Neuroprotective effect of PACAP against kainic acid-induced neurotoxicity in rat retina

Annals of the New York Academy of Sciences

Volumn 1070, Issue , 2006, Pages 531-534

  Seki, Tamotsu ^a,b   Nakatani, Masayoshi ^c   Taki, Chisato ^c   Shinohara, Yuko ^c   Ozawa, Motoki ^c   Nishimura, Shigeru ^c   Ito, Hiroyuki ^a   Shioda, Seiji ^b  

^a Ophthalmology   (Japan)

^b SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NIDEK CO LTD   (Japan)

Author keywords

Ganglion cell; Kainic acid; PACAP (pituitary adenylate cyclase activating polypeptide); Rat retina

Indexed keywords

HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; KAINIC ACID;

ANIMAL CELL; CELL DEATH; CELL SURVIVAL; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; RAT; RETINA;

RODENTIA;

EID: 33746405106     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1317.074     Document Type: Conference Paper

References (13)

1. SHIODA, S. 2000. Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors in the brain. Kaibogaku Zasshi 75: 487-507.
2. VAUDRY, D., B.J. GONZALEZ, M. BASILLE, ET AL. 2000. Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to function. Pharmacol. Rev. 52: 269-324.
3. SEKI, T., S. SHIODA, et al. 1997. Distribution and ultrastructural localization of a receptor for pituitary adenylate cyclase activating polypeptide and its mRNA in the rat retina. Neurosci. Lett. 238: 127-130.
4. SEKI, T., S. IZUMI, et al. 2000. Gene expression for PACAP receptor mRNA in the rat retina by in situ hybridization and in situ RT-PCR. Ann. N. Y. Acad. Sci. 921: 366-369.
5. SHOGE, K. et al. 1999. Attenuation by PACAP of glutamate-induced neurotoxicity in cultured retinal neurons. Brain Res. 839: 66-73.
6. TAMAS, A., R. GABRIEL, et al. 2004. Effects of pituitary adenylate cyclase activating polypeptide in retinal degeneration induced by monosodium-glutamate. Neurosci. Lett. 372: 110-113.
7. SEKI, T., S. IZUMI, et al. 2003. Pituitary adenylate cyclase-activating polypeptide (PACAP) protects ganglion cell death against cutting of optic nerve in the rat retina. Regul. Pept. 115: 55.
8. KASHIWAGI, K., B. OU, S. NAKAMURA, et al. 2003. Increase in dephosphorylation of the heavy neurofilament subunit in the monkey chronic glaucoma model. Invest. Ophthalmol. Vis. Sci. 44: 154-159.
9. ZHANG, X., M. CHENG, et al. 2004. Kainic acid-mediated upregulation of matrix metalloproteinase-9 promotes retinal degeneration. Invest. Ophthalmol. Vis. Sci. 45: 2374-2383.
10. MENDONCA TORRES, P.M. & E.G. DE ARAUJO. 2001. Interleukin-6 increases the survival of retinal ganglion cells in vitro. J. Neuroimmunol. 117: 43-50.
11. CHILDOW, G. & N.N. OSBORNE. 2003. Rat retinal ganglion cell loss caused by kainate, NMDA and ischemia correlates with a reduction in mRNA and protein of Thy-1 and neurofilament light. Brain Res. 963: 298-306.
12. SHIODA, S., H. OZAWA, K. DOHI, et al. 1998. PACAP protects hippocampal neurons against apoptosis: involvement of JNK/SAPK signaling pathway. Ann. N. Y. Acad. Sci. 865: 111-117.
13. SEKI, T., Y. SHINOHARA, C. TAKI, et al. 2006. PACAP stimulates the release of Interleukin-6 in cultured rat Müller cells. Ann. N. Y. Acad. Sci. In press.