Regulation of cough by secondary sensory inputs

Respiratory Physiology and Neurobiology

Volumn 152, Issue 3, 2006, Pages 282-297

  Hanacek, Jan ^a   Tatar, Milos ^a   Widdicombe, John ^b  

^a Physics and Informatics   (Slovakia)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Blood gases; Cardiac afferents; Cough; Laryngeal afferents; Nasal afferents; Oesophageal and splanchnic afferents; Tracheobronchial afferents

Indexed keywords

CAPSAICIN; IRRITANT AGENT; SLOW ADAPTING RECEPTOR;

ARTICLE; BLOOD CHEMISTRY; BRAIN STEM; BRONCHUS; CENTRAL NERVOUS SYSTEM; COUGHING; ESOPHAGUS; EXPIRED AIR; HEART; HUMAN; HYPERCAPNIA; HYPEROXIA; HYPOXIA; INHIBITION KINETICS; JOINT; LARYNX; LUNG; LUNG RECEPTOR; MUSCLE; NERVE ENDING; NONHUMAN; NOSE; PATHOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; RECEPTOR BLOCKING; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REFLEX; REGULATORY MECHANISM; RESPIRATORY SYSTEM; SENSITIVITY ANALYSIS; SENSORY NERVE; SENSORY STIMULATION; SKIN RECEPTOR; SPLANCHNIC NERVE; THORAX WALL; TRACHEOBRONCHIAL TREE; VIBRATION; VOCAL CORD;

AFFERENT PATHWAYS; ANIMALS; COUGH; HEART; HUMANS; PULMONARY STRETCH RECEPTORS; RESPIRATORY PHYSIOLOGY; RESPIRATORY SYSTEM;

EID: 33745835483     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2006.02.014     Document Type: Article

References (128)

1. Barnes P.J. Neurogenic inflammation in the airways. Respir. Physiol. 125 (2001) 145-154
2. Bean J.W. Intestine in reflex chemical control of breathing. Am. J. Physiol. 171 (1952) 522-527
3. Benini L., Ferrari M., Sembenini C., Olivieri M., Micciolo R., Zuccali V., Bulighin G.M., Fiorino F., Ederle A., Lo Cascio V., and Vantini I. Cough threshold in reflux oesophagitis: influence of acid and of laryngeal and oesophageal damage. Gut 46 (2000) 762-767
4. Bishop B. Reflex control of abdominal muscles during positive pressure breathing. J. Appl. Physiol. 19 (1964) 224-232
5. Blackshaw L.A., Page A.J., and Partosoedarso E.R. Acute effects of capsaicin on gastrointestinal vagal afferents. Neuroscience 96 (2000) 407-416
6. Bolser D.C., and Davenport P.W. Functional organization of the central cough generation mechanism. Pulm. Pharmacol. Ther. 15 (2002) 221-227
7. Bolser D.C., Hey J.A., and Chapman R.W. Influence of central antitussive drugs on the cough motor pattern. J. Appl. Physiol. 86 (1999) 1017-1024
8. Bolser, D.C., Poliacek, I., Jakus, J., Davenport, P.W., 2006. Neurogenesis of cough, other airway defensive behaviours and breathing: a holonarchical supersystem? Respir. Physiol. Neurobiol., doi:10.1016/j.resp.2006.01.008, in press.
9. Bonham A.C., Sezikawa S.-i., and Joad J.P. Plasticity of central mechanisms for cough. Pulm. Pharmacol. Ther. 17 (2004) 453-458
10. Brozmanova M., Hanacek J., Tatar M., Strapkova A., and Szepe P. Effects of hyperoxia and allergic airway inflammation on cough reflex intensity in guinea pigs. Physiol. Res. 51 (2002) 529-536
