Shear stress induces hepatocyte PAI-1 gene expression through cooperative Sp1/Ets-1 activation of transcription

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 291, Issue 1, 2006, Pages

  Nakatsuka, Hideki ^a   Sokabe, Takaaki ^b   Yamamoto, Kimiko ^b   Sato, Yoshinobu ^a   Hatakeyama, Katsuyoshi ^a   Kamiya, Akira ^b   Ando, Joji ^b  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Hemodynamic force; Immediate early gene; Liver regeneration; Partial hepatectomy; Portal flow

Indexed keywords

PROTEIN; PROTEIN PAI 1; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; RAT; SHEAR RATE; SHEAR STRESS; TRANSCRIPTION INITIATION;

ANIMALS; CELLS, CULTURED; GENE EXPRESSION REGULATION; HEPATOCYTES; MALE; MECHANOTRANSDUCTION, CELLULAR; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTO-ONCOGENE PROTEIN C-ETS-1; RATS; RATS, WISTAR; SHEAR STRENGTH; SIGNAL TRANSDUCTION; SP1 TRANSCRIPTION FACTOR; STRESS, MECHANICAL; TRANS-ACTIVATION (GENETICS);

BLOOD; ELECTROPHORETIC MOBILITY; SHEAR FLOW; TRANSCRIPTION;

BLOOD FLOW; CONSENSUS SEQUENCE; FLOWING BLOOD; GENES EXPRESSION; HEMODYNAMIC CHANGES; HEPATOCYTES; IMMEDIATE EARLY GENES; MECHANICAL FORCE; PLASMINOGEN ACTIVATOR INHIBITOR-1; RAT HEPATOCYTES;

SHEAR STRESS;

EID: 33745774823     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00467.2005     Document Type: Article

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