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Volumn 6, Issue 3, 2006, Pages 266-277

Real time insights into bioprocesses using calorimetry: State of the art and potential

Author keywords

[No Author keywords available]

Indexed keywords

CALORIMETRY; MICROBIOLOGY; PROCESS CONTROL; STOICHIOMETRY; THERMODYNAMICS;

EID: 33746031849     PISSN: 16180240     EISSN: 16182863     Source Type: Journal    
DOI: 10.1002/elsc.200520123     Document Type: Review
Times cited : (36)

References (73)
  • 3
    • 0041002666 scopus 로고
    • Note sur al chaleur et le travail mecanique produits lar In fermentation vineuse
    • M. Dubrunfaut, Note sur al chaleur et le travail mecanique produits lar In fermentation vineuse, C. R. Acad. Sci. 1856, 42, 945-948.
    • (1856) C. R. Acad. Sci. , vol.42 , pp. 945-948
    • Dubrunfaut, M.1
  • 4
    • 0000799121 scopus 로고
    • Large-scale calorimetry and biotechnology
    • U. von Stockar, I. W. Marison, Large-scale calorimetry and biotechnology, Thermochim. Acta 1991, 193, 215-242.
    • (1991) Thermochim. Acta , vol.193 , pp. 215-242
    • von Stockar, U.1    Marison, I.W.2
  • 5
    • 0037156362 scopus 로고    scopus 로고
    • Heat flux as an on-line indicator of metabolic activity in pilot scale bioreactor during the production of Bacillus thuringiensis var. Galleriae-based biopesticides
    • R. K. I. Anderson, K. Jayaraman, D. Voisard, I. W. Marison, U. von Stockar, Heat flux as an on-line indicator of metabolic activity in pilot scale bioreactor during the production of Bacillus thuringiensis var. Galleriae-based biopesticides, Thermochim. Acta 2002, 386, 127-138.
    • (2002) Thermochim. Acta , vol.386 , pp. 127-138
    • Anderson, R.K.I.1    Jayaraman, K.2    Voisard, D.3    Marison, I.W.4    von Stockar, U.5
  • 7
    • 8644230857 scopus 로고    scopus 로고
    • Development of biocalorimetry as a technique for process monitoring and control in technical scale fermentations
    • M. Türker, Development of biocalorimetry as a technique for process monitoring and control in technical scale fermentations, Thermochim. Acta 2004, 419, 73-81.
    • (2004) Thermochim. Acta , vol.419 , pp. 73-81
    • Türker, M.1
  • 10
    • 0033719368 scopus 로고    scopus 로고
    • "Gie me ae spark o' nature's fire" an insight into cell physiology from calorimetry
    • R. B. Kemp, "Gie me ae spark o' nature's fire" an insight into cell physiology from calorimetry, J. Therm. Anal. Cal. 2000, 60, 831-843.
    • (2000) J. Therm. Anal. Cal. , vol.60 , pp. 831-843
    • Kemp, R.B.1
  • 12
    • 33746102484 scopus 로고    scopus 로고
    • www.vivactis.be
    • www.vivactis.be
  • 14
    • 0014518757 scopus 로고
    • Measurement of heat evolution and correlation with oxygen consumption during microbial growth
    • C. L. Cooney, D. I. C. Wang, R. I. Mateles, Measurement of heat evolution and correlation with oxygen consumption during microbial growth, Biotechnol. Bioeng. 1968, 11, 269-281.
    • (1968) Biotechnol. Bioeng. , vol.11 , pp. 269-281
    • Cooney, C.L.1    Wang, D.I.C.2    Mateles, R.I.3
  • 15
    • 0000799125 scopus 로고
    • Bench-scale calorimetry in biotechnology
    • B. Zentgraf, Bench-scale calorimetry in biotechnology, Thermochim. Acta 1991, 193, 243-251.