11. Bucher K. Pathophysiology and pharmacology of cough. Pharmacol. Rev. 10 (1958) 43-58
12. Canning, B., Mazzone, S., 2006. Sensory receptors for cough. Respir. Physiol. Neurobiol., this issue.
13. Carr M.J. Plasticity of vagal afferent fibres mediating cough. Pulm. Pharmacol. Ther. 17 (2004) 447-452
14. Cassidy S.S. Stimulus-response curve of the lung inflation cardio-depressor reflex. Respir. Physiol. 57 (1984) 259-268
15. Cherniack N.S., Edelman N.H., and Lahiri S. Hypoxia and hypercapnia as respiratory stimulants and depressants. Respir. Physiol. 11 (1970) 113-126
16. In: Chung F., Widdicombe J.G., and Boushey H. (Eds). Cough - Causes, Mechanisms and Therapy (2003), Blackwell Publishing, Oxford 304
17. Curley F.J., Irwin R.S., Pratter M.R., Stiress D.H., Doern G.V., Vernaglie P.A., Larkin A.B., and Baker S.P. Cough and the common cold. Am. Rev. Respir. Dis. 138 (1988) 305-311
18. Daly M.B., Litherland A.S., and Wood L.M. The reflex effects of inflation of the lungs on the heart rate and hind limb vascular resistence in the cat. IRCS Med. Sci. Libr. Compend. 11 (1983) 859-860
19. Davies A., Dixon M., Callanan D., Huszczuk A., Widdicombe J.G., and Wise J.C.M. Lung reflexes in rabbits during lung stretch receptors block by sulphur dioxide. Respir. Physiol. 84 (1978) 83-101
20. Dawes G.S., and Comroe Jr. J.H. Chemoreceptors from the heart and lungs. Physiol. Rev. 34 (1954) 167-201
21. DiMarco A.F., von Euler C., Romaniuk J.R., and Yamamoto Y. Positive feedback facilitation of external intercostal and phrenic inspiratory activity by pulmonary stretch receptors. Acta Physiol. Scand. 113 (1981) 375-386
22. Ezure K., Tanaka I., and Miyazaki M. Pontine projections of pulmonary slowly adapting receptors relay neurons in the cat. Neurol. Rep. 9 (1998) 411-414
23. Ezure K., and Tanaka I. Lung inflation inhibits slowly adapting receptor relay neurons. Neurol. Rep. 11 (2000) 1709-1712
24. Fontana G.A., Pantaleo T., Lavorini F., Mutolo D., Polli G., and Pistolesi M. Coughing in laryngectomized patients. Am. J. Respir. Crit. Care Med. 160 (1999) 1578-1584
25. Fontana G.A. Motor mechanisms and the mechanics of cough. In: Chung F., Widdicombe J.G., and Boushey H. (Eds). Cough - Causes, Mechanisms and Therapy (2003), Blackwell Publishing, Oxford 193-205
26. Fontana G., and Widdicombe J.G. Physiological down-regulation of cough. Pulm. Pharmacol. Ther. 17 (2004) 465-468
27. Forsberg K., Karlsson J.-A., Lundberg J.M., and Zackrisson C. Effect of partial laryngeal denervation on irritant-induced cough and bronchoconstriction in conscious guinea pigs. J. Physiol. 422 (1990) 34P
28. on slowly adapting stretch receptors. J. Appl. Physiol. 60 (1986) 2048-2055
29. Hanacek J., and Korpas J. Modification of the intensity of the expiration reflex during short-term inflation of the lung in rabbits. Physiol. Bohemoslov. 31 (1982) 169-174
30. Hanacek J., Turcan J., and Korpas J. The role of the vagus nerve in mechanisms of expiration reflex increase by lung inflation. Bull. Eur. Physiopathol. Respir. 19 (1983) 33-34
31. Hanacek J. Relation between the airway receptors and the defensive reflexes of the respiratory tract. Fol. Med. Mart. 10 (1984) 45-65
32. Hanacek J. Influence of sulphur dioxide breathing on defensive reflexes of the airways. Acta Physiol. Hung. 70 (1987) 227-233
33. Hanacek J. Cough reflex changes in cats after sulphur dioxide breathing. In: Salat D., Badalik L., Krcmery V., and Day S.B. (Eds). Proceedings of 1st High Tatras International Health Symposium, Health and Quality of Life in Changing Europe in the Year 2000 (1992), Postgraduate Medical School, School of Public Health, Bratislava, Czecho-Slovakia 272-279
