Gastric H,K-ATPase as a drug target

Digestive Diseases and Sciences

Volumn 51, Issue 5, 2006, Pages 823-833

  Shin, Jai Moo ^a,b   Sachs, George ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (PYRIDIN 2 YL)ETHANETHIOAMIDE; 2,4 DIAMINOQUINAZOLINE DERIVATIVE; 8 BENZYLOXY 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 ACETONITRILE; ACID PUMP ANTAGONIST; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMOXICILLIN; ANTIBIOTIC AGENT; BENATOPRAZOLE; BYK 36399; CIMETIDINE; CLARITHROMYCIN; ESOMEPRAZOLE; GASTROINTESTINAL AGENT; HISTAMINE H2 RECEPTOR ANTAGONIST; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; ILAPRAZOLE; IMIDAZOPYRIDINE DERIVATIVE; LAFUTIDINE; LANSOPRAZOLE; METRONIDAZOLE; OMEPRAZOLE; PANTOPRAZOLE; PICOPRAZOLE; POTASSIUM COMPETITIVE ACID BLOCKER; PROTON PUMP INHIBITOR; RABEPRAZOLE; REVAPRAZAN; TIMOPRAZOLE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL TISSUE; CATALYSIS; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBUNIT; GASTROESOPHAGEAL REFLUX; HELICOBACTER PYLORI; HUMAN; NONHUMAN; PEPTIC ULCER; PRIORITY JOURNAL; PROTON TRANSPORT; RAT; REVIEW; SARCOPLASMIC RETICULUM; STOMACH ACID SECRETION; STOMACH MUCOSA; STOMACH PARIETAL CELL; STOMACH ULCER; THREE DIMENSIONAL IMAGING;

ANTI-ULCER AGENTS; ENZYME INHIBITORS; GASTRIC ACID; H(+)-K(+)-EXCHANGING ATPASE; HELICOBACTER PYLORI; HUMANS; IMIDAZOLES; MOLECULAR STRUCTURE; PEPTIC ULCER; PROTON PUMPS;

EID: 33745825932     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-9042-8     Document Type: Review

References (89)

