The potential of stem cells in orthopaedic surgery

Journal of Bone and Joint Surgery - Series B

Volumn 88, Issue 7, 2006, Pages 841-851

  Lee, E H ^a   Hui, J H P ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ANTIINFECTIVE AGENT; BIOLOGICAL MARKER; BONE MORPHOGENETIC PROTEIN 2; CYTOKINE RECEPTOR; DYSTROPHIN; GROWTH FACTOR; RECOMBINANT DNA; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3;

ARTICULAR CARTILAGE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BLASTOCYST; BONE DISEASE; BONE GRAFT; CARTILAGE CELL; CELL BASED GENE THERAPY; CELL DIFFERENTIATION; CELL FUSION; CELL INTERACTION; CELL LINEAGE; CELL TYPE; CELLULAR DISTRIBUTION; CHEMOTHERAPY; CHONDROPATHY; CHROMOSOME 17Q; DONOR; DRUG MEGADOSE; EMBRYONIC STEM CELL; EPIPHYSIS INJURY; FERTILIZATION IN VITRO; FUNDING; GENE EXPRESSION REGULATION; GOVERNMENT REGULATION; HEALTH CARE ORGANIZATION; HEART MUSCLE CELL; HEMATOPOIETIC STEM CELL; HISTOPATHOLOGY; HUMAN; INTERNATIONAL COOPERATION; INTERVERTEBRAL DISK DEGENERATION; JUVENILE RHEUMATOID ARTHRITIS; KARYOTYPE; KNEE MENISCUS RUPTURE; LIGAMENT INJURY; LIVER CELL; MESENCHYMAL STEM CELL; METAPHYSIS; MULTIPOTENT STEM CELL; MUSCULAR DYSTROPHY; NONHUMAN; ORTHOPEDIC SURGERY; OSTEOGENESIS IMPERFECTA; OSTEOLYSIS; PEDIATRICS; PLURIPOTENT STEM CELL; POLITICS; PRIORITY JOURNAL; QUALITY CONTROL; RESEARCH ETHICS; REVIEW; SPINAL CORD INJURY; STANDARDIZATION; STEM CELL TRANSPLANTATION; TENDON INJURY; TISSUE ENGINEERING; TOTIPOTENT STEM CELL; VIRAL GENE DELIVERY SYSTEM;

ADULT; ARTHRITIS, JUVENILE RHEUMATOID; BONE AND BONES; CARTILAGE, ARTICULAR; CELL DIFFERENTIATION; CHILD; HUMANS; LIGAMENTS; MESENCHYMAL STEM CELLS; MUSCULAR DYSTROPHIES; ORTHOPEDIC PROCEDURES; OSTEOGENESIS IMPERFECTA; SPINAL DISEASES; STEM CELL TRANSPLANTATION; STEM CELLS; TENDON INJURIES;

EID: 33745950257     PISSN: 0301620X     EISSN: None     Source Type: Journal    
DOI: 10.1302/0301-620X.88B7.17305     Document Type: Review

References (95)

1. Bongso A, Lee EH. Stem cells: their definition, classification and sources. In: Bongso A, Lee EH, eds. Stem cells: from bench to bedside. Singapore: World Scientific Publishing, 2005:1.
2. Caplan AI. The mesengenic process. Clin Plast Surg 1994;21:429-35.
3. Verfaillie CM. Multipotent adult progenitor cells: an update. Norvatis Found Symp 2005;265:55-61.
4. Badorff C, Brandes RP, Popp R, et al. Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes. Circulation 2003;107:1024-32.
5. Song L, Tuan RS. Trans differentiation potential of human mesenchymal stem cells derived from bone marrow. FASEB J 2004;18:980-2.
6. Bongso A, Richards M. History and perspective of stem cell research. In: Fisk N, Itskovitz J, eds. Best practice & research clinical obstetrics and gynaecology. London: Elsevier Ltd, 2004.
7. Bongso A, Fng CY, Ng SC, Ratnam S. Isolation and culture of inner cell mass cells from human blastocytes. Hum Reprod 1994;9:2110-17.