34. Hanacek J., Davies A., and Widdicombe J.G. Influence of lung stretch receptors on the cough reflex in rabbit. Respiration 45 (1984) 161-168
35. Hanacek J. Changes in the intensity of cough in non-anaesthetized cats with inflammation of the respiratory organs induced by croton oil. Bratisl. Lek. Listy 85 (1986) 444-450
36. Hanacek J., Brozmanova M., Strapkova A., Szepe P., and Nagyova B. Functional and morphological changes of the respiratory organs in cats after long-term exposure to pure normobaric oxygen. Bratisl. Lek. Listy 97 (1996) 251-259
37. Hanacek J., Brozmanova M., Tatar M., Karcolova D., Strapkova A., and Szepe P. Effect of long-term high oxygen concentration breathing on defensive respiratory reflexes in guinea pigs. Pulm. Pharmacol. 9 (1996) 367-368
38. Hanacek J. Reflex inputs to cough. Eur. Respir. Rev. 85 12 (2002) 259-263
39. Hersh M.I., Satchel P.M., Sullivan C.E., and McLeod J.G. Abnormal pulmonary slowly adapting receptors in canine acrylamide neuropathy. J. Appl. Physiol. 60 (1986) 376-384
40. Higenbottam T., Jackson M., Woolman P., Lowry R., and Wallwork J. The cough response to ultrasonically nebulized distilled water in heart-lung transplantation patients. Am. Rev. Respir. Dis. 140 (1989) 58-61
41. Iber C., Simon P., Skatrud J.B., Mahowald M.W., Dempsey J.A., Reicks M., and McArthur C. The Breuer-Hering reflex in humans: effect of pulmonary denervation and hypocapnia. Am. J. Respir. Crit. Care Med. 152 (1995) 217-224
42. Ing A.J., Ngu M.C., and Breslin A.B.X. Pathogenesis of chronic persistent cough associated with gastroesophageal reflux. Am. J. Respir. Crit. Care Med. 149 (1994) 160-167
43. Irwin R.S., Boulet L.-P., Cloutier M.M., Fuller R., Gold P.M., Hoffstein V., Ing A.J., McCool D., O'Byrne P., Poe R.H., Prakash U.B.S., Pratter M.R., and Rubin B.K. Managing cough as a defense mechanism and as a symptom: a consensus panel report of the American College of Chest Physicians. Chest 114 (1998) 133-181
44. Ishrat-Husain S. Rhinolith-a rare cause of chronic cough. Can. Med. Assoc. J. 7 (1967) 540-541
45. Javorka K., Kulisek V., and Calkovska A. Defensive reflexes of the repiratory system in anaesthetized rabbits during high frequency jet ventilation. Exp. Physiol. 79 (1994) 967-973
46. Javorka K., Michalik J., Caklos S., and Bevilaqua J. Effect of increased intrapulmonary pressure on defensive reflexes of the respiratory tract. Bratisl. Lek. Listy 77 (1982) 612-620
47. Joad J.P., Kott K.S., and Bonham A.C. Nitric oxide contributes to substance P-induced increase in lung rapidly adapting receptors activity in guinea pigs. J. Physiol. 503 (1997) 635-643
48. Karlson J.A., and Fuller R.W. Pharmacological regulation of the cough reflex - from experimental model to antitussive effect in man. Pulm. Pharmacol. Ther. 12 (1999) 215-228
49. Karlsson J.-A., Sant Ambrogio G., and Widdicombe J.G. Afferent neural pathways in cough and reflex bronchoconstriction. J. Appl. Physiol. 65 (1988) 1007-1023
50. Knowlton G.C., and Larrabee M.G. Unitary analysis of pulmonary volume receptors. Am. J. Physiol. 147 (1946) 100-114
51. Kohl J., and Kohler E.A. Heterogenous activity of pulmonary vagal receptors during high-frequency oscillation ventilation. Lung 173 (1995) 281-290
52. Kollarik M., Plevkova J., Brozmanova M., Revallo M., Varechova S., Bartos V., Plank L., and Tatar M. The effect of chemical stimulation of esophageal mucosa on citric acid induced cough and specific airway resistance in guinea pig. Bratisl. Lek. Listy 106 (2005) 101-106
53. Kollarik, M., Undem, B., 2006. Membrane receptors and channels on 'sensory cough receptors'. Respir. Physiol. Neurobiol., this issue.
