IgE antibodies to betalactams: Relationship between the triggering hapten and the specificity of the immune response

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 61, Issue 8, 2006, Pages 940-946

  Antunez C ^a   Fernandez T ^a   Blanca Lopez, N ^b   Torres, M J ^a   Mayorga, C ^a   Canto, G ^b   Fernandez J ^c   Moya, M C ^d   Blanca, M ^a  

^a HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^c Elche University Hospital   (Spain)

^d HOSPITAL TORRECÁRDENAS   (Spain)

Author keywords

Allergy; Betalactams; Boosting response; Immunoglobulin E; Specificity

Indexed keywords

AMOXICILLIN; BETA LACTAM ANTIBIOTIC; HAPTEN; IMMUNOGLOBULIN E ANTIBODY; PENICILLIN G;

ANAPHYLAXIS; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; CLINICAL ARTICLE; CONJUGATE; CONTROLLED STUDY; CROSS REACTION; DRUG HYPERSENSITIVITY; FOLLOW UP; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOASSAY; PRIORITY JOURNAL; URTICARIA;

ANTIBODY SPECIFICITY; B-LYMPHOCYTES; BETA-LACTAMS; CROSS REACTIONS; DRUG HYPERSENSITIVITY; FEMALE; HAPTENS; HUMANS; IMMUNOGLOBULIN E; IMMUNOLOGIC MEMORY; MALE; TIME FACTORS;

EID: 33745805193     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2006.01120.x     Document Type: Article

References (21)

1. Qiao HL, Yang J, Zhang YW. Specific serum IgE levels and FcepsilonRIbeta genetic polymorphism in patients with penicillins allergy. Allergy 2004;59:1326-1332.
2. Rodriguez-Pena R, Antunez C, Martin E, Blanca-Lopez N, Mayorga C, Torres MJ. Allergic reactions to beta-lactams. Expert Opin Drug Saf 2006;5:31-48.
3. Aalbarse R. Cross-reactivity of allergens IgE. Allergy 2001;56:478-490.
4. Mohapatra SS. Determinant spreading: implications in allergic disorders. Immunol Today 1994;15:596-597.
5. Ahmed R, Gray D. Immunological memory and protective immunity: understanding their relation. Science 1999;272:54-59.
6. Bernasconi NL, Traggiai E, Lanzavecchia A. Maintenance of serological memory by polyclonal activation of human memory B cell. Science 2002;298:2199-2202.
7. Tangye SG, Avery DT, Deenick EK, Hodgkin PD. Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses. J Immunol 2003;170:686-694.
8. Fish S, Zenowich E, Fleming M, Manser T. Molecular analysis of original antigenic sin: I. Clonal selection, somatic mutation, and isotype switching during a memory B cell response. J Exp Med 1989;170:1191-1209.
9. Blanca M, Vega JM, García J, Carmona M, Terrados S, Avila M et al. Allergy to amoxicillin with good tolerance to other penicillins. Study of the incidence in patients allergic to betalactams. Clin Exp Allergy 1990;20:475-481.
10. Blanca M, Mayorga C, Sanchez F, Vega JM, Fernandez J, Juarez C et al. Differences in serum IgE antibody activity to benzylpenicillin and amoxicillin measured by RAST in a group of penicillin allergic subjects. Allergy 1991;46:632-638.
11. Moreno F, Blanca M, Mayorga C, Terrados S, Moya C, Pérez E et al. Studies of the specificities of IgE antibodies found in sera from subjects with allergic reactions to penicillins. Int Arch Allergy Immunol 1995;108:74-81.
12. Fazekas de St Groth S, Webster RG. Disquisition on original antigenic sin: I. Evidence in man. J Exp Med 1966;124:331-345.
13. Torres MJ, Blanca M, Fernandez J, Romano A, de Weck A, Aberer W et al. and ENDA and the EAACI Interest Group on Drug Hypersensitivity. Diagnosis of immediate allergic reactions to betalactam antibiotics. Allergy 2003;58:961-972.
14. Romano A, Blanca M, Mayorga C, Venuti A, Gasbarrini G. Immediate hypersensitivity to penicillins. Studies on Italian subjects. Allergy 1997;52:89-93.
15. Romano A, Quarantino D, Aimone-Gastin I, Mayorga C, Papa G, Venuti A et al. Cephalosporin allergy: characterization of unique and cross-reacting cephalosporin antigens. Int J Immunopathol Pharmacol 1997;10:187-191.
16. Romano A, Mayorga C, Torres MJ, Artesani MC, Suau R, Sanchez F et al. Immediate allergic reactions to cephalosporins: cross-reactivity and selective responses. J Allergy Clin Immunol 2000;106:1177-1183.
17. Terrados S, Blanca M, Garcia J, Vega JM, Torres MJ, Carmona MJ et al. Non-immediate reactions to betalactams: prevalence and role of the different penicillins. Allergy 1995;50:563-567.
18. Romano A, Quarantino D, Di Fonso M, Papa G, Venuti A, Gasbarrini G. A diagnostic protocol for evaluating non-immediate reactions to aminopenicillins. J Allergy Clin Immunol 1999;103:1186-1190.
19. Romano A, Gueant-Rodriguez RM, Viola M, Pettinato R, Gueant JL. Cross-reactivity and tolerability of cephalosporins in patients with immediate hypersensitivity to penicillins. Ann Intern Med 2004;141:16-22.
20. Messaad D, Sahla H, Benahmed S, Godard P, Bousquet J, Demoly P. Drug provocation tests in patients with a history suggesting an immediate drug hypersensitivity reaction. Ann Intern Med 2004;40:1001-1006.
21. Blanca M, García J, Vega JM, Miranda A, Carmona MJ, Mayorga C et al. Anaphylaxis to penicillins after non-therapeutic exposure: an immunological investigation. Clin Exp Allergy 1996;26:335-340.