    • (1991) Thermochim. Acta , vol.193 , pp. 243-251
    • Zentgraf, B.1
  • 16
    • 0027909091 scopus 로고
    • Continuous measurement of microbial heat production in laboratory fermenters
    • B.H.A. van Kleeff, J. G. Kuenen, J. J. Heijnen, Continuous measurement of microbial heat production in laboratory fermenters, Biotechnol. Bioeng. 1993, 41, 541-549.
    • (1993) Biotechnol. Bioeng. , vol.41 , pp. 541-549
    • van Kleeff, B.H.A.1    Kuenen, J.G.2    Heijnen, J.J.3
  • 17
    • 0028836574 scopus 로고
    • Model based optimization of equipment and control for heat flux measurements in a laboratory fermenter
    • B.H.A. van Kleeff, J.G. Kuenen, G. Honderd, J. J. Heijnen, Model based optimization of equipment and control for heat flux measurements in a laboratory fermenter, Biotechnol. Prog. 1995, 11, 525-532.
    • (1995) Biotechnol. Prog. , vol.11 , pp. 525-532
    • van Kleeff, B.H.A.1    Kuenen, J.2    Honderd, G.3    Heijnen, G.J.J.4
  • 18
    • 0030198736 scopus 로고    scopus 로고
    • Heat flux measurements for the fast monitoring of dynamic responses to glucose additions by yeasts that were subjected to different feeding regimes in continuous culture
    • B.H.A. van Kleeff, J.G. Kuenen, J. J. Heijnen, Heat flux measurements for the fast monitoring of dynamic responses to glucose additions by yeasts that were subjected to different feeding regimes in continuous culture, Biotechonol. Prog. 1996, 12, 510-518.
    • (1996) Biotechonol. Prog. , vol.12 , pp. 510-518
    • van Kleeff, B.H.A.1    Kuenen, J.G.2    Heijnen, J.J.3
  • 19
    • 0012999118 scopus 로고    scopus 로고
    • Using heat-flow measurements for the feed control of a fed batch fermentation of Saccharomyces cerevisiae
    • B.H.A. van Kleeff, J. G. Kuenen, G. Honderd, J. J. Heijnen, Using heat-flow measurements for the feed control of a fed batch fermentation of Saccharomyces cerevisiae, Thermochim. Acta 1998, 309, 175-180.
    • (1998) Thermochim. Acta , vol.309 , pp. 175-180
    • van Kleeff, B.H.A.1    Kuenen, J.G.2    Honderd, G.3    Heijnen, J.J.4
  • 21
    • 0001696767 scopus 로고    scopus 로고
    • Biological reaction calorimetry: Development of high sensitivity bio-calorimeters
    • I. W. Marison, J. S. Liu, S. Ampuero, U. von Stockar, B. Schenker, Biological reaction calorimetry: Development of high sensitivity bio-calorimeters, Thermochim. Acta 1998, 309, 157-173.
    • (1998) Thermochim. Acta , vol.309 , pp. 157-173
    • Marison, I.W.1    Liu, J.S.2    Ampuero, S.3    von Stockar, U.4    Schenker, B.5
  • 22
    • 0037068083 scopus 로고    scopus 로고
    • The development and characterization of a high resolution bioreaction calorimeter for weakly exothermic cultures
    • M. C. García-Payo, S. Ampuero, J. S. Liu, I. W. Marison, U. von Stockar, The development and characterization of a high resolution bioreaction calorimeter for weakly exothermic cultures, Thermochim. Acta 2002, 391, 25-39.
    • (2002) Thermochim. Acta , vol.391 , pp. 25-39
    • García-Payo, M.C.1    Ampuero, S.2    Liu, J.S.3    Marison, I.W.4    von Stockar, U.5
  • 23
    • 0002055463 scopus 로고    scopus 로고
    • Calorimetric investigations of bacterial growth on phenol: Efficiency and velocity of growth as a function of the assimilation pathways
    • T. Maskow, W. Babel, Calorimetric investigations of bacterial growth on phenol: Efficiency and velocity of growth as a function of the assimilation pathways, Thermochim. Acta 1998, 309, 97-103.