54. Kondo T., Kobayashi I., Hayama N., and Ohta Y. An increase in the threshold of citric acid-induced cough during chest wall vibration in healthy humans. Jpn. J. Physiol. 48 (1998) 341-345
55. Korpas J. Differentiation of the expiration and the cough reflex. Physiol. Bohemoslov. 21 (1972) 677-680
56. Korpas J., and Tomori Z. Cough and Other Respiratory Reflexes (1979), Karger, Basel, Switzerland p. 234
57. Kulik A.M., Tarakanov I.A., Tatar M., and Korpas J. Cough reflex in hypercapnia. Bull. Eur. Physiopathol. Respir. 23 Suppl. 10 (1987) 63
58. Lavorini F., Fontana G.A., Cresci F., Polli G., Dallay S., Mutolo D., and Pantaleo T. Cough reflex in laryngectomized patients. Eur. Respir. J. 7 (1994) 25
59. Lalloo U.G., Fox A.J., Belvisi M.G., Chung K.F., and Barnes P.J. Capsazepine inhibits cough induced by capsaicin and citric acid and by hypertonic saline in guinea pigs. J. Appl. Physiol. 79 (1995) 1082-1087
60. Lee L.-Y., Kou Y.R., Fang L.B., and Frazier D.T. Effect of single breath of cigarette smoke on slowly adapting receptors in canine lungs. Respir. Physiol. 88 (1992) 181-192
61. Lee L.-Y., Kwong K., Lin Y.S., and Qihai G. Hypersensitivity of bronchopulmonary C-fibres induced by airway mucosal inflammation: cellular mechanism. Pulm. Pharmacol. Ther. 15 (2002) 199-204
62. Lee M.-G., Kolerik M., Chuaychoo B., and Undem B.J. Ionotropic and metabolotropic receptor mediated airway sensory nerve activation. Pulm. Pharmacol. Ther. 17 (2004) 355-360
63. Leith D.E. Cough. In: Brain J.D., Proctor D.F., and Reid L.F. (Eds). Respiratory Defence Mechanisms. Part II (1977), Marcel Decker, New York 545-592
64. Lung M.A., and Widdicombe J.G. Lung reflexes and nasal vascular resistance in the anaesthetized dog. J. Physiol. 386 (1987) 465-474
65. Mason N.P., Barry P.W., Despiau G., Gardette B., and Richalet J.P. Cough frequency and cough receptor sensitivity to citric acid challenge during simulated ascent to extreme altitude. Eur. Respir. J. 13 (1999) 508-513
66. Mazzone S.B. Sensory regulation of the cough reflex. Pulm. Pharmacol. Ther. 17 (2004) 361-368
67. Mazzone S.B., and Canning B.J. Plasticity of the cough reflex. Eur. Respir. Rev. 12 (2002) 236-242
68. Mazzone S.B., Canning B.J., and Widdicombe J.G. Sensory pathways for the cough reflex. In: Chung F., Widdicombe J.G., and Boushey H.A. (Eds). Cough: Causes, Mechanisms and Therapy (2003), Blackwell Scientific Publishing, Oxford 161-172
69. Mazzone S.B., Mori N., and Canning B.J. Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs. J. Physiol. Lond. 569 (2005) 559-573
70. Morikawa T., Gallico L., and Widdicombe J.G. Actions of moguisteine on cough and pulmonary rapidly adapting receptors in the guinea pig. Pharmacol. Res. 35 (1997) 113-118
71. 2 on airway defensive reflexes in enflurane-anesthetized humans. J. Appl. Physiol. 66 (1989) 2642-2646
72. Nishino T., Sugimori K., Hiraga K., and Honda Y. Influence of CPAP on reflex responses to tracheal irritation in anaesthetized humans. J. Appl. Physiol. 67 (1989) 954-958
73. Nishino T., Kochi T., and Ishii M. Differences in respiratory reflex responses from the larynx, the trachea, and the bronchi in anaesthetized female subject. Anesthesiology 84 (1996) 70-74
