Possible consequences of acetylcholinesterase inhibition in organophosphate poisoning. Discussion continued;Możliwe nastȩpstwa inhibicji acetylocholinoesterazy w zatruciu zwia̧zkami fosforoorganicznymi. Dyskusji cia̧g dalszy

Medycyna Pracy

Volumn 57, Issue 3, 2006, Pages 291-302

  Gralewicz, Sławomir ^a,b  

^a NOFER INSTITUTE OF OCCUPATIONAL MEDICINE   (Poland)

^b NONE   (Poland)

Author keywords

Acetylcholinesterase; Organophosphorous pesticides; Stress

Indexed keywords

ACETYLCHOLINESTERASE; INSECTICIDE; OBIDOXIME; ORGANOPHOSPHATE; ORGANOPHOSPHORUS COMPOUND;

CENTRAL NERVOUS SYSTEM DISEASE; CHEMICALLY INDUCED DISORDER; COGNITION; COGNITIVE DEFECT; DRUG EFFECT; HUMAN; REVIEW;

ACETYLCHOLINESTERASE; CENTRAL NERVOUS SYSTEM DISEASES; COGNITION; COGNITION DISORDERS; HUMANS; INSECTICIDES; OBIDOXIME CHLORIDE; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHORIC ACID ESTERS;

EID: 33745762211     PISSN: 04655893     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (83)

