메뉴 건너뛰기




Volumn 36, Issue 4, 2006, Pages 249-257

Genotypic changes in human immunodeficiency virus type 1 envelope glycoproteins on treatment with the fusion inhibitor enfuvirtide and their influence on changes in drug susceptibility in vitro

Author keywords

Enfuvirtide; Fusion inhibitors; HIV; T 20; TORO

Indexed keywords

AMINO ACID; ENFUVIRTIDE; GLYCOPROTEIN E1; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; VIRUS FUSION PROTEIN;

EID: 33745993903     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcv.2006.03.007     Document Type: Article
Times cited : (24)

References (40)
  • 1
    • 4344685176 scopus 로고    scopus 로고
    • An inducible HIV type 1 gp41 HR-2 peptide-binding site on HIV type 1 envelope gp120
    • Alam S.M., Paleos C.A., Liao H.X., Scearce R., Robinson J., et al. An inducible HIV type 1 gp41 HR-2 peptide-binding site on HIV type 1 envelope gp120. AIDS Res Hum Retroviruses 20 (2004) 836-845
    • (2004) AIDS Res Hum Retroviruses , vol.20 , pp. 836-845
    • Alam, S.M.1    Paleos, C.A.2    Liao, H.X.3    Scearce, R.4    Robinson, J.5
  • 2
    • 17144417071 scopus 로고    scopus 로고
    • TORO: 96 week virological and immunological response and safety evaluation of enfuvirtide with an optimized background regimen
    • Bangkok, Thailand, 11-16 July [Abstract MoOrB1058]
    • Arastéh K., Lazzarin A., Clotet B., Lalezari J.P., Cooper D., et al. TORO: 96 week virological and immunological response and safety evaluation of enfuvirtide with an optimized background regimen. 15th International AIDS Conference. Bangkok, Thailand, 11-16 July (2004) [Abstract MoOrB1058]
    • (2004) 15th International AIDS Conference
    • Arastéh, K.1    Lazzarin, A.2    Clotet, B.3    Lalezari, J.P.4    Cooper, D.5
  • 3
    • 27744541149 scopus 로고    scopus 로고
    • Computational methods for the design of effective therapies against drug resistant HIV strains
    • Beerenwinkel N., Sing T., Lengauer T., Rahnenfuehrer J., Roomp K., et al. Computational methods for the design of effective therapies against drug resistant HIV strains. Bioinformatics 21 (2005) 3943-3950
    • (2005) Bioinformatics , vol.21 , pp. 3943-3950
    • Beerenwinkel, N.1    Sing, T.2    Lengauer, T.3    Rahnenfuehrer, J.4    Roomp, K.5
  • 4
    • 7644236011 scopus 로고    scopus 로고
    • Emergence of a drug-dependent human immunodeficiency virus type 1 variant during therapy with the T20 fusion inhibitor
    • Baldwin C.E., Sanders R.W., Deng Y., Jurriaans S., Lange J.M., et al. Emergence of a drug-dependent human immunodeficiency virus type 1 variant during therapy with the T20 fusion inhibitor. J Virol 78 (2004) 12428-12437
    • (2004) J Virol , vol.78 , pp. 12428-12437
    • Baldwin, C.E.1    Sanders, R.W.2    Deng, Y.3    Jurriaans, S.4    Lange, J.M.5
  • 5
    • 0027499917 scopus 로고
    • Effects of amino acid changes in the extracellular domain of the human immunodeficiency virus type 1 gp41 envelope glycoprotein
    • Cao J., Bergeron L., Helseth E., Thali M., Repke H., et al. Effects of amino acid changes in the extracellular domain of the human immunodeficiency virus type 1 gp41 envelope glycoprotein. J Virol 67 (1993) 2747-2755
    • (1993) J Virol , vol.67 , pp. 2747-2755
    • Cao, J.1    Bergeron, L.2    Helseth, E.3    Thali, M.4    Repke, H.5
  • 6
    • 0029857253 scopus 로고    scopus 로고