8. Kim HS, Oh SK, Park YB, et al. Methods for deprivation of human embryonic stem cells. Stem Cells 2005;23:1228-33.
9. Burley J. Stem cells and translation medicine ethics, law and policy. In: Bongso A, Lee EH, eds. Stem cells: from bench to bedside. Singapore: World Scientific Publishing, 2005;10:187-210.
10. Bianco P, Riminucci M. The bone marrow stroma in vivo: ontogeny, structure, cellular composition and changes in disease. In: Beresford JN, Cambridge ME, eds. Marrow stromal cell culture: handbooks in practical animal cell biology. Cambridge: Cambridge University Press, 1998:10-25.
11. Pittenger MF, Flake AM, Deans RJ. Stem cell culture: mesenchymal stem cells from bone marrow. In: Atala A, Lanza RP, eds. Methods of tissue engineering. San Diego: Academic Press, 2002:461-9.
12. Foster LJ, Zeemann PA, Li C, et al. Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteablast differentiation. Stem Cells 2005;23:1367-77.
13. Bing Lim. Probing the responsiveness of ES cells genome [abstract]. Stem Cell Symposium Singapore, 2005.
14. Keyser KA, Morris JC, Kiem HP. Genetically modified CD34+ cells do not contribute to the mesenchymal compartment after autologous transplantation in the baboon. Cytotherapy 2005;7:345-52.
15. Li WG, Xu XX. The expression of N-cadherin, fibronectin during chondrogenic differentiation of MSC induced by TGF-beta(1). Chin J Traumatol 2005;8:349-51.
16. Hunziker EB. Articular cartilage repair: basic science and clinical progress: a review of the current status and prospects. Osteoarthritis Cartilage 2002;10:432-63.
17. Buckwalter JA, Mankin HJ. Articular cartilage: degeneration and osteoarthritis, repair, regeneration and transplantation. Instr Course Lect 1998;47:487-504.
18. Blevins FT, Steadman JR, Rodrigo JJ, Silliman J. Treatment of articular cartilage defects in athletes: an analysis of functional outcome and lesion appearance. Orthopedics 1998;21:761-7.
19. Knutsen G, Engrebtsen L, Ludvigsen TC, et al. Autologous chondrocyte implantation compared with microfracture in the knee: a randomized trial. J Bone Joint Surg [Am] 2004;86-A:455-64.
20. Bentley G, Greer RB 3rd. Homotransplantation of isolated epiphyseal and articular cartilage chondrocytes into joint surfaces of rabbits. Nature 1971;230:385-8.
21. Hendrickson DA, Nixon AJ, Grande DA, et al. Chondrocyte-fibrin matrix transplants for resurfacing extensive articular cartilage defects. J Orthop Res 1994;12: 485-97.
22. Gallay SH, Miura Y, Commisso CN, Fitzsimmons JS, O'Driscoll SW. Relationship of donor site to chondrogenic potential of periosteum in vitro. J Orthop Res 1994; 12:515-25.
23. Wakitani S, Imoto K, Yamamoto T, et al. Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage 2002;10:199-206.
24. Brittberg M, Lindahl A, Nilsson A, et al. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994;331:889-95.
25. Hui JH, Chen F, Thambyah A, Lee EH. Treatment of chondral lesions in advanced osteochondritis dissecans: a comparative study of the efficacy of chondrocytes, mesenchymal stem cells, periosteal graft, and mosaicplasty (osteochondral autograft) in animal models. J Pediatr Orthop 2004;24:427-33.
26. Goshima J, Goldberg VM, Caplan AI. Osteogenic potential of culture-expanded rat marrow cells as assayed in vivo with porous calcium phosphate ceramic. Biomaterials 1991;12:253-8.
27. Gundle R, Joyner CJ, Triffitt JT. Human bone tissue formation in diffusion chamber culture in vivo by bone-derived cells and marrow stromal fibroblastic cells. Bone 1995; 16:597-601.
