Opioids disrupt Ca2+ homeostasis and induce carbonyl oxyradical production in mouse astrocytes in Vitro: Transient increases and adaptation to sustained exposure

Experimental Neurology

Volumn 151, Issue 1, 1998, Pages 70-76

  Hauser, Kurt F ^a   Harris White, Marni E ^a   Jackson, Jennifer A ^a   Opanashuk, Lisa A ^a   Carney, John M ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Drug tolerance; Intracellular calcium; Neuroglia; Opiate drug abuse; Reactive oxygen species

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; CALCIUM ION; CARBONYL DERIVATIVE; DELTA OPIATE RECEPTOR; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; FURA 2; KAPPA OPIATE RECEPTOR; MORPHICEPTIN[3 (N METHYLPHENYLALANINE) 4 DEXTRO PROLINAMIDE]; MU OPIATE RECEPTOR; OPIATE; OXYGEN RADICAL; REACTIVE OXYGEN METABOLITE; REAGENT; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ANALGESIC AGENT; CALCIUM; ENDORPHIN; ENKEPHALIN; MORPHICEPTIN, N ME PHE(3); MORPHICEPTIN, N-ME-PHE(3)-; NALOXONE; NARCOTIC AGENT; NARCOTIC ANTAGONIST;

ADAPTATION; ANIMAL CELL; ARTICLE; ASTROCYTE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; DRUG ABUSE; DRUG TOLERANCE; LONG TERM EXPOSURE; MACROGLIA; MOUSE; NERVE CELL LESION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HOMEOSTASIS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; OXIDATIVE STRESS;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANALGESICS; ANALGESICS, NON-NARCOTIC; ANIMALS; ASTROCYTES; CALCIUM; DRUG TOLERANCE; ENDORPHINS; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; HOMEOSTASIS; MICE; MICE, INBRED ICR; NALOXONE; NARCOTIC ANTAGONISTS; NARCOTICS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU;

EID: 0032068748     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1998.6788     Document Type: Article

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