Chronic morphine treatment induces oxidant and apoptotic damage in the mice liver

Life Sciences

Volumn 79, Issue 10, 2006, Pages 972-980

  Payabvash, Seyedmehdi ^a   Beheshtian, Azadeh ^a   Salmasi, Amirali Hassanzadeh ^a   Kiumehr, Saman ^a   Ghahremani, Mohammad Hossein ^b   Tavangar, Seyed Mohammad ^c   Sabzevari, Omid ^b   Dehpour, Ahmad R ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antioxidant enzymes; Apoptosis; Cysteine; Glutathione; Opioids

Indexed keywords

GLUTATHIONE; LIVER ENZYME; MORPHINE; NALTREXONE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER PAIN; CANCER REGRESSION; CANCER SIZE; CHRONIC DRUG ADMINISTRATION; CHRONIC PAIN; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MEGADOSE; ENZYME INDUCTION; ENZYME SYNTHESIS; LIVER CELL; LIVER INJURY; LIVER MICROSOME METABOLISM; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL SURVIVAL; CHRONIC DISEASE; GLUTATHIONE; LIVER; MALE; MICE; MORPHINE; NALTREXONE; NARCOTIC ANTAGONISTS; OXIDATIVE STRESS; PAIN; SIGNAL TRANSDUCTION;

EID: 33745964129     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2006.05.008     Document Type: Article

References (49)