1. Walker B., Nidiry J.: Current concepts: Organophosphate toxicity. Inhalation Toxicol., 2002;14:975-990
2. Ecobichon D.J.: Pesticide use in developing countries. Toxicology, 2001;160:27-33
3. Feldman R.G.: Organophosphorus compounds. W: Feldman R.G. [red.]. Occupational and Environmental Neurotoxicology. Lippincott-Raven, Philadelphia - New York, 1999, ss. 421-441
4. Abou-Donia M.B.: Organophosphorus ester-induced chronic neurotoxicity. Arch. Environ. Health, 2003;58:484-497
5. Senanayake N., Karalliedde L.: Neurotoxic effects of Organophosphorus insecticides. An intermediate syndrome. N. Engl. J. Med., 1987;316:761-763
6. John M., Oommen A., Zachariah A.: Muscle injury in organophosphorous poisoning and its role in the development of intermediate syndrome. Neurotoxicology, 2003;24:43-53
7. Kaufer D., Soreq H.: Tracking cholinergic pathways from psychological and chemical stressors to variable neurodeterioration paradigms. Curr. Opin. Nurol., 1999;12:739-743
8. Kaufer D., Friedman A., Seidman S., Soreq H.: Anticholinesterases induce multigenic transcriptional feedback response suppressing cholinergic transmission. Chem. Biol. Interact., 1999;119-120:349-360
9. Mesulam M.M., Geula C.: Acetylcholinesterase-rich neurons of the human cerebral cortex: cytoarchitectonic and ontogenetic patterns of distribution. J. Comp. Neurol., 1991;306:193-220
10. Greenfield S., Vaux D.J.: Commentary: Parkinsons disease, Alzheimer's disease and motor neurone disease: identifying a common mechanism. Neuroscience, 2002;113:485-492
11. Grisaru D., Sternfeld M., Amiram E., Click D., Soreq H.: Structural roles of acetylcholinesterase variants in biology and pathology. Eur. J. Biochem., 1999;264:672-686
12. Greenfield S.: Critique: Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochem. Int., 1996;28:485-490
13. Soreq H., Seidman S.: Acetylcholinesterase: New roles for an old actor. Nat. Rev. Neurosci., 2001;2:294-302
14. Silman I., Sussman J.L.: Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology. Curr. Opin. Pharmacol., 2005;5(3):293-302
15. Munoz F.J., Aldunate R., Inestrosa N.C.: Peripheral binding site is involved in the neurotrophic activity of acetylcholinesterase. Neuroreport, 1999;10:3621-3625
16. Chacon M.A., Reyes A.E., Inestrosa N.C.: Acetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus. J. Neurochem., 2003;87:195-208
17. Gralewicz S.: Possible consequences of AChE inhibition in organophosphate poisoning. A new approach to an old problem. Med. Pr., 1997;48(4):469-472
18. Appleyard M.E.: Acetylcholinesterase induces long-term potentiation in CA1 piramidal cells by a mechanism dependent on metabotropis glutamate receptors. Neurosci. Lett., 1995;190:25-28
19. Small D.H., Michaelson S., Sberna G.: Non-classical actions of cholinesterases: Role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochem. Int., 1996;28:453-486
20. Massoulie J.: The origin of the molecular diversity and functional anchoring of cholinesterases. Neurosignals, 2002;11:130-143
21. Massoulie J., Bon S., Perrier N., Falasca C: The C-terminal peptides of acetylcholinesterase: cellular trafficking, oligomerization and functional anchoring. Chem. Biol. Interact., 2005;157-158:3-14
22. Massoulie J., Anselmet A., Bon S., Krejci E., Legay C., Morel N. i wsp.: Acetylcholinesterase: C-terminal domains, molecular forms and functional localization. J. Physiology (Paris), 1998;92:183-190
23. Pick M., Flores-Flores C., Soreq H.: From brain to blood: Alternative splicing evidence for the cholinergic basis of the mammalian stress response. Ann. NY Acad. Sci., 2004;1018:85-98
24. Sussman J.L., Harel M., Frolow F., Oefner C., Goldman A., Toker L., i wsp.: Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein. Science, 1991;253(5022):872-879
25. Ordentlich A., Barak D., Kronman C., Flashner Y., Leitner M., Segall Y,. i wsp.: Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket. J. Biol. Chem., 1993;268:17083-17095
26. Szegletes T., Mallender W.D., Thomas P.J., Rosenberry T.L.: Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect. Biochemistry, 1999;38:122-133
27. Radie Z., Reiner E., Taylor P.: Role of the peripheral anionic site on acetylcholinesterase: inhibition by substrates and coumarin derivatives. Mol. Pharmacol., 1991;39:98-104
28. Marcel V., Gagnoux-Palacios L., Pertuy C., Massen P. Fournier D.: Two invertebrate acetylcholinesterases show activation followed by inhibition with substrate concentration. Biochem. J., 1998;329:329-334
29. Shafferman A., Velan B., Ordentlich A., vKronman C., Grosfeld H., Leitner M. i wsp.: Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center. EMBO J., 1992;11:3561-3568
