Afferent receptors in the airways and cough

Respiration Physiology

Volumn 114, Issue 1, 1998, Pages 5-15

  Widdicombe, J G ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Afferent nerves; Airway receptors; Airways; C fibres; Cough; Humans; Irritant receptors; Mammals; Rapidly adapting receptors; Receptors

Indexed keywords

NEUROKININ 1 RECEPTOR; RECEPTOR; SUBSTANCE P; TACHYKININ;

AIRWAY; ANIMAL TISSUE; APNEA; BREATHING; COUGHING; EXTRAVASATION; HUMAN; HUMAN TISSUE; LARYNX; NONHUMAN; PRIORITY JOURNAL; REVIEW; SENSORY NERVE; TRACHEA MUCOSA; TRACHEOBRONCHIAL TREE;

AFFERENT PATHWAYS; ANIMALS; COUGH; IRRITANTS; MAMMALS; NERVE FIBERS; RECEPTORS, SENSORY; RESPIRATION; TRACHEA;

EID: 0031732187     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(98)00076-0     Document Type: Review

References (57)

1. Advenier C., Emonds-Alt X. Tachykinin receptor antagonists and cough. Pulm. Pharmacol. 9:1996;329-334.
2. Advenier C., Lagente V., Boichot E. The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough. Eur. Respir. J. 10:1997;1892-1906.
3. Baluk P., Nadel J.A., McDonald D.M. Substance P immunoreactive sensory axons in the rat respiratory tract: a quantitative study of their distribution and role in neurogenic inflammation. J. Comp. Neurol. 319:1992;586-598.
4. Baluk P., Nadel J.A., McDonald D.M. Calcitonin gene-related peptide in secretory granules of serous cells in the rat tracheal epithelium. Am. J. Respir. Cell Mol. Biol. 8:1993;446-453.
5. Bonham A.C., Kott K.S., Ravi K., Kappagoda C.T., Joad J.P. Substance P contributes to rapidly adapting receptor responses to pulmonary venous congestion in rabbits. J. Physiol. Lond. 493:1996;229-238.
6. Coleridge J.C.C., Coleridge H.M. Afferent vagal C-fibre innervation of the lungs and airways and its functional significance. Rev. Physiol. Biochem. Pharmacol. 99:1984;1-110.
7. Coleridge, H.M., Coleridge, J.C.C., 1986. Reflexes evoked from the tracheobronchial tree and lungs. In: Cherniack, N.S., Widdicombe, J.G. (Eds.), Handbook of Physiology, Section 3: The Respiratory System, vol. II: Control of Breathing, part 1. American Physiological Society, Washington D.C., pp. 395-429.
8. Ebihara T., Sekizawa K., Ohrui T., Nazakawa H., Sasaki H. Angiotensin-converting enzyme inhibitor and danazol increase sensitivity of cough reflex in female guinea pigs. Am. J. Respir. Crit. Care Med. 153:1996;812-819.
9. Fischer A., Mundel P., Mayer B., Preissler U., Phillipson B., Kummer W. Nitric oxide synthase in guinea pig lower airway innervation. Neurosci. Lett. 149:1993;157-160.
10. Forsberg K., Karlsson J.-A., Theodorson E., Lundberg J.M., Persson C.G.A. Cough and bronchoconstriction mediated by capsaicin-sensitive sensory neurons in guinea pigs. Pulm. Pharmacol. 1:1988;33-39.
11. Forsberg K., Karlsson J.A., Lundberg J.M., Zackrisson C. Effect of partial laryngeal denervation on irritant-induced cough and bronchoconstriction in conscious guinea pigs. J. Physiol. Lond. 422:1990;34.
12. Fox A.J., Urban L., Barnes P.J., Dray A. An in vitro study of the properties of single afferents innervating guinea pig airways. J. Physiol. Lond. 469:1993;21-35.
13. Fox A.J. Mechanisms and modulation of capsaicin activity on airway afferent nerves. Pulm. Pharmacol. 8:1995;207-214.
14. Fox A.J. Modulation of cough and airway sensory fibres. Pulm. Pharmacol. 9:1996;335-342.
15. Fox A.J., Bernareggi M., Lalloo U.G., Chung K.F., Barnes P.J., Belvesi M.G. The effect of substance P on the cough reflex and airway sensory nerves in guinea-pigs. Am. J. Respir. Crit. Care Med. 153:1996;161.