1. Aebi H. Catalase in vitro. Methods in Enzymology 105 (1984) 121-126
2. Bhat R.S., Bhaskaran M., Mongia A., Hitosugi N., and Singhal P.C. Morphine-induced macrophage apoptosis: oxidative stress and strategies for modulation. Journal of Leukocyte Biology 75 6 (2004) 1131-1138
3. Bird M.A., Black D., Lange P.A., C.M. S., Hayden M., and Behrns K.E. NFB inhibition decreases hepatocyte proliferation but does not alter apoptosis in obstructive jaundice. Journal of Surgical Research Experimental Neurology 114 2 (2003) 110-118
4. Correia M.A., Krowech G., Caldera-Munoz P., Yee S.L., Straub K., and Castagnoli N.J. Morphine metabolism revisited: II. Isolation and chemical characterization of a glutathionylmorphine adduct from rat liver microsomal preparations. Chemico-Biological Interactions 51 1 (1984) 13-24
5. Czaja M.J. Induction and regulation of hepatocyte apoptosis by oxidative stress. Antioxidants & Redox Signalling 4 5 (2002) 759-767
6. Di Francesco P., Tavazzi B., Gaziano R., Lazzarino G., Casalinuovo I.A., Di Pierro D., and Garaci E. Differential effects of acute morphine administrations on polymorphonuclear cell metabolism in various mouse strains. Life Science 63 24 (1998) 2167-2174
7. Enrico P., Esposito G., Mura M.A., Migheli R., Serra P.A., Desole M.S., Miele E., De Natale G., and Miele M. Effects of allopurinol on striatal dopamine, ascorbate and uric acid during an acute morphine challenge: ex vivo and in vivo studies. Pharmacological Research 35 6 (1997) 577-585
8. Fuggetta M.P., Di Francesco P., Falchetti R., Cottarelli A., Rossi L., Tricarico M., and Lanzilli G. Effect of morphine on cell-mediated immune responses of human lymphocytes against allogenic malignant cells. Journal of Experimental & Clinical Cancer Research 24 2 (2005) 255-263
9. Fujii J., and Taniguchi N. Down regulation of superoxide dismutases and glutathione peroxidase by reactive oxygen and nitrogen species. Free Radical Research 31 4 (1999) 301-308
10. Gaitonde M.K. A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids. Biochemical Journal 104 (1967) 627-633
11. Goudas L.C., Langlade A., Serrie A., Matson W., Milbury P., Thurel C., Sandouk P., and Carr D.B. Acute decreases in cerebrospinal fluid glutathione levels after intracerebroventricular morphine for cancer pain. Anesthesia and Analgesia 89 5 (1999) 1209-1215
12. Griffith O.W. Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radical Biology & Medicine 27 9-10 (1999) 922-935
13. Habig W.H., Pabst M.J., and Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry 249 (1974) 7130-7139
14. 2+ homeostasis and induce carbonyl oxyradical production in mouse astrocytes in vitro: transient increases and adaptation to sustained exposure. 151 (1), 70-76.
15. Hu S., Sheng W.S., Lokensgard J.R., and Peterson P.K. Morphine induces apoptosis of human microglia and neurons. Experimental Neurology 42 6 (2002) 829-836
16. James R.C., Goodman D.R., and Harbison R.D. Hepatic glutathione and hepatotoxicity: changes induced by selected narcotics. Journal of Pharmacology and Experimental Therapeutics 221 3 (1982) 708-714
17. Jaume M., Jacquet S., Cavailles P., Mace G., Stephan L., Blanpied C., Demur C., Brousset P., and Dietrich G. Opioid receptor blockade reduces Fas-induced hepatitis in mice. Hepatology 40 5 (2004) 1136-1143
18. Jiang X., Shi E., Nakajima Y., and Sato S. Inducible nitric oxide synthase mediates delayed cardioprotection induced by morphine in vivo. Anesthesiology 101 1 (2004) 82-88
19. Kapasi A.A., Coscia S.A., Pandya M.P., and Singhal P.C. Morphine modulates HIV-1 gp160-induced murine macrophage and human monocyte apoptosis by disparate ways. Journal of Neuroimmunology 148 1-2 (2004) 86-96
20. Kawase M., Sakagami H., Furuya K., Kikuchi H., Nishikawa H., Motohashi N., Morimoto Y., Varga A., and Molnar J. Cell death-inducing activity of opiates in human oral tumor cell lines. Anticancer Research 22 1A (2002) 211-214
21. Kretzschmar M., and Klinger W. Gamma-Glutamyltranspeptidase in liver homogenates of rats of different ages: enzyme kinetics and age course of Km and Vmax. Zeitschrift für Versuchstierkunde 32 (1989) 41-47
22. Kumagai Y., Todaka T., and Toki S. A new metabolic pathway of morphine: in vivo and in vitro formation of morphinone and morphine-glutathione adduct in guinea pig. Journal of Pharmacology and Experimental Therapeutics 255 2 (1990) 504-510
23. LeVier D.G., McCay J.A., Stern M.L., Harris L.S., Page D., Brown R.D., Musgrove D.L., Butterworth L.F., White K.L.J., and Munson A.E. Immunotoxicological profile of morphine sulfate in B6C3F1 female mice. Fundamental and Applied Toxicology 22 4 (1994) 525-542
24. Lewis J.W., Shavit Y., Terman G.W., Gale R.P., and Liebeskind J.C. Stress and morphine affect survival of rats challenged with a mammary ascites tumor (MAT 13762B). Natural Immunity and Cell Growth Regulation 3 1 (1984) 43-50
25. Ludwig L.M., Patel H.H., Gross G.J., Kersten J.R., Pagel P.S., and Warltier D.C. Morphine enhances pharmacological preconditioning by isoflurane: role of mitochondrial K(ATP) channels and opioid receptors. Anesthesiology 98 3 (2003) 705-711
