Estrogenic activity of pharmaceuticals and pharmaceutical mixtures in a yeast reporter gene system

Reproductive Toxicology

Volumn 22, Issue 2, 2006, Pages 175-185

  Fent, Karl ^a,b   Escher, Claudia ^a,b   Caminada, Daniel ^a,c  

^a UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Ecotoxicological effects; Endocrine disrupters; Environmental toxicology; Estrogenic activity; Mixture activity; Pharmaceuticals

Indexed keywords

ACEBUTOLOL; ANALGESIC AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIINFLAMMATORY AGENT; ANTILIPEMIC AGENT; ATENOLOL; ATORVASTATIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BEZAFIBRATE; CARBAMAZEPINE; CIMETIDINE; CLOFIBRIC ACID; DICLOFENAC; ENDOCRINE DISRUPTOR; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FENOFIBRATE; FUROSEMIDE; IBUPROFEN; MEFENAMIC ACID; METFORMIN; METHOTREXATE; METOPROLOL; NAPROXEN; PARACETAMOL; PHENAZONE; PRAVASTATIN; TAMOXIFEN; UNINDEXED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DRUG ACTIVITY; ECOTOXICOLOGY; ESTROGEN ACTIVITY; FUNGAL GENETICS; NONHUMAN; REPORTER GENE; YEAST;

DRUG INTERACTIONS; ESTROGEN RECEPTOR ALPHA; ESTROGENS; GENES, REPORTER; PHARMACEUTICAL PREPARATIONS; YEASTS;

EID: 33745750345     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2006.04.010     Document Type: Article

References (37)

