rhesus monkeys: The University of Wisconsin study. Exp Gerontol 35:1131-1149
24. Roberts CK, Barnard RJ (2005) Effects of exercise and diet on chronic disease. J Appl Physiol 98: 3-30
25. Roth GS, Ingram DK, Cutler RG (1991) Calorie restriction in non-human primates: A progress report. Aging: Clin Exp Res 3:391-392
26. Roth GS, Ingram DK, Lane MA (1999) Calorie restriction in primates: Will it work and how will we know? J Am Geriatr Soc 47:896-903
27. Roth GS, Lane MA, Ingram DK, Mattison J, Elahi D, Tobin J, Muller D, Metter EJ (2002) Biomarkers of caloric restriction may predict longevity in humans. Science 297:881
28. Roth GS, Mattison JA, Ottinger MA, Chachich M, Lane MA, Ingram DK (2004) Aging in rhesus monkeys: Relevance to human health interventions. Science 305:1423-1426
29. Roth GS, Lane MA, Ingram DK (2005) Caloric restriction mimetics: The next phase. Ann NY Acad Sci 1057:365-371
30. Samaras TT, Storms LH, Elrick H (2002) Longevity, mortality and body weight. Ageing Res Rev 1:673-691
31. Samaras TT, Elrick H, Storms LH (2003) Is height related to longevity? Life Sci 72:1781-802
32. Shanley DP, Kirkwood TB (2000) Calorie restriction and aging: A life-history analysis. Evolution Int J Org Evol 54:740-750
33. Shiner JS, Uehlinger DE (2001) Body mass index: A measure for longevity. Med Hypotheses 57:780-783
34. Smith JV, Heilbronn LK, Ravussin E (2004) Energy restriction and aging. Curr Opin Clin Nutr Metab Care 7:615-622
35. Sinclair DA (2005) Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev 126:987-1002
36. Spindler SR (2005) Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction. Mech Ageing Dev 126:960-966
37. Suzuki M, Wilcox BJ, Wilcox CD (2001) Implications from and for food cultures for cardiovascular disease: Longevity. Asia Pac J Clin Nutr 10:165-171
38. Warner HR, Ingram D, Miller RA, Nadon NL, Richardson AG (2000) Program for testing biological interventions to promote healthy aging. Mech Ageing Dev 115: 199-207