    • (1998) Thermochim. Acta , vol.309 , pp. 97-103
    • Maskow, T.1    Babel, W.2
  • 24
    • 0033977764 scopus 로고    scopus 로고
    • Calorimetrically recognized maximum yield of poly-3-hydroxybutyrate (PHB) continuously synthesized from toxic substrates
    • T. Maskow, W. Babel, Calorimetrically recognized maximum yield of poly-3-hydroxybutyrate (PHB) continuously synthesized from toxic substrates, J. Biotechnol. 2002, 77, 247-253.
    • (2002) J. Biotechnol. , vol.77 , pp. 247-253
    • Maskow, T.1    Babel, W.2
  • 25
    • 0035093484 scopus 로고    scopus 로고
    • A calorimetrically based method to convert toxic compounds into poly-3-hydroxybutyrate and to determine the efficiency and velocity of conversion
    • T. Maskow, W. Babel, A calorimetrically based method to convert toxic compounds into poly-3-hydroxybutyrate and to determine the efficiency and velocity of conversion, Appl. Microbiol. Biotechnol. 2001, 55, 234-238.
    • (2001) Appl. Microbiol. Biotechnol. , vol.55 , pp. 234-238
    • Maskow, T.1    Babel, W.2
  • 26
    • 0037203847 scopus 로고    scopus 로고
    • Calorimetric analysis of microorganisms in transient growth states to quantify changes of metabolic fluxes in response to nutrient deficiencies and osmostress
    • T. Maskow, W. Babel, Calorimetric analysis of microorganisms in transient growth states to quantify changes of metabolic fluxes in response to nutrient deficiencies and osmostress, Thermochim. Acta 2002, 382, 229-237.
    • (2002) Thermochim. Acta , vol.382 , pp. 229-237
    • Maskow, T.1    Babel, W.2
  • 27
    • 33746032488 scopus 로고    scopus 로고
    • Calorimetric bioprocess control with slightly modified standard bioreactors
    • submitted
    • T. Schubert, T. Maskow, U. Breuer, H. Harms, Calorimetric bioprocess control with slightly modified standard bioreactors, J. Biotechnol. 2006, submitted.
    • (2006) J. Biotechnol.
    • Schubert, T.1    Maskow, T.2    Breuer, U.3    Harms, H.4
  • 28
    • 0002273676 scopus 로고
    • Impact of carbon dioxide evolution on the calorimetric monitoring of fermentations
    • M. Meier-Schneiders, F. Schäfer, U. Grosshans, C. Busch, Impact of carbon dioxide evolution on the calorimetric monitoring of fermentations, Thermochim. Acta 1995, 251, 85-97.
    • (1995) Thermochim. Acta , vol.251 , pp. 85-97
    • Meier-Schneiders, M.1    Schäfer, F.2    Grosshans, U.3    Busch, C.4
  • 29
    • 0021861304 scopus 로고
    • Correlation between cell composition and carbon conversion efficiency in microbial growth: A theoretical study
    • W. Babel, R. H. Müller, Correlation between cell composition and carbon conversion efficiency in microbial growth: a theoretical study, Appl. Microbiol. Biotechnol. 1985, 22, 201-207.
    • (1985) Appl. Microbiol. Biotechnol. , vol.22 , pp. 201-207
    • Babel, W.1    Müller, R.H.2
  • 31
    • 84914424260 scopus 로고
    • Selected values of beats of combustion and heats of formation of organic compounds containing the elements C, H, N, O, P, and S
    • E. S. Domalski, Selected values of beats of combustion and heats of formation of organic compounds containing the elements C, H, N, O, P, and S, J. Phys. Chem. Ref. Data 1972, 1, 221-273.
    • (1972) J. Phys. Chem. Ref. Data , vol.1 , pp. 221-273
    • Domalski, E.S.1
  • 32
    • 0023094970 scopus 로고
    • The relationship between elemental composition and heat of combustion of microbial biomass
    • J. L. Cordier, B. M. Butsch, B. Birou, U. von Stockar, The relationship between elemental composition and heat of combustion of microbial biomass, Appl. Microbiol. Biotechnol. 1987, 25, 305-312.
