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Volumn 42, Issue 13, 2003, Pages 1486-1490

Amphiphilic dendrimers: Novel self-assembling vectors for efficient gene delivery

Author keywords

Amphiphiles; Cross coupling; Dendrimers; DNA recognition; Gene transfection

Indexed keywords

BINDING ENERGY; CHEMICAL REACTIONS; DNA; HYDROPHOBICITY;

EID: 0345352683     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200250284     Document Type: Article
Times cited : (148)

References (42)
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    • (1998) Angew. Chem. Int. Ed. , vol.37 , pp. 1769-1785
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    • M. A. W. Eaton, T. S. Baker, C. F. Catterall, K. Crook, G. S. Macaulay, B. Mason, T. J. Norman, D. Parker, J. J. B. Perry, R. J. Taylor, A. Turner, A. N. Weir, Angew. Chem. 2000, 112, 4229-4233; Angew. Chem. Int. Ed. 2000, 39, 4063-4067.
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    • note
    • -1 per base pair (bp), 1 μg of DNA is assumed to carry 3 nmol negative charges. The CE has no unit.
  • 31
    • 0344987793 scopus 로고    scopus 로고
    • unpublished results
    • Self-assembly of 1-3 was observed by dynamic light scattering measurements in aqueous HEPES buffer after sonication. Preliminary data show a particle size distribution with a maximum centered around 100 nm for all compounds. Both 1 and 3 exhibit one additional maximum centered around 5 nm; D. Joester, S. Bufali, P. Walde, P. L. Luisi, F. Diederich, unpublished results.
    • Joester, D.1    Bufali, S.2    Walde, P.3    Luisi, P.L.4    Diederich, F.5
  • 34
    • 0345418982 scopus 로고    scopus 로고
    • PicoGreen is a proprietary cyanine dye of Molecular Probes (Lucerne, Switzerland). It exhibits a 1000-fold increase in fluorescence upon binding to DNA. For more information, see http://www.probes.com/handbook/sections/0803.html.
  • 36
    • 0344987790 scopus 로고    scopus 로고
    • note
    • HEPES: N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid
  • 37
    • 0344987789 scopus 로고    scopus 로고
    • note
    • -1 glucose) from Invitrogen life technologies (Basel, Switzerland).
  • 38
    • 0345418977 scopus 로고    scopus 로고
    • note
    • TE is defined as the number of transfected cells divided by the total number of cells.
  • 39
    • 0344125293 scopus 로고    scopus 로고
    • note
    • DOTAP is an aqueous dispersion of N-[1-(2,3-dioleoyl-oxy)-propyl]-N, N, N-trimethylammonium methyl-sulfate from Roche Diagnostics. It carries one permanent charge and is a classic small-molecule amphiphile.
  • 40
    • 0344125294 scopus 로고    scopus 로고
    • note
    • SuperFect is an activated (that is, fractured) PAMAM dendrimer formulation from Qiagen (Basel, Switzerland).
  • 41
    • 0344987785 scopus 로고    scopus 로고
    • note
    • W = 600 000-1 000 000 from FLUKA (Buchs, Switzerland) is a randomly branched cationic polymer.
  • 42
    • 0344987784 scopus 로고    scopus 로고
    • note
    • Live/Dead Kit from Molecular Probes (Lucerne, Switzerland).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.