Small Rho GTPases are important for acinus formation in a human salivary gland cell line

Cell and Tissue Research

Volumn 325, Issue 3, 2006, Pages 493-500

  Crema, Virgínia O ^a,b   Hamassaki, Dânia E ^a   Santos, Marinilce F ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF UBERABA   (Brazil)

Author keywords

Actin; Cytoskeleton; Human; Rho GTPases; Salivary gland cell line; Submandibular gland

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; LYSOPHOSPHATIDIC ACID; MATRIGEL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN CDC42; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN;

ACINAR CELL; ACTIN POLYMERIZATION; ARTICLE; CELL MIGRATION; CELL STIMULATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; SALIVARY GLAND; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ACTINS; CELL CULTURE TECHNIQUES; CELL LINE; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR MATRIX; FIBROBLAST GROWTH FACTOR 2; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; FLUORESCENT DYES; HUMANS; IMMUNOHISTOCHEMISTRY; LYSOPHOSPHOLIPIDS; MICROSCOPY, CONFOCAL; MONOMERIC GTP-BINDING PROTEINS; PHALLOIDINE; RHODAMINES; SALIVARY GLANDS; SIGNAL TRANSDUCTION;

EID: 33746399381     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00441-006-0192-6     Document Type: Article

References (35)

1. Amano M, Chihara K, Kimura K, Fukata Y, Nakamura N, Matsuura Y, Kaibuchi K (1997) Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 275:1308-1311
2. Bishop AL, Hall A (2000) Rho GTPases and their effector proteins. Biochem J 348:241-255
3. Bokoch GM, Vlahos C, Wang Y, Knaus UG, Traynor-Kaplan AE (1996) Rac GTPase interacts specifically with phosphatidylinositol 3-kinase. Biochem J 315:775-779
4. Bradford MA (1976) A rapid and sensitive method for the quantitation of microgram amounts of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
5. Burridge K, Wennerberg K (2004) Rho and Rac take center stage. Cell 116:167-179
6. Etienne-Manneville S, Hall A (2002) Rho GTPases in cell biology. Nature 420:629-635
7. Genot EM, Arrieumerlou C, Ku G, Burgering BMT, Weiss A, Kramer IM (2000) The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase. Mol Cell Biol 20:5469-5478
8. Hall A, Nobes CD (2000) Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton. Philos Trans R Soc Lond B Biol Sci 355:965-970
9. Hawkins PT, Eguinoa A, Qiu RG, Stokoe D, Cooke FT, Walters R, Wennstrom S, Claesson-Welsh L, Evans T, Symons M, et al (1995) PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr Biol 5:393-403
10. Hiramatsu Y, Kagami H, Horie K, Okazaki Y, Shigetomi T, Hata K, Kobayashi S, Ueda M (2000) Effects of basic fibroblast growth factor on cultured rat and human submandibular salivary gland cells. Arch Oral Biol 45:593-599
11. Hoffman MP, Kibbey MC, Letterio JJ, Kleinman HK (1996) Role of laminin-1 and TGF-β3 in acinar differentiation of a human submandibular gland cell line (HSG). J Cell Sci 109:2013-2021
12. Hoffman MP, Nomizu M, Roque E, Lee S, Jung DW, Yamada Y, Kleinman HK (1998) Laminin-1 and laminin-2 G-domain synthetic pep tides bind syndecan-1 and are involved in acinar formation of a human submandibular gland cell line. J Biol Chem 273:28633-28641
13. Just I, Wilm M, Selzer J, Rex G, Eichel-Streiber C von, Mann M, Aktories K (1995) The enterotoxin from Clostridium difficile (Tox A) monoglucosylates the Rho proteins. J Biol Chem 270:13932-13936
14. Kleinman HK, Martin GR (2005) Matrigel: basement membrane matrix with biological activity. Semin Cancer Biol 15:378-386
15. Koyama N, Kashimata M, Sakashita H, Sakagami H, Gresik EW (2003) EGF-stimulated signaling by means of PI3K, PLCγ1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland. Dev Dyn 227:216-226
16. 3 in submandibular gland branching morphogenesis. Dev Biol 255:178-191
17. Menko AS, Kreidberg JA, Ryan TT, Van Bockstaele E, Kukuruzinska MA (2001) Loss of alpha3beta1 integrin function results in an altered differentiation program in the mouse submandibular gland. Dev Dyn 220:337-349
18. Menko AS, Zhang L, Schiano F, Kreidberg JA, Kukuruzinska MA (2002) Regulation of cadherin junctions during mouse submandibular gland development. Dev Dyn 224:321-333
19. Nobes CD, Hall A (1999) Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol 144:1235-1244
20. Radeff-Huang J, Seasholtz TM, Matteo RG, Brown JH (2004) G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival. J Cell Biochem 92:949-966
21. Raftopoulou M, Hall A (2004) Cell migration: Rho GTPases lead the way. Dev Biol 265:23-32
22. Ridley AJ (2001a) Rho GTPases and cell migration. J Cell Sci 114:2713-2722
23. Ridley AJ (2001b) Rho proteins, PI 3-kinase, and monocyte/macrophage motility. FEBS Lett 498:168-171
24. Ridley AJ, Hall A (1992) The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389-399
25. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A (1992) The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling. Cell 70:401-410
26. Royce LS, Kibbey MC, Mertz P, Kleinman HK, Baum BJ (1993) Human neoplastic submandibular intercalated duct cells express an acinar phenotype when cultured on a basement membrane matrix. Differentiation 52:247-255
27. Santos MF, McCormack SA, Guo Z, Okolicany J, Johnson LR, Tigyi G (1997) Rho proteins play a critical role in cell migration during the early phase of mucosal restitution. J Clin Invest 100:216-225
28. Sato N, Kyakumoto S, Sawano K, Ota M (1996) Proliferative signal transduction by epidermal growth factor (EGF) in the human salivary gland adenocarcinoma (HSG) cell line. Biochem Mol Biol Int 38:597-606
29. Schmitz AAP, Govek E, Bottner B, Van Aelst L (2000) Rho GTPases: signaling, migration, and invasion. Exp Cell Res 261:1-12
30. Schwartz-Arad D, Arber L, Arber N, Zajicek G, Michaeli Y (1988) The rat parotid gland - a renewing cell population. J Anat 161:143-151
31. Shirasuna K, Sato M, Miyazaki T (1981) A neoplastic epithelial duct cell line established from an irradiated human salivary gland. Cancer 48:745-752
32. Steinberg Z, Myers C, Heim VM, Lathrop CA, Rebustini IT, Stewart JS, Larsen M, Hoffman MP (2005) FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development 132:1223-1234
33. Takai Y, Sasaki T, Matozaki T (2001) Small GTP-binding proteins. Physiol Rev 81:153-208
34. Vukicevic S, Kleinman HK, Luyten FP, Roberts AB, Roche NS, Reddi AH (1992) Identification of multiple active growth factors in basement membrane Matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components. Exp Cell Res 202:1-8
35. Zheng C, Hoffman MP, McMillan T, Kleinman HK, O'Connell BC (1998) Growth factor regulation of the amylase promoter in a differentiating salivary acinar cell line. J Cell Physiol 177:628-635