    • Direct interaction between the envelope and matrix proteins of HIV-1
    • Cosson P. Direct interaction between the envelope and matrix proteins of HIV-1. EMBO J 15 (1996) 5783-5788
    • (1996) EMBO J , vol.15 , pp. 5783-5788
    • Cosson, P.1
  • 7
    • 0033856458 scopus 로고    scopus 로고
    • Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120
    • Derdeyn C.A., Decker J.M., Sfakianos J.N., Wu X., O'Brien W.A., et al. Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120. J Virol 74 (2000) 8358-8367
    • (2000) J Virol , vol.74 , pp. 8358-8367
    • Derdeyn, C.A.1    Decker, J.M.2    Sfakianos, J.N.3    Wu, X.4    O'Brien, W.A.5
  • 8
    • 0034890660 scopus 로고    scopus 로고
    • Sensitivity of human immunodeficiency virus type 1 to fusion inhibitors targeted to the gp41 first heptad repeat involves distinct regions of gp41 and is consistently modulated by gp120 interactions with the coreceptor
    • Derdeyn C.A., Decker J.M., Sfakianos J.N., Zhang Z., O'Brien W.A., et al. Sensitivity of human immunodeficiency virus type 1 to fusion inhibitors targeted to the gp41 first heptad repeat involves distinct regions of gp41 and is consistently modulated by gp120 interactions with the coreceptor. J Virol 75 (2001) 8605-8614
    • (2001) J Virol , vol.75 , pp. 8605-8614
    • Derdeyn, C.A.1    Decker, J.M.2    Sfakianos, J.N.3    Zhang, Z.4    O'Brien, W.A.5
  • 9
    • 0031959601 scopus 로고    scopus 로고
    • Capture of an early fusion-active conformation of HIV-1 gp41
    • Furuta R.A., Wild C.T., Weng Y., and Weiss C.D. Capture of an early fusion-active conformation of HIV-1 gp41. Nat Struct Biol 5 (1998) 276-279
    • (1998) Nat Struct Biol , vol.5 , pp. 276-279
    • Furuta, R.A.1    Wild, C.T.2    Weng, Y.3    Weiss, C.D.4
  • 10
    • 0012823617 scopus 로고    scopus 로고
    • Baseline (BL) and on-treatment susceptibility to enfuvirtide seen in TORO 1 and TORO 2 through 24 weeks
    • Boston, MA, USA, 10-14 February [Abstract 141]
    • Greenberg M., Melby T., Sista P., DeMasi R., Cammack N., et al. Baseline (BL) and on-treatment susceptibility to enfuvirtide seen in TORO 1 and TORO 2 through 24 weeks. 10th Conference on Retroviruses and Opportunistic Infections. Boston, MA, USA, 10-14 February (2003) [Abstract 141]
    • (2003) 10th Conference on Retroviruses and Opportunistic Infections
    • Greenberg, M.1    Melby, T.2    Sista, P.3    DeMasi, R.4    Cammack, N.5
  • 11
    • 4444375658 scopus 로고    scopus 로고
    • Resistance to enfuvirtide, the first HIV fusion inhibitor
    • Greenberg M.L., and Cammack N. Resistance to enfuvirtide, the first HIV fusion inhibitor. J Antimicrob Chemother 54 (2004) 333-340
    • (2004) J Antimicrob Chemother , vol.54 , pp. 333-340
    • Greenberg, M.L.1    Cammack, N.2
  • 13
    • 3142779320 scopus 로고    scopus 로고
    • Determinants of human immunodeficiency virus type 1 baseline susceptibility to the fusion inhibitors enfuvirtide and T-649 reside outside the peptide interaction site
    • Heil M.L., Decker J.M., Sfakianos J.N., Shaw G.M., Hunter E., et al. Determinants of human immunodeficiency virus type 1 baseline susceptibility to the fusion inhibitors enfuvirtide and T-649 reside outside the peptide interaction site. J Virol 78 (2004) 7582-7589
    • (2004) J Virol , vol.78 , pp. 7582-7589
