COX-2: A link between airway inflammation and disordered chloride secretion in cystic fibrosis?

Thorax

Volumn 61, Issue 7, 2006, Pages 552-553

  Clayton, A ^a   Knox, A J ^a  

^a NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CHLORIDE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 3; DEFENSIN; MEMBRANE PHOSPHOLIPID; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; PROSTAGLANDIN F; PROSTAGLANDIN F2; PROSTANOID; TRANSMEMBRANE CONDUCTANCE REGULATOR;

CHEMICAL ANALYSIS; CHLORIDE TRANSPORT; CYSTIC FIBROSIS; EDITORIAL; GENE MUTATION; HUMAN; MORBIDITY; MORTALITY; PATHOPHYSIOLOGY; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

CHLORIDES; CYCLOOXYGENASE 2; CYSTIC FIBROSIS; HUMANS;

EID: 33745856574     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.2006.060293     Document Type: Editorial

References (22)

1. Riordan JR, Rommens JM, Kerem B, et al. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 1989;245:1066-73.
2. Vankeerberghen A, Cuppens H, Cassiman JJ. The cystic fibrosis transmembrane conductance regulator: an intriguing protein with pleiotropic functions. J Cyst Fibros 2002;1:13-29.
3. Zabner J, Smith JJ, Karp PH, et al. Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro. Mol Cell 1998;2:397-403.
4. Widdicombe JH, Bastacky SJ, Wu DX, et al. Regulation of depth and composition of airway surface liquid. Eur Respir J 1997;10:2892-7.
5. Matsui H, Grubb BR, Tarran R, et al. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 1998;95:1005-15.
6. Smith JJ, Travis SM, Greenberg EP, et al. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 1996;85:229-36.
7. Thomas SR, Jaffe A, Geddes DM, et al. Pulmonary disease severity in men with deltaF508 cystic fibrosis and residual chloride secretion. Lancet 1999;353:984-5.
8. Bronsveld I, Mekus F, Bijman J, et al. Chloride conductance and genetic background modulate the cystic fibrosis phenotype or Delta F508 homozygous twins and siblings. J Clin Invest 2001;108:1705-15.
9. Xie WL, Chipman JG, Robertson DL, et al. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA 1991;88:2692-6.
10. Vane J. Towards a better aspirin. Nature 1994;367:215-6.
11. DeWitt DL. Prostaglandin endoperoxide synthase: regulation of enzyme expression. Biochim Biophys Acta 1991;1083:121-34.
12. Fu JY, Masferrer JL, Seibert K, et al. The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J Biol Chem 1990;265:16737-40.
13. Chandrasekharan NV, Dai H, Roos KL, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci USA 2002;99:13926-31.
14. Widdicombe JH, Ueki IF, Emery D, et al. Release of cyclooxygenase products from primary cultures of tracheal epithelia of dog and human. Am J Physiol 1989;257:L361-5.
15. Konstan MW, Byard PJ, Hoppel CL, et al. Effect of high-dose ibuprofen in patients with cystic fibrosis. N Engl J Med 1995;332:848-54.
16. Roca-Ferrer J, Pujols L, Gartner S, et al. Upregulation of COX-1 and COX-2 in nasal polyps in cystic fibrosis. Thorax 2006;61:592-6.
17. Korhonen R, Kosonen O, Korpela R, et al. The expression of COX2 protein induced by Lactobacillus rhamnosus GG, endotoxin and lipoteichoic acid in T84 epithelial cells. Lett Appl Microbiol 2004;39:19-24.
18. Breder CD, Saper CB. Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide. Brain Res 1996;713:64-9.
19. Tordjman C, Coge F, Andre N, et al. Characterisation of cyclooxygenase 1 and 2 expression in mouse resident peritoneal macrophages in vitro: interactions of non-steroidal anti-inflammatory drugs with COX2. Biochim Biophys Acta 1995;1256:249-56.
20. Osika E, Cavaillon JM, Chadelat K, et al. Distinct sputum cytokine profiles in cystic fibrosis and other chronic inflammatory airway disease. Eur Respir J 1999;14:339-46.
21. 2-mediated cAMP accumulation and chloride efflux from Calu-3 bronchial epithelial cells. Role of receptor changes, adenylyl cyclase, cyclo-oxygenase 2, and protein kinase A. J Biol Chem 2005;280:23451-63.
22. Van Hecken A, Schwartz JI, Depre M, et al. Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers. J Clin Pharmacol 2000;40:1109-20.