1. Sachs G, Chang HH, Rabon E, Schackman R, Lewin M, Saccomani G (1976) J Biol Chem 251:7690-7698
2. Helander HF, Hirschowitz BI (1972) Gastroenterology 63:951-961
3. Wolosin JM, Forte JG (1983) J Membr Biol 71:195-207
4. Vagin O, Munson K, Lambrecht N, Karlish SJ, Sachs G (2001) Biochemistry 40:7480-7490
5. Vagin O, Denevich S, Munson K, Sachs G (2002) Biochemistry 41:12755-12762
6. Munson K, Vagin O, Sachs G, Karlish S (2003) Ann NY Acad Sci 986:106-110
7. Maeda M, Oshiman K, Tamura S, Futai M (1990) J Biol Chem 265:9027-9032
8. Shyjan AW, Canfield VA, Levenson R (1991) Genomics 11:435-442
9. Maeda M, Ishizaki J, Futai M (1988) Biochem Biophys Res Commun 157:203-209
10. Hall K, Perez G, Anderson D, Gutierrez C, Munson K, Hersey SJ, Kaplan JH, Sachs G (1990) Biochemistry 29:701-706
11. Reuben MA, Lasater LS, Sachs G (1990) Proc Natl Acad Sci USA 87:6767-6771
12. Shin JM, Sachs G (1994) J Biol Chem 269:8642-8646
13. Melle-Milovanovic D, Milovanovic M, Nagpal S, Sachs G, Shin JM (1998) J Biol Chem 273:11075-11081
14. Shin JM, Sachs G (1996) J Biol Chem 271:1904-1908
15. Shull GE, Lingrel JB (1986) J Biol Chem 261:16788-16791
16. Bamberg K, Mercier F, Reuben MA, Kobayashi Y, Munson KB, Sachs G (1992) Biochim Biophys Acta 1131:69-77
17. Song I, Mortell MP, Gantz I, Brown DR, Yamada T (1993) Biochem Biophys Res Commun 196:1240-1247
18. Lane LK, Kirley TL, Ball WJJr (1986) Biochem Biophys Res Commun 138:185-192
19. Crowson MS, Shull GE (1992) J Biol Chem 267:13740-13748
20. Toh BH, Gleeson PA, Simpson RJ, et al. (1990) Proc Natl Acad Sci USA 87:6418-6422
21. Vagin O, Turdikulova S, Sachs G (2004) J Biol Chem 279:39026-39034
22. Toyoshima C, Nomura H (2002) Nature 418:605-611
23. Toyoshima C, Nomura H, Sugita Y (2003) Ann NY Acad Sci 986:1-8
24. Toyoshima C, Asahi M, Sugita Y, Khanna R, Tsuda T, MacLennan DH (2003) Proc Natl Acad Sci USA 100:467-472
25. Jorgensen PL, Hakansson KO, Karlish SJ (2003) Annu Rev Physiol 65:817-849
26. Lee AG (2002) Biochim Biophys Acta 1565:246-266
27. Sweadner KJ, Donnet C (2001) Biochem J 356:685-704
28. Munson K, Garcia R, Sachs G (2005) Biochemistry 44:5267-5284
29. Sachs G, Spenney JG, Rehm WS (1977) Int Rev Physiol 12:127-171
30. Forte JG, Lee HC (1977) Gastroenterology 73:921-926
31. Brimblecombe RW, Duncan WA, Durant GJ, Emmett JC, Ganellin CR, Leslie GB, Parsons ME (1978) Gastroenterology 74:339-347
32. Olbe L, Carlsson E, Lindberg P (2003) Nature Drug Disc 2:132-139
33. Wallmark B, Sachs G, Mardh S, Fellenius E (1983) Biochim Biophys Acta 72:831-838
34. Fellenius E, Berglindh T, Sachs G, Olbe L, Eler B, Sjostr SE, Wallmark B (1981) Nature 290:159-161
35. Lindberg P, Nordberg P, Alminger T, Brstrom A, Wallmark B (1986) J Med Chem 29:1327-1329
36. Nagaya H, Satoh H, Kubo K, Maki Y (1989) J Pharmacol Exp Ther 248:799-805
37. Sturm E, Kruger U, Senn-Bilfinger J, et al. (1987) J Organ Chem 52:4573-1581
38. Lindberg P, Brstrom A, Wallmark B, Mattsson H, Rikner L, Hoffmann KJ (1990) Med Res Rev 10:101-154
39. Kohl B, Sturm E, Senn-Bilfinger J, et al. (1992) J Med Chem 35:1049-1057
40. Ife RJ, Dyke CA, Keeling DJ, Meenan E, Meeson ML, Parsons ME, Price CA, Theobald CJ, Underwood A (1989) J Med Chem 32:1970-1977
41. Nochi S, Yokoyama Y, Narukawa M, Ebine K, Murahashi M, Kawakami Y, Asakawa N, Sato T (1996) Chem Pharm Bull (Jpn) 44:552-558
42. Senn-Bilfinger J, Kruger U, Sturm E, et al. (1987) J Med Chem 52:4582-1592
43. Kim EJ, Lee RK, Lee SM, Kim DY (2001) Arzneimittellorschung 51:51-59
44. Shin JM, Cho YM, Sachs G (2004) J Am Chem Soc 126:7800-7811
45. Heler HF, Ramsay CH, Regardh CG (1985) Scand J Gastroenterol Suppl 108:95-104
