Role of peroxisome proliferator-activated receptor-α in acute pancreatitis induced by cerulein

Immunology

Volumn 118, Issue 4, 2006, Pages 559-570

  Genovese, Tiziana ^a   Mazzon, Emanuela ^a   Rosanna, Di Paola ^a   Muià, Carmelo ^a   Crisafulli, Concetta ^a   Malleo, Giuseppe ^a   Esposito, Emanuela ^b   Cuzzocrea, Salvatore ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Adhesion molecules; Inflammation; Neutrophil infiltration; Pancreatitis; PPAR

Indexed keywords

AMYLASE; CERULETIDE; INTERCELLULAR ADHESION MOLECULE 1; MYELOPEROXIDASE; PADGEM PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TRIACYLGLYCEROL LIPASE; VASCULOTROPIN;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EDEMA; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KNOCKOUT MOUSE; LUNG PARENCHYMA; MORTALITY; MOUSE; NECROSIS; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; SURVIVAL RATE; SURVIVAL TIME; UPREGULATION; WILD TYPE;

ACUTE DISEASE; AMYLASES; ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CAERULEIN; INTERCELLULAR ADHESION MOLECULE-1; ISLETS OF LANGERHANS; LIPASE; MICE; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; P-SELECTIN; PANCREATITIS; PEROXIDASE; PPAR ALPHA; RANDOM ALLOCATION; SURVIVAL RATE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33746067082     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2006.02393.x     Document Type: Article

References (45)