    • Heil, M.L.1    Decker, J.M.2    Sfakianos, J.N.3    Shaw, G.M.4    Hunter, E.5
  • 14
    • 0037334568 scopus 로고    scopus 로고
    • Rational site-directed mutations of the LLP-1 and LLP-2 lentivirus lytic peptide domains in the intracytoplasmic tail of human immunodeficiency virus type 1 gp41 indicate common functions in cell-cell fusion but distinct roles in virion envelope incorporation
    • Kalia V., Sarkar S., Gupta P., and Montelaro R.C. Rational site-directed mutations of the LLP-1 and LLP-2 lentivirus lytic peptide domains in the intracytoplasmic tail of human immunodeficiency virus type 1 gp41 indicate common functions in cell-cell fusion but distinct roles in virion envelope incorporation. J Virol 77 (2003) 3634-3646
    • (2003) J Virol , vol.77 , pp. 3634-3646
    • Kalia, V.1    Sarkar, S.2    Gupta, P.3    Montelaro, R.C.4
  • 15
    • 0032543307 scopus 로고    scopus 로고
    • Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
    • Kwong P.D., Wyatt R., Robinson J., Sweet R.W., Sodroski J., et al. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393 (1998) 648-659
    • (1998) Nature , vol.393 , pp. 648-659
    • Kwong, P.D.1    Wyatt, R.2    Robinson, J.3    Sweet, R.W.4    Sodroski, J.5
  • 16
    • 0032712246 scopus 로고    scopus 로고
    • Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity
    • LaBranche C.C., Hoffman T.L., Romano J., Haggarty B.S., Edwards T.G., et al. Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity. J Virol 73 (1999) 10310-10319
    • (1999) J Virol , vol.73 , pp. 10310-10319
    • LaBranche, C.C.1    Hoffman, T.L.2    Romano, J.3    Haggarty, B.S.4    Edwards, T.G.5
  • 17
    • 0038576281 scopus 로고    scopus 로고
    • Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America
    • Lalezari J.P., Henry K., O'Hearn M., Montaner J.S., Piliero P.J., et al. Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America. N Engl J Med 348 (2003) 2175-2185
    • (2003) N Engl J Med , vol.348 , pp. 2175-2185
    • Lalezari, J.P.1    Henry, K.2    O'Hearn, M.3    Montaner, J.S.4    Piliero, P.J.5
  • 18
    • 0037849954 scopus 로고    scopus 로고
    • Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia
    • Lazzarin A., Clotet B., Cooper D., Reynes J., Arasteh K., et al. Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia. N Engl J Med 348 (2003) 2186-2195
    • (2003) N Engl J Med , vol.348 , pp. 2186-2195
    • Lazzarin, A.1    Clotet, B.2    Cooper, D.3    Reynes, J.4    Arasteh, K.5
  • 19
    • 15744393651 scopus 로고    scopus 로고
    • Different from the HIV fusion inhibitor C34, the anti-HIV drug Fuzeon (T-20) inhibits HIV-1 entry by targeting multiple sites in gp41 and gp120
    • Liu S., Lu H., Niu J., Xu Y., Wu S., et al. Different from the HIV fusion inhibitor C34, the anti-HIV drug Fuzeon (T-20) inhibits HIV-1 entry by targeting multiple sites in gp41 and gp120. J Biol Chem 280 (2005) 11259-11273
    • (2005) J Biol Chem , vol.280 , pp. 11259-11273
    • Liu, S.1    Lu, H.2    Niu, J.3    Xu, Y.4    Wu, S.5
  • 20
    • 3042799046 scopus 로고    scopus 로고
    • Relative replicative fitness of human immunodeficiency virus type 1 mutants resistant to enfuvirtide (T-20)
    • Lu J., Sista P., Giguel F., Greenberg M., and Kuritzkes D.R. Relative replicative fitness of human immunodeficiency virus type 1 mutants resistant to enfuvirtide (T-20). J Virol 78 (2004) 4628-4637
