New and old diagnostic markers of meningitis in cerebrospinal fluid (CSF)

Brain Research Bulletin

Volumn 61, Issue 3, 2003, Pages 287-297

  Kleine, Tilmann O ^a,c   Zwerenz, Peter ^b   Zöfel, Peter ^c   Shiratori, Kiyoshi ^a  

^a UNIVERSITY HOSPITAL MARBURG   (Germany)

^b DPC Biermann GmbH   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Aseptic meningitis; Bacterial meningitis; L Lactate; Monokines; Multiple sclerosis; Statistical tests

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LACTIC ACID; LIPOPOLYSACCHARIDE BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ASEPTIC MENINGITIS; BACTERIAL MENINGITIS; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID ANALYSIS; CEREBROSPINAL FLUID CYTOLOGY; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE MARKER; DRUG CEREBROSPINAL FLUID LEVEL; FEMALE; GRANULOCYTE; HUMAN; LABORATORY DIAGNOSIS; LEUKOCYTE; MALE; MENINGITIS; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; STATISTICAL ANALYSIS; VIRUS MENINGITIS;

EID: 0041589187     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(03)00092-3     Document Type: Conference Paper

References (49)

1. Arditi M., Manogue K.R., Caplan M., Yogev R. Cerebrospinal fluid cachectin/tumor necrosis factor-α and platelet-activating factor concentrations and severity of bacterial meningitis in children. J. Infect. Dis. 162:1990;139-147.
2. Asi-Bautista M.C., Heidemann S.M., Meert K.L., Canady A.I., Samaik A.P. Tumor necrosis factor-α, interleukin-1β, and interleukin-6 concentrations in cerebrospinal fluid predict ventriculoperitoneal shunt infection. Crit. Care Med. 25:1997;1713-1716.
3. Bailey E.M., Domenico P., Cunha B.A. Bacterial or viral meningitis? Measuring lactate in CSF can help you know quickly. Postgrad. Med. 88:1990;217-223.
4. Body B.A., Oneson R.H., Herold D.A. Use of cerebrospinal fluid lactic acid concentration in diagnosis of fungal meningitis. Ann. Clin. Lab. Sci. 17:1987;429-434.
5. Bolan G., Barza M. Acute bacterial meningitis in children and adults. Med. Clin. North Am. 69:1985;231-241.
6. Briem H. Comparison between cerebrospinal fluid concentrations of glucose, total protein, chloride, lactate, and total amino acids for differential diagnosis of patients with meningitis. Scand. J. Infect. Dis. 15:1983;277-284.
7. Chaka W., Heyderman R., Gangaidzo I., Robertson V., Mason P., Verhoef J., Verheul A., Hoepelman A.I.M. Cytokine profiles in cerebrospinal fluid of human immunodeficiency virus-infected patients with cryptococcal meningitis: no leukocytosis despite high interleukin-8 levels. J. Infect. Dis. 176:1997;1633-1636.
8. Chavanet P., Bonnotte B., Guiguet M., Zeller V., Solary E., Maurice L., Casasnovas O., Caillot D., Waldner A., Kisterman J.P., Portier H. High concentrations of intrathecal interleukin-6 in human bacterial and nonbacterial meningitis. J. Infect. Dis. 166:1992;428-431.
9. Curtis G.D.W., Slack M.P.E., Tompkins D.S. Cerebrospinal fluid lactate and the diagnosis of meningitis. J. Infect. 3:1981;159-165.
10. Dulkerian S.J., Kilpatrick L., Costarino A.T., McCawley L., Fein J., Corcoran L., Zirin S., Harris M.C. Cytokine elevations in infants with bacterial and aseptic meningitis. J. Pediatr. 126:1995;872-876.
11. Endo S., Inada K., Ceska M., Takakuwa T., Yamada Y., Nakae H., Kasai T., Yamashita H., Taki K., Yoshida M. Plasma interleukin 8 and polymorphonuclear leukocyte elastase concentrations in patients with septic shock. J. Inflamm. 45:1995;136-142.
12. Frei K., Nadal D., Fontana A. Intracerebral synthesis of tumor necrosis factor-α and interleukin-6 in infectious meningitis. Ann. N.Y. Acad. Sci. 594:1990;326-333.
