Effects of polychlorinated biphenyls, hexachlorocyclohexanes, and mercury on human neutrophil apoptosis, actin cytoskelton, and oxidative state

Environmental Toxicology and Pharmacology

Volumn 22, Issue 2, 2006, Pages 179-188

  Sweet, Leonard I ^a   Passino Reader, Dora R ^a,b   Meier, Peter G ^a   Omann, Geneva M ^c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b U S GEOLOGICAL SURVEY   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; F actin; Immunomodulation; Necrosis; Oxidants

Indexed keywords

ACTIN; CYCLOHEXANE DERIVATIVE; F ACTIN; MERCURY; ORGANOCHLORINE DERIVATIVE; POLYCHLORINATED BIPHENYL DERIVATIVE; THIOL DERIVATIVE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOSKELETON; HEALTH; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IN VITRO STUDY; NEUTROPHIL; OXIDATION; PRIORITY JOURNAL;

EID: 33745945729     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2006.03.005     Document Type: Article

References (95)

1. Anderson H.A., Falk C., Hanrahan L., Olson J., Burse V.W., Needham L., Paschal D., Patterson Jr. D., Hill Jr. R.H., and The Great Lakes Consortium. Profiles of Great Lakes critical pollutants: a sentinel analysis of human blood and urine. Environ. Health Perspect. 106 (1998) 279
2. ATSDR Tox Profiles www.atsdr.cdc.gov.
3. Baccarelli A., Pesatori A.C., Masten S.A., Patterson Jr. D.G., Needham L.L., Mocarelli P., Caporaso N.E., Consonni D., Grassman J.A., Bertazzi P.A., and Landi M.T. Aryl-hydrocarbon receptor-dependent pathway and toxic effects of TCDD in humans: a population-based study in Seveso, Italy. Toxicol. Lett. 149 (2004) 287
4. Baginski B. Effect of mercuric chloride on microbicidal activities of human polymorphonuclear leukocytes. Toxicology 50 (1988) 247
5. Bhattacharya S. Mechanisms of signal transduction in the stress response of hepatocytes. In: Jeon K.W. (Ed). International Review of Cytology vol. 184 (1998), Academic Press, San Diego, CA 109
6. Bigazzi P.E. Autoimmunity caused by xenobiotics. Toxicology 119 (1997) 1
7. Botella B., Crespo J., Rivas A., Cerrillo I., Olea-Serrano M.F., and Olea N. Exposure of women to organochlorine pesticides in Southern Spain. Environ. Res. 96 (2004) 34
8. Brown A.P., and Ganey P.E. Neutrophil degranulation and superoxide production induced by polychlorinated biphenyls are calcium dependent. Toxicol. Appl. Pharmacol. 131 (1995) 198
9. Brown A.P., Olivero-Verbel J., Holdan W.L., and Ganey P.E. Neutrophil activation by polychlorinated biphenyls: structure-activity relationships. Toxicol. Sci. 46 (1998) 308
10. Bunce N.J. Aspects of the environmental chemistry of the elements. In: Nierenberg W. (Ed). Encyclopedia of Environmental Biology vol. 1 (1995), Academic Press, San Diego, CA 105-138
11. Cok I., and Satiroglu M.H. Polychlorinated biphenyl levels in adipose tissue of primiparous women in Turkey. Environ. Int. 30 (2004) 7
12. Contrino J., Marucha P., Ribaudo R., Ference R., Bigazzi P.E., and Kreutzer D.L. Effects of mercury on human polymorphonuclear leukocyte function in vitro. Am. J. Pathol. 132 (1988) 110
13. Crane J.L. Carcinogenic human health risks associated with consuming contaminated fish from five Great Lakes areas of concern. J. Great Lakes Res. 22 (1996) 653
14. Dunier M., and Siwicki A.K. Effects of pesticides and other organic pollutants in the aquatic environment on immunity of fish: a review. Fish Shellfish Immunol. 3 (1993) 423
15. Egeland G.M., and Middaugh J.P. Balancing fish consumption benefits with mercury exposure. Science 278 (1997) 1904
16. Eisenmann C.J., and Miller R.K. Placental transport, metabolism, and toxicity of metals. In: Chang L.W., Magos L., and Suzuki T. (Eds). Toxicology of Metals (1996), CRC Press, Boca Raton, FL 1003
17. English D., Schell M., Siakotos A., and Gabig T.G. Reversible activation of the neutrophil superoxide generating system by hexachlorocyclohexane: correlation with effects on a subcellular superoxide-generating fraction. J. Immunol. 137 (1986) 283
