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Peng ZY, Serkova NJ, Kominsky DJ, et al. Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death following injury is dependent on heat shock factor-1 expression. JPEN J Parenter Enterai Nutr 2006 (in press). Laboratory in-vitro study in HSF-1 cells showing that GLN can protect against heat stressed induced metabolic failure in HSF-1+/+ cells. No protection was observed in HSF-1-/- cells. Paper indicates that GLN-mediated metabolic protection appears to be dependent on presence of HSF-1 and HSP expression.
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JPEN J Parenter Enterai Nutr
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Singleton KD, Wischmeyer PE. Oral glutamine decreases gut permeability and improves survival following hyperthermia: role of heat shock protein expression. Shock 2005 (in press). Laboratory study examining the effect of oral GLN supplementation on gut permeability following lethal heatstroke injury. GLN attenuated gut permeability, plasma endotoxin, and improved survival following heatstroke injury. These beneficial effects were correlated with enhanced gut tissue HSF-1 phosphorylation and HSP-70 expression. This is the first study showing oral GLN can enhance HSF-1 activation and HSP-70 expression in the gut.
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Curi R, Lagranha CJ, Doi SQ, et al. Glutamine-dependent changes in gene expression and protein activity. Cell Biochem Funct 2005; 23:77-84. Extensive review showing glutamine can effect the expression of many genes related to metabolism, signal transduction, cell defense and repair, and to activate intracellular signaling pathways.
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