Monitoring of cytochrome P-450 1A activity by determination of the urinary pattern of caffeine metabolites in Wistar and hyperbilirubinemic Gunn rats

Toxicology

Volumn 144, Issue 1-3, 2000, Pages 229-236

  Jorritsma, Ute ^a   Schrader, Eberhard ^a   Klaunick, Götz ^a   Kapitulnik, Jaime ^b   Hirsch Ernst, Karen I ^a   Kahl, Georg F ^a   Foth, Heidi ^c  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

5,6 benzoflavone; Caffeine metabolism; Cytochrome P 450 induction; Gunn rats; Hyperbilirubinemia; Indole 3 carbinol

Indexed keywords

3 INDOLEMETHANOL; BETA NAPHTHOFLAVONE; CAFFEINE; CYTOCHROME P450 ISOENZYME;

ANIMAL EXPERIMENT; ARTICLE; BILIRUBIN BLOOD LEVEL; BIOLOGICAL MONITORING; CONTROLLED STUDY; CRIGLER NAJJAR SYNDROME; DEMETHYLATION; DRUG EXCRETION; DRUG METABOLISM; ENZYME ACTIVITY; HYPERBILIRUBINEMIA; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BETA-NAPHTHOFLAVONE; BILIRUBIN; BIOLOGICAL MARKERS; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; ENZYME INDUCTION; FEMALE; HYPERBILIRUBINEMIA; INDOLES; MALE; RATS; RATS, GUNN; RATS, WISTAR; SPECIES SPECIFICITY;

RATTUS NORVEGICUS;

EID: 0034599817     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(99)00211-5     Document Type: Article

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