Cough frequency and cough receptor sensitivity to citric acid challenge during a simulated ascent to extreme altitude

European Respiratory Journal

Volumn 13, Issue 3, 1999, Pages 508-513

  Mason, N P ^a   Barry, P W ^b   Despiau, G ^c   Gardette, B ^d   Richalet, J P ^e  

^a HÔPITAL TENON   (France)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c UNIVERSITÉ DE TOULOUSE   (France)

^d COMEX Industries ^*  (France)

^e ARPE   (France)

Author keywords

Citric acid; Cough; High altitude; Hypobaric chamber

Indexed keywords

CITRIC ACID;

ADULT; AEROSOL; ALTITUDE; ALTITUDE DISEASE; ARTICLE; COUGHING; DEMOGRAPHY; ENVIRONMENTAL FACTOR; FORCED EXPIRATORY FLOW; HUMAN; HUMAN EXPERIMENT; HUMIDITY; HYPOTHESIS; HYPOXIA; OXYGEN SATURATION; PRIORITY JOURNAL; SPIROMETRY; TEMPERATURE;

EID: 0032924662     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.99.13350899     Document Type: Article

References (38)

1. Somervell TH. After Everest. London, Hodder and Stoughton, 1936.
2. Tasker J. Everest the Cruel Way. London, Eyre Methuen, 1981.
3. Steele P. Medicine on Mount Everest 1971. Lancet 1971; ii: 32-39.
4. Murdoch DR. Symptoms of infection and altitude illness among hikers in the Mount Everest region of Nepal. Aviat Space Environ Med 1995; 66: 148-151.
5. Ward MP, Milledge JS, West JB. High Altitude Medicine and Physiology, 2nd edn. London, Chapman and Hall, 1995; p. 390.
6. Barry PW, Mason NP, Riordan M, O'Callaghan C. Cough frequency and cough receptor sensitivity are increased in man at altitude. Clin Sci 1997; 93: 181-186.
7. Banner AS, Chausow A, Green J. The tussive effect of hyperpnea with cold air. Am Rev Respir Dis 1985; 131: 362-367.
8. Altman DG. Practical Statistics for Medical Research. London, Chapman and Hall, 1991.
9. Ryan G, Dolovich MB, Obminski G, Cockroft DW, Juniper E, Hargreaves FE. Standardisation of inhalation provocation tests: influence of nebuliser output, particle size and method of inhalation. J Allergy Clin Immunol 1981; 67: 156-161.
10. Barros MJ, Zammattio SJ, Rees PJ. Importance of inspiratory flow rate in the cough response to citric acid inhalation in normal subjects. Clin Sci 1990; 78: 521-525.
11. Pounsford JC, Saunders KB. Diurnal variation and adaption of the cough response to citric acid in normal subjects. Thorax 1985; 40: 657-661.
12. Empey DW, Laitinen LA, Young GA, Bye CA, Hughes DTD. Comparison of the antitussive effect of codeine phosphate 20 mg, dextromethorphan 30 mg and noscapine 30 mg using citric acid induced cough in normal subjects. Eur J Clin Pharmacol 1979; 16: 393-397.
13. Hackett P. Lake Louise Consensus statement on the definition of altitude illness. In: Sutton JR, Coates G, Houston CS, eds. Hypoxia and Mountain Medicine. Burlington, CS Houston, 1992; pp. 327-330.
14. Pollard AJ, Mason NP, Barry PW, et al. Effect of altitude on spirometric parameters and the performance of peak flow meters. Thorax 1996; 51: 175-178.
15. Irwin RS, Rosen MJ. Cough: a comprehensive review. Arch Intern Med 1977; 137: 1186-1191.
16. Banner AS, Green J, O'Conner M. Relation of respiratory water loss to coughing after exercise. N Engl J Med 1984; 311: 833-836.
17. Pugh LGCE, Gill MB, Lahiri S, et al. Muscular exercise at great altitude. J Appl Physiol 1964; 19: 431-440.
18. West JB, Boyer SJ, Graber DJ, et al. Maximal exercise at extreme altitudes on Mount Everest. J Appl Physiol 1983; 55: 688-698.
19. Ward MP, Milledge JS, West JB. High Altitude Medicine and Physiology, 2nd edn. London, Chapman & Hall, 1995; p. 478.
20. Andersen I, Lundqvist GR, Jensen PL, Proctor DF. Human response to 78-hour exposure to dry air. Arch Environ Health 1974; 29: 319-324.
21. Strauss RH, McFadden ER, Ingram RH, Jaegar JJ. Enhancement of exercise-induced asthma by cold air. N Engl J Med 1977; 297: 743-747.
22. Pounsford JC, Birch MJ, Saunders KB. Effect of bronchodilators on the cough response to citric acid in normal and asthmatic subjects. Thorax 1985; 40: 662-667.
23. Belcher N, Rees PJ. Effects of pholcodine and salbutamol on citric acid induced cough in normal subjects. Thorax 1986; 41: 74-75.
24. Gray GW, McFadden MD, Houston CS, Bryan AC. Changes in the single-breath nitrogen washout curve on exposure to 17,600 ft. J Appl Physiol 1975; 39: 652-656.
25. Kronenburg RS, Safar P, Lee J, et al. Pulmonary artery pressure and alveolar gas exchange in man during acclimatisation to 12,470 ft. J Clin Invest 1971; 150: 827-837.
26. Richalet J-P. High altitude pulmonary oedema: still a place for controversy? Thorax 1995; 50: 923-929.
27. Peacock AJ. High altitude pulmonary oedema: who gets it and why? Eur Respir J 1995; 8: 1819-1821.
28. Widdecombe JG. Neurophysiology of the cough reflex. Eur Respir J 1995; 8: 1193-1202.
29. Maggiorini M, Bartsch P, Oelz O. Association between raised body temperature and acute mountain sickness: cross sectional study. Br Med J 1997; 315: 403-404.
30. Schoene RB, Swenson ER, Pizzo CJ, et al. The lung at high altitude: bronchoalveolar lavage in acute mountain sickness and pulmonary oedema. J Appl Physiol 1988; 64: 2605-2613.
31. Hansen JM, Olsen NV, Feldt-Rasmussen B, et al. Albuminuria and overall capillary permeability of albumin in acute hypoxia. J Appl Physiol 1994; 76: 1922-1927.
32. Richalet J-P, Hornych A, Rathat C, Aumont J, Larmignat P, Remy P. Plasma prostaglandins, leukotrienes and thromboxane in acute high altitude hypoxia. Respir Physiol 1991; 85: 205-215.
33. 2 in altitude acclimatization. In: Cunningham DJC, Lloyd BB, eds. The Regulation of Human Respiration. Oxford, Blackwell Science, 1963; pp. 379-394.
34. 2 in normal subjects. Am Rev Respir Dis 1988; 137: 647-650.
35. Barry PW, Mason NP, Nickol A, et al. Cough receptor sensitivity and dynamic ventilatory response to carbon dioxide in man acclimatised to high altitude (Abstract). J Physiol 1996; 497P: 29-30.
36. Irwin SI, Rosen MJ, Braman SS. Cough: a comprehensive review. Arch Intern Med 1997; 137: 1186-1191.
37. Campbell MJ, Machin D. Medical Statistics: A Common Sense Approach. Chichester, John Wiley & Sons, 1994.
38. Lippman M, Esch J. Effect of lung airway branching pattern and gas composition on particle deposition. Exp Lung Res 1988; 14: 311-320.