13. Genton B., Berger J.P. Cerebrospinal fluid lactate in 78 cases of adult meningitis. Intensive Care Med. 15:1983;277-284.
14. Glimaker M., Kragsbjerg P., Forsgren M., Olcen P. Tumor necrosis factor-α (TNFα) in cerebrospinal fluid from patients with meningitis of different etiologies: high levels of TNF-α indicate bacterial meningitis. J. Infect. Dis. 167:1993;882-889.
15. Hack C.E., Hart M., Strack van Schijndel R.J.M., Eerenberg A.J.M., Nuijens J.H., Thijs L.G., Aarden L.A. Interleukin-8 in sepsis: relation to shock and inflammatory mediators. Infect. Immun. 60:1992;2835-2842.
16. Halstensen A., Ceska M., Brandtzaeg P., Redl H., Naess A., Waage A. Interleukin-8 in serum and cerebrospinal fluid from patients with meningococcal disease. J. Infect. Dis. 167:1993;471-475.
17. Hashim A., Walsh A., Hart C.A., Shenkin A. Cerebrospinal fluid interleukin-6 and its diagnostic values in the investigation of meningitis. Ann. Clin. Biochem. 32:1995;289-296.
18. Helle M., Boeije L., Aarden L.A. Functional discrimination between interleukin-6 and interleukin-1. Eur. J. Immunol. 18:1988;1535-1540.
19. Heumann D., Gallay P., Barras C., Albrecht H., de Flaugergues J.C., Steck A., Glauser M.P. Lipopolysaccharide binding protein (LBP) as a marker of protein leakage in cerebrospinal fluid. J. Endotoxin Res. 2:1995;1-7.
20. Houssiau F.A., Bukasa K., Sindic C.J.M., Van Damme J., Van Snick J. Elevated levels of the 26 K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system. Clin. Exp. Immunol. 71:1988;320-323.
21. T.O. Kleine (Ed.), Neue Labormethoden für die Liquordiagnostik, Thieme, Stuttgart, 1980.
22. Kleine T.O. Valuation of bacterial and viral antigen detection against lactate determination and leukocyte counts in CSF meningitis diagnosis. J. Clin. Chem. Clin. Biochem. 27:1989;901-903.
23. T.O. Kleine, Nervensystem, in: H. Greiling, A.M. Gressner (Eds.), Lehrbuch der Klinischen Chemie und Pathobiochemie, Schattauer, Stuttgart, 1989, pp. 860-893.
24. Kleine T.O. Mechanisierte Zählung und Differenzierung von Liquorzellen. Lab. Med. 15:1991;51-59.
25. T.O. Kleine, Blood-brain barrier (BBB) markers, in: E. Melo (Ed.), XX World Congress of Pathology and Laboratory Medicine, Sao Paulo, 1999, Monduzzi Editore, Bologna, 1999, pp. 89-94.
26. T.O. Kleine, L. Benes, D-Lactate and L-lactate emergency diagnosis, in: E. Melo (Ed.), XX World Congress of Pathology and Laboratory Medicine, Sao Paulo, 1999, Monduzzi Editore, Bologna, 1999, pp. 151-155.
27. Kleine T.O., Baerlocher K., Niederer V., Keller H., Reutter F., Tritschler W., Bablok W. Diagnostische Bedeutung der Lactatbetimmung im Liquor bei Meningitis. Dtsch. Med. Wschr. 104:1979;553-557.
28. Kleine T.O., Hackler R., Schlenska G.K., Hase H.L., Rytlewski D. Zur Evaluierung der intrathekalen Immunglobulin-Produktion. Lab. Med. 15:1991;193-203.
29. Kleine T.O., Merten B. Rapid manual of immunoturbidimetric and immunonephelometric assays of prealbumin IgG, IgA and IgM in cerebrospinal fluid. J. Clin. Chem. Clin. Biochem. 19:1981;245-254.
30. Lindquist L., Linn, T., Hansson L.O., Kalin M., Axelsson G. Value of cerebrospinal fluid analysis in the differential diagnosis of meningitis: a study of 710 patients with suspected central system infection. Eur. J. Clin. Microbiol. Infect. Dis. 7:1988;374-380.
31. Lopez-Cortes L.F., Cruz-Ruiz M., Gomez-Mateos J., Jimenez-Hermandez D., Palomino J., Jimenez E. Measurement of levels of tumor necrosis factor-α and interleukin-1β in the CSF of patients with meningitis of different etiologies: utility in the differential diagnosis. Clin. Infect. Dis. 16:1993;534-539.
