Matrix-mediated gene transfer to brain cortex and dorsal root ganglion neurones by retrograde axonal transport after dorsal column lesion

Journal of Gene Medicine

Volumn 8, Issue 7, 2006, Pages 901-909

  Gonzalez, Ana Maria ^a   Berry, Martin ^a   Greenlees, Lydia ^c   Logan, Ann ^a   Baird, Andrew ^a,b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b LA JOLLA INSTITUTE FOR MOLECULAR MEDICINE   (United States)

^c Neurome Inc   (United States)

Author keywords

CNS; Dorsal root ganglion neurones; Gene therapy; Matrix; Retrograde axonal transport; Spinal cord injury

Indexed keywords

CELL MARKER; COLLAGEN; MESSENGER RNA; THYMIDINE KINASE;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL INVASION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA DETERMINATION; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST; GENE EXPRESSION; GENE LOCATION; GLIA CELL; HISTOPATHOLOGY; IN SITU HYBRIDIZATION; INFLAMMATORY CELL; NERVE CELL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; RAT; REPORTER GENE; RETROGRADE NERVE FIBER TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCAR FORMATION; SPINAL CORD INJURY; SPINAL GANGLION;

ANIMALS; AXONAL TRANSPORT; CEREBRAL CORTEX; DNA, RECOMBINANT; FEMALE; GANGLIA, SPINAL; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENES, REPORTER; IN SITU HYBRIDIZATION; NEURONS; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; RNA, MESSENGER; SPINAL CORD INJURIES; THYMIDINE KINASE;

EID: 33746256599     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.919     Document Type: Article

References (32)

1. Blesch A, Tuszynski MH. Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury. Prog Brain Res 2002; 137: 415-423.
2. Sandvig A, Berry M, Barrett LB, Butt A, Logan A. Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration. Glia 2004; 46: 225-251.
3. Logan A, Berry M. Cellular and molecular determinants of glial scar formation. Adv Exp Med Biol 2002; 513: 115-158.
4. Lorber B, Berry M, Hendriks W, den Hertog J, Pulido R, Logan A. Stimulated regeneration of the crushed adult rat optic nerve correlates with attenuated expression of the protein tyrosine phosphatases RPTPalpha, STEP, and LAR. Mol Cell Neurosci 2004; 27: 404-416.
5. Kwon BK, Fisher CG, Dvorak MF, Tetzlaff W. Strategies to promote neural repair and regeneration after spinal cord injury. Spine 2005; 30: S3-13.
6. Pardridge WM. Targeting neurotherapeutic agents through the blood-brain barrier. Arch Neurol 2002; 59: 35-40.
7. Blesch A, Lu P, Tuszynski MH. Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair. Brain Res Bull 2002; 57: 833-838.
8. Blits B, Boer GJ, Verhaagen J. Pharmacological, cell, and gene therapy strategies to promote spinal cord regeneration. Cell Transplant 2002; 11: 593-613.
9. Berry M, Barrett L, Seymour L, Baird A, Logan A. Gene therapy for central nervous system repair. Curr Opin Mol Ther 2001; 3: 338-349.
10. Tuszynski MH, Grill R, Jones LL, McKay HM, Blesch A. Spontaneous and augmented growth of axons in the primate spinal cord: effects of local injury and nerve growth factor-secreting cell grafts. J Comp Neurol 2002; 449: 88-101.
11. Blesch A, Uy HS, Grill RJ, Cheng JG, Patterson PH, Tuszynski MH. Leukemia inhibitory factor augments neurotrophin expression and corticospinal axon growth after adult CNS injury. J Neurosci 1999; 19: 3556-3566.
12. Grill RJ, Blesch A, Tuszynski MH. Robust growth of chronically injured spinal cord axons induced by grafts of genetically modified NGF-secreting cells. Exp Neurol 1997; 148: 444-452.
13. Grill R, Murai K, Blesch A, Gage FH, Tuszynski MH. Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J Neurosci 1997; 17: 5560-5572.
14. Liu Y, Kim D, Himes BT, et al. Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function. J Neurosci 1999; 19: 4370-4387.
15. Ramon-Cueto A, Cordero MI, Santos-Benito FF, Avila J. Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Neuron 2000; 25: 425-435.
16. Teng YD, Lavik EB, Qu X, et al. Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci U S A 2002; 99: 3024-3029.
17. Ruitenberg MJ, Plant GW, Hamers FP, et al. Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia: effects on rubrospinal tract regeneration, lesion size, and functional recovery after implantation in the injured rat spinal cord. J Neurosci 2003; 23: 7045-7058.
18. Blits B, Dijkhuizen PA, Boer GJ, Verhaagen J. Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function. Exp Neurol 2000; 164: 25-37.
19. Coumans JV, Lin TT, Dai HN, et al. Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins. J Neurosci 2001; 21: 9334-9344.
20. Lagord C, Berry M, Logan A. Expression of TGFbeta2 but not TGFbeta1 correlates with the deposition of scar tissue in the lesioned spinal cord. Mol Cell Neurosci 2002; 20: 69-92.
21. Ahmed Z, Dent RG, Suggate EL, et al. Disinhibition of neurotrophin-induced dorsal root ganglion cell neurite outgrowth on CNS myelin by siRNA-mediated knockdown of NgR, p75NTR and Rho-A. Mol Cell Neurosci 2005; 28: 509-523.
22. Ahmed Z, Dent RG, Leadbeater WE, Smith C, Berry M, Logan A. Matrix metalloproteases: degradation of the inhibitory environment of the transected optic nerve and the scar by regenerating axons. Mol Cell Neurosci 2005; 28: 64-78.
23. Berry M, Gonzalez AM, Clarke W, et al. Sustained effects of gene-activated matrices after CNS injury. Mol Cell Neurosci 2001; 17: 706-716.
24. Sosnowski BA, Gonzalez AM, Chandler LA, Buechler YJ, Pierce GF, Baird A. Targeting DNA to cells with basic fibroblast growth factor (FGF2). J Biol Chem 1996; 271: 33 647-33 653.
25. Doukas J, Chandler LA, Gonzalez AM, et al. Matrix immobilization enhances the tissue repair activity of growth factor gene therapy vectors. Hum Gene Ther 2001; 12: 783-798.
26. Chandler LA, Gu DL, Ma C, et al. Matrix-enabled gene transfer for cutaneous wound repair. Wound Repair Regen 2000; 8: 473-479.
27. Bonadio J, Smiley E, Patil P, Goldstein S. Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration. Nat Med 1999; 5: 753-759.
28. Grimpe B, Silver J. The extracellular matrix in axon regeneration. Prog Brain Res 2002; 137: 333-349.
29. Geller HM, Fawcett JW. Building a bridge: engineering spinal cord repair. Exp Neurol 2002; 174: 125-136.
30. Schmidt CE, Leach JB. Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng 2003; 5: 293-347.
31. Stokols S, Tuszynski MH. The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury. Biomaterials 2004; 25: 5839-5846.
32. Houweling DA, Lankhorst AJ, Gispen WH, Bar PR, Joosten EA. Collagen containing neurotrophin-3 (NT-3) attracts regrowing injured corticospinal axons in the adult rat spinal cord and promotes partial functional recovery. Exp Neurol 1998; 153: 49-59.