Indole-3-carbinol alters placental cytochrome P450 1A1 and P-glycoprotein levels in rats: A potential role in intensifying fetal intrauterine growth-retardation produced by tobacco smoke

Experimental and Toxicologic Pathology

Volumn 58, Issue 1, 2006, Pages 39-47

  Yan, You E ^a   Wang, Hui ^a   Wang, Ting ^a   Zeng, Han Gao ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Cytochrome P450 1A1; Indole 3 carbinol; Intrauterine growth restriction; P glycoprotein; Placenta; Tobacco

Indexed keywords

3 INDOLEMETHANOL; CYTOCHROME P450 1A1; GLYCOPROTEIN P; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; PLACENTA PROTEIN; TOBACCO SMOKE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRTH WEIGHT; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; FEMALE; FETUS MALFORMATION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INTRAUTERINE GROWTH RETARDATION; MALE; NEWBORN; NIDATION; NONHUMAN; PHYSICAL DEVELOPMENT; PRENATAL DEVELOPMENT; PRENATAL DRUG EXPOSURE; PROGENY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX RATIO; TAIL; TOXICITY TESTING;

NICOTIANA TABACUM;

EID: 33746185548     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2006.05.004     Document Type: Article

References (34)

1. Arnao M.B., Sanchez-Bravo J., and Acosta M. Indole-3-carbinol as a scavenger of free radicals. Biochem Mol Biol Int 39 (1996) 1125-1134
2. Arora A., and Shukla Y. Modulation of vinca-alkaloid induced P-glycoprotein expression by indole-3-carbinol. Cancer Lett 189 (2003) 167-173
3. Baldwin W.S., and LeBlanc G.A. The anti-carcinogenic plant compound indole-3-carbinol differentially modulates P450-mediated steroid hydroxylase activities in mice. Chem Biol Interact 83 (1992) 155-169
4. Bradlow H.L., Michnovicz J., Telang N.T., and Osborne M.P. Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice. Carcinogenesis 12 (1991) 1571-1574
5. Chatelain P. Children born with intra-uterone growth retardation (IUGR) or small for gestational age (SGA): long term growth and metabolic consequences. Endocr Regul 34 (2000) 33-36
6. Christensen J.G., and LeBlanc G.A. Reversal of multidrug resistance in vivo by dietary administration of the phytochemical indole-3-carbinol. Cancer Res 56 (1996) 574-581
7. Colombo A., Bonfanti P., Orsi F., and Camatini M. Differential modulation of cytochrome P-450 and P-glycoprotein expression by aryl hydrocarbon receptor agonists and thyroid hormone in Xenopus laevis liver and intestine. Aquat Toxicol 63 (2003) 173-186
8. Danger D.P., Baldwin W.S., and LeBlanc G.A. Photo affinity labeling of steroid hormone-binding glutathione S-transferases with (3H)-methyltrienolone. Inhibition of steroid binding activity by the anticarcinogen indole-3-carbinol. Biochem J 288 (1992) 361-367
9. Dawson A.B. Note on the staining of the skeleton of cleared specimens with alizarin red S. Stain Technol 1 (1926) 123-124
10. Gottesman M.M. How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation award lecture. Cancer Res 53 (1993) 747-754
11. Grubbs C.J., Steele V.E., Casebolt T., Juliana M.M., Eto I., Whitaker L.M., et al. Chemoprevention of chemically induced mammary carcinogenesis by indole-3-carbinol. Anticancer Res 15 (1995) 709-716
12. Gupta RC, Sastry BV. Toxicology of the placenta. In: Ballantyne B, Marrs T, Syversen T, editors. General and applied toxicology. New York; 2000. p. 1233-63.
13. Jorritsma U., Schrader E., tz Klaunick G., Kapitulnik J., Hirsch-Ernst K.I., Kahl G.F., et al. Monitoring of cytochrome P-450 1A activity by determination of the urinary pattern of caffeine metabolites in Wistar and hyperbilirubinemic Gunn rats. Toxicology 144 (2000) 229-236
