Use of recombinant human bone morphogenetic protein-2 to enhance tendon healing in a bone tunnel

American Journal of Sports Medicine

Volumn 27, Issue 4, 1999, Pages 476-488

  Rodeo, Scott A ^a,c   Suzuki, Katsunori ^a   Deng, Xiang Hua ^a   Wozney, John ^b   Warren, Russell F ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b PFIZER INC   (United States)

^c HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; DRUG CARRIER; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN 2; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE RADIOGRAPHY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; HEALING; HISTOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; SPONGE; TENDON GRAFT; TIBIA;

EID: 0032816071     PISSN: 03635465     EISSN: None     Source Type: Journal    
DOI: 10.1177/03635465990270041201     Document Type: Article

References (22)

1. Andersson SM, Nilsson BE: Changes in bone mineral content following ligamentous knee injuries. Med Sci Sports 11: 351-353, 1979
2. Bolander ME: Inducers of osteogenesis, in Friedlander GE, Goldberg VM (eds): Bone and Cartilage Allografts: Biology and Clinical Applications. Park Ridge, IL, American Academy of Orthopaedic Surgeons, 1991, pp 75-83
3. Cole AA, Walters LM: Tartrate-resistant acid phosphatase in bone and cartilage following decalcification and cold-embedding in plastic. J Histochem Cytochem 35: 203-206, 1987
4. Cole BJ, Bostrom MPG, Pritchard TL, et al: Use of bone morphogenetic protein 2 on ectopic porous coated implants in the rat. Clin Orthop 345: 219-228, 1997
5. David SM, Murakami T, Tabor O, et al: Lumbar spinal fusion using recombinant human bone morphogenetic protein-2 (rhBMP-2): A randomized, blinded, and controlled study. Trans Comb Orthop Res Soc: 295, 1995
6. Fahey M, Indelicato PA: Bone tunnel enlargement after anterior cruciate ligament replacement. Am J Sports Med 22: 410-414, 1994
7. Hoher J, Withrow J, Livesay G, et al: Early stress causes graft-tunnel motion in hamstring grafts. Trans Orthop Res Soc 23: 44, 1998
8. Honl M, Muller V, Morlock M, et al: Dynamic in-vitro comparison of fixation methods used in ACL reconstruction. Trans Orthop Res Soc 23: 43, 1998
9. Kanatani M, Sugimoto T, Kaji H, et al: Stimulatory effect of bone morphogenetic protein-2 on osteoclast-like cell formation and bone-resorbing activity. J Bone Miner Res 10: 1681-1690, 1995
10. Kannus PA, Sievanen H, Jarvinen M, et al: A cruciate ligament injury produces considerable, permanent osteoporosis in the affected knee. J Bone Miner Res 7: 1429-1434, 1992
11. Kato F: Experimental study of chemical spinal fusion in the rabbit by means of bone morphogenetic protein [in Japanese]. Nippon Seikeigeka Gakkai Zasshi 64: 442-452, 1990
12. Kawaguchi H, Kurokawa T, Hoshino Y, et al: Immunohistochemical demonstration of bone morphogenetic protein-2 and transforming growth factor-β in the ossification of the posterior longitudinal ligament of the cervical spine. Spine 17: 33S-36S, 1992
13. Lind M, Overgaard S, Søballe K, et al: Transforming growth factor-β1 enhances bone healing to unloaded tricalcium phosphate coated implants: An experimental study in dogs. J Orthop Res 14: 343-350, 1996
14. Miyamoto S, Takaoka K, Yonenobu K, et al: Ossification of the ligamentum flavum induced by bone morphogenetic protein: An experimental study in mice. J Bone Joint Surg 74B: 279-283, 1992
15. Rodeo SA, Arnoczky SP, Torzilli PA, et al: Tendon healing in a bone tunnel: A biomechanical and histologic study in the dog. J Bone Joint Surg 75A: 1795-1803, 1993
16. Sciadini MF, Dawson JM, Berman LM, et al: Dose-response characteristics of recombinant human bone morphogenetic protein-2 (rhBMP-2) in a canine segmental defect model. Trans Orthop Res Soc 20: 594, 1995
17. Sumner DR, Turner TM, Purchio AF, et al: Enhancement of bone ingrowth by transforming growth factor-β. J Bone Joint Surg 77A: 1135-1147, 1995
18. Sumner DR, Turner TM, Urban RM, et al: rhBMP-2 enhances bone ingrowth and gap healing. Trans Orthop Res Soc 23: 599, 1998
19. Wolfman NM, Celeste AJ, Cox K, et al: Preliminary characterization of the biological activities of rhBMP-12. J Bone Miner Res 10 (Suppl 1): 38, 1995
20. Woo SL-Y, Taylor BJ, Schmidt CC, et al: The effect of dose levels of growth factors on the healing of the rabbit medial collateral ligament. Trans Orthop Res Soc 21: 97, 1996
21. Wozney JM, Rosen V, Celeste AJ, et al: Novel regulators of bone formation: Molecular clones and activities. Science 242: 1528-1534, 1988
22. Yasko AW, Lane JM, Fellinger EJ, et al: The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2): A radiographic, histological, and biomechanical study in rats. J Bone Joint Surg 74A: 659-670, 1992