Upregulation of renal eNOS by high-sodium diet facilitates hypertension in doxorubicin-treated rats through enhanced oxidative stress

Toxicology

Volumn 225, Issue 2-3, 2006, Pages 81-89

  Hirai, Toshihisa ^a   Okumura, Kenji ^a   Nishimoto, Yasuhiro ^a   Shumiya, Takanori ^a   Murakami, Ryuichiro ^a   Takahashi, Ryotaro ^a   Asai, Toru ^a   Murakami, Hisashi ^a   Numaguchi, Yasushi ^b   Matsui, Hideo ^a   Murohara, Toyoaki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Doxorubicin; Hypertension; Kidney; Nitric oxide synthase; Oxidative stress; Salt sensitive

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BIOLOGICAL MARKER; DOXORUBICIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HIGH SODIUM INTAKE; HYPERTENSION; IMMUNOHISTOLOGY; KIDNEY; KIDNEY CORTEX; KIDNEY DISTAL TUBULE; KIDNEY MEDULLA; KIDNEY PARENCHYMA; KIDNEY PROXIMAL TUBULE; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STAINING; STATISTICAL SIGNIFICANCE; SYSTOLIC BLOOD PRESSURE; UPREGULATION; URINARY EXCRETION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLOOD PRESSURE; DEOXYGUANOSINE; DOXORUBICIN; FOOD-DRUG INTERACTIONS; HYPERTENSION; IMMUNOENZYME TECHNIQUES; KIDNEY; MALE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM, DIETARY; UP-REGULATION;

EID: 33746297074     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.05.013     Document Type: Article

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