    • (2004) J Virol , vol.78 , pp. 4628-4637
    • Lu, J.1    Sista, P.2    Giguel, F.3    Greenberg, M.4    Kuritzkes, D.R.5
  • 21
    • 33746119203 scopus 로고    scopus 로고
    • Analysis of virological response and enfuvirtide resistance through 48 weeks in the TORO 1 and 2 studies
    • Tenerife, Spain, 8-12 June [Abstract 165]
    • Melby T., DeMasi R., Kuritzkes D., Heilek-Snyder G., Salgo M., et al. Analysis of virological response and enfuvirtide resistance through 48 weeks in the TORO 1 and 2 studies. XIII International HIV Drug Resistance Workshop. Tenerife, Spain, 8-12 June (2004) [Abstract 165]
    • (2004) XIII International HIV Drug Resistance Workshop
    • Melby, T.1    DeMasi, R.2    Kuritzkes, D.3    Heilek-Snyder, G.4    Salgo, M.5
  • 23
    • 4344685387 scopus 로고    scopus 로고
    • Genotype and phenotype patterns of human immunodeficiency virus type 1 resistance to enfuvirtide during long-term treatment
    • Menzo S., Castagna A., Monachetti A., Hasson H., Danise A., et al. Genotype and phenotype patterns of human immunodeficiency virus type 1 resistance to enfuvirtide during long-term treatment. Antimicrob Agents Chemother 48 (2004) 3253-3259
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3253-3259
    • Menzo, S.1    Castagna, A.2    Monachetti, A.3    Hasson, H.4    Danise, A.5
  • 24
    • 1642294438 scopus 로고    scopus 로고
    • Correlation of gp41 binding and antiviral potencies of the T-20 fusion inhibitor using clinical trial isolate-derived sequences
    • Chicago, IL, USA, 4-8 February [Abstract 474]
    • Mink M., Janumpalli S., Davison D., Mosier S., Erickson J.B., et al. Correlation of gp41 binding and antiviral potencies of the T-20 fusion inhibitor using clinical trial isolate-derived sequences. 8th Conference on Retroviruses and Opportunistic Infections. Chicago, IL, USA, 4-8 February (2001) [Abstract 474]
    • (2001) 8th Conference on Retroviruses and Opportunistic Infections
    • Mink, M.1    Janumpalli, S.2    Davison, D.3    Mosier, S.4    Erickson, J.B.5
  • 25
    • 11144236493 scopus 로고    scopus 로고
    • Mutations conferring resistance to human immunodeficiency virus type 1 fusion inhibitors are restricted by gp41 and Rev-responsive element functions
    • Nameki D., Kodama E., Ikeuchi M., Mabuchi N., Otaka A., et al. Mutations conferring resistance to human immunodeficiency virus type 1 fusion inhibitors are restricted by gp41 and Rev-responsive element functions. J Virol 79 (2005) 764-770
    • (2005) J Virol , vol.79 , pp. 764-770
    • Nameki, D.1    Kodama, E.2    Ikeuchi, M.3    Mabuchi, N.4    Otaka, A.5
  • 26
    • 15244353557 scopus 로고    scopus 로고
    • Variants of human immunodeficiency virus type 1 that efficiently use CCR5 lacking the tyrosine-sulfated amino terminus have adaptive mutations in gp120, including loss of a functional N-glycan
    • Platt E.J., Shea D.M., Rose P.P., and Kabat D. Variants of human immunodeficiency virus type 1 that efficiently use CCR5 lacking the tyrosine-sulfated amino terminus have adaptive mutations in gp120, including loss of a functional N-glycan. J Virol 79 (2005) 4357-4368
    • (2005) J Virol , vol.79 , pp. 4357-4368
    • Platt, E.J.1    Shea, D.M.2    Rose, P.P.3    Kabat, D.4
  • 27
    • 3342981347 scopus 로고    scopus 로고