    • (1987) Appl. Microbiol. Biotechnol. , vol.25 , pp. 305-312
    • Cordier, J.L.1    Butsch, B.M.2    Birou, B.3    von Stockar, U.4
  • 33
    • 0000991952 scopus 로고
    • The relation of oxygen to the heat of combustion of organic compounds
    • W. M. Tbornton, The relation of oxygen to the heat of combustion of organic compounds, Philos. Mag. 1917, 33, 196-203.
    • (1917) Philos. Mag. , vol.33 , pp. 196-203
    • Tbornton, W.M.1
  • 34
    • 0004234375 scopus 로고    scopus 로고
    • Spektrum Akademischer Verlag, Heidelberg
    • G. Michal, Biochemical Pathways, Spektrum Akademischer Verlag, Heidelberg 1999.
    • (1999) Biochemical Pathways
    • Michal, G.1
  • 35
    • 33746095358 scopus 로고    scopus 로고
    • The MetaCyc metabolic pathway database
    • (Eds: B. N. Kholodenko, H. V. Westerhoff), Horizon Bioscience, Norfolk
    • P. D. Karp, The MetaCyc metabolic pathway database, in Metabolic Engineering in the Post Genomic Era (Eds: B. N. Kholodenko, H. V. Westerhoff), Horizon Bioscience, Norfolk 2004, 139-154.
    • (2004) Metabolic Engineering in the Post Genomic Era , pp. 139-154
    • Karp, P.D.1
  • 36
    • 0015910716 scopus 로고
    • A theoretical study of the amount of ATP required for synthesis of microbial cell material
    • A. H. Stouthamer, A theoretical study of the amount of ATP required for synthesis of microbial cell material, Antonie Leeuwenhoek 1973, 39, 545-565.
    • (1973) Antonie Leeuwenhoek , vol.39 , pp. 545-565
    • Stouthamer, A.H.1
  • 37
    • 0035797085 scopus 로고    scopus 로고
    • Calorimetrically obtained information about efficiency of synthesis of ectoine from glucose by Halomonas elongata
    • T. Maskow, W. Babel, Calorimetrically obtained information about efficiency of synthesis of ectoine from glucose by Halomonas elongata, Biochem. Biophys. Acta 2001, 1527, 4-10.
    • (2001) Biochem. Biophys. Acta , vol.1527 , pp. 4-10
    • Maskow, T.1    Babel, W.2
  • 39
    • 0025240751 scopus 로고
    • The spectrum of compatible solutes in heterotrophic halophilic cubacteria of the family Halomonadaceae
    • A. Wohlfahrth, J. Severin, E. A. Galinski, The spectrum of compatible solutes in heterotrophic halophilic cubacteria of the family Halomonadaceae, J. Gen. Microbiol. 1990, 136, 705-712.
    • (1990) J. Gen. Microbiol. , vol.136 , pp. 705-712
    • Wohlfahrth, A.1    Severin, J.2    Galinski, E.A.3
  • 41
    • 0033022073 scopus 로고    scopus 로고
    • Bioenergetic aspects of halophilism
    • A. Oren, Bioenergetic aspects of halophilism, Microbiol. Molec. Biol. Rev. 1999, 63, 334-348.
    • (1999) Microbiol. Molec. Biol. Rev. , vol.63 , pp. 334-348
    • Oren, A.1
  • 43
    • 16544386795 scopus 로고    scopus 로고
    • Carbon- and energy fluxes during haloadaptation of a Halomonas sp. EF11 growing on phenol
    • T. Maskow, S. Kleinsteuber, Carbon- and energy fluxes during haloadaptation of a Halomonas sp. EF11 growing on phenol, Extremophiles 2004, 8, 133-141.
    • (2004) Extremophiles , vol.8 , pp. 133-141
    • Maskow, T.1    Kleinsteuber, S.2
  • 44
    • 0016078613 scopus 로고
    • Calorimetric studies of microorganisms-producers of enzymes destroying yeast cellular walls
    • V. V. Koryagin, S. P. Vorotilo, S. A. Konovalov, I. M. Chirkov, Calorimetric studies of microorganisms-producers of enzymes destroying yeast cellular walls, Appl. Biochem. Microbiol. 1974, 10, 621-623.