32. Marie C., Fitting C., Cheval C., Losser M.R., Carlet J., Payen D., Foster K., Cavaillon J.M. Presence of high levels of leukocyte-associated interleukin-8 upon cell activation and in patients with sepsis syndrome. Infect. Immun. 65:1997;865-871.
33. Matsuzono Y., Narita M., Akutsu Y., Togashi T. Interleukin-6 in cerebrospinal fluid of patients with central nervous system infections. Acta Paediatr. 84:1995;879-883.
34. Moller B., Mogensen S.C., Wendelboe P., Bendtzen K., Pertersen C.M. Bioactive and inactive forms of tumor necrosis factor alpha in spinal fluid from patients with meningitis. J. Infect. Dis. 163:1991;886-889.
35. Ohga S., Aoki T., Okada K., Akeda H., Fujioka K., Ohshima A., Mori T., Minamishima I., Ueda K. Cerebrospinal fluid concentrations of interleukin-1β, tumour necrosis factor-α and interferon gamma in bacterial meningitis. Arch. Dis. Child. 70:1994;123-125.
36. Ostergaard C., Benfield T.L., Sellebjerg F., Kronborg G., Lohse N., Lundgren J.D. Interleukin-8 in cerebrospinal fluid from patients with septic and aseptic meningitis. Eur. J. Clin. Microbiol. Dis. 15:1996;166-169.
37. Poser C.M., Paty D.W., Scheinberg L., McDonald W.I., Davis F.A., Ebers G.C., Johnson K.P., Sibley W.A., Silberberg D.H., Tourtellotte W.W. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 13:1983;227-231.
38. Rusconi F., Parizzi F., Garlaschi L., Assael B.M., Sironi M., Ghezzi P., Mantovani A. Interleukin 6 activity in infants and children with bacterial meningitis. Pediatr. Infect. Dis. J. 10:1991;117-121.
39. Schumann R.R., Zweigner J. A novel acute-phase marker: lipopolysaccharide binding protein (LBP). Clin. Chem. Lab. Med. 37:1999;271-274.
40. Seki T., Joh K., Oh-Ishi T. Augmented production of interleukin-8 in cerebrospinal fluid in bacterial meningitis. Immunology. 80:1993;333-335.
41. Sharief M.K., Ciardi M., Thompson E.J. Blood-brain barrier damage in patients with bacterial meningitis: association with tumor necrosis factor-α but not interleukin-1β J. Infect. Dis. 166:1992;350-358.
42. Silveira R.C., Procianoy R.S. Evaluation of interleukin-6, tumor necrosis factor-α and interleukin-1β for early diagnosis of neonatal sepsis. Acta Paediatr. 88:1999;647-650.
43. Stearman M., Southgate H.J. The use of cytokine and C-reactive protein measurements in cerebrospinal fluid during acute infective meningitis. Ann. Clin. Biochem. 31:1994;255-261.
44. Tang L.M. Serial lactate determinations in tuberculous meningitis. Scand. J. Infect. Dis. 20:1988;81-83.
45. Thompson E.J., Keir G. Laboratory investigation of cerebrospinal fluid proteins. Ann. Clin. Biochem. 27:1990;425-435.
46. Tsai M.L., Chen W.C., Wang Y.C., Hung K.L. Cerebrospinal fluid interleukin-6, interleukin-8, and tumor necrosis factor-α in children with central nervous system infections. Acta Paediatr. Sin. 37:1996;16-21.
47. van Deuren M., van der Ven-Jongekrijg J., Bartelink A.K.M., van Dalen R., Sauerwein R.W., van der Meer J.W.M. Correlation between proinflammatory cytokines and antiinflammatory mediators and the severity of disease in meningococcal infections. J. Infect. Dis. 172:1995;433-439.
48. Waage A., Halstensen A., Shalaby R., Brandtzaeg P., Kierulf P., Espevik T. Local production of tumor necrosis factor α, interleukin 1, and interleukin 6 in meningococcal meningitis. J. Exp. Med. 170:1989;1859-1867.
49. P. Zöfel (Ed.), Statistik verstehen. Ein Begleitbuch zur computergestützten Anwendung, München, Boston, Addison-Wesley, 2001.