    • Evolution of genotypic and phenotypic resistance to Enfuvirtide in HIV-infected patients experiencing prolonged virologic failure
    • Poveda E., Rodes B., Labernardiere J.L., Benito J.M., Toro C., et al. Evolution of genotypic and phenotypic resistance to Enfuvirtide in HIV-infected patients experiencing prolonged virologic failure. J Med Virol 74 (2004) 21-28
    • (2004) J Med Virol , vol.74 , pp. 21-28
    • Poveda, E.1    Rodes, B.2    Labernardiere, J.L.3    Benito, J.M.4    Toro, C.5
  • 28
    • 0037059049 scopus 로고    scopus 로고
    • Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics
    • Reeves J.D., Gallo S.A., Ahmad N., Miamidian J.L., Harvey P.E., et al. Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics. Proc Natl Acad Sci USA 99 (2002) 16249-16254
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 16249-16254
    • Reeves, J.D.1    Gallo, S.A.2    Ahmad, N.3    Miamidian, J.L.4    Harvey, P.E.5
  • 29
    • 16244380203 scopus 로고    scopus 로고
    • Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralization
    • Reeves J.D., Lee F.H., Miamidian J.L., Jabara C.B., Juntilla M.M., et al. Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralization. J Virol 79 (2005) 4991-4999
    • (2005) J Virol , vol.79 , pp. 4991-4999
    • Reeves, J.D.1    Lee, F.H.2    Miamidian, J.L.3    Jabara, C.B.4    Juntilla, M.M.5
  • 30
    • 0031883832 scopus 로고    scopus 로고
    • Determinants of human immunodeficiency virus type 1 resistance to gp41-derived inhibitory peptides
    • Rimsky L.T., Shugars D.C., and Matthews T.J. Determinants of human immunodeficiency virus type 1 resistance to gp41-derived inhibitory peptides. J Virol 72 (1998) 986-993
    • (1998) J Virol , vol.72 , pp. 986-993
    • Rimsky, L.T.1    Shugars, D.C.2    Matthews, T.J.3
  • 31
    • 0032546952 scopus 로고    scopus 로고
    • A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding
    • Rizzuto C.D., Wyatt R., Hernandez-Ramos N., Sun Y., Kwong P.D., et al. A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science 280 (1998) 1949-1953
    • (1998) Science , vol.280 , pp. 1949-1953
    • Rizzuto, C.D.1    Wyatt, R.2    Hernandez-Ramos, N.3    Sun, Y.4    Kwong, P.D.5
  • 32
    • 0038078724 scopus 로고    scopus 로고
    • Uncommon mutations at residue positions critical for enfuvirtide (T-20) resistance in enfuvirtide-naive patients infected with subtype B and non-B HIV-1 strains
    • Roman F., Gonzalez D., Lambert C., Deroo S., Fischer A., et al. Uncommon mutations at residue positions critical for enfuvirtide (T-20) resistance in enfuvirtide-naive patients infected with subtype B and non-B HIV-1 strains. J Acquir Immune Defic Syndr 33 (2003) 134-139
    • (2003) J Acquir Immune Defic Syndr , vol.33 , pp. 134-139
    • Roman, F.1    Gonzalez, D.2    Lambert, C.3    Deroo, S.4    Fischer, A.5
  • 33
    • 4444310448 scopus 로고    scopus 로고
    • Characterization of determinants of genotypic and phenotypic resistance to enfuvirtide in baseline and on-treatment HIV-1 isolates
    • Sista P.R., Melby T., Davison D., Jin L., Mosier S., et al. Characterization of determinants of genotypic and phenotypic resistance to enfuvirtide in baseline and on-treatment HIV-1 isolates. AIDS 18 (2004) 1787-1794
    • (2004) AIDS , vol.18 , pp. 1787-1794
