IGF-1R tyrosine kinase expression and dependency in clones of IGF-1R knockout cells (R-)

Biochemical and Biophysical Research Communications

Volumn 347, Issue 4, 2006, Pages 1059-1066

  Rosengren, Linda ^a   Vasilcanu, Daiana ^a   Vasilcanu, Radu ^a   Fickenscher, Sandra ^a   Sehat, Bita ^a   Natalishvili, Nathalia ^a   Naughton, Sean ^a   Yin, Shucheng ^a   Girnita, Ada ^a   Girnita, Leonard ^a   Axelson, Magnus ^a   Larsson, Olle ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

IGF 1 receptor; IGF 1R; Knockout; Microtubule; PPP; R ; Transformation

Indexed keywords

PICROPODOPHYLLIN; PODOPHYLLOTOXIN; PROTEIN; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; SOMATOMEDIN C RECEPTOR; TUBULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BETA CHAIN; CELL CLONING; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; HUMAN; HUMAN CELL; KNOCKOUT GENE; MICROTUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RECEPTOR SENSITIVITY;

ANIMALS; CELL SURVIVAL; DOWN-REGULATION; HUMANS; MICE; MICE, KNOCKOUT; PODOPHYLLOTOXIN; RECEPTOR, IGF TYPE 1; RNA, SMALL INTERFERING; TUBULIN; TUMOR CELLS, CULTURED;

EID: 33746567306     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.07.006     Document Type: Article

References (44)