1. Fent K., Weston A.A., and Caminada D. Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76 (2006) 122-159
2. Laville N., Ait-Aissa S., Gomez E., Casellas C., and Porcher J.M. Effects of human pharmaceuticals on cytotoxicity, EROD activity and ROS production in fish hepatocytes. Toxicology 196 (2004) 41-55
3. Daughton C.G., and Ternes T.A. Pharmaceuticals and personal care products in the environment: agents of subtle change?. Environ Health Persp 107 Suppl 6 (1999) 907-938
4. Halling-Sorensen B., Nors Nielsen S., Lanzky P.F., Ingerslev F., Holten Lutzhoft H.C., and Jorgensen S.E. Occurrence, fate and effects of pharmaceutical substances in the environment-a review. Chemosphere 36 (1998) 357-393
5. Kümmerer K. Pharmaceuticals in the environment. 2nd ed. (2004), Springer Verlag
6. Ternes T., Jos A., and Siegrist H. Scrutinizing pharmaceutical and personal care products in wastewater treatment. Environ Sci Technol (2004) 393-399
7. Kolpin D.W., Skopec M., Meyer M.T., Furlong E.T., and Zaugg S.D. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. Environ Sci Technol 36 (2002) 1202-1211
8. Fent K. Ecotoxicological effects at contaminated sites. Toxicology 205 (2004) 223-240
9. Hartmann A., Alder A.C., Koller T., and Widmer R.M. Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater. Environ Toxicol Chem 17 (1998) 377-382
10. Heberer T. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol Lett 131 (2002) 5-17
11. Kümmerer K. Significance of antibiotics in the environment. J Antimicrob Chemo 52 (2003) 5-7
12. Ashton D., Hilton M., and Thomas K.V. Investigating the environmental transport of human pharmaceuticals to streams in the United Kingdom. Sci Total Environ 333 (2004) 167-184
13. Brian J.V., Harries C.A., Scholze M., Backhaus T., Booy P., Lamoree M., et al. Accurate prediction of the response of freshwater fish to a mixture of estrogenic chemicals. Environ Health Perspect 113 (2005) 722-728
14. Sumpter J.P., and Johnson A.C. Lessons from endocrine disruption and their application to other issues concerning trace organics in the aquatic environment. Environ Sci Technol 39 (2005) 4321-4332
15. Thorpe K.L., Cummings R.I., Hutchinson T.H., Scholze M., Brighty G., Sumpter J.P., et al. Relative potencies and combination effects of steroidal estrogens in fish. Environ Sci Technol 37 (2003) 1142-1149
16. Purdum C.E., Hardiman P.A., Bye V.J., Eno N.C., Tyler C.R., and Sumpter J.P. Oestrogenic effects of effluent from sewage treatment works. Chem Ecol 8 (1994) 275-285
17. Van Aerle R., Rounds N., Hutchinson T.H., Maddix S., and Tyler C.R. Window of sensitivity for the estrogenic effects of ethinylestradiol in early life-stages of fathead minnow. Ecotoxicology 11 (2002) 423-434
18. Länge R., Hutchinson T.H., Croudace C.P., and Siegmund F. Effects of the synthetic estrogen 17 alpha-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas). Environ Toxicol Chem 20 (2001) 1216-1227
19. Nash J.P., Kime D.E., Van der Ven L.T., Wester P.W., Brion F., Maack G., et al. Long-term exposure to environmental concentrations of the pharmaceutical ethynylestradiol causes reproductive failure in fish. Environ Health Perspect 112 (2004) 1725-1735
20. Damstra T, Barlow S, Bergman A, Kavlock R, van der Kraak G., Global assessment of the state of the science of endocrine disruptors. WHO/PCS/EDC/022 2002.
21. Rajapakse N., Silva E., Scholze M., and Kortenkamp A. Deviation from additivity with estrogenic mixtures containing 4-nonylphenol and 4-tert-ocylphenol detected in the E-SCREEN assay. Environ Sci Technol 38 (2004) 6343-6352
22. Kunz P.Y., Galicia H.F., and Fent K. Comparison of in vitro and in vivo estrogenic activity of UV filters in fish. Toxicol Sci 90 (2006) 349-361
23. Vom Saal F.S., and Hughes C. An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment. Environ Health Perspect 113 (2005) 926-933
24. Swan S.H., et al. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect 113 (2005) 1056-1061
25. Kortenkamp A., and Altenburger R. Synergisms with mixtures of xenoestrogens: a reevaluation using the method of isoboles. Sci Total Environ 221 (1998) 59-73
26. Silva E., Rajapakse N., and Kortenkamp A. Something from "nothing"-eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects. Environ Sci Technol 36 (2002) 1751-1756
27. Rajapakse N., Silva E., and Kortenkamp A. Combining xenoestrogens at levels below individual no-observed effect concentrations dramatically enhances steroid hormone action. Environ Health Perspect 110 (2002) 917-921
28. Payne J., Rajapakse N., Wilkins M., and Kortenkamp A. Prediction and assessment of effects of mixtures of four xenoestrogens. Environ Health Perspect 108 (2000) 983-987
29. Backhaus T., Arrhenius A., and Blanck H. Toxicity of a mixture of dissimilarly acting substances to natural algal communities: predictive power and limitations of independent action and concentration addition. Environ Sci Technol 38 (2004) 6363-6370
30. Gagne F., Blaise C., and Andre C. Occurrence of pharmaceutical products in a municipal effluent and toxicity to rainbow trout (Oncorhynchus mykiss) hepatocytes. Ecotox Environ Saf (2005)
31. Mimeault C., Woodhouse A.J., Miao X.S., Metcalfe C.D., Moon T.W., and Trudeau V.L. The human lipid regulator, gemfibrozil bioconcentrates and reduces testosterone in the goldfish, Carassius auratus. Aquat Toxicol 73 (2005) 44-54
32. Routledge E.J., and Sumpter J.P. Estrogenic activity of surfactans and some of their degradation products assessed using a recombinant yeast screen. Environ Toxicol Chem 15 (1996) 241-248
33. Altenburger R., Walter H., and Grote M. What contributes to the combined effect of a complex mixture?. Environ Sci Technol 38 (2000) 6353-6362
34. Sohoni P., and Sumpter J.P. Several environmental oestrogens are also anti-androgens. J Endocrinol 158 (1998) 327-339
35. Castiglioni S., Bagnati R., Fanelli R., Calamari D., and Zuccato E. Removal of pharmaceuticals in sewage treatment plants in Italy. Environ Sci Technol 40 (2006) 357-363
36. EMEA. Note for guidance on environmental risk assessment of medicinal products for human use, CMPC/SWP/4447/draft. The European Agency for the evaluation of medicinal products (EMEA), London, 20 January 2005.
37. Weigel S., Berger U., Jensen E., Kallenborn R., Thorensen H., and Hühnerfuss H. Determination of selected pharmaceuticals and caffeine in sewage and seawater from Tromso/Norway with emphasis on ibuprofen and its metabolites. Chemosphere 56 (2004) 583-592