14. Kall M.A., Vang O., and Clausen J. Effects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of caffeine, oestrone and chlorzoxazone metabolism. Carcinogenesis 17 (1996) 793-799
15. Kwan P., Sills G.J., Butler E., Gant T.W., and Brodie M.J. Differential expression of multidrug resistance genes in naive rat brain. Neurosci Lett 339 (2003) 33-36
16. Lin J.H. Drug-drug interaction mediated by inhibition and induction of P-glycoprotein. Adv Drug Deliv Rev 55 (2003) 53-81
17. Li Y., and Wang H. In utero exposure to tobacco and alcohol modifies neurobehavioral development in mice offspring: consideration a role of oxidative stress. Pharmacol Res 49 (2004) 67-73
18. Morris D.L., and Davila J.C. Analysis of rat cytochrome P450 isoenzyme expression using semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Biochem Pharmacol 52 (1996) 781-792
19. Nishimura K. A microdissection method for detecting thoracic visceral malformations in mouse and rat fetuses. Congenital Anomalies 14 (1974) 23-40
20. Niwa T., Swaneck G., and Bradlow H.L. Alteration in estradiol metabolism in MFC-7 cells induced by treatment withindole-3-carbinol and related compounds. Steroids 59 (1994) 523-527
21. Pasanen M. The expression and regulation of drug metabolism in human placenta. Adv Drug Deliv Rev 38 (1999) 81-97
22. Pavek P., Staud F., Fendrich Z., Sklenarova H., Libra A., Novotna M., et al. Examination of the Functional activity of P-glycoprotein in the rat placental barrier using rhodamine 123. J Pharmacol Exp Ther 305 (2003) 1239-1250
23. Schinkel A.H., Mayer U., Wagenaar E., Mol C.A., van Deemter L., Smit J.J., et al. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc Natl Acad Sci USA 94 (1997) 4028-4033
24. Schuetz E.G., Umbenhauer D.R., Yasuda K., Brimer C., Nguyen L., Relling M.V., et al. Altered expression of hepatic cytochrome P-450 in mice deficient in one or more mdr1 genes. Mol Pharmacol 57 (2000) 188-197
25. Sinha R., Rothman N., Brown E.D., Mark S.D., Hoover R.N., Caporaso N.E., et al. Pan-fried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans. Cancer Res 54 (1994) 6154-6159
26. Smit J.W., Huisman M.T., Tellingen O., Wiltshire H.R., and Schinkel A.H. Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. J Clin Invest 104 (1999) 1441-1447
27. Takagi Y., Nikaido T., Toki T., Kita N., Kanai M., Ashida T., et al. Levels of oxidative stress and redox-related molecules in the placenta in preeclampsia and fetal growth restriction. Virchows Arch 444 (2004) 49-55
28. Takahashi N., Dashwood R.H., Bjeldanes L.F., Williams D.E., and Bailey G.S. Mechanisms of indole-3-carbinol (I3C) anticarcinogenesis: Inhibition of aflatoxin B1-DNA adduction and mutagenesis by I3C acid condensation products. Food Chem Toxicol 33 (1995) 851-857
29. Vistisen K., Poulsen H.E., and Loft S. Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine. Carcinogenesis 13 (1992) 1561-1568
30. Whitlock J.P. Induction of cytochrome P4501A1. Annu Rev Pharmacol Toxicol 39 (1999) 103-125
31. Wilker C., Johnson L., and Safe S. Effects of developmental exposure to indole-3-carbinol or 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive potential of male rat offspring. Toxicol Appl Pharmacol 141 (1996) 68-75
32. Wilson J.G. Methods for administering agents and detecting malformations in experimental animals. In: Wilson J.G., and Warkany J. (Eds). Teratology: principles and techniques (1965), University of Chicago Press, Chicago 262-277
33. Yan Y.E., Wang H., and Feng Y.H. Alterations of placental cytochrome P450 1A1 and P-glycoprotein in tobacco-induced intrauterine growth retardation in rats. Acta Pharmacol Sinica 26 (2005) 1387-1394
34. Younoszai M.K., Peloso J., and Haworth J.C. Fetal growth retardation in rat exposed to cigarette tobacco during pregnancy. Am J Obstet Gynecol 104 (1969) 1027