Further development of a robust workup process for solution-phase high-throughput library synthesis to address environmental and sample tracking issues

Journal of Combinatorial Chemistry

Volumn 8, Issue 4, 2006, Pages 505-512

  Kuroda, Noritaka ^a   Hird, Nick ^a   Cork, David G ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; POLYSORBATE; SOLVENT; SURFACTANT; VALERIC ACID DERIVATIVE;

ARTICLE; CHEMICAL MODEL; CHEMISTRY; COMBINATORIAL CHEMISTRY; FILTRATION; LIQUID CHROMATOGRAPHY; METHODOLOGY; SYNTHESIS; TIME; VOLATILIZATION;

AMIDES; CHROMATOGRAPHY, LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; FILTRATION; MODELS, CHEMICAL; PENTANOIC ACIDS; POLYSORBATES; SOLVENTS; SURFACE-ACTIVE AGENTS; TIME FACTORS; VOLATILIZATION;

EID: 33746352366     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc060004l     Document Type: Article

References (27)

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13. Modular high-throughput apparatuses include Myriad Core System, Myriad Personal Synthesizer (Mettler Toledo, Japan), Genesis multichannel liquid handler (Tecan, Manndorf, Switzerland), centrifugal evaporator (Genevac, Ipswich, U.K.), preparative HPLC purification system (Gilson, Wisconsin, U.S.A.), LC/Mass instruments (Shimadzu, Kyoto, Japan and Waters, Massachusetts, U.S.A.), and Automated weigher (Mettler Toledo, U.S.A.).
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15. The stirring rack to contain the reaction vessels and the filter rack to hold phase separation tubes and the Exchanger 96 to transfer the vials from the polypropylene rack to the aluminum rack were all custom-made by Unitech Ltd. (Unitech, Osaka, Japan).
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