30. Stojan J., Brochier L., Alies C., Colletier J.P., Fournier I.: Inhibition of Drosophila melanogaster acetylcholinesterase by high concentration of the substrate. Eur. J. Biochem., 2004;271:1364-1371
31. Marchot P.: The fasciculin-acetyicholinesterase interaction. J. Soc. Biol., 1999;193:505-508
32. Marchot P., Khelif A., Ji Y.H., Mansuelle P., Bougis P.E.: Binding of 1251-fasciculin to rat brain acetylcholinesterase. The complex still binds diisopropyl fluorophosphate. J. Biol. Chem. 1993;268:12458-12467
33. Brimijoin S., Koenigsberger C.: Cholinesterases in neural development: new findings and lexicological implications. Environ Health Perspectives, 1999;107(Suppl.1):59-69
34. Olivera S., Rodriguez-Ithurralde D., Henleya J.M.: Acetylcholinesterase promotes neurite elongation, synapse formation, and surface expression of AMPA receptors in hippocampal neurones. Mol. Cell. Neurosci., 2003;23:96-106
35. Day T., Greenfield S.: A noncholinergic, trophic action of acetylcholinesterase on hippocampal neurones in vitro: molecular mechanisms. Neuroscience, 2002;111:649-656
36. Srivatsan M., Peretz B.: Acetylcholinesterase promotes regeneration of neurites in cultured adult neurons of aplysia. Neuroscience, 1997;77:921-931
37. Bigbee J.W., Sharma K.V., Gupta J.J., Dupree J.L.: Morphogenic role for acetylcholinesterase in axonal outgrowth during neural development. Environ. Health Perspectives, 1999;107(Supl. 1):81-87
38. Johnson G., Moore S.W.: The adhesion function on acetylcholinesterase is located at the peripheral anionic site. Biochem. Biophys. Res. Comm., 1999;258:758-762
39. Dong H., Xiang Y.Y., Farchi N., Ju W., Wu Y., Chen L., i wsp.: Excessive expression of acetylcholinesterase impairs glutamatergic synaptogenesis in hippocampal neurons. J. Neurosci., 2004;24:8950-8960
40. Dori A., Cohen J., Silverman WE, Pollack Y., Soreq H.: Functional manipulations of acetylcholinesterase splice variants highlight alternative splicing contributions to murine neocortica development. Cerebral Cortex, 2005;15:420-430
41. Altman J., Bayer S.A.: Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal period. J. Comp. Neurol., 1990;301:365-381
42. Gould E., McEwen B.S., Tanapat P., Galea J.A.M., Fuchs E.: Neurogenesis in the dentate gyrus of the adult tree shrew is regulatec by psychosocial stress and NMDA receptor activation. J. Neurosci., 1997;17:2492-2498
43. Harman A., Meyer P., Ahmat A.: Neurogenesis in the hippocampus of an adult marsupial. Brain Behav. Evol., 2003;62:1-12
44. Holmes C., Jones S.A., Budd T.C., Greenfield S.A.: Non-cholinergic, trophic action of recombinant acetylcholinesterase on mid-brain dopaminergic neurons. J. Neurosci. Res., 1997;49:207-18
45. Appleyard M.E., Vercher J., Greenfield S.A.: Release of acetylcholinesterase from the guinea-pig cerebellum in vivo. Neuroscience, 1988;25:133-138
46. Heiland B., Greenfield S.A.: Rat locomotion and release of acetylcholinesterase. Pharmacol. Biochem. Behav., 1999;62:81-7
47. Hawkins C.A., Greenfield S.A.: Non-cholinergic action of exogenous acetylcholinesterase in the rat substantia nigra. II. Long-term interactions with dopamine metabolism. Behav. Brain. Res., 1992;48:159-63
48. Vanderschuren L.J., Kalivas P.W.: Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies. Psychopharmacology (Berl), 2000;151:99-120
49. Dally J.J., Schaefer M., Greenfield S.A.: The spontaneous release of acetylcholinesterase in rat substantia nigra is altered by local changes in extracellular levels of dopamine. Neurochem. Int., 1996;29:629-35
50. Talesa V.N.: Acetylcholinesterase in Alzheimer's disease. Mech. Ageing Dev., 2001;122:1961-1969
51. Fishman E.B., Siek G.C., MacCallum R.D., Bird E.D., Volicer L., Marquis J.K.: Distribution of the molecular forms of acetylcholinesterase in human brain: alterations in dementia of the Alzheimer type. Ann. Neurol., 1986;19:246-252
52. Geula C., Mesulam M.: Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease. Brain. Res., 1989;498:185-189
53. Inestrosa N.C., Alvarez A., Perez C.A., Moreno R.D., Vicente M., Linker C. i wsp.: Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme. Neuron, 1996;16:881-891
54. Carafoli E.: The ambivalent nature of the calcium signal. J. Endocrinol. Invest., 2004;27:134-136
55. Arendt T.: Alzheimer's disease as disorder of mechanisms underlying structural brain self-organization. Neuroscience, 2001;102:723-765
56. Layer P.G.: Nonclassical roles of cholinesterases in the embryonic brain and possible links to Alzheimer disease. Alzheimer. Dis. Assoc. Disord., 1995;9:29-36
57. + hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferation. Experim. Hematology, 2002;30:1153-1164
58. Branduardi D., Gervasio F.L., Cavalli A., Recanatini M., Parinello M.: The role of the peripheral anionic sole and cation-pi interactions in the ligand penetration of the human AChE gorge. Am. Chem. Soc., 2005;127:9147-9155