28. Bruder SP, Kurth AA, Shea M, et al. Bone regeneratuion by implantation of purified culture-expanded human mesenchymal stem cells. J Orthop Res 1998;16:155-62.
29. Jaiswal N, Haynesworth SE, Caplan AI, Bruder SP. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem 1997;64:295-312.
30. Bruder SP, Fink DJ, Caplan AI. Mesencymal stem cells in bone development, bone repair and skeletal regeneration therapy. J Cell Biochem 1994;56:283-94.
31. Quarto R, Mastrogiacomo M, Cancedda T, et al. Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 2001;344:385-6.
32. Young BH, Peng H, Huard J. Muscle-based gene therapy and tissue engineering to improve bone healing. Clin Orthop 2002;403(Suppl):243-51.
33. Yoshikawa H, Myoui A. Bone tissue engineering with porous hydroxyapatite ceramics. J Artif Organs 2005;8:131-6.
34. Wiesmann HP, Joos U, Meyer U. Biological and biophysical principles in extracorporal bone tissue engineering: part II. Int J Oral Maxillofac Surg 2004;33:523-30.
35. Urist MR. Bone: formation by autoinduction. Science 1965;150:893-9.
36. Ripamonti U, Ma SS, van den Heever B, Reddi AH. Osteogenin, a bone morphogenetic protein, adsorbed on porous hydroxyapatite substrata, induces rapid bone differentiation in calvarial defects of adult primates. Plast Reconstr Surg 1992;90: 382-93.
37. Yasko AW, Lane JM, Fellinger EJ et al. The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2): a radiographic, histological, and biomechanical study in rats. J Bone Joint Surg [Am] 1992; 74-A:659-70.
38. Lieberman JR, Le LQ, Wu L, et al. Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. J Orthop Res 1998;16:330-9.
39. Reddi AH. Initiation of fracture repair by bone morphogenetic proteins. Clin Orthop 1998;355(Suppl):66-72.
40. Niyibizi C, Baltzer A, Latterman C, et al. Potential role for gene therapy in the enhancement of fracture healing. Clin Orthop 1998;355(Suppl):148-53.
41. Jullig M, Zhang WV, Stott NS. Gene therapy in orthopaedic surgery: the current status. ANZ J Surg 2004;74:46-54.
42. Baltzer AW, Lattermann C, Whalen JD, et al. Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Ther 2000;7:734-9.
43. Shen FH, Visger JM, Balian G, Hurwitz SR, Diduch DR. Systemically administered mesenchymal stromal cells transduced with insulin-like growth factor-I localize to a fracture site and potentiate healing. J Orthop Trauma 2002;16:651-9.
44. Brown TD, Fu FH, Hanley EN Jr. Comparative assessment of the early mechanical integrity of repaired tendon achillis ruptures in the rabbit. J Trauma 1981;21:951-7.
45. Badylak SF Tullius R, Kokini K, et al. The use of xenogeneic small intestinal submucosa as a biomaterial for achilles tendon repair in a dog model. J Biomed Mater Res 1995;29:977-85.
46. Lieberman JR, Lozman J, Czajka J, Dougherty J. Repair of achilles tendon ruptures with Dacron vascular graft. Clin Orthop 1988;234:204-8.
47. Ozaki J, Fujiki J, Sugimoto K, Tamai S, Masuhara K. Reconstruction of neglected Achilles tendon rupture with Marlex mesh. Clin Orthop 1989;238:204-8.
48. Young RG, Butler DL, Weber W, et al. Use of mesenchymal stem cells in a collagen matrix for Achilles tendon repair. J Orthop Res 1998;16:406-13.
49. Awad HA, Boivin GP, Dressler MR, et al. Repair of patellar tendon injuries using a cell-collagen composite. J Orthop Res 2003;21:420-31.
50. Ouyang HW, Goh JC, Thambyah A, Teoh SH, Lee EH. Knitted poly-lactide-co-glycolide scaffold loaded with bone marrow stromal cells in repair and regeneration of rabbit achilles tendon. Tissue Eng 2003;9:431-9.