    • (1974) Appl. Biochem. Microbiol. , vol.10 , pp. 621-623
    • Koryagin, V.V.1    Vorotilo, S.P.2    Konovalov, S.A.3    Chirkov, I.M.4
  • 45
    • 85143463680 scopus 로고
    • Thermodynamic estimation of development and growth of microorganisms
    • (Eds: I. Lamprecht, A. I. Zotin), Walter de Gruyter & Co, Berlin
    • V. V. Koryagin, S. A. Konovalov, Thermodynamic estimation of development and growth of microorganisms, in Thermodynamics and Kinetics of Biological Processes (Eds: I. Lamprecht, A. I. Zotin), Walter de Gruyter & Co, Berlin 1983, 445-451.
    • (1983) Thermodynamics and Kinetics of Biological Processes , pp. 445-451
    • Koryagin, V.V.1    Konovalov, S.A.2
  • 47
    • 0035846181 scopus 로고    scopus 로고
    • Thin-films thermoelectric devices with high room-temperature figures of merit
    • R. Venkatasubramanian, E. Siivola, T. Colpitts, B. O'Quinn, Thin-films thermoelectric devices with high room-temperature figures of merit, Nature 2001, 413, 597-602.
    • (2001) Nature , vol.413 , pp. 597-602
    • Venkatasubramanian, R.1    Siivola, E.2    Colpitts, T.3    O'Quinn, B.4
  • 49
    • 70350332452 scopus 로고    scopus 로고
    • Nonscanning calorimetry
    • (Ed: P. Gallagher), Elsevier, Amsterdam
    • R. B. Kemp, Nonscanning calorimetry, in Handbook of Thermal Analysis and Calorimetry (Ed: P. Gallagher), Elsevier, Amsterdam 1998, 577-675.
    • (1998) Handbook of Thermal Analysis and Calorimetry , pp. 577-675
    • Kemp, R.B.1
  • 50
    • 0032966577 scopus 로고    scopus 로고
    • Detection of the changing substrate requirements of cultured animal cells by stoichiometric growth equations validated by enthalpy balances
    • Y. H. Guan, R. B. Kemp, Detection of the changing substrate requirements of cultured animal cells by stoichiometric growth equations validated by enthalpy balances, J. Biotechnol. 1999, 69, 95-114.
    • (1999) J. Biotechnol. , vol.69 , pp. 95-114
    • Guan, Y.H.1    Kemp, R.B.2
  • 51
    • 1442303172 scopus 로고    scopus 로고
    • Flow calorimetry and dielectric spectroscopy to control the bacterial conversion of toxic substrates into polyhydroxyalkanoates
    • T. Maskow, D. Olomolaiye, U. Breuer, R. B. Kemp, Flow calorimetry and dielectric spectroscopy to control the bacterial conversion of toxic substrates into polyhydroxyalkanoates, Biotechnol. Bioeng. 2004, 85, 547-552.
    • (2004) Biotechnol. Bioeng. , vol.85 , pp. 547-552
    • Maskow, T.1    Olomolaiye, D.2    Breuer, U.3    Kemp, R.B.4
  • 52
    • 0026352929 scopus 로고
    • Calorimetric control of fed-batch cultures of Saccharomyces cerevisiae
    • C. Larsson, G. Liden, C. Niklasson, L. Gustafsson, Calorimetric control of fed-batch cultures of Saccharomyces cerevisiae, Bioprocess Eng. 1991, 7, 151-155.
    • (1991) Bioprocess Eng. , vol.7 , pp. 151-155
    • Larsson, C.1    Liden, G.2    Niklasson, C.3    Gustafsson, L.4
  • 53
    • 0026206357 scopus 로고
    • The use of microcalorimetric monitoring in establishing continuous energy balances and in continuous determinations of substrate and product concentrations of batch-growth Saccharomyces cerevisiae
    • C. Larsson, A. Blomberg, L. Gustafsson, The use of microcalorimetric monitoring in establishing continuous energy balances and in continuous determinations of substrate and product concentrations of batch-growth Saccharomyces cerevisiae. Biotechnol. Bioeng. 1991, 38. 447-458.