46. Scott DR, Besancon M, Sachs G, Heler H (1994) Dig Dis Sci 39:2118-2126
47. Wallmark B, Jaresten BM, Larsson H, Ryberg B, Brstrom A, Fellenius E (1983) Am J Physiol 245:G64-G71
48. Wallmark B, Brstrom A, Larsson H (1984) Biochim Biophys Acta 778:549-558
49. Im WB, Blakeman DP, Sachs G (1985) Biochim Biophys Acta 845:54-59
50. Shin JM, Sachs G (2002) Gastroenterology 123:1588-1597
51. Lorentzon P, Jackson R, Wallmark B, Sachs G (1987) Biochim Biophys Acta 897:41-51
52. Keeling DJ, Fallowfield C, Underwood AH (1987) Biochem Pharmacol 36:339-344
53. Besancon M, Simon A, Sachs G, Shin JM (1997) J Biol Chem 272:22438-22446
54. Kromer W, Kruger U, Huber R, Hartmann M, Steinijans VW (1998) Pharmacology 56:57-70
55. Sachs G, Shin JM, Besancon M, Prinz C (1993) Aliment Pharmacol Ther 7:4-12, discussion 29-31
56. Besancon M, Shin JM, Mercier F, Munson K, Miller M, Hersey S, Sachs G (1993) Biochemistry 32:2345-2355
57. Shin JM, Besancon M, Simon A, Sachs G (1993) Biochim Biophys Acta 1148:223-233
58. Shin JM, Besancon M, Prinz C, Simon A, Sachs G (1994) Aliment Pharmacol Ther 8:11-23
59. Gedda K, Scott D, Besancon M, Lorentzon P, Sachs G (1995) Gastroenterology 109:1134-1141
60. Katashima M, Yamamoto K, Tokuma Y, Hata T, Sawada Y, Iga T (1998) Eur J Drug Metab Pharmacokinet 23:19-26
61. Keeling DJ, Laing SM, Senn-Bilfinger J (1988) Biochem Pharmacol 37:2231-2236
62. Munson KB, Sachs G (1988) Biochemistry 27:3932-3938
63. Munson KB, Gutierrez C, Balaji VN, Ramnarayan K, Sachs G (1991) J Biol Chem 266:18976-18988
64. Mendlein J, Sachs G (1990) J Biol Chem 265:5030-5036
65. Wallmark B, Briving C, Fryklund J, Munson K, Jackson R, Mendlein J, Rabon E, Sachs G (1987) J Biol Chem 262:2077-2084
66. Van der Hijden HT, Koster HP, Swarts HG, De Pont JJ (1991) Biochim Biophys Acta 1061:141-148
67. Shin JM, Sachs G (2005) Biochemistry (submitted)
68. Keeling DJ, Taylor AG, Schudt C (1989) J Biol Chem 264:5545-5551
69. Mendlein J, Sachs G (1989) J Biol Chem 264:18512-18519
70. Fukushima Y, Nakao M (1980) J Biol Chem 255:7813-7819
71. Fukushima Y, Post RL (1978) J Biol Chem 253:6853-6862
72. Abe K, Kaya S, Hayashi Y, Imagawa T, Kikumoto M, Oiwa K, Katoh T, Yazawa M, Taniguchi K (2003) Biochemistry 42:15132-15138
73. Mendlein J, Ditmars ML, Sachs G (1990) J Biol Chem 265:15590-15598
74. Shin JM, Sachs G (2004) Biochem Pharmacol 68:2117-2127
75. Lorentzon P, Sachs G, Wallmark B (1988) J Biol Chem 263:10705-10710
76. Aihara T, Nakamura, E, Amagase K, Tomita K, Fujishita T, Furutani K, Okabe S (2003) Pharmacol Ther 98:109-127
77. Marshall BJ, Warren JR (1984) Lancet 1:1311-1315
78. Suerbaum S, Michetti P (2002) N Engl J Med 347:1175-1186
79. Raghunath AS, O'Morain C, McLoughlin RC (2005) Aliment Pharmacol Ther 22(Suppl 1):55-63
80. Moss SF, Armstrong D, Arnold R, et al. (2003) Digestion 67:111-117
81. Shaker R (2004) Best Pract Res Clin Gastroenterol Suppl 18:31-38
82. Delaney B, McColl K (2005) Aliment Pharmacol Ther 22(Suppl 1):32-40
83. Walsh JH, Peterson WL (1995) N Engl J Med 333:984-991
84. Blaser MJ (2005) Sci Am 292:38-45
85. Galmiche JP, Sacher-Huvelin S, Bruley des Varannes S, Vavasseur F, Taccoen A, Fiorentini P, Homerin M (2005) Aliment Pharmacol Ther 21:575-582
86. Periclou AP, Goldwater R, Lee SM, Park DW, Kim DY, Cho KD, Boileau F, Jung WT (2000) Clin Pharmacol Ther 68:304-311
87. Nagahama K, Yamato M, Kato S, Takeuchi K (2003) J Pharmacol Sci 93:55-61
88. Parsons ME, Keeling DJ (2005) Expert Opin Invest Drugs 14:411-421
89. Lambrecht NW, Yakubov I, Scott D, Sachs G (2005) Physiol Genomics 21:81-91