74. O'Connell F., Thomas V.E., Pride N.B., and Fuller R.W. Capsaicin cough sensitivity decreases with successful treatment of chronic cough. Am. J. Respir. Crit. Care Med. 150 (1996) 374-380
75. Paintal A.S. Impulses in vagal afferent fibers from specific pulmonary deflation receptors. The response of these receptors to phenyl diguanide, potato starch, 5-hydroxytryptamine and nicotine and their role in respiratory and cardiovascular reflexes. Q. J. Physiol. 40 (1955) 89-111
76. Palacek F., Sant Ambrogio G., Sant Ambrogio F.B., and Mathew O.P. Reflex responses to capsaicin: intravenous, aerosol and intratracheal administration. J. Appl. Physiol. 67 (1989) 1428-1437
77. Pecova R., Frlickova Z., Pec J., and Tatar M. Cough sensitivity in localized sclerodermia with no clinical symptoms from lower airways. J. Physiol. Pharmacol. 54 (2003) 25-28
78. Pecova R., Frlickova Z., Pec J., and Tatar M. Cough sensitivity in atopic dermatitis. Pulm. Pharmacol. Ther. 16 (2003) 203-206
79. Pecova R., Tatar M., and Vrlik M. Cough sensitivity in allergic rhinitis. J. Physiol. Pharmacol. 56 Suppl. 4 (2005) 171-178
80. Plevkova J., Brozmanova M., and Tatar M. The effect of intensified nasal breathing on the cough reflex intensity in guinea pigs with ovalbumin induced rhinitis. Acta Med. Mart. 4 (2004) 3-11
81. Plevkova J., Brozmanova M., Pecova R., and Tatar M. Effects of intranasal capsaicin challenge on cough reflex in healthy human volunteers. J. Physiol. Pharmacol. 55 Suppl. 3 (2004) 101-106
82. Plevkova J., Brozmanova M., Kollarik M., Revallo M., Varechova S., and Tatar M. Modulation of experimentally-induced cough reflex by the stimulation of nasal mucosa in cats and guinea pigs. Respir. Physiol. Neurobiol. 142 (2004) 225-235
83. Romaniuk J.R., Kowalski K.E., and Dick T.E. The role of pulmonary stretch receptors during cough in dogs. Acta Neurobiol. Exp. 57 (1997) 21-29
84. Sampson S.R. Sensory neurophysiology of airways. Am. Rev. Respir. Dis. 115 (1977) 99-105
85. Sant Ambrogio G., Sant Ambrogio F.B., and Davies A. Airway receptors in cough. Bull. Eur. Physiopathol. Respir. 45 (1984) 954-958
86. Sant Ambrogio G., and Sant Ambrogio F.B. Reflexes from the airway, lung, chest wall, and limbs. In: Crystal R.G., West J.B., et al. (Eds). The Lung: Scientific Foundations (1991), Raven Press, New York 1383-1395
87. Sant Ambrogio G. Coughing: an airway defensive reflex. In: Andrews P., and Widdicombe J.G. (Eds). Pathophysiology of the Gut and Airways (1993), Portland Press, London and Chapel Hill 89-96
88. Sant Ambrogio G., Kuna S.T., Vanoye C.R., and Sant Ambrogio F.B. Activation of intrinsic laryngeal muscles during cough. Am. J. Respir. Crit. Care Med. 155 (1997) 637-641
89. Sekizawa K., Ebihara T., and Sasaki H. Role of substance P in cough during bronchoconstriction in awake guinea-pigs. Am. J. Respir. Crit. Care Med. 151 (1995) 815-821
90. Sekizawa S., and Tsubone H. Nasal receptors responding to noxious chemical irritants. Respir. Physiol. 96 (1994) 37-48
91. Shannon R., Baekey D.M., Morris K.F., Li Z., and Lindsey B.G. Functional connectivity among ventrolateral medullary neurons and responses during fictive cough in the cat. J. Physiol. 525 (2000) 207-224