51. Hyman J, Rodeo SA. Injury and repair of tendons and ligaments. Phys Med Rehabil Clin N Am 2000;11:267-68.
52. Fu FH, Bennett CH, Lattermann C, Ma CB. Current trends in anterior cruciate ligament reconstruction. Part 1: biology and biomechanics of reconstruction. Am J Sports Med 1999;27:821-30.
53. Rodeo SA, Suzuki K, Deng XH, Wozney J, Warren RF. Use of recombinant human bone morphogenetic protein-2 to enhance tendon healing in a bone tunnel. Am J Sports Med 1999;27:476-88.
54. Hattersley G, Cox K, Soslowsky LJ, et al. Bone morphogenic proteins 2 and 12 alter the attachment of tendon to bone in rat model: a histological and biomechanical investigation. Trans Orthop Res Soc 1998;23:96.
55. Lim JK, Hui J, Li L, et al. Enhancement of tendon graft osteointegration using mesenchymal stem cells in a rabbit model of anterior cruciate ligament reconstruction. Arthroscopy 2004;20:899-910.
56. Northmore-Ball MD, Dandy DJ. Long-term results of arthroscopic partial meniscectomy. Clin Orthop 1982;167:34-42.
57. Allen PR, Denham RA, Swan AV. Late degenerative changes after meniscectomy: factors affecting the knee after operation. J Bone Joint Surg [Br] 1984;66-B:666-71.
58. Peretti GM, Caruso EM, Randolph MA, Zaleske DJ. Meniscal repair using engineered tissue. J Orthop Res 2001;19:278-85.
59. Dutton A, Hui JPP, Lee EH, Goh J. Enhancement of meniscal repair using mesenchymal stem cells in a porcine model. Procs 5th Combined Meeting of the Orthopaedic Research Societies of USA, Canada, Japan & Europe, 2004.
60. Shim CS, Lee SH, Park CW, et al. Partial disc replacement with the PDN prosthetic disc nucleus device: early clinical results. J Spinal Disord Tech 2003;16:324-30.
61. Brisby H, Tao H, Ma DD, Diwan AD. Cell therapy for disc degeneration: potentials and pitfalls. Orthop Clin North Am 2004;35:85-93.
62. Crevensten G, Walsh AJ, Ananthakrishnan D, et al. Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discs. Ann Biomed Eng 2004;32:430-4.
63. Steinmann JC, Herkowitz HN. Pseudarthrosis of the spine. Clin Orthop 1992;284: 80-90.
64. Boden SD, Martin GJ Jr, Morone M, et al. The use of coralline hydroxyapatite with bone marrow, autogenous bone graft, or osteoinductive bone protein extract for posterolateral lumbar spine fusion. Spine 1999;24:320-7.
65. Itoh H, Ebara S, Kamimura M, et al. Experimental spinal fusion with use of recombinant human bone morphogenetic protein 2. Spine 1999;24:1402-5.
66. Boden SD, Schimandle JH, Hutton WC. 1995 Volvo Award in basic sciences: the use of an osteoinductive growth factor for lumbar spinal fusion. Part II: study of dose, carrier, and species. Spine 1995;20:2633-44.
67. Cui Q, Ming Xiao Z, Balian G, Wang GJ. Comparison of lumbar spine fusion using mixed and closed marrow cells. Spine 2001;26:2305-10.
68. Cinotti G, Patti AM, Volcano A, et al. Experimental posterolateral spinal fusion with porous ceramics and mesenchymal stem cells. J Bone Joint Surg [Br] 2004;86-B: 135-42.
69. van Gaalen SM, Dhert WJ, van den Muysenberg A, et al. Bone tissue engineering for spine fusion: an experimental study on ectopic and orthotopic implants in rats. Tissue Eng 2004;10:231-9.
70. Barami K, Diaz FG. Cellular transplantation and spinal cord injury. Neurosurgery 2000;47:691-700.
71. Akiyama Y, Radtke C, Honmou O, Kocsis JD. Remyelination of the spinal cord following intravenous delivery of bone marrow cells. Glia 2002;39:229-36.