18. Evans M.D., Griffiths H.R., and Lunec J. Reactive oxygen species and their cytotoxic mechanisms. In: Bittar E.E., and Chipman J.K. (Eds). Advances in Molecular and Cell Biology: Mechanisms of Cell Toxicity vol. 20 (1997), JAI Press, Inc., Greenwich, CT 25
19. Ewers U., Krause C., Schulz C., and Wilhelm M. Reference values and human biological monitoring values for environmental toxins. Int. Arch. Occup. Environ. Health 72 (1999) 255
20. Flint R.W., and Vena J. Human Health Risks from Chemical Exposure: The Great Lakes Ecosystem (1991), Lewis Publishers, Inc., Chelsea, MI p. 295
21. Ganey P.E., and Roth R.A. Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents. Toxicology 169 (2001) 195
22. Ganey P.E., Sirois J.E., Denison M., Robinson J.P., and Roth R.A. Neutrophil function after exposure to polychlorinated biphenyls in vitro. Environ. Health Perspect. 101 (1993) 430
23. Gerhard I., Monga B., Krahe J., and Runnebaum B. Chlorinated hydrocarbons in infertile women. Environ. Res. 80 (1999) 299
24. Grasman K.A., Fox G.A., Scanlon P.F., and Ludwig J.P. Organochlorine-associated immunosuppresion in prefledgling Caspian terns and herring gulls from the Great Lakes: an ecoepidemiological study. Environ. Health Perspect. 104 Suppl. 4 (1996) 829
25. Hill R.A., Chapman P.M., Mann G.S., and Lawrence G.S. Level of detail in ecological risk assessments. Mar. Pollut. Bull. 40 (2000) 471
26. Hirata H., Takahashi A., Kobayashi S., Yonehara S., Sawai H., Okazaki T., Yamamoto K., and Sasada M. Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. J. Exp. Med. 187 (1998) 587
27. Holsapple M.P., Karras J.G., Ledbetter J.A., Scheiven G.L., Burchiel S.W., Davila D.R., Schatz A.R., and Kaminski N.E. Molecular mechanisms of toxicant-induced immunosuppression: role of second messengers. Annu. Rev. Pharmacol. Toxicol. 36 (1996) 131
28. 14C] chloroacetonitrile (CAN). Quantitative whole-body autoradiographic study in pregnant mice. Toxicol. Ind. Health 14 (1998) 533
29. Jansson G., and Harms-Ringdahl M. Stimulating effects of mercuric- and silver ions on the superoxide anion production in human polymorphonuclear leukocytes. Free Radic. Res. Commun. 18 (1993) 87
30. Jung D., Becher H., Edler L., Flesch-Janys D., Gurn P., Konietzko J., Manz A., and Papke O. Elimination of beta-hexachlorocyclohexane in occupationally exposed persons. J. Toxicol. Environ. Health 51 (1997) 23
31. Kaplan S.S., Zdziarski U.E., Kuhns D.B., and Basford R.E. Inhibition of cell movement and associated changes by hexachlorocyclohexanes due to unregulated intracellular calcium increases. Blood 71 (1988) 677
32. Keller J.M., Kucklick J.R., Stamper M.A., Harms C.A., and McClellan-Green P.D. Associations between organochlorine contaminant concentrations and clinical health parameters in loggerhead sea turtles from North Carolina, USA. Environ. Health Perspect. 12 (2004) 1074
33. - production and calcium release in human polymorphonuclear leukocytes. Blood 68 (1986) 535
34. Lakowicz J.R., Hogen D., and Omann G.M. Diffusion and partitioning of a pesticide, lindane, into phosphatidylcholine bilayers: a new fluorescence quenching method to study chlorinated hydrocarbon-membrane interactions. Biochim. Biophys. Acta 471 (1977) 401
35. Langmuir M.E., Yang J.-R., Moussa A.M., Laura R., and LeCompte K.A. New naphthopyranone based fluorescent thiol probes. Tetrahedron Lett. 36 (1995) 3989
36. Langmuir M.E., Yang J.R., LeCompte K.A., and Durand R.E. New thiol active fluorophores for intracellular thiols and glutatione measurements. In: Slavik J. (Ed). Fluorescent Microscopy and Fluorescent Probes (1996), Plenum Press, New York, NY 229
37. Lawrence D.A., and McCabe Jr. M.J. Immunomodulation by metals. Int. Immunopharmacol. 2 (2002) 293
38. Luster M.I., Simeonova P.P., Gallucci R.M., Matheson J.M., and Yucesoy B. Immunotoxicology: role of inflammation in chemical-induced hepatotoxicity. Int. J. Immunopharmacol. 22 (2000) 1143