1. Romagnani S. Th1/Th2 cells. Inflamm Bowel Dis 1999; 5:285-94.
2. Groux H, O'Garra A, Bigler M. A CD4 T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997; 389:737-42.
3. Githens S. Differentiation and development of the pancreas in animals. In: Go VLW, Di Magno EP, Gardner JD, Labental E, Reber HA, Scheele GA, eds. The Pancreas Biology, Pathobiology and Disease. New York: Raven Press, 1993:21-56.
4. Kiehne K, Otte JM, Folsch UR, Herzig KH. Growth factors in development and diseases of the exocrine pancreas. Pancreatology 2001; 1:15-23.
5. Menke A, Lutz PM, Ludwig CU, Gress TM, Adler G. Regeneration of acute pancreatitis: influence of peptide growth factors. In: Buchler MW, Uhl W, Friess H, Malfertheiner P, eds. In: Acute Pancreatitis. Novel Concepts in Biology and Therapy. Berlin, Vienna: Blackwell Science, 1999:129-41.
6. Menke A, Yamaguchi H, Giehl K, Adler G. Hepatocyte growth factor and fibroblast growth factor 2 are overexpressed after cerulein-induced acute pancreatitis. Pancreas 1999; 18:28-33.
7. Calvo EL, Bernatchez G, Pelletier G, Iovanna JL, Morisset J. Downregulation of IGF-I mRNA expression during postnatal pancreatic development and overexpression after subtotal pancreatectomy and acute pancreatitis in the rat pancreas. J Mol Endocrinol 1997; 18:233-42.
8. Konturek PC, Dembinski A, Warzecha Z, Ceranowicz P, Konturek SJ, Stachura J, Hahn. EG. Expression of transforming growth factor-beta 1 and epidermal growth factor in caerulein-induced pancreatitis in rat. J Physiol Pharmacol 1997; 48:59-72.
9. Friess H, Lu Z, Riesle E et al. Enhanced expression of TGF-betas and their receptors in human acute pancreatitis. Ann Surg 1998; 227:95-104.
10. di Mola FF, Friess H, Riesle E et al. Connective tissue growth factor is involved in pancreatic repair and tissue remodeling in human and rat acute necrotizing pancreatitis. Ann Surg 2002; 235:60-7.
11. Ebert M, Yokoyama M, Ishiwata T, Friess H, Buchler MW, Malfertheiner P, Korc M. Alteration of fibroblast growth factor and receptor expression after acute pancreatitis in humans. Pancreas 1999; 18:240-6.
12. Mews P, Phillips P, Fahmy R, Korsten M, Pirola R, Wilson J, Apte M. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut 2002; 50:535-41.
13. Oruc N, Ozutemiz AO, Yukselen V, Nart D, Celik HA, Yuce G, Batur Y. Infliximab: a new therapeutic agent in acute pancreatitis? Pancreas 2004; 28:e1-8.
14. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994; 76:301-14.
15. Picarella D, Hurlbut P, Rottman J, Shi X, Butcher E, Ringler DJ. Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of seid mice reconstituted with CD45RBhigh CD4+ T cells. J Immunol 1997; 158:2099-106.
16. Gille H, Kowalski J, Li B, LeCouter J, Moffat B, Zioncheck TF, Pelletier N, Ferrara N. Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants. J Biol Chem 2001; 276:3222-30.
17. Isner JM, Losordo DW. Therapeutic angiogenesis for heart failure. Nat Med 1999; 5:491-2.
18. Ferrara N. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol 2001; 280:C1358-66.
19. Warzecha Z, Dembinski A, Ceranowicz P et al. Immunohistochemical expression of FGF-2, PDGF-A, VEGF and TGF beta RII in the pancreas in the course of ischemia/reperfusion-induced acute pancreatitis. J Physiol Pharmacol 2004; 55:791-810.
20. Yoo BM, Yeo M, Oh TY et al. Amelioration of pancreatic fibrosis in mice with defective TGF-beta signaling. Pancreas 2005; 30:e71-9.
21. Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1988; 240:889-95.
22. Moras D, Gronemeyer H. The nuclear receptor ligand-binding domain: structure and function. Curr Opin Cell Biol 1998; 10:384-91.
23. Murphy GJ, Holder JC. PPAR-gamma agonists: therapeutic role in diabetes, inflammation and cancer. Trends Pharmacol Sci 2000; 21:469-74.
24. Wayman NS, McDonald MC, Threadgill MD, Thiemermann C. 5 Amino isoquinolinone, a potent inhibitor of poly (adenosine 5′-diphosphate ribose) polymerase, reduces myocardial infarct size. Eur J Pharmacol 2001; 430:93-100.
25. Escher P, Braissant O, Basu-Modak S, Michalik L, Wahli W, Desvergne B. Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology 2001; 142:4195-202.
26. Sher T, Yi HF, McBride OW, Gonzalez FJ. cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 1993; 32:5598-604.
27. Lovett-Racke AE, Hussain RZ, Northrop S et al. Peroxisome proliferator-activated receptor alpha agonists as therapy for autoimmune disease. J Immunol 2004; 172:5790-8.
28. Devchand PR, Keller H, Peters JM, Vazquez M, Gonzalez FJ, Wahli W. The PPARalpha-leukotriene B4 pathway to inflammation control. Nature 1996; 384:39-43.
29. Staels B, Koenig W, Habib A et al. Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators. Nature 1998; 393:790-3.
30. Cuzzocrea S, Di Paola R, Mazzon E, Genovese T, Muia C, Centorrino T, Caputi AP. Role of endogenous and exogenous ligands for the peroxisome proliferators activated receptors alpha (PPAR-alpha) in the development of inflammatory bowel disease in mice. Lab Invest 2004; 84:1643-54.
31. Genovese T, Mazzon E, Di Paola R, Cannavo G, Muia C, Bramanti P, Cuzzocrea S. Role of endogenous ligands for the peroxisome proliferators activated receptors alpha in the secondary damage in experimental spinal cord trauma. Exp Neurol 2005; 194:267-78.
32. Hopken UE, Lu B, Gerard NP, Gerard C. The C5a chemoattractant receptor mediates mucosal defence to infection. Nature 1996; 383:86-9.
33. Cuzzocrea S, McDonald MC, Mazzon E et al. The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation. Am J Pathol 2000; 157:145-58.
34. Minutoli L, Altavilla D, Marini H. Protective effects of SP600125, a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis. Life Sci 2004; 75:2853-66.
35. Mullane KM, Kraemer R, Smith B. Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 1985; 14:157-67.
36. Hill MR, Clarke S, Rodgers K, Thornhill B, Peters JM, Gonzalez FJ, Gimble JM. Effect of peroxisome proliferator-activated receptor alpha activators on tumor necrosis factor expression in mice during endotoxemia. Infect Immun 1999; 67:3488-93.
37. Grady T, Saluja AK, Kaiser A, Steer ML. Edema and intrapancreatic trypsinogn activation precedes glutathione depletion during caerulein pancreatitis. Am J Physiol 1996; 271:G20-6.
38. Gervois P, Vu-Dac N, Kleemann R et al. Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta. J Biol Chem 2001; 276:33471-7.
39. Izumi T, Saito Y, Kishimoto I et al. Blockade of the natriuretic peptide receptor guanylyl cyclase-A inhibits NF-kappaB activation and alleviates myocardial ischemia/reperfusion injury. J Clin Invest 2001; 108:203-13.
40. Konturek PC, Duda A, Brzozowski T et al. Activation of genes for superoxide dismutase, interleukin-1beta, tumor necrosis factor-alpha, and intercellular adhesion molecule-1 during healing of ischemia-reperfusion-induced gastric injury. Scand J Gastroenterol 2000; 35:452-63.
41. Gress T, Muller-Pillasch F, Elsasser HP, Bachem M, Ferrara C, Weidenbach H, Lerch M, Adler G. Enhancement of transforming growth factor beta 1 expression in the rat pancreas during regeneration from caerulein-induced pancreatitis. Eur J Clin Invest 1994; 24:679-85.
42. Adler G, Hupp T, Kern HF. Course and spontaneous regression of acute pancreatitis in the rat. Virchows Arch a Pathol Anat Histol 1979; 382:31-47.
43. Cuzzocrea S, Genovese T, Mazzon E, Di Paola R, Muia C, Britti D, Salvemini D. Reduction in the development of cerulein-induced acute pancreatitis by treatment with M40401, a new selective superoxide dismutase mimetic. Shock 2004; 22:254-61.
44. Balachandra S, Genovese T, Mazzon E, Di Paola R, Thiemerman C, Siriwardena AK, Cuzzocrea S. Inhibition of tyrosine-kinase-mediated cellular signaling by tyrphostins AG 126 and AG556 modulates murine experimental acute pancreatitis. Surgery 2005; 138:913-23.
45. Mentula P, Kylanpaa ML, Kemppainen E, Eklund KK, Orpana A, Puolakkainen P, Haapiainen R, Repo H. Serum levels of mast cell tryptase, vascular endothelial growth factor and basic fibroblast growth factor in patients with acute pancreatitis. Pancreas 2003; 27:e29-33.