72. Rosenfeld JV, Gillett GR. Ethics, stem cells and spinal cord repair. Med J Aust 2004;180:637-9.
73. Mizuta T, Benson WM, Foster BK, Paterson DC, Morris LL. Statistical analysis of the incidence of physeal injuries. J Pediatr Orthop 1987;7:518-23.
74. Langenskiold A. Surgical treatment of partial closure of the growth plate. J Pediatr Orthop 1981;1:3-11.
75. Bright RW. Operative correction of partial epiphyseal plate closure by osseous-bridge resection and silicone-rubber implant: an experimental study in dogs. J Bone Joint Surg [Am] 1974;56-A:655-64.
76. Martiana K, Low CK, Tan SK, Pang MW. Comparison of various interpositional materials in the prevention of transphyseal bone bridge formation. Clin Orthop 1996; 325:218-24.
77. Lee EH, Gao GX, Bose K. Management of partial growth arrest: physis, fat, or silastic? J Pediatr Orthop 1993;13:368-72.
78. Foster BK, Hansen AL, Gibson GJ, et al. Reimplantation of growth plate chondrocytes into growth plate defects in sheep. J Orthop Res 1990;8:555-64.
79. Lee EH, Chen F, Chan J, Bose K. Treatment of growth arrest by transfer of cultured chondrocytes into physeal defects. J Pediatr Orthop 1998;18:155-60.
80. Tobita M, Ochi M, Uchio Y, et al. Treatment of growth plate injury with autogenous chondrocytes: a study in rabbits. Acta Orthop Scand 2002;73:352-8.
81. Chen F, Hui JH, Chan WK, Lee EH. Cultured mesenchymal stem cell transfers in the treatment of partial growth arrest. J Pediatr Orthop 2003;23:425-9.
82. Ahn JI, Terry Canale S, Butler SD, Hasty KA. Stem cell repair of physeal cartilage. J Orthop Res 2004;22:1215-21.
83. Wakitani S, Goto T, Pineda SJ, et al. Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg [Am] 1994;76-A:579-92.
84. Gussoni E, Soneoka Y, Strickland CD, et al. Dystrophin expression in the MDX mouse restored by stem cell transplantation. Nature 1999;401:390-4.
85. Wakitani S, Saito T, Caplan AI. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 1995;18:1417-26.
86. Nilsson SK, Donner MS, Weier HU, et al. Cells capable of bone production engraft from whole bone marrow transplants in nonablated mice. J Exp Med 1999; 189:729-34.
87. Pereira RF, O'Hara MD, Laptex AV, et al. Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Proc Natl Acad Sci USA 1998;95:1142-7.
88. Horwitz EM, Prockop DJ, Fitzpatrick LA, et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 1999;5:309-13.
89. Marmont AM. Stem cell transplantation for severe autoimmune disorders, with special reference to rheumatic diseases. J Rheumatol Suppl 1997;48:13-18.
90. Wicks I, Cooley H, Szer J. Autologous hemopoietic stem cell transplantation: a possible cure for rheumatoid arthritis? Arthritis Rheum 1997;40:1005-11.
91. Joske DJ, Ma DT, Langlands DR, Owen ET. Autologous bone-marrow transplantation for rheumatoid arthritis. Lancet 1997;350:337-8.
92. Euler HH, Marmont AM, Bacigalupo A, et al. Early recurrence or persistence of autoimmune diseases after unmanipulated autologous stem cell transplantation. Blood 1996;88:3621-5.
93. Barron KS, Wallace C, Woolfrey CEA, et al. Autologous stem cell transplantation for pediatric rheumatic diseases. J Rheumatol 2001;28:2337-58.
94. Wulffraat NM, Sanders LA, Kuis W. Autologous hemopoetic stem-cell transplantation for children with refractory autoimmune disease. Curr Rheumatol Rep 2000;2: 316-23.
95. Goncalves MA, de Vries AA, Holkers M, et al. Human mesenchymal stem cells ectopically expressing full-length dystrophin can complement Duchenne muscular dystrophy myotubes by cell fusion. Hum Mole Genet 2006;15:213-21.