Semi-automated high throughput combinatorial solid-phase organic synthesis

Biotechnology and Bioengineering

Volumn 61, Issue 3, 1999, Pages 135-141

  Krchňák, Viktor ^a  

^a SIDDCO   (United States)

Author keywords

Chemist tools; Gaseous cleavage; Instrumentation; Parallel synthesis; Reaction vessel; Solid phase organic synthesis

Indexed keywords

ARTICLE; AUTOMATION; INSTRUMENTATION; ORGANIC CHEMISTRY; SOLID PHASE EXTRACTION; SYNTHESIS;

EID: 0033600003     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(1998)61:3<135::AID-CC1>3.0.CO;2-S     Document Type: Article

References (20)

1. Hermkens, P.H.H.; Ottenheijm, H.C.J.; Rees D.C. Tetrahedron 1996, 52, 4527-4554.
2. Hermkens, P.H.H.; Ottenheijm, H.C.J.; Rees D.C. Tetrahedron 1997, 53, 5643-5678.
3. Furka, A.; Sebestyen, F.; Asgedom, M.; Dibo, G. Intl J Pept Protein Res 1991, 37, 487-493.
4. Houghten, R.A.; Pinilla C.; Blondelle, S.E.; Appe, J.R.; Dooley, C.T.; Cuervo, J.H. Nature 1991, 354, 84-86.
5. Lam, K.S.; Salmon, S.E.; Hersh, E.M .; Hruby, V.J.; Kazmierski, W.M.; Knapp, R.J. Nature 1991, 354, 82-84.
6. Kerr, J.M.; Banville, S.C.; Zuckermann, R.N. J Am Chem Soc 1993, 115, 2529-2531.
7. Nikolaev, V.; Stierandova, A.; Krchňák, V.; Seligmann, B.; Lam, K.S.; Salmon, S.E.; Lebl, M. Peptide Res 1993, 6, 161-170.
8. Ohlmeyer, M.H.J.; Swanson, R.N.; Dillard, L.W.; Reader, J.C.; Asouline, G.; Kobayashi, R.; Wigler, M.; Still, W.C. Proc Natl Acad Sci USA 1993, 90, 10922-10926.
9. Baldwin, J.J.; Burbaum, J.J.; Henderson, I.; Ohlmeyer, M.H.J. J Am Chem Soc 1995, 117, 5588-5589.
10. Baldwin, J.J.; Burbaum, J.J.; Chelsky, D.; Dillard, L.W.; Henderson, I.; Li, G.; Ohlmeyer, M.H.J.; Randle, T.L.; Reader, J.C. Eur J Med Chem 1995, 30, S349-S358.
11. Burbaum, J.J.; Ohlmeyer, M.H.J.; Reader, J.C.; Henderson, I.; Dillard, L.W.; Li, G.; Randle, T.L.; Sigal, N.H.; Chelsky, D.; Baldwin, J.J. Proc Natl Acad Sci USA 1995, 92, 6027-6031.
12. Moran, E.J.; Sarshar, S.; Cargill, J.F.; Shahbaz, M.M.; Lio, A.; Mjalli, A.M.M.; Armstrong, R.W. J Am Chem Soc 1995, 117, 10787-10788.
13. Nicolaou, K.C.; Xiao, X.Y.; Parandoosh, Z.; Senyei, A.; Nova, M.P. Angew Chem Int Ed 1995, 34, 2289-2291.
14. Cargill, J.F.; Lebl, M. Curr Opin Chem Biol 1997, 1, 67-71.
15. Krchňák, V.; Padera, V. Bioorg Med Chem Lett 1998, 22, 3261-3264.
16. Krchňák, V.; Weichsel, A.S.; Lebl, M.; Felder, S. Bioorg Med Chem Lett 1997, 7, 1013-1016.
17. Krchňák, V.; Vagner, J.; Safar, P.; Lebl, M. Collect Czech Chem Commun 1988, 53, 2542-2548.
18. Lebl, M.; Krchňák, V. In: Epton R, editor. Innovation & Perspectives in Solid Phase Synthesis; Mayflower Scientific Limited: Birmingham, 1999.
19. Bray, A.M.; Maeji, N.J.; Jhingran, A.G.; Valerio, R.M. Tetrahedron Lett 1991, 32, 6163-6166.
20. Krchňák, V.; Weichsel, A.S. Tetrahedron Lett 1997, 38, 7299-7302.