    • (1991) Biotechnol. Bioeng. , vol.38 , pp. 447-458
    • Larsson, C.1    Blomberg, A.2    Gustafsson, L.3
  • 54
    • 0000430376 scopus 로고    scopus 로고
    • A calorimetric flow vessel optimised for measuring the metabolic activity of animal cells
    • Y.H. Guan, P.C. Loyd, R.B. Kemp, A calorimetric flow vessel optimised for measuring the metabolic activity of animal cells, Thermochim. Acta 1999, 332, 211-220.
    • (1999) Thermochim. Acta , vol.332 , pp. 211-220
    • Guan, Y.H.1    Loyd, P.C.2    Kemp, R.B.3
  • 55
    • 0010468530 scopus 로고    scopus 로고
    • The application of heat flux measurements to improve the growth of mammalian cells in culture
    • R.B. Kemp, Y.H. Guan, The application of heat flux measurements to improve the growth of mammalian cells in culture, Thermochim. Acta 2000, 332, 23-30.
    • (2000) Thermochim. Acta , vol.332 , pp. 23-30
    • Kemp, R.B.1    Guan, Y.H.2
  • 56
    • 0345327824 scopus 로고    scopus 로고
    • Calorimetry and thermodynamics of living system
    • I. Lamprecht, Calorimetry and thermodynamics of living system Thermochim. Acta 2003, 405, 1-13.
    • (2003) Thermochim. Acta , vol.405 , pp. 1-13
    • Lamprecht, I.1
  • 57
    • 32544458181 scopus 로고    scopus 로고
    • Control of continuous polyhydroxyalkanoate synthesis using calorimetry and flow cytometry
    • DOI: 10.1002/bit.20743
    • T. Maskow, S. Müller, A. Lösche, R. B. Kemp, H. Harms, Control of continuous polyhydroxyalkanoate synthesis using calorimetry and flow cytometry, Biotechnol. Bioeng. 2006, 93, 541-552. DOI: 10.1002/bit.20743.
    • (2006) Biotechnol. Bioeng. , vol.93 , pp. 541-552
    • Maskow, T.1    Müller, S.2    Lösche, A.3    Kemp, R.B.4    Harms, H.5
  • 58
    • 84984082223 scopus 로고
    • A mathematical model for the continuous culture of microorganisms utilizing inhibitory substrates
    • J.F. Andrews, A mathematical model for the continuous culture of microorganisms utilizing inhibitory substrates, Biotechnol. Bioeng. 1968, 10, 707-719.
    • (1968) Biotechnol. Bioeng. , vol.10 , pp. 707-719
    • Andrews, J.F.1
  • 60
    • 0026679844 scopus 로고
    • Production of unusual bacterial polyesters by Pseudomonas oleovorans through cometabolism
    • R.W. Lenz, Y.B. Kim, R.C. Fuller, Production of unusual bacterial polyesters by Pseudomonas oleovorans through cometabolism, FEMS Microbiol. Rev. 1992, 103, 207-214.
    • (1992) FEMS Microbiol. Rev. , vol.103 , pp. 207-214
    • Lenz, R.W.1    Kim, Y.B.2    Fuller, R.C.3
  • 61
    • 0029018968 scopus 로고
    • Diversity of bacterial polyhydroxyalkanoic acids
    • A. Steinbüchel, H.E. Valentin, Diversity of bacterial polyhydroxyalkanoic acids, FEMS Microbiol. Lett. 1995, 128, 219-228.