26. Macchia I., Palamara A.T., Bue C., Savini P., Ciriolo M., Gaziano R., and di Francesco P. Increased replication of Sendai virus in morphine-treated epithelial cells: evidence for the involvement of the intracellular levels of glutathione. International Journal of Immunopharmacology 21 3 (1999) 185-193
27. Maneckjee R., and Minna J.D. Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth & Differentiation 5 10 (1994) 1033-1040
28. McNicol E., Horowicz-Mehler N., Fisk R.A., Bennett K., Gialeli-Goudas M., Chew P.W., Lau J., and Carr D. Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review. Journal of Pain 4 5 (2003) 156-231
29. Meilhac O., Zhou M., Santanam N., and Parthasarathy S. Lipid peroxides induce expression of catalase in cultured vascular cells. Journal of Lipid Research 41 8 (2000) 1205-1213
30. Miyoshi H., Rust C., Guicciardi M.E., and Gores G.J. NF-kB is activated in cholestasis and functions to reduce liver injury. American Journal of Pathology 158 3 (2001) 967-975
31. Nelson C.J., Schneider G.M., and Lysle D.T. Involvement of central mu-but not delta- or kappa-opioid receptors in immunomodulation. Brain, Behavior, and Immunity 14 3 (2000) 170-184
32. Paglia D.E., and Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. Journal of Laboratory and Clinical Medicine 70 (1967) 158-169
33. Paoletti F., and Mocali A. Determination of superoxide dismutase activity by purely chemical system based on NAD(P)H oxidation. Methods in Enzymology 186 (1990) 209-220
34. Paroni R., De Vecchi E., Cighetti G., Arcelloni C., Fermo I., Grossi A., and Bonini P. HPLC with o-phthalaldehyde precolumn derivatization to measure total, oxidized, and protein-bound glutathione in blood, plasma, and tissue. Clinical Chemistry 41 (1995) 448-454
35. Patel J., Manjappa N., Bhat R., Mehrotra P., Bhaskaran M., and Singhal P.C. Role of oxidative stress and heme oxygenase activity in morphine-induced glomerular epithelial cell growth. American Journal of Physiology. Renal Physiology 285 5 (2003) F861-F869
36. Patel K., Bhaskaran M., Dani D., Reddy K., and Singhal P.C. Role of heme oxygenase-1 in morphine-modulated apoptosis and migration of macrophages. Journal of Infectious Diseases 187 1 (2003) 47-54
37. Portenoy R.K., and Lesage P. Management of cancer pain. Lancet 353 9165 (1999) 1695-1700
38. Radbruch L., Grond S., Zech D.J., and Bischoff A. High-dose oral morphine in cancer pain management: a report of twelve cases. Journal of Clinical Anesthesia 8 (1996) 144-150
39. Ribeiro P.S., Cortez-Pinto H., Sola S., Castro R.E., Ramalho R.M., Baptista A., Moura M.C., Camilo M.E., and Rodrigues C.M. Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. American Journal of Gastroenterology 99 9 (2004) 1708-1717
40. Roberts S.M., Skoulis N.P., and James R.C. A centrally-mediated effect of morphine to diminish hepatocellular glutathione. Biochemical Pharmacology 36 18 (1987) 3001-3005
41. Sasamura T., Nakamura S., Iida Y., Fujii H., Murata J., Saiki I., Nojima H., and Kuraishi K. Morphine analgesia suppresses tumor growth and metastasis in a mouse model of cancer pain produced by orthotopic tumor inoculation. European Journal of Pharmacology 441 3 (2002) 185-191
42. Schultz J.J., Hsu A.K., and Gross G.J. Morphine mimics the cardioprotective effect of ischemic preconditioning via a glibenclamide-sensitive mechanism in the rat heart. Circulation Research 78 6 (1996) 1100-1104
43. Seelig G.F., and Meister A. γ-Glutamylcysteine synthetase. Journal of Biological Chemistry 259 (1984) 3534-3538
44. Sueoka E., Sueoka N., Kai Y., Okabe S., Suganuma M., Kanematsu K., Yamamoto T., and Fujiki H. Anticancer activity of morphine and its synthetic derivative, KT-90, mediated through apoptosis and inhibition of NF-kB activation. Biochemical and Biophysical Research Communications 252 3 (1998) 566-570
45. Tanaka K., Ludwig L.M., Kersten J.R., Pagel P.S., and Warltier D.C. Mechanisms of cardioprotection by volatile anesthetics. Anesthesiology 100 3 (2004) 707-721
46. Tegeder I., and Geisslinger G. Opioids as modulators of cell death and survival-unraveling mechanisms and revealing new indications. Pharmacological Reviews 56 3 (2004) 351-369
47. Tejwani G.A., Gudehithlu K.P., Hanissian S.H., Gienapp I.E., Whitacre C.C., and Malarkey W.B. Facilitation of dimethylbenz(a)anthranceinduced rat mammary tumorigenesis by restraint stress: role of betaendorphine, prolactin and naltrexone. Carcinogenesis 12 (1991) 637-641
48. Van Loon G.R., Appel N.M., and Ho D. Beta-endorphin-induced stimulation of central sympathetic outflow: beta-endorphin increases plasma concentrations of epinephrine, norepinephrine, and dopamine in rats. Endocrinology 109 1 (1981) 46-53
49. Yamauchi N., Shibasaki T., Wakabayashi I., and Demura H. Brain beta-endorphin and other opioids are involved in restraint stress-induced stimulation of the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system, and the adrenal medulla in the rat. Brain Research 777 1-2 (1997) 140-146