59. Chiappa S., Padilla S., Koenigsberger C., Moser V., Brimijoin S.: Slow accumulation of acetylcholinesterase in rat brain during enzyme inhibition by repeated dosing with chlorpyriphos. Biochem. Pharmacol., 1995;49:955-963
60. Wilson B.W., Nieberg P.S.: Recovery of acetylcholinesteraze forms in quail muscle cultures after intoxication with diisopropylfluorophosphate. Biochem. Pharmacol., 1983;32:911-918
61. Cisson C.M., Wilson B.W.: Recovery of acetylcholinesterase in cultured chick embryo muscle treated with paraoxon. Biochem. Pharmacol., 1977;26:1955-1960
62. Kaufer D., Friedman A., Seidman S., Soreq H.: Acute stress facilitates long-lasting changes in cholinergic gene expression, Nature, 1998;393:373-377
63. Nitch R.M., Rossner S., Albrecht C., Mayhaus M., Enderich J., Schliebs R. i wsp.: Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. J. Physiol. (Paris), 1998;92:257-264
64. Shapira M., Tur-Kaspa I., Bosgraaf L., Livni N., Grant A.D., Grisaru D. i wsp.: A transcription-activating polymorphism in the ACHE promoter associated with acute sensitivity to anti-acetylcholinesterases. Hum. Mol. Genet., 2000;9:1273-1281
65. Meshorer E., Toiber D., Zurel D., Sahly I., Amir Dori A., Cagnano E. i wsp: Combinatorial complexity of 5′ alternative acetylcholinesterase transcripts and protein products. J. Biol. Chem., 2004;279:29740-29751
66. Grisaru D., Deutsch V., Shapira M., Pick M., Sternfeld M., Melamed-Book N. i wsp: ARP, a peptide derived from the stress-associated acetylcholinesterase variant has hematopoietic growth promoting activities. Mol. Med., 2001;7:93-105
67. Nijholt I., Farchi N., Kye M., Sklan E.H., Shoham S., Verbeure B. i wsp: Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiation. Mol. Psychiatry, 2004;9:174-183
68. Aluigi M.G., Angelini C., Falugi C., Fossa R., Genever P., Gallus L. i wsp.: Interaction between organophosphate compounds and cholinergic functions during development. Chem. Biol. Interact., 2005;157-158:305-316
69. Slotkin T.A.: Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: A personal view from an academic perspective. Neurotoxicology, 2004;25:631-640
70. Zdankiewicz-Ścigała E, Przybylska M.: Trauma: Proces i Diagnoza. W: Jurkowlaniec Z. [red.], Mechanizmy psychoneurofizjologiczne. Wydawnictwo Instytutu Psychologii PAN, Szkoła Wyższa Psychologii Spolecznej, Warszawa 2002
71. Birikh K., Sklan E., Shoham S., Soreq H.: Interaction of "Readthrough" acetylcholinesterase with RACK1 PKCβII correlates with intensified fear induced conflict behavior. Proc. Natl. Acad. Sci. USA, 2003;100:283-288
72. Cohen O., Erb C., Ginzberg D., Pollak Y., Seidman S., Shoham S. i wsp.: Neuronal overexpression of "readthrough" acetylcholinesterase is associated with antisense-suppressible behavioral impairments. Mol. Psychiatry, 2002;7:874-885
73. Ray D.E., Richards P.G.: The potentialfor toxic effercts of chronic, low-dose exposure to organophosphates. Toxicol. Lett., 2001;120:343-351
74. Kamel F., Hoppion J.: Association of pesticide exposure with neurologic dysfunction and disease. Environ. Health. Perspect., 2004;112:950-958
75. Antelman S.M., Eichler A.J., Black C.A., Kocan D.: Interchangeability of stress and amphetamine in sensitization. Science 1980;207:329-331
76. Gralewicz S., Lutz P., Tomas T.: Behavioural responsiveness to amphetamine or scopolamine following repeated exposure to chlorphenvinphos in rats. Act Neurobiol. Exp. (Wars), 2002;62:75-83
77. Brenner T., Hamra-Amitay Y., Evron T., Boneva N., Seidman S., Soreq H.:: The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis. FASEB J., 2003;17:214-222
78. Farchi N., Soreq H., Hochner B.: Chronic acetylcholinesterase overexpression induces multilevelled aberrations in mouse neuromuscular physiology. J. Physiol., 2003;546:165-173
79. Lev-Lehman E., Evron T., Broide R.S., Meshorer E., Ariel I., Seidman S. i wsp.: Synaptogenesis and myopathy under acetylcholinesterase overexpression. J. Mol. Neurosci., 2000;14:93-105
80. van Praag H., Schinder A.F., Christie B.R., Toni N., Palmer T.D., Gage F.H. Functional neurogenesis in the adult hippocampus. Nature, 2002;415:1030-1034
81. Eriksson P.S., Perfilieva E., Bjork-Ericksson T, Alborn A.M., Nordborg C., Peterson D.A. i wsp.: Neurogenesis in the adult human hippocampus. Nat. Med., 1998;4:1313-1317
82. Kempermann G., Kronenberg G.: Depressed new neurons-adult hippocampal neurogensis and a cellular plasticity hypothesis of major depression. Biol. Psychiatry, 2003;54:499-503
83. Gralewicz S., Lutz P., Kur B.: Pretreatment with footshock alters some effects of subsequent organophosphate exposure. Neurotoxicology, 2005;26:159-171