    • (1995) FEMS Microbiol. Lett. , vol.128 , pp. 219-228
    • Steinbüchel, A.1    Valentin, H.E.2
  • 62
    • 0033527827 scopus 로고    scopus 로고
    • Closed-loop control of bacterial high-cell-density fed-batch cultures: Production of mcl-PHAs by Pseudomonas putida KT2442 under single-substrate and cofeeding conditions
    • M.B. Kellerhals, B. Kessler, B. Witholt, Closed-loop control of bacterial high-cell-density fed-batch cultures: Production of mcl-PHAs by Pseudomonas putida KT2442 under single-substrate and cofeeding conditions, Biotechnol. Bioeng. 1999, 65, 306-315.
    • (1999) Biotechnol. Bioeng. , vol.65 , pp. 306-315
    • Kellerhals, M.B.1    Kessler, B.2    Witholt, B.3
  • 63
    • 33746032486 scopus 로고    scopus 로고
    • Stabilitäten und Kompatibilitäten mit hohen Probendurchsatz ermitteln - Das TAM 48 Channel
    • Freiberg (Saxony), Germany
    • T. Lemke, Stabilitäten und Kompatibilitäten mit hohen Probendurchsatz ermitteln - das TAM 48 Channel, in Proc. of the 15th Ulm-Freiberger Kalorimetrietage, Freiberg (Saxony), Germany 2003.
    • (2003) Proc. of the 15th Ulm-Freiberger Kalorimetrietage
    • Lemke, T.1
  • 66
    • 33645366995 scopus 로고    scopus 로고
    • A miniaturized chip-calorimeter for the monitoring of whole cell biotransformation
    • DOI: 10.1016/j.jbiotec.2005.10.008
    • T. Maskow, J. Lerchner, M. Peitzsch, H. Harms, G. Wolf, A miniaturized chip-calorimeter for the monitoring of whole cell biotransformation, J. Biotechnol. 2006, 122, 431-442. DOI: 10.1016/j.jbiotec.2005.10.008.
    • (2006) J. Biotechnol. , vol.122 , pp. 431-442
    • Maskow, T.1    Lerchner, J.2    Peitzsch, M.3    Harms, H.4    Wolf, G.5
  • 68
    • 2542477216 scopus 로고    scopus 로고
    • Direct monitoring of biochemical processes using micro-structured heat power detectors
    • J. Lerchner, A. Wolf, R. Hüttl, G. Wolf, Direct monitoring of biochemical processes using micro-structured heat power detectors, Chem. Eng. J. 2004, 101, 187-194.
    • (2004) Chem. Eng. J. , vol.101 , pp. 187-194
    • Lerchner, J.1    Wolf, A.2    Hüttl, R.3    Wolf, G.4
  • 71
    • 32044458422 scopus 로고    scopus 로고
    • Thermodynamics of microbial growth and metabolism: An analysis of the current situation
    • DOI: 10.1016/j.jbiotec.2005.08.012
    • U. von Stockar, T. Maskow, J. Liu, I. W. Marison, R. Patiño, Thermodynamics of microbial growth and metabolism: an analysis of the current situation, J. Biotechnol. 2006, 121, 517-533. DOI: 10.1016/ j.jbiotec.2005.08.012.
    • (2006) J. Biotechnol. , vol.121 , pp. 517-533
    • von Stockar, U.1    Maskow, T.2    Liu, J.3    Marison, I.W.4    Patiño, R.5
  • 72
    • 0035852883 scopus 로고    scopus 로고
    • Bioreactor performance: A more scientific approach for practice
    • A. Lübbert, S.B. Jørgensen, Bioreactor performance: a more scientific approach for practice, J. Biotechnol. 2001, 85, 187-212.
    • (2001) J. Biotechnol. , vol.85 , pp. 187-212
    • Lübbert, A.1    Jørgensen, S.B.2
  • 73
    • 0034691773 scopus 로고    scopus 로고
    • Influence of scale up on the quality of recombinant human growth hormone 73
    • F. Bylung, A. Castan, R. Mikkola, A. Viede, G. Larsson, Influence of scale up on the quality of recombinant human growth hormone, Biotechnol. Bioeng. 2002, 69, 119-128.
    • (2002) Biotechnol. Bioeng. , vol.69 , pp. 119-128
    • Bylung, F.1    Castan, A.2    Mikkola, R.3    Viede, A.4    Larsson, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.