1. Baserga R. The IGF-I receptor in cancer research. Exp. Cell Res. 253 (1999) 1-6
2. Le Roith D., Karas M., Yakar S., Qu B.H., Wu Y., and Blakesley V.A. The role of the insulin-like growth factors in cancer. Isr. Med. Assoc. J. 1 (1999) 25-30
3. Baserga R. The insulin-like growth factor I receptor: a key to tumor growth?. Cancer Res. 55 (1995) 249-252
4. Baserga R., Hongo A., Rubini M., Prisco M., and Valentinis B. The IGF-I receptor in cell growth, transformation and apoptosis. Biochim. Biophys. Acta 1332 (1997) F105-F126
5. Girnita L., Girnita A., Brodin B., Xie Y., Nilsson G., Dricu A., Lundeberg J., Wejde J., Bartolazzi A., Wiman K.G., and Larsson O. Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact. Cancer Res. 60 (2000) 5278-5283
6. Girnita L., Girnita A., and Larsson O. Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor. Proc. Natl. Acad. Sci. USA 100 (2003) 8247-8252
7. All-Ericsson C., Girnita L., Seregard S., Bartolazzi A., Jager M.J., and Larsson O. Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target. Invest Ophthalmol. Vis. Sci. 43 (2002) 1-8
8. LeRoith D., Werner H., Beitner-Johnson D., and Roberts Jr. C.T. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr. Rev. 16 (1995) 143-163
9. Yu H., and Rohan T. Role of the insulin-like growth factor family in cancer development and progression. J. Natl. Cancer Inst. 92 (2000) 1472-1489
10. Kanter-Lewensohn L., Girnita L., Girnita A., Dricu A., Olsson G., Leech L., Nilsson G., Hilding A., Wejde J., Brismar K., and Larsson O. Tamoxifen-induced cell death in malignant melanoma cells: possible involvement of the insulin-like growth factor-1 (IGF-1) pathway. Mol. Cell Endocrinol. 165 (2000) 131-137
11. Larsson O., Girnita A., and Girnita L. Role of insulin-like growth factor 1 receptor signalling in cancer. Br. J. Cancer 92 (2005) 2097-2101
12. Wang M., Xie Y., Girnita L., Nilsson G., Dricu A., Wejde J., and Larsson O. Regulatory role of mevalonate and N-linked glycosylation in proliferation and expression of the EWS/FLI-1 fusion protein in Ewing's sarcoma cells. Exp. Cell Res. 246 (1999) 38-46
13. Liu J.P., Baker J., Perkins A.S., Robertson E.J., and Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75 (1993) 59-72
14. Abbott A.M., Bueno R., Pedrini M.T., Murray J.M., and Smith R.J. Insulin-like growth factor I receptor gene structure. J. Biol. Chem. 267 (1992) 10759-10763
15. Sell C., Dumenil G., Deveaud C., Miura M., Coppola D., DeAngelis T., Rubin R., Efstratiadis A., and Baserga R. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol. Cell Biol. 14 (1994) 3604-3612
16. Sell C., Rubini M., Rubin R., Liu J.P., Efstratiadis A., and Baserga R. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc. Natl. Acad. Sci. USA 90 (1993) 11217-11221
17. Baserga R. Oncogenes and the strategy of growth factors. Cell 79 (1994) 927-930
18. Baserga R., Prisco M., and Hongo A. IGFs and cell growth. In: Rosenfeld J.R.G., and Roberts C.T. (Eds). The IGF System (1999), Humana Press, Totowa, NJ 329-353
19. Baserga R. The contradictions of the insulin-like growth factor 1 receptor. Oncogene 19 (2000) 5574-5581
20. Baserga R., Peruzzi F., and Reiss K. The IGF-1 receptor in cancer biology. Int. J. Cancer 107 (2003) 873-877
21. Baserga R., Resnicoff M., and Dews M. The IGF-I receptor and cancer. Endocrine 7 (1997) 99-102
22. Valentinis B., Morrione A., Taylor S.J., and Baserga R. Insulin-like growth factor I receptor signaling in transformation by src oncogenes. Mol. Cell Biol. 17 (1997) 3744-3754
23. Girnita A., Girnita L., del Prete F., Bartolazzi A., Larsson O., and Axelson M. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res. 64 (2004) 236-242
24. Vasilcanu D., Girnita A., Girnita L., Vasilcanu R., Axelson M., and Larsson O. The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway. Oncogene 23 (2004) 7854-7862
25. Menu E., Jernberg-Wiklund H., Stromberg T., De Raeve H., Girnita L., Larsson O., Axelson M., Asosingh K., Nilsson K., Van Camp B., and Vanderkerken K. Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model. Blood 107 (2006) 655-660
26. Stromberg T., Ekman S., Girnita L., Dimberg L.Y., Larsson O., Axelson M., Lennartsson J., Hellman U., Carlson K., Osterborg A., Vanderkerken K., Nilsson K., and Jernberg-Wiklund H. IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells. Blood 107 (2006) 669-678
27. Ayres D.C., and Loike J.D. Lignans, Chemical, Biological and Clinical Properties (1990), Cambridge University Press, Cambridge 121
28. Loike J.D., Brewer C.F., Sternlicht H., Grensler W.J., and Horowitz S.B. Structure activity study of the inhibition of microtubule assembly in vitro by podophyllotoxin and its congeners. Cancer Res. 38 (1978) 2688-2693
29. Buchardt O., Jensen R.B., Hansen H.F., Nielsen P.E., Andersen D., and Chinoin I. Thermal chemistry of podophyllotoxin in ethanol and a comparison of the cytostatic activity of the thermolysis products. J. Pharm. Sci. 75 (1986) 1076-1080
30. Rubini M., Hongo A., D'Ambrosio C., and Baserga R. The IGF-I receptor in mitogenesis and transformation of mouse embryo cells: role of receptor number. Exp. Cell Res. 230 (1997) 284-292
31. Tahir S.K., Kovar P., Rosenberg S.H., and Ng S.C. Rapid colchicine competition-binding scintillation proximity assay using biotin-labeled tubulin. Biotechniques 29 (2000) 156-160
32. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
33. Girnita L., Shenoy S.K., Sehat B., Vasilcanu R., Girnita A., Lefkowitz R.J., and Larsson O. β-arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J. Biol. Chem. 280 (2005) 24412-24419
34. Gensler W.J., and Gatsonis C.D. The podophyllotoxin-picropodophyllin equilibrium. J. Org. Chem. 31 (1966) 3224-3227
35. Girnita A., All-Ericsson C., Economou M.A., Astrom K., Axelson M., Seregard S., Larsson O., and Girnita L. The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells. Clin. Cancer Res. 12 (2006) 1383-1391
36. Ulfarsson E., Karstrom A., Yin S., Girnita A., Vasilcanu D., Thoren M., Kratz G., Hillman J., Axelson M., Larsson O., and Girnita L. Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach. Clin. Cancer Res. 11 (2005) 4674-4680
37. Vasilcanu D., Weng W.H., Girnita A., Lui W.O., Vasilcanu R., Axelson M., Larsson O., Larsson C., and Girnita L. The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection. Oncogene 25 (2006) 3186-3195
38. Colon E., Strand M.L., Carlsson-Skwirut C., Wahlgren A., Svechnikov K.V., Cohen P., and Soder O. Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis. J. Cell Physiol. 208 (2006) 373-385
39. Colon E., Svechnikov K.V., Carlsson-Skwirut C., Bang P., and Soder O. Stimulation of steroidogenesis in immature rat Leydig cells evoked by interleukin-1alpha is potentiated by growth hormone and insulin-like growth factors. Endocrinology 146 (2005) 221-230
40. Liu J.L., Blakesley V.A., Gutkind J.S., and LeRoith D. The constitutively active mutant Galpha13 transforms mouse fibroblast cells deficient in insulin-like growth factor-I receptor. J. Biol. Chem. 272 (1997) 29438-29441
41. Himmelmann B., Terry C., Dey B.R., Lopaczynski W., and Nissley P. Anchorage-independent growth of fibroblasts that express a truncated IGF-I receptor. Biochem. Biophys. Res. Commun. 286 (2001) 472-477
42. Favelyukis S., Till J.H., Hubbard S.R., and Miller W.T. Structure and autoregulation of the insulin-like growth factor 1 receptor kinase. Nat. Struct. Biol. 8 (2001) 1058-1063
43. Lopaczynski W., Terry C., and Nissley P. Autophosphorylation of the insulin-like growth factor I receptor cytoplasmic domain. Biochem. Biophys. Res. Commun. 279 (2000) 955-960
44. Spence S.L., Shaffer A.L., Staudt L.M., Amde S., Manney S., Terry C., Weisz K., and Nissley P. Transformation of late passage insulin-like growth factor-I receptor null mouse embryo fibroblasts by SV40 T antigen. Cancer Res. 66 (2006) 4233-4239