Pulmonary disease severity in men with ΔF508 cystic fibrosis and residual chloride secretion

Lancet

Volumn 353, Issue 9157, 1999, Pages 984-985

  Thomas, Stephen R ^a   Jaffe, Adam ^a   Geddes, Duncan M ^a   Hodson, Margaret E ^a   Alton, Eric W F W ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; CHLORIDE CHANNEL; CHLORIDE ION; ISOPRENALINE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CYSTIC FIBROSIS; DISEASE SEVERITY; FORCED EXPIRATORY VOLUME; GENE MUTATION; HOMOZYGOTE; HUMAN; LUNG DISEASE; MALE; PRIORITY JOURNAL;

EID: 0033586473     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(98)05447-6     Document Type: Article

References (5)

1. Dorin J.R., Farley R., Webb S.et al. A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction. Gene Ther. 3:1996;797-801.
2. Clarke L.L., Grubb B.R., Yankaskas J.R., Cotton C.U., McKenzie A., Boucher R.C. Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice. Proc Natl Acad Sci USA. 91:1994;479-483.
3. Middleton P.G., Geddes D.M., Alton E.W. Protocols for in vivo measurement of the ion transport defects in cystic fibrosis nasal epithelium. Eur Respir J. 7:1994;2050-2056.
4. Sweezey N.B., Gauthier C., Gagnon S., Ferretti E., Kopelman H. Progesterone and estradiol inhibit CFTR-mediated ion transport by pancreatic epithelial cells. Am J Physiol. 271( pt1):1996;G747-754.
5. Rosenfeld M., Davis R., FitzSimmons S., Pepe M., Ramsey B. Gender gap in cystic fibrosis mortality. Am J Epidemiol. 145:1997;794-803.