39. Malamud D., Dietrich S.A., and Shapiro I.M. Low levels of mercury inhibit the respiratory burst in human polymorphonuclear leukocytes. Biochem. Biophys. Res. Commun. 128 (1985) 1145
40. Miller G.G., Sweet L.I., Adams J.V., Omann G.M., Passino-Reader D.R., and Meier P.G. In vitro toxicity and interactions of environmental contaminants (Arochlor 1254 and mercury) and immunomodulatory agents (lipopolysaccharide and cortisol) on thymocytes from Lake Trout (Salvelinus namaycush). Fish Shellfish Immunol. 13 (2002) 11
41. Mills J.C., Stone N.L., and Pittman R.N. Extranuclear apoptosis: the role of the cytoplasm in the execution phase. J. Cell Biol. 146 (1999) 703
42. Moisan E., Arbour S., Nguyen N., Hebert M.J., Girard D., Bernier J., Fournier M., and Kouassi E. Prolongation of human neutrophil survival by low-level mercury via inhibition of spontaneous apoptosis. J. Toxicol. Environ. Health (Part A) 65 (2002) 183
43. Nordlind K., and Liden S. Mercuric chloride inhibition of leucocyte migration. Inmmunopharmacol. Immunotoxicol. 12 (1990) 715
44. Obel N., Hansen B., Christensen M.M., Nielsen S.L., and Rungby J. Methyl mercury, mercuric chloride, and silver lactate decrease superoxide anion formation and chemotaxis in human polymorphonuclear leucocytes. Hum. Exp. Toxicol. 12 (1993) 361
45. Oberley L.W., and Oberley T.D. Oxyradicals and malignant transformation. In: Bittar E.E., and McCord J.M. (Eds). Advances in Molecular and Cell Biology: Oxyradicals in Medical Biology vol. 25 (1998) 58
46. Oishi K., and Machida K. Inhibition of neutrophil apoptosis by antioxidants in culture medium. Scand. J. Immunol. 45 (1997) 21
47. 2+/calmodulin during activation of rat neutrophils by polychlorinated biphenyls. Biochem. Pharmacol. 62 (2001) 1125
48. 2 by organochlorine compounds. Chem. Res. Toxicol. 15 (2002) 153
49. Olivero-Verbel J., and Ganey P.E. Effect of three polychlorinated biphenyls on f-met-leu-phe-induced degranulation in rat neutrophils. Toxicol. Lett. 98 (1998) 195
50. Omann G.M. Actin polymerization in human neutrophils. In: Robinson J.P., and Babcock G.F. (Eds). Phagocytic Function: A Guide for Research and Clinical Evaluation (1998), Wiley-Liss, Inc., New York, NY 155
51. Omann G.M. Physiology and molecular mechanisms of chemotaxis of white blood cells. In: Eisenbach M. (Ed). Chemotaxis (2004), Imperial College Press, London 308
52. Omann G.M., and Glaser M. Biosynthetic incorporation of fluorescent carbazolylundecanoic acid into membrane phospholipids of LM cells and determination of quenching constants and partition coefficients of hydrophobic quenchers. Biochemistry 23 (1984) 4962
53. Omann G.M., and Glaser M. Dynamic quenchers in fluorescently-labeled membranes: theory for quenching in a three-phase system. Biophys. J. 47 (1985) 623
54. Omann G.M., and Hinshaw D.B. Inflammation. In: Greenfield L.J., Mulholland M.W., Oldham K.T., Zelenock G.B., and Lillemoe K.D. (Eds). Essentials of Surgery: Scientific Principles and Practice. second ed. (1997), Lippincott-Raven Publishers, Philadelphia 44
55. Omann G.M., and Lakowicz J.R. Pesticide uptake into membranes measured by fluorescence quenching. Science 197 (1977) 465
56. Omann G.M., and Lakowicz J.R. Interactions of chlorinated hydrocarbon insecticides with membranes. Biochim. Biophys. Acta 684 (1982) 83
57. Omann G.M., and Sklar L.A. Spectrofluorometric analyses of cell responses: activation of neutrophils by chemoattractants and hexachlorocyclohexanes. In: Goldberg M.C. (Ed). Luminescence Applications in Biological, Chemical, Environmental, and Hydrological Sciences (1989), ACS Publications, Washington, DC 23
58. Otero R., Santiago-Silva M., and Grimalt J.O. Hexachlorocyclohexanes in human blood serum. J. Chromatog. A 778 (1997) 87
59. Passino-Reader, D.R., Hudson, P.L., Hickey, J.P., 1995. Baseline Risk Assessment for Aquatic Life for the Buffalo River, New York, Area of Concern. Great Lakes National Program Office. U.S. Environmental Protection Agency, Chicago, IL. EPA 905-R95-001.