16. Hanacek J., Davies A., Widdicombe J.G. Influence of lung stretch receptors on the cough reflex in rabbits. Respiration. 45:1984;161-168.
17. Higenbottam T., Jackson M., Woolman P., Lowry R., Wallwork J. The cough response to ultrasonically nebulized distilled water in heart-lung transplantation patients. Am. Rev. Respir. Dis. 140:1989;58-61.
18. Ishinose M., Nakajima M., Takahashi T., Yamauchi H., Inoue H., Takashima T. Protection against bradykinin-induced bronchoconstriction in asthmatic patients by neurokinin receptor antagonist. Lancet. 340:1992;1248-1251.
19. Jackson D.M., Norris A.A., Eady R.P. Nedocromil sodium and sensory nerves in the dog lung. Pulm. Pharmacol. 2:1989;179-184.
20. Joos G.F., Pauwels R.A., van der Straeten M.E. Effect of inhaled substance P and neurokinin A on the airways of normal and asthmatic subjects. Thorax. 42:1987;779-783.
21. Karlsson J.-A., Sant'Ambrogio G., Widdicombe J. G. Afferent neural pathways in cough and reflex bronchoconstriction. J. Appl. Physiol. 65:1988;1007-1023.
22. Karlsson J.-A. A role for capsaicin positive, tachykinin containing nerves in chronic coughing and sneezing, but not in asthma: a hypothesis. Thorax. 48:1993;396-400.
23. Karlsson J.-A. The role of capsaicin-sensitive C-fibre afferent nerves in the cough reflex. Pulm. Pharmacol. 9:1996;315-322.
24. Katsumata U., Sekizawa K., Inoue H., Sasaki H., Takishima T. Inhibitory actions of procaterol, a beta-2 stimulant, on substance P-induced cough in normal subjects durimg upper respiratory tract infiction. Tohoko J. Exp. Med. 158:1989;105-106.
25. Matsumoto S., Yamasaki M., Kanno T., Yagayama T., Tanno M., Shimizu T. Substance P antagonist does not block the stimulation of rapidly adapting pulmonary stretch receptors by ammonia. Lung. 172:1994;31-45.
26. Mortola J.P., Sant'Ambrogio G., Clement M.G. Localization of irritant receptors in the airways of the dog. Respir. Physiol. 24:1975;107-114.
27. Myers J.D., Shakur B.H., El-Khushman H., Ind P.W. Sensitivity to prostaglandin F2a, substance P and low chloride in persistent cough. Am. J. Respir. Crit. Care Med. 157:1998;824.
28. Nishino T., Hiraga K., Mizuguchi T., Honda Y. Respiratory reflex responses to stimulation of tracheal mucosa in enfluane-anesthetized humans. J. Appl. Physiol. 65:1988;1069-1074.
29. Nishino T., Togaito Y., Isono S. Cough and other reflexes on irritation of airway mucosa in man. Pulm. Pharmacol. 9:1996;285-292.
30. Paintal, A.S., 1983. Lung and airway receptors. In: Pallot, D.J. (Ed.), Control of Respiration. Croom Helm, London, pp.78-107.
31. Palecek F., Sant'Ambrogio G., Sant'Ambrogio F.B., Mathew O.P. Reflex responses to capsaicin: intravenous, aerosol and intratracheal administration. J. Appl. Physiol. 67:1989;1428-1437.
32. Palecek F., Mathew O.P., Sant'Ambrogio F.B., Sant'Ambrogio G. Cardiorespiratory responses to inhaled laryngeal irritants. Inhal. Toxicol. 2:1990;93-104.
33. Persson, C.G., 1992. Plasma exudation from tracheobronchial microvessels in health and disease. In: Butler, J. (Ed.),The Bronchial Circulation. Marcel Dekker, New York, pp. 443-473.
34. Prabhakar N.R., Renuld M., Yamamoto Y., Lagercrantz H., Cherniack N.S., von Euler C. Role of the vagal afferents in substance P-induced respiratory responses in anaesthetized rabbits. Acta Physiol. Scand. 131:1987;63-71.
35. Raj H., Singh V.K., Anand A., Paintal A.S. Sensory origin of lobeline induced sensations: a correlative study in man and cat. J. Physiol. Lond. 482:1995;235-246.
