3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 13, 2006, Pages 3524-3528

  Bignan, Gilles C ^a   Battista, Kathleen ^a   Connolly, Peter J ^a   Orsini, Michael J ^a   Liu, Jingchun ^a   Middleton, Steven A ^a   Reitz, Allen B ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Agonist; Anxiety; Indole; Learning; Memory; N OFQ peptide (NOP); Nociceptin; Opioid receptor like (ORL); ORL 1; Orphanin FQ (OFQ); Piperidine; Pyridine; Stress

Indexed keywords

1H PYRROLO[2,3 B]PYRIDINE; 3 (4 PIPERIDINYL)INDOLE; 3 (4 PIPERIDINYL)PYRROLO [2,3 B]PYRIDINE; INDOLE DERIVATIVE; NITROGEN; OPIATE AGONIST; OPIATE ANTAGONIST; OPIATE RECEPTOR; OPIOID RECEPTOR LIKE 1; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; LIGAND; NOCICEPTIN RECEPTOR; PIPERIDINE DERIVATIVE; PYRROLE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CELL STRAIN HEK293; DRUG BINDING; DRUG INTERACTION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG POTENTIATION; SYNTHESIS;

BINDING SITES; INDOLES; LIGANDS; MOLECULAR STRUCTURE; PIPERIDINES; PYRIDINES; PYRROLES; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33746655450     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.03.094     Document Type: Article

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