92. Sleight P., and Widdicombe J.G. Action potentials in fibres from receptors in the epicardium and myocardium of the dog's left ventricle. J. Physiol. Lond. 181 (1965) 235-258
93. Stockwell M., Lang S., Zintel T., White C., and Gallagher G. Lack of importance of the superior laryngeal nerves in citric acid cough in humans. J. Appl. Physiol. 75 (1993) 613-617
94. Tatar M., Korpas J., Polacek H., and Zahradny V. Study of the respiratory defensive reflexes in conscious cats in the acute phase of deficient oxygen supply into the organism. Bratisl. Lek. Listy 84 (1985) 157-164
95. Tatar M., Korpas J., Polacek H., and Zahradny V. Effects of hypoxia on respiratory defence reflexes. Effects of thirty hours' oxygen deficiency on cough, the expiration reflex and sneezing in awake cats. Physiol. Bohemoslov. 34 (1985) 41-48
96. Tatar M., Korpas J., Polacek H., and Zahradny V. Changes induced by severe hypoxia in respiratory defence reflexes in anaesthetised cats. Respiration 49 (1986) 114-121
97. Tatar M., Polacek H., and Pullmann R. Changes of airway defence reflexes in the course of five-hour hypercapnia in conscious cats. Bratisl. Lek. Listy 85 (1986) 533-540
98. Tatar M. Effect of denervation of peripheral chemoreceptors on cough during hypoxia. Bull. Eur. Physiopathol. Respir. 23 Suppl. 10 (1987) 65
99. Tatar M., Tarkanov A., Korpas J., and Kulik A.M. Effect of hypoxia and hypercapnia on the airways defence reflexes. Acta Physiol. Hung. 70 (1987) 195-200
100. Tatar M., Webber S.E., and Widdicombe J.G. Lung C-fibre receptor activation and defensive reflexes in anesthetized cats. J. Physiol. 402 (1988) 411-420
101. Tatar M., and Nagyova B. Mechanically-induced cough is depressed by acute hyperoxia in anaesthetized cats. International Congress of Physiological Sciences. Helsinky, July 9-14 (1989) 386-387
102. Tatar M., and Nagyova B. Effects of lung inflation on airways defence reflexes. Eur. Respir. J. 3 Suppl. 10 (1990) 141s
103. Tatar, M., Nagyova, B., 1991. Abdominal capsaicin-sensitive receptor activation and mechanically-induced cough in anesthetized cats. Abstracts of Regional Meeting of International Union of Physiological Sciences, Prague, June 30-July 5, p. 98.
104. Tatar M., Nagyova B., and Widdicombe J.G. Veratrine-induced reflexes and cough. Respir. Med. 85 Suppl. A (1991) 51-55
105. Tatar M., and Pecova R. Laryngeal and tracheobronchial cough in anaesthetized cats and guinea-pigs. Stud. Pneumol. Phtiseol. 54 (1994) 143-145
106. Tatar M., Sant Ambrogio G., and Sant Ambrogio F.B. Laryngeal and tracheobronchial cough in anesthetized dogs. J. Appl. Physiol. 76 (1994) 2672-2679
107. Tatar M., and Pecova R. The effect of experimental gastroesophageal reflux on the cough in anaesthetized cats. Bratisl. Lek. Listy 97 (1996) 284-288
108. Tatar M., Karcolova D., Pecova R., and Brozmanova M. The role of partial laryngeal denervation on the cough reflex in awake guinea-pigs and rabbits. Pulm. Pharmacol. 9 (1996) 371-372
109. Tatar, M., 1997. Intensity of cough reflex is modulated by peripheral chemoreceptors. Abstracts of Minisymposium "Disorders of Breathing Control", Martin, October 8, p. 3.