36. Ravi K., Kappagoda C.T. Reflex effects of pulmonary venous congestion: role of vagal afferents. News Physiol. Sci. 5:1990;95-99.
37. Ravi K., Bonham A.C., Kappagoda C.T. Effect of pulmonary lymphatic obstruction and plasmapheresis on respiratory rate in rabbits. J. Physiol. Lond. 480:1994;161-169.
38. Riccio M.N., Kummer W., Biglari B., Myers A.C., Undem B.J. Interganglionic segregation of distinct vagal afferent fibre phenotypes in guinea pig airways. J. Physiol. Lond. 496:1996;521-530.
39. Sant'Ambrogio G., Sant'Ambrogio F.B., Davies A. Airway receptors in cough. Bull. Eur. Physiopathol. Respir. 20:1984;43-47.
40. Sant'Ambrogio G., Tsubone H., Sant'Ambrogio F.B. Sensory information from the upper airway: role in the control of breathing. Respir. Physiol. 102:1995;1-16.
41. Sant'Ambrogio G. Role of the larynx in cough. Pulm. Pharmacol. 9:1996;379-382.
42. Sant'Ambrogio G., Sant'Ambrogio F.B. Role of laryngeal afferents in cough. Pulm. Pharmacol. 9:1996;309-314.
43. Sekizawa K., Jia Y.X., Ebihara T., Hirose Y., Hirayama Y., Sasaki H. Role of substance P in cough. Pulm. Pharmacol. 9:1996;323-328.
44. Stockwell M., Lang S., Yip R., Zintel T., White C., Gallagher C.G. Lack of importance of the superior laryngeal nerves in citric acid cough in humans. J. Appl. Physiol. 75:1993;613-617.
45. Tatar M., Korpas J., Polacek H., Zahradny U. Effects of hypoxia on respiratory defence reflexes. Effects of thirty hours oxygen deficiency on cough. the expiration reflex and sneezing in awake cats. Physiol. Bohemoslov. 34:1985;41-48.
46. Tatar, M., Polacek, H., Pullmann, R., 1986. Changes in defense reflexes of the airways in the course of five-hour hypercapnia in conscious cats. Bratis. lek. Listy. 85, 533-540. (In Slovakian).
47. Tatar M., Webber S.E., Widdicombe J.G. Lung C-fibre receptor activation and defensive reflexes in anaesthetized cats. J. Physiol. Lond. 402:1988;411-420.
48. Tatar M., Sant'Ambrogio G., Sant'Ambrogio F.B. Laryngeal and tracheobronchial cough in anesthetized dogs. J. Appl. Physiol. 76:1994;2672-2679.
49. Tatar M., Karkolova D., Pecova R., Brozmanova M. The role of partial laryngeal denervation on the cough reflex in awake guinea-pigs, rats and rabbits. Pulm. Pharmacol. 9:1996;371-372.
50. Tsubone H., Sant'Ambrogio G., Anderson J.W., Orani G.P. Laryngeal afferent activity and reflexes in the guinea pig. Respir. Physiol. 86:1991;215-231.
51. Ujiie Y., Sekizawa K., Aikawa T., Sasaki H. Evidence for substance P as an endogenous substance causing cough in guinea pigs. Am. Rev. Respir. Dis. 148:1993;1628-1632.
52. Widdicombe J.G. Receptors in the trachea and bronchi of the cat. J. Physiol. Lond. 123:1954;71-104.
53. Widdicombe, J.G., Sant'Ambrogio, G., Mathew, O.P., 1988. Nerve receptors of the upper airway. In: Mathew O.P., Sant'Ambrogio, G. (Eds.), Respiratory Function of the Upper Airway. Marcel Dekker, New York, pp. 193-232.
54. WiddicombeJ.G., 1989. Nervous receptors in the tracheobronchial tree. In: Cevero, F., Morrison, J.F.B. (Eds.), Visceral Sensation: Progress in Brain Research 67, pp. 49-64.
55. Widdicombe J.G. Neurophysiology of the cough reflex. Eur. Respir. J. 8:1995;1193-1202.
56. Widdicombe J.G. Sensory mechanisms. Pulm. Pharmacol. 9:1996;383-388.
57. Widdicombe, J.G. 1997. Airway surface liquid: concepts and measurements. In: Rogers, D.F., Letham, M.I. (Eds.), Airway Mucus: Basic Mechanisms and Clinical Perspectives. Birkhauser Verlag, Basel, pp. 1-18.