    • Sista, P.R.1    Melby, T.2    Davison, D.3    Jin, L.4    Mosier, S.5
  • 34
    • 3042570574 scopus 로고    scopus 로고
    • Determinants of susceptibility to enfuvirtide (ENF) map to gp41 in ENF-naive HIV-1
    • [Abstract]
    • Stanfield-Oakley S.A., Jeffrey J., McDanal C.B., et al. Determinants of susceptibility to enfuvirtide (ENF) map to gp41 in ENF-naive HIV-1. Antiviral Ther 8 (2003) S25 [Abstract]
    • (2003) Antiviral Ther , vol.8
    • Stanfield-Oakley, S.A.1    Jeffrey, J.2    McDanal, C.B.3
  • 35
    • 0036090585 scopus 로고    scopus 로고
    • Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy
    • Wei X., Decker J.M., Liu H., Zhang Z., Arani R.B., et al. Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy. Antimicrob Agents Chemother 46 (2002) 1896-1905
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 1896-1905
    • Wei, X.1    Decker, J.M.2    Liu, H.3    Zhang, Z.4    Arani, R.B.5
  • 36
    • 1842457792 scopus 로고    scopus 로고
    • Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tail
    • Wyma D.J., Jiang J., Shi J., Zhou J., Lineberger J.E., et al. Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tail. J Virol 78 (2004) 3429-3435
    • (2004) J Virol , vol.78 , pp. 3429-3435
    • Wyma, D.J.1    Jiang, J.2    Shi, J.3    Zhou, J.4    Lineberger, J.E.5
  • 37
    • 0037119027 scopus 로고    scopus 로고
    • Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral-naive and -experienced patients
    • Xu L., Hue S., Taylor S., Ratcliffe D., Workman J.A., et al. Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral-naive and -experienced patients. AIDS 16 (2002) 1684-1686
    • (2002) AIDS , vol.16 , pp. 1684-1686
    • Xu, L.1    Hue, S.2    Taylor, S.3    Ratcliffe, D.4    Workman, J.A.5
  • 38
    • 20044371998 scopus 로고    scopus 로고
    • Emergence and evolution of enfuvirtide resistance following long-term therapy involves heptad repeat 2 mutations within gp41
    • Xu L., Pozniak A., Wildfire A., Stanfield-Oakley S.A., Mosier S.M., et al. Emergence and evolution of enfuvirtide resistance following long-term therapy involves heptad repeat 2 mutations within gp41. Antimicrob Agents Chemother 49 (2005) 1113-1119
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1113-1119
    • Xu, L.1    Pozniak, A.2    Wildfire, A.3    Stanfield-Oakley, S.A.4    Mosier, S.M.5
  • 39
    • 2342466810 scopus 로고    scopus 로고
    • CD4-induced T-20 binding to human immunodeficiency virus type 1 gp120 blocks interaction with the CXCR4 coreceptor
    • Yuan W., Craig S., Si Z., Farzan M., and Sodroski J. CD4-induced T-20 binding to human immunodeficiency virus type 1 gp120 blocks interaction with the CXCR4 coreceptor. J Virol 78 (2004) 5448-5457
    • (2004) J Virol , vol.78 , pp. 5448-5457
    • Yuan, W.1    Craig, S.2    Si, Z.3    Farzan, M.4    Sodroski, J.5
  • 40
    • 0035805185 scopus 로고    scopus 로고
    • Primary genotypic resistance of HIV-1 to the fusion inhibitor T-20 in long-term infected patients
    • Zollner B., Feucht H.H., Schroter M., Schafer P., Plettenberg A., et al. Primary genotypic resistance of HIV-1 to the fusion inhibitor T-20 in long-term infected patients. AIDS 15 (2001) 935-936
    • (2001) AIDS , vol.15 , pp. 935-936
    • Zollner, B.1    Feucht, H.H.2    Schroter, M.3    Schafer, P.4    Plettenberg, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.