A molecular motif required for the activation of rat neutrophil phospholipase A2 by organochlorine compounds

Chemical Research in Toxicology

Volumn 15, Issue 2, 2002, Pages 153-159

  Olivero, Jesus ^a   Bezdecny, Steven A ^a   Ganey, Patricia E ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 (BROMOETHYLENE)TETRAHYDRO 3 (1 NAPHTHALENYL) 2H PYRAN 2 ONE; CHLORPHENOTANE; HEXACHLOROCYCLOHEXANE; METHYLARACHIDONYLFLUOROPHOSPHONATE; ORGANOCHLORINE DERIVATIVE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; POLYCHLORINATED BIPHENYL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVATION; HYDROPHOBICITY; IMMUNE SYSTEM; LEUKOCYTE ACTIVATION; MALE; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL SEPARATION; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROCARBONS, CHLORINATED; INSECTICIDES; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEUTROPHILS; PERITONEAL CAVITY; PHOSPHOLIPASES A; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0036167913     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0155449     Document Type: Article

References (48)

1. Neutrophil function after exposure to polychlorinated biphenyls in vitro
2. Polychlorinated biphenyl immunotoxicity: Dependence on isomer planarity and the Ah gene complex
3. Bioaccumulated chlorinated hydrocarbons and red/white blood cell parameters
4. Reversible activation of the neutrophil superoxide generating system by hexachlorocyclohexane: Correlation with effects on a subcellular superoxide-generating fraction
5. Hexachlorocyclohexanes, potent stimuli of O2- production and calcium release in human polymorphonuclear leukocytes
6. Effect of organochlorine pesticides on the phagocytic activity of bovine milk cells
7. Dieldrin activates rat neattrophils in vitro
8. Suppression of chemokine-induced chemotaxis of monkey neutrophils and monocytes by chlorinated hydrocarbon insecticides
9. 2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls
10. Structure-dependent induction of CYP1A by polychlorinated biphenyls in hepatocytes of cynomolgus monkeys (Macaca fascicularis)
11. Neutrophil activation by polychlorinated biphenyls: Structure-activity relationship
12. 3H]phorbol ester binding in rat cerebellar granule cells
13. Structure - Activity relationships of potentially neurotoxic PCB congeners in the rat
14. Differential effects of polychlorinated biphenyl congeners on phosphoinositide hydrolysis and protein kinase C translocation in rat cerebellar granule cells
15. 3H]phorbol ester binding in rat cerebellar granule cells by polychlorinated biphenyl mixtures and congeners: Structure - Activity relationships
16. 2+-sequestration in rat cerebellum by polychlorinated biphenyl mixtures and congeners. Structure - Activity relationships
17. A QSAR evaluation of Ah receptor binding of halogenated aromatic xenobiotics
18. Binding of polychlorinated biphenyls to the aryl hydrocarbon receptor
19. Affinities for the aryl hydrocarbon receptor, potencies as aryl hydrocarbon hydroxylase inducers and relative toxicities of polychlorinated biphenyls. A congener specific approach
20. The distribution and excretion of 2,4,5,2′,5′-pentachlorobiphenyl in the rat
21. Polychlorinated biphenyls as hormonally active structural analogues
22. Lightly chlorinated ortho-substituted PCB congeners decrease dopamine in nonhuman primate brain and in tissue culture
23. Empirical modeling of an in vitro activity of polychlorinated biphenyl congeners and mixtures
24. Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: Structure - Activity relationships
25. Effect of pesticides on the release of histamine, chemotactic factors and leukotrienes from rat mast cells and human basophils
26. Mechanisms of toxic action and structure-activity relationships for organochlorine and synthetic pyrethroid insecticides
27. Characterization of skin tumor promotion by mirex: Structure - Activity relationships, sexual dimorphism and presence of Ha-ras mutation
28. Activation of respiratory burst in human granulocytes by polychlorinated biphenyls: A structure - Activity study
29. Effect of three polychlorinated biphenyls on f-met-leu-phe-induced degranulation in rat neutrophils
30. 2 regulate the release of arachidonic acid for eicosanoid production and superoxide anion generation in neutrophils
31. Lactate dehydrogenase UV assay with pyruvate and NADH
32. AM1: A new general purpose quantum mechanical molecular model
33. Self-consisted molecular orbital methods. I. Use of Gaussian expansion of Slater-type atomic orbitals
34. 2+/calmodulin during activation of rat neutrophils by polychlorinated biphenyls
35. 2 isoform. Fast atom bombardment mass spectroscopic and reversephase high-pressure liquid chromatography identification of choline and ethanolamine glycerophospholipid substrates
36. 2 by bromoenol lactone and trifluoromethyl ketones
37. 2 contains eight ankyrin motifs
38. 4 in chemotactic peptide-stimulated human neutrophils
39. 2 are dissociated by inhibiters of the kinases p42 (ERK2) and p38 (SAPK) and by methyl arachidonyl fluorophosphonate, the dual inhibitor of cytosolic and calcium-independent phospholipase A2
40. Involvement of cytosolic phospholipase A2 and secretory phospholipase A2 in arachidonic acid release from human neutrophils
41. 2 by methyl arachidonyl fluorophosphonate
42. 2
43. 2
44. 2 by organochlorine compounds
45. Involvement of picrotoxinin receptor in the action of cyclodiene insecticides
46. Prediction of rodent carcinogenicity bioassays from molecular structure using inductive logic programming
47. Resolution of ambiguities in structure - Property studies by use of orthogonal descriptors
48. The new chemicals process at the Environmental Protection Agency (EPA): Structure - Activity relationships for hazard identification and risk assessment