60. Perlingeiro R.C.R., and Queiroz M.L.S. Polymorphonuclear phagocytosis and killing in workers exposed to inorganic mercury. Int. J. Immunopharmacol. 16 (1994) 1011
61. Perlingeiro R.C.R., and Queiroz M.L.S. Measurement of the respiratory burst and chemotaxis in polymorphonuclear leukocytes from mercury-exposed workers. Hum. Exp. Toxicol. 14 (1995) 281
62. Rebbapragada A., Keil M.L., Solomon N.L., Traynor-Kaplan A.E., and Omann G.M. Lindane stimulates neutrophils by selectively activating phospholipase C and phosphoinositide-kinase activity. Environ. Toxicol. Pharmacol. 19 (2005) 313
63. Rosenthal G.J., and Luster M.I. Immunotoxicity and inflammation: an overview. In: Schook L.B., and Laskin D.L. (Eds). Xenobiotics and Inflammation (1994), Academic Press, New York 1
64. Roth R.A., Harkema J.R., Pestka J.P., and Ganey P.E. Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents?. Toxicol. Appl. Pharmacol. 147 (1997) 300
65. Samuels A.J., and Milby T.H. Human exposure to lindane. Clinical, hematological and biochemical effects. J. Occup. Med. 13 (1971) 147
66. Sanchez-Alonso J.A., Lopez-Aparicio P., Recio M.N., and Perez-Albarsanz M.A. Polychlorinated biphenyl mixtures (Aroclors) induce apoptosis via Bcl-2, Bax and caspase-3 proteins in neuronal cell cultures. Toxicol. Lett. 153 (2004) 311
67. Sanders G., Hamilton-Taylor J., and Jones K.C. PCB and PAH dynamics in a small rural lake. Environ. Sci. Technol. 30 (1996) 2958
68. Scapigliati G., Rappuoli R., Silvestri S., and Pallini V. Cytoskeletal alterations as a parameter for assessment of toxicity. Xenobiotica 18 (1988) 715
69. Schober S.E., Sinks T.H., Jones R.L., Bolger P.M., McDowell M., Osterloh J., Garrett E.S., Canady R.A., Dillon C.F., Sun Y.U., Joseph C.B., and Mahaffey K.R. Blood mercury levels in US children and women of childbearing age, 1999-2000. J. Am. Med. Assoc. 289 (2003) 1667
70. Shenker B.J., Pankoski L., Zekavat A., and Shapiro I.M. Mercury-induced apoptosis in human lymphocytes: caspase activation is linked to redox status. Antioxid. Redox. Signal. 4 (2002) 379
71. Shi H., Hudson L.G., and Liu K.J. Oxidative stress and apoptosis in metal ion-induced carcinogensis. Free Radic. Biol. Med. 37 (2004) 582
72. Sidhu K.S., and Chadzynski L. Communication of health risks associated with polychlorinated biphenyls contaminated soil near an elementary school. Technol.: J. Franklin Inst. 333A (1996) 7
73. Simonian N.A., and Coyle J.T. Oxidative stress in neurodegenerative diseases. Annu. Rev. Pharmacol. Toxicol. 36 (1996) 83
74. Sklar L.A., Omann G.M., and Painter R.G. Relationship of actin polymerization and depolymerization to light scattering in human neutrophils: dependence on receptor occupancy and intracellular calcium. J. Cell Biol. 101 (1985) 1161
75. Splettstoesser W.D., and Schuff-Werner P.S. Oxidative stress in phagocytes-"The enemy within". Microsc. Res. Tech. 57 (2002) 441
76. Sweet L.I., and Zelikoff J.T. Toxicology and immunotoxicology of mercury: a comparative review in fish and humans. J. Toxicol. Environ. Health (Part B) 4 (2001) 161
77. Sweet L.I., Passino-Reader D.R., Meier P.G., and Omann G.M. Detecting contaminant-induced apoptosis and necrosis in lake trout thymocytes via flow cytometry. In: Stolen J.S., Fletcher T.C., Rowley A.F., Zelikoff J.T., Kaatari S.L., and Smith S.A. (Eds). Techniques in Fish Immunology, vol. 3. second ed. (1997), SOS Publications, Fair Haven, NJ 203
78. Sweet L.I., Passino-Reader D.R., Meier P.G., and Omann G.M. Fish thymocyte viability, apoptosis, and necrosis: effects of organochlorine contaminants. Fish Shellfish Immunol. 8 (1998) 77
79. Sweet L.I., Passino-Reader D.R., Meier P.G., and Omann G.M. Xenobiotic-induced apoptosis: significance and potential application as a general biomarker of response. Biomarkers 4 (1999) 237
80. Tithof P.K., Contreras M.L., and Ganey P.E. Aroclor 1242 stimulates the production of inositol phosphates in polymorphonuclear neutrophils. Toxicol. Appl. Pharmacol. 131 (1995) 136
81. 2 by organochlorine compounds. Toxicol. Sci. 53 (2000) 40
82. 2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls. Environ. Health Perspect. 104 (1996) 52
83. Tithof P.K., Watts S., and Ganey P.E. Protein tyrosine kinase involvement in the production of superoxide anion by neutrophils exposed to Aroclor 1242, a mixture of polychlorinated biphenyls. Biochem. Pharmacol. 53 (1833)
84. Tolley J.O., Omann G.M., and Jesaitis A.J. A high yield, high purity elutriation method for preparing human granulocytes demonstrating enhanced longevity and chemoattractant induced responses. J. Leukoc. Biol. 42 (1987) 43
85. Torres M., and Coates T.D. Function of the cytoskeleton in human neutrophils and method for evaluation. J. Immunol. Methods 232 (1999) 89
86. van Grevenynghe J., Sparfel L., Vee M.L., Gilot D., Drenou B., Fauchet R., and Fardel O. Cytochrome P450-dependent toxicity of environmental polycyclic aromatic hydrocarbons towards human macrophages. Biochem. Biophys. Res. Commun. 317 (2004) 708
87. Vimercati L., Santarelli L., Pesola G., Drago I., Lasorsa G., Valentino M., Vacca A., and Soleo L. Monocyte-macrophage system and polymorphonuclear leukocytes in workers exposed to low levels of metallic mercury. Sci. Total Environ. 270 (2001) 157
88. Walker K., Vallero D.A., and Lewis R.G. Factors influencing the distribution of lindane and other hexachlorocyclohexanes in the environment. Environ. Sci. Technol. 33 (1999) 4373
89. 4 biosynthesis in human polymorphonuclear leukocytes. Arch. Biochem. Biophys. 311 (1994) 263
90. Wilhelm M., Ewers U., and Schulz C. Revised and new reference values for some persistent organic pollutants (POPs) in blood for human biomonitoring in environmental medicine. Int. J. Hygiene Environ. Health 206 (2003) 223
91. Wilhelm M., Ewers U., and Schulz C. Revised and new reference values for some trace elements in blood and urine for human biomonitoring in environmental medicine. Int. J. Hygiene Environ. Health 207 (2004) 69
92. Whyte M.K.B., Savill J., Meagher L.C., Lee A., and Haslett C. Coupling of neutrophil apoptosis to recognition by macrophages: coordinated acceleration by protein synthesis inhibitors. J. Leukoc. Biol. 62 (1997) 195
93. Willett K.L., Ulrich E.M., and Hites R.A. Differential toxicity and environmental fates of hexachlorocyclohexane isomers. Environ. Sci. Technol. 32 (1998) 2197
94. Worth R.G., Esper R.M., Warr N.S., Kindzelskii A.L., Rosenspire A.L., Todd III R.F., and Petty H.R. Mercury inhibition of neutrophil activity: evidence of aberrant cellular signaling and incoherent cellular metabolism. Scand. J. Immunol. 53 (2001) 49
95. Zahir F., Rizwi S.J., Haq S.K., and Khan R.H. Low dose mercury toxicity and human health. Environ. Toxicol. Pharmacol. 20 (2005) 351