110. Tatar M., Karcolova D., and Kollarik M. The effect of experimental rhinitis on chemically-induced cough in awake guinea-pigs. Eur. Respir. J. 10 Suppl. 25 (1997) 182
111. Tatar M., Karcolova D., Pecova R., Kollarik M., Plevkova J., and Brozmanova M. Experimental modulation of the cough reflex. Eur. Respir. Rev. 12 (2002) 264-269
112. Tatar M., Javorkova N., Demete r.M., Dilova Z., Biringer K., Pecova R., Balaz D., and Hyrdel R. Effect of acidification of distal esophagus on cough sensitivity in patient with gastroesophageal reflux disease. Eur. Respir. J. 22 Suppl. 45 (2003) 172
113. Taylor R.F., Lee L.-Y., Jewell L.A., and Frazier D.T. Effect of nicotine aerosol on slowly adapting receptors in the airways of the dog. J. Neurol. Res. 15 (1986) 583-593
114. Turcan J., Hanacek J., and Korpas J. Expiration reflex intensity in rats induced by the inflation of the lung. Physiol. Bohemoslov. 30 (1981) 465
115. Turcan J., Hanacek J., and Korpas J. Influence of short-term lung inflation on the magnitude of expiratory reflex in the ferrets under normal condition and during experimental pneumothorax. Bratisl. Lek. Listy 79 (1983) 33-34
116. Widdicombe J.G. Respiratory reflexes from the trachea and bronchi of the cat. J. Physiol. 123 (1954) 55-70
117. Widdicombe J.G. Respiratory reflexes in man and other mammalian species. Clin. Sci. 21 (1961) 163-170
118. Widdicombe J.G. Neurophysiology of the cough reflex. Eur. Respir. J. 8 (1995) 1193-1202
119. Widdicombe J.G. Sensory mechanisms of cough. Pulm. Pharmacol. 9 (1996) 383-388
120. Widdicombe J.G. Afferent receptors in the airways and cough. Respir. Physiol. 114 (1998) 5-15
121. Widdicombe, J., Fontana, G., 2006. Cough: what's in a name. Eur. J. Respir., in press.
122. Widdicombe J.G. Airway receptors. Respir. Physiol. (2001) 3-15
123. Widdicombe J.G., and Singh V. Physiological and pathophysiological down-regulation of cough. Respir. Physiol. Neurobiol. 150 (2006) 105-117
124. Williams C.B.J. Report of experiments on the physiology of the lungs and air-tubes. Rep. Br. Assn. Adv. Sci. Aug. (1841) 411-420
125. Winning A.J., Hamilton R.D., Shea S.A., and Guz A. Respiratory and cardiovascular effects of central and peripheral intravenous injection of capsaicin in man: evidence for pulmonary chemosensitivity. Clin. Sci. 71 (1986) 519-526
126. Wolff A.P., and May M. The tympanic membrane: a source of the cough reflex. JAMA 23 (1973) 1269
127. Yeo W.W., Higgins K.S., Foster G., Jackson R.P., and Ramsay L.E. Effect of dose adjustment on enalapril-induced cough and the response to inhaled capsaicin. Br. J. Clin. Pharmacol. 39 (1995) 271-276
128. Yoshihara S., Abe T., Fukuda N., Ando T., Asai H., and Ichimura T. Skin stimulation with cold water inhibits capsaicin-induced cough, and decreases substance P-like immunoreactivity in guinea-pig lungs